11 results about "Oxysterol" patented technology

Compounds are provided according to Formula (III):and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R2, R3, R5, and n are as defined herein, and at least one hydrogen is replaced with a deuterium. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

The application provides application of oxysterol binding protein OSBPL2 as a colorectal cancer molecular marker and a treatment target, relates to the technical field of colorectal cancer, and provides application of oxysterol binding protein OSBPL2 as a colorectal cancer molecular marker, application of oxysterol binding protein OSBPL2 in preparation of reagents for detecting colorectal cancer, tissue chips and patient serum, and use of an activator of OSBPL2 gene or OSBPL2 protein in preparation of a drug for preventing and / or treating colorectal cancer. The discovery of OSBPL2 as the colorectal cancer molecular marker can be used for predicting, diagnosing and detecting colorectal cancer, provides a new experimental theoretical basis and a new direction for further studying the pathogenesis of colorectal cancer and exploring the treatment target of colorectal cancer, and can be applied in the field of preparing reagents for predicting, diagnosing and detecting colorectal cancer patients or colorectal cancer treatment drugs, and enriches the diagnosis, detection and treatment means of colorectal cancer.

Pesticide mixtures comprising as active compounds: 1) 1-[(1RS)-1,2-dimethylpropyl]-N-ethyl-5-methyl-N-pyridazin-4-yl-1H-pyrazol-4-carboxamide and 2) at least one other compound B selected from B.1) succinate dehydrogenase inhibitors as defined in the description; B.2) oxysterol-binding protein inhibitors as defined in the description; B.3) complex III inhibitors at the Qi site selected from: a) fluoroylpicoxamid, and b) fenpicoxamid; B.4) strobilurins as defined in the description; B.5) C14-demethylase inhibitors in sterol biosynthesis as defined in the description; B.6) Cell division and cytoskeleton inhibitors as defined in the descriptive memorandum, B.7) Other compounds of unknown mode of action as defined in the descriptive memorandum; and B.8) N-[[2-fluoro-4-[(2S,3S)-2-hydroxy-3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]phenyl]methyl]cyclopropancarboxamide; wherein Component 1) and Component 2) are present in a weight ratio of 1000:1 to 1:1000; methods and use of these mixtures for combating invertebrate pests such as insects, arachnids, nematodes and / or harmful fungi in and on plants, and for protecting such plants against infestation by pests and / or harmful fungi.