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5 results about "Oxysterol" patented technology

An oxysterol is a derivative of cholesterol obtained by oxidation involving enzymes and / or pro-oxidants. Such compounds play important roles in various biological processes such as cholesterol homeostasis, lipid metabolism (sphingolipids, fatty acids), apoptosis, autophagy, and prenylation of proteins; the mode of action of oxysterols in these effects is still poorly understood. Several oxysterols are associated with age-related diseases such as cardiovascular disease, eye disease (cataract, age-related macular degeneration), certain neurodegenerative diseases and cancers. The activities of oxysterols in these diseases could be due to their pro-oxidative and pro-inflammatory activities and their ability to act on cellular organelles (mitochondria, peroxisome, lysosome) that can contribute to activate apoptosis and autophagy. There are lot of arguments supporting that oxysterols have important roles in atherosclerosis progression which is involved in several cardiovascular diseases.

PESTICIDE MIXTURES COMPRISING A PYRAZOLE COMPOUND

ActiveMX431395BPyridazineNematode
Pesticide mixtures comprising as active compounds: 1) 1-[(1RS)-1,2-dimethylpropyl]-N-ethyl-5-methyl-N-pyridazin-4-yl-1H-pyrazol-4-carboxamide and 2) at least one other compound B selected from B.1) succinate dehydrogenase inhibitors as defined in the description; B.2) oxysterol-binding protein inhibitors as defined in the description; B.3) complex III inhibitors at the Qi site selected from: a) fluoroylpicoxamid, and b) fenpicoxamid; B.4) strobilurins as defined in the description; B.5) C14-demethylase inhibitors in sterol biosynthesis as defined in the description; B.6) Cell division and cytoskeleton inhibitors as defined in the descriptive memorandum, B.7) Other compounds of unknown mode of action as defined in the descriptive memorandum; and B.8) N-[[2-fluoro-4-[(2S,3S)-2-hydroxy-3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]phenyl]methyl]cyclopropancarboxamide; wherein Component 1) and Component 2) are present in a weight ratio of 1000:1 to 1:1000; methods and use of these mixtures for combating invertebrate pests such as insects, arachnids, nematodes and / or harmful fungi in and on plants, and for protecting such plants against infestation by pests and / or harmful fungi.
Owner:BASF SE