18 results about "Oxysterol" patented technology

The invention provides a 5alpha, 8alpha-peroxysterol compound, or a stereoisomer, a tautomer, a geometric isomer, a deuterated compound and a pharmaceutically acceptable salt thereof, the structural formula of the 5alpha, 8alpha-peroxysterol compound is as follows: # imgabs0 #, the # imgabs1 # represents a single bond or a double bond, and the # imgabs2 # represents a single bond or a double bond; r1 is selected from # imgabs2 # R1a, R2a and R3a are respectively selected from hydrogen and C1-6 alkyl groups; and R2 is selected from a hydroxyl group and a C1-6 alkoxy group. The invention also provides an application of the 5alpha, 8alpha-peroxysterol compound in preparation of an anti-inflammatory drug, especially an anti-neuroinflammation drug.

Compounds are provided according to Formula (III):and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R2, R3, R5, and n are as defined herein, and at least one hydrogen is replaced with a deuterium. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

The application provides application of oxysterol binding protein OSBPL2 as a colorectal cancer molecular marker and a treatment target, relates to the technical field of colorectal cancer, and provides application of oxysterol binding protein OSBPL2 as a colorectal cancer molecular marker, application of oxysterol binding protein OSBPL2 in preparation of reagents for detecting colorectal cancer, tissue chips and patient serum, and use of an activator of OSBPL2 gene or OSBPL2 protein in preparation of a drug for preventing and / or treating colorectal cancer. The discovery of OSBPL2 as the colorectal cancer molecular marker can be used for predicting, diagnosing and detecting colorectal cancer, provides a new experimental theoretical basis and a new direction for further studying the pathogenesis of colorectal cancer and exploring the treatment target of colorectal cancer, and can be applied in the field of preparing reagents for predicting, diagnosing and detecting colorectal cancer patients or colorectal cancer treatment drugs, and enriches the diagnosis, detection and treatment means of colorectal cancer.

The invention relates to the technical field of biological materials, and discloses a sulfated polysaccharide hypoxic sterol derivative as well as a preparation method and application thereof, and the preparation method comprises the following steps: (1) synthesizing a sterol derivative modified by a hypoxic response group; and (2) synthesizing the sulfated polysaccharide hypoxic sterol derivative. A thrombolytic drug urokinase is used as a model drug, sulfated polysaccharide is used as a raw material, a block copolymer sulfated polysaccharide hypoxic sterol derivative is synthesized through azobenzene bond (hypoxic response) coupling and other amide reactions, and the sulfated polysaccharide hypoxic sterol derivative (at) UK liposome with hypoxic response can be further obtained through a multiple emulsion method. The liposome can be specifically combined with high-expression P-selectin at the thrombus part, so that the liposome has targeting property, and can realize directional administration with loaded urokinase, so that the medicament can be loaded into the focus part in a targeted manner, the bleeding side effect of the thrombolytic medicament urokinase is reduced, the half-life period of the thrombolytic medicament urokinase is prolonged, and the bioavailability of the urokinase is improved.

Pesticide mixtures comprising as active compounds: 1) 1-[(1RS)-1,2-dimethylpropyl]-N-ethyl-5-methyl-N-pyridazin-4-yl-1H-pyrazol-4-carboxamide and 2) at least one other compound B selected from B.1) succinate dehydrogenase inhibitors as defined in the description; B.2) oxysterol-binding protein inhibitors as defined in the description; B.3) complex III inhibitors at the Qi site selected from: a) fluoroylpicoxamid, and b) fenpicoxamid; B.4) strobilurins as defined in the description; B.5) C14-demethylase inhibitors in sterol biosynthesis as defined in the description; B.6) Cell division and cytoskeleton inhibitors as defined in the descriptive memorandum, B.7) Other compounds of unknown mode of action as defined in the descriptive memorandum; and B.8) N-[[2-fluoro-4-[(2S,3S)-2-hydroxy-3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]phenyl]methyl]cyclopropancarboxamide; wherein Component 1) and Component 2) are present in a weight ratio of 1000:1 to 1:1000; methods and use of these mixtures for combating invertebrate pests such as insects, arachnids, nematodes and / or harmful fungi in and on plants, and for protecting such plants against infestation by pests and / or harmful fungi.

The present invention addresses the problem of providing a new prophylactic or therapeutic agent for a kidney diseases. Provided is a prophylactic or therapeutic agent for polycystic kidney disease, the agent comprising, as an active ingredient, a compound that promotes intermolecular interaction between an oxysterol-binding protein-related protein-3 (ORP3) and an endoplasmic vesicle protein-associated protein-A (VAP-A) in a cell, and has a cholesterol increasing effect in primary cilia of the cell, or a pharmaceutically acceptable salt thereof.