161 results about "Mode of action" patented technology

A method and system for utilizing neurophysiologic information obtained by techniques such as quantitative electroencephalography (QEEG), electrode recordings, MRI in appropriately matching patients with therapeutic entities is disclosed. The present invention enables utilization of neurophysiologic information, notwithstanding its weak correlation with extant diagnostic schemes for mental disorders, for safer and expeditious treatment for mental disorders, discovering new applications for therapeutic entities, improved testing of candidate therapeutic entities, inferring the presence or absence of a desirable response to a treatment, and deducing the mode of action of one or more therapeutic entities. In particular, methods for effectively comparing neurophysiologic information relative to a reference set are disclosed along with database-based tools for deducing therapeutic entity actions on particular patients such that these tools are readily accessible to remote users.

Nanocells allow the sequential delivery of two different therapeutic agents with different modes of action or different pharmacokinetics. A nanocell is formed by encapsulating a nanocore with a first agent inside a lipid vesicle containing a second agent. The agent in the outer lipid compartment is released first and may exert its effect before the agent in the nanocore is released. The nanocell delivery system may be formulated in pharmaceutical composition for delivery to patients suffering from diseases such as cancer, inflammatory diseases such as asthma, autoimmune diseases such as rheumatoid arthritis, infectious diseases, and neurological diseases such as epilepsy. In treating cancer, a traditional antineoplastic agent is contained in the outer lipid vesicle of the nanocell, and an antiangiogenic agent is loaded into the nanocore. This arrangement allows the antineoplastic agent to be released first and delivered to the tumor before the tumor's blood supply is cut off by the antianiogenic agent.

The subject invention relates in part to Cry34Ab/35Ab in combination with Cry6Aa. The subject invention relates in part to the surprising discovery that combinations of Cry34Ab/Cry35Ab and Cry6Aa are useful for preventing development of resistance (to either insecticidal protein system alone) by a corn rootworm (Diabrotica spp.) population. Included within the subject invention are plants producing these insecticidal Cry proteins, which are useful to mitigate concern that a corn rootworm population could develop that would be resistant to either of these insecticidal protein systems alone. Plants (and acreage planted with such plants) that produce these two insecticidal protein systems are included within the scope of the subject invention. The subject invention also relates in part to combinations of Cry34Ab/35Ab and Cry3Aa proteins “triple stacked” with a Cry6Aa protein. Transgenic plants, including corn, comprising a cry6Aa gene, cry34Ab/35Ab genes, and a cry3Aa gene are included within the scope of the subject invention. Thus, such embodiments target rootworms with three modes of action.

The problem of the present invention is to provide a preventive and/or therapeutic agent for diabetes and/or complications of diabetes based on the novel mode of action.

The protease-inhibiting compound according to the present invention is a compound represented by the general formula (I)

[wherein all the symbols have the same meanings as described in the specification], its salt or solvate, or a prodrug thereof, is useful as a preventive and/or therapeutic agent for diabetes and/or complications of diabetes.

A modular electrical switch and electrical switching device includes a housing detachably mounted relative to the switching element and replaceable by another housing for a different control, and detachably fixed relative to the switching element in order to change to electrical function of the switching element or the mode of action of the switching element. The invention is particularly applicable in truck-like vehicles.

To make a laminated structure comprising a panel made of composite materials and placed flat against at least one metal plate, the panel and the plate are presented in a stack, this stack is drilled to form a fastening borehole, a fastening rod is introduced into the bore and the fastener is fixed. In the invention, during the drilling, a negative clearance is made between a diameter of the bore and a diameter of the fastener, and when the fastener is being introduced, it is introduced from the metal plate. This mode of action prompts a positive interference that promotes the lasting nature of the fastener.

According to the present invention a new isolate of a Pseudomonas spp, DSM 21663, has been shown to possess unique properties. This Pseudomonas is a plant growth-promoting rhizobacterium (PGPR). Among its modes of action involved in plant growth-promotion are anti-biotic production (2,4-diacetylphloroglucinol, (DAPG); pyrrolnitrin, PRN and others), indole-3-acetic acid (IAA) production and phosphate solubilization, and production of unique volatiles. The strain is fluorescent, oxidase-positive, and has the ability to suppress soil-borne root and foliar pathogens of both fungal and bacterial origin.

The instant invention features compounds, for example, 5-HT₃ receptor antagonists, having a peripherally restricted mode of action such that the compounds affect 5-HT₃ receptors of the peripheral nervous system with diminished or reduced effects in the central nervous system. The compounds are particularly useful in treating disorders or conditions ameliorated by antagonism of peripheral 5-HT₃ receptors. Moreover, side-effects attributable to antagonism of central 5-HT₃ receptors can be lessened or reduced using the peripherally restricted compounds of the invention.

Aerosols that include ceragenin compounds (i.e., ceragenin-containing aerosols), methods for delivering such aerosols, and devices for delivering such aerosols. Ceragenins can be used to kill a broad range of microbes (e.g., bacteria, viruses, fungi, bacterial spores, fungal spores, and the like), yet they are thought to be completely non-toxic to humans and other higher eukaryotes. Aerosols can penetrate into the nooks and crannies of a space and kill microbes that may lurk in a space. In addition, ceragenins have a extended mode of action, which allows them to continue killing microbes in a space for an extended period of time.

The invention relates to a method for treating tetracycline waste water with an iron-modified attapulgite adsorbent, which is characterized in that concentration of tetracycline in the waste water is 5-150mg/L. The iron-modified attapulgite adsorbent is added in the tetracycline waste water, and mass ratio of the tetracycline waste water to the adsorbent is 1: (4-6). The adsorption process adopts a static mode of action and/or an oscillating and stirring mode of action at the temperature of 0-50 DEG C. The method aims at the waste water polluted by tetracycline and removes tetracycline by adding the iron-modified attapulgite adsorbent in the waste water for adsorption. The method has the advantages of having high adsorption efficiency for tetracycline compounds, simple operational process, low requirements for adsorption conditions, low cost of adsorption materials and high regeneration efficiency and being easy to popularize. The method is used for removing tetracycline compounds in a water body and has good economic and environmental benefits.

The invention discloses a method for simulating urban expansion based on the division of spatial functions. The method of the invention fully considers the widespread existence of obstacles in urban expansion, the existence of multi-space entities, and the different modes of action of each entity. Heterogeneity features reasonably divide urban space, define the spatial function of different morphological entities, and construct reasonable conversion rules for each region. The process of urban expansion can be more realistically simulated by adopting the method of the invention.

An ATR-FTIR device and system are described that defect live-cell responses to stimuli and perturbations in real-time. The system and device can monitor perturbations resulting from exposures to various physical, chemical, and biological materials in real-time, as well as those sustained over a long period of time, including those associated with stimuli having unknown modes-of-action (e.g. nanoparticles). The device and system can also be used to identify specific chemical species or substances that profile cellular responses to these perturbations.

The invention provides an evaluation method of an overall process dynamic voltage stabilization margin based on time domain simulation. The method comprises the steps that (1) a network topology and a system dynamic element model are constructed according to a computation requirement; a tidal stream file and a stable file required by system computation are established; element parameters are input according to actual conditions of a system; (2) tidal stream data is read in; a tidal stream solution is computed; a destination file is generated; (3) stable data is read in; a fault type and a load growth area or a bus name and a load growth rate are determined; action modes of dynamic elements such as a load, a ULTC (under load tap changer) and overexictation limitation are considered; a fault card and a load growth control statement are filled in; stability computation is performed; and (4) result analysis is performed according to the sustainable load growth time obtained according to simulation computation. According to the evaluation method, a result of successive action of load growth and the generator overexictation limitation or the ULTC can be computed, and a result of synchronous action of each element can be obtained, so that a simulation result can correspond with actual running conditions more.

The invention relates to a drilling tool for breaking rocks by producing the compound action through a rotary-percussion mode. The drilling tool is fixedly installed on the upper portion of a drill bit and comprises a power end, a percussion shaft assembly and a lower tool assembly; the rear end of the percussion shaft is connected with the power end, and the front end of the percussion shaft is connected with the lower tool assembly; the power end enables a turbine to work under the slurry pressure and drives an upper shaft to rotate, the turning moment and the torque are transmitted to the percussion shaft through a square active connection, the percussion shaft impacts an anvil, and the impact force of the rotary-percussion mode action is applied to the drill bit. The mode of action of the novel drilling tool is the percussion action mode, the up and down reciprocating action of the percussion shaft is achieved by means of interaction of cam mechanisms, the novel drilling tool breaks the rocks in an oscillation and shearing mode, the contact time with the bottom layer can be shortened, the wearing degree of the drill bit can be reduced, the service life of the drill bit is prolonged, and meanwhile the borehole quality can be optimized.

The invention discloses an active above-knee prosthesis terminal sliding mode control method based on a disturbance observer. The method includes the steps that basic information data of a patient is collected in an off-line mode, and a data report is generated; on the premise of not changing the basic structure and the interaction mode, the lower limbs of the human body are simplified into a two-link model to be analyzed, the lower limb kinetic model of the supporting period and the swing period is obtained aiming at the difference between the swing period and supporting period motion form in the human body walking process; the disturbance observer and a terminal sliding mode controller are designed for the lower limb kinetic model. The sliding mode variable structure control theory is introduced into control over active above-knee prosthesis, while advantages of disturbance resisting capacity and quick response of traditional sliding mode control are reserved, the buffeting degree of controlled quantity is weakened, and the tracking errors of a model system can be converged to zero within limited time. The method has the advantages of being high in control accuracy, high in disturbance resisting capacity and good in timeliness.

Random sequence oligonucleotides that have antiviral activity are described, along with their use as antiviral agents. In many cases, the oligonucleotides are greater than 40 nucleotides in length. Also described are methods for the prophylaxis or treatment of a viral infection in a human or animal, and a method for the prophylaxis treatment of cancer caused by oncoviruses in a human or animal. The methods typically involve administering to a human or animal in need of such treatment, a pharmacologically acceptable, therapeutically effective amount of at least oligonucleotide that does not act by a sequence complementary mode of action.