34results about How to "Symptoms improved" patented technology

The application discloses a method for controlling thiolated bacterial covalent colonization by chemical reaction and application. The application provides a unique in-situ chemical reaction mediated bacterial covalent colonization strategy. Through a simple one-step iminothiolane ring-opening reaction, the primary amino group on the surface of bacteria can be converted into a free thiol group under cell-compatible conditions. Surface thiolation can be used for modification of different strains, and the number of thiol groups introduced by each bacterium can be adjusted by different feeding ratios. These chemically reactive bacteria can spontaneously bind to the mucus layer through a sulfur-sulfur exchange reaction between the newly converted non-native thiol group on the surface of the bacteria and the disulfide bond contained in mucin without catalyst. The application converts the bacteria through surface modification to form a "living chemical reagent", and the surface-converted living reactive bacteria provide an unprecedented method for chemical control of bacterial colonization, which has guiding significance for the development of the next generation of living bacterial biological agents.

The application relates to the field of medicines, and discloses a preparation method of a Yi medicine composition, a decoction, granules, pills and a plaster, wherein the Yi medicine composition comprises, by weight, 20-50g of Bauhinia championii Benth, 20-60g of pilea pumila L., 20-40g of Dioscorea panthaica Prain et Buckl, 10-20g of Atractylodes lancea (Thunb.) DC, 20-30g of Foeniculum vulgare Mill, 10-25g of Amomum villosum Lour, 10-15g of Aucklandia lappa Decne, 9-15g of Punica granatum Linn, and 5-8g of Glycyrrhiza uralensis Fisch. The Yi medicine composition is mainly used for removing dampness and turbidity, promoting stagnation and benefiting the intestines, and has the treatment effects of regulating qi and relieving pain, expanding the middle and regulating qi, invigorating the spleen and promoting appetite, etc. The Yi medicine composition can effectively improve the symptoms of increased stool frequency, changed fecal quality, lassitude, poor appetite, etc. of patients with diarrhea caused by qi weakness and spleen and stomach dysfunction.

The application discloses a traditional Chinese medicine extract with antibacterial, anti-inflammatory and antipyretic effects and an active component self-assembled nanomaterial of the traditional Chinese medicine extract and application, wherein the polygonum capitatum extract and the active component self-assembled nanomaterial have the effects of inhibiting bacteria and relieving inflammation and can be used for treating atopic dermatitis. The in-vitro bacteriostatic experiment and animal experiment results verify that the polygonum capitatum extract and the active component self-assembled nanomaterial have the effects of resisting bacteria and inflammation and can effectively treat atopic dermatitis.

A myoregulin inhibitor such as an antisense oligonucleotide against myoregulin or an anti-myoregulin antibody is used as an active ingredient of a prophylactic or therapeutic agent for a muscle disease such as muscular dystrophy, inclusion body myositis, amyotrophic lateral sclerosis, disused muscular atrophy, and sarcopenia.

The application provides an animal Bifidobacterium lactis HNU329 with the ability of reducing uric acid and an application thereof, the animal Bifidobacterium lactis HNU329 has been preserved in the Guangdong Microbial Culture Collection Center (GDMCC), the preservation address is the 5th floor of the 59th building of the courtyard, No. 100, Jiefang Road, Guangzhou, the preservation date is April 22, 2024, the preservation number is GDMCC No: 64546, and the classification and naming are Bifidobacterium animalis subsp. Lactis. The strain has good degradation abilities of nucleosides and purines in vitro, also shows good uric acid reducing ability and anti-inflammatory ability in animal model evaluation, and can regulate the intestinal flora of hyperuricemia mice and improve the symptoms of hyperuricemia. The strain is non-toxic and has no side effects, is safe, and has a wide application prospect.

The present application relates to a kind of probiotic oil agent for improving non-alcoholic fatty liver disease, preparation method and application, the probiotic oil agent includes active ingredient A and active ingredient B, the active ingredient A is mucinophilic Akkermansia Akk11, and the preservation number is CCTCC NO:M2024119;The active ingredient B is Omega-3 fatty acid.The present application is combined with mucinophilic Akkermansia Akk11 and Omega-3 fatty acid, and is prepared into oil agent, and the improvement of NAFLD symptom can play the coordinated synergistic effect, can be used for the prevention and treatment of NAFLD.

The present disclosure provides methods and compositions for treating polymyalgia rheumatica (PMR) in a subject previously treated with a steroid. Also provided are methods of treating the subject with an interleukin-6 inhibiting therapy.

The present invention relates to promoters for differentiation into chondrocytes, chondrocyte proliferation promoter, and cartilaginous matrix production promoter, each containing a glycoside of liquiritigenin. According to the present invention, promoters for differentiation into chondrocytes, promoters for proliferation of chondrocytes, and promoters for cartilaginous matrix production, that are superior in the stability and safety, have a superior promoting action on differentiation into chondrocytes, a superior promoting action on proliferation of chondrocytes, and a superior promoting action on cartilaginous matrix production, and effective for regeneration of cartilage and further, prophylaxis or improvement of symptoms and diseases caused by the damage and inflammation of cartilage, or symptoms and diseases showing the loss of cartilage such as osteoarthritis and the like.

The invention relates to a neural stem cell exosome miR-106b compound and application of the neural stem cell exosome miR-106b compound in treatment of neurodegenerative diseases. It is found for the first time that the miR-106b-carrying neural stem cell exosome compound can effectively reduce damage to neurons and synapses and relieve neuroinflammation in in-vitro and in-vivo experiments. Animal experiment results show that in-vivo injection of the compound or the miR-106b simulant can be used as a treatment means for inhibiting neuroinflammation, and cognitive function decline related to neurodegenerative diseases can be resisted.

To provide a compound useful as an active ingredient of a pharmacological composition for the treatment of urinary storage symptoms, dysuria, lower urinary tract diseases, and the like. [Solution] The inventors perfected the present invention after discovering that thiazole derivatives substituted at position 2 by pyrazinylcarbonylamino are exceptional muscarinic M3 receptor positive allosteric modulators and can be expected to serve as agents for the prevention or treatment of urinary bladder and urinary tract diseases involving bladder contraction mediated by muscarinic M3 receptors. The 2-acylaminothiazole derivatives or salts thereof of the present invention can be expected to serve as agents for the prevention or treatment of urinary bladder and urinary tract diseases involving bladder contraction mediated by muscarinic M3 receptors, e.g., underactive bladder and the like.

Compositions and methods use Bifidobacterium longum NCC3001 (ATCC BAA-999) to treat or prevent a depressive symptom. Prolonged anti-depressive effects can continue after administration of the compositions is ended. Non-limiting examples of a depressive symptom which can be treated or prevented include depressed mood; sadness; anxiety; "empty" feelings; loss of interest or pleasure; irritability; restlessness; changes in appetite or weight; sleep disturbances; lack of or decreased energy; feelings of worthlessness; guilt; helplessness; anger and hostility; difficulty in thinking, concentrating, or making decisions; hopelessness; tiredness; fatigue; memory difficulties; tearfulness; brooding; phobias; excessive worry over physical health; sexual dysfunction; persistent physical symptoms that do not respond to treatment; and combinations thereof. These depressive symptoms can be associated with a depressive state or depressive disorder or can be found sub-clinically or not associated with these depressive states / disorders (e.g., not part of a syndrome or psychiatric disorder).

The invention relates to a traditional Chinese medicine composition and a preparation method and application thereof, and belongs to the technical field of biological medicine. The traditional Chinese medicine composition is prepared from thirty traditional Chinese medicine raw materials such as bull penis, cortex cinnamomi and alfalfa seeds and refined honey. The traditional Chinese medicine raw materials are crushed and mixed and then are prepared into honeyed boluses with the refined honey to obtain the traditional Chinese medicine composition. The traditional Chinese medicine composition disclosed by the invention has the effects of warming and nourishing brain and kidney, and benefiting heart and replenishing essence, and can be used for effectively treating impotence, depression, spermatorrhea, premature ejaculation, body deficiency, emaciation, neurasthenia, premature ovarian insufficiency, ovarian reserve hypofunction, climacteric syndrome, infertility and / or infertility. The dracocephalum moldavica, the anchusa, the chicory and the hawthorn are further added, so that the efficacy of treating the impotence can be improved, and the effect of treating the hyperlipidemia is achieved.

The invention discloses histamine oxidase protein and application thereof. The amino acid sequence of the histamine oxidase protein is shown as SEQ ID NO. 1. The histamine oxidase protein PAO can be used for preparing the medicine for treating allergic rhinitis; according to the invention, histamine is locally degraded through nasal mucosa, so that local histamine aggregation of nasal mucosa is reduced, symptoms such as sneezing and the like of allergic rhinitis are improved, and nasal 2-type inflammatory response is relieved, so that a treatment effect on allergic rhinitis is achieved, and a brand-new view angle and target spot are provided for treatment of allergic rhinitis.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition capable of eliminating pulmonary nodules and a preparation method thereof. The traditional Chinese medicine comprises astragalus membranaceus, codonopsis pilosula, poria cocos, roasted rhizoma atractylodis macrocephalae, honey-fried licorice root and the like, treats both symptoms and root causes, breaks through the limitation of traditional pulmonary nodule treatment, and can accelerate blood flow and condition physique while treating pulmonary nodule; the traditional operation method is broken through by eliminating phlegm, removing dampness, promoting blood circulation to remove blood stasis and softening hardness to dissipate stagnation, and pulmonary nodules caused by imbalance of viscera and imbalance of yin and yang can be adjusted; according to the traditional Chinese medicine composition, a plurality of medicines are combined and comprehensively attacked, the lung function is improved, yin-yang balance is corrected, and nodules are eliminated.

The invention relates to the technical field of microorganisms, and discloses a plant lactobacillus IMAUJBP6 strain and application thereof. The plant lactobacillus IMAUJBP6 is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.36779, and the preservation date is November 26, 2025. The plant lactobacillus IMAUJBP6 obtained by screening can play an anti-oxidation role by inhibiting the activity of alpha-amylase and alpha-glucosidase and improving the DPPH free radical scavenging rate, the superoxide anion free radical scavenging rate and the hydroxyl free radical scavenging rate at the same time, so that the effect of reducing blood sugar is synergistically achieved. When the strain is applied to preparation of fermented milk, a fermented milk product with excellent quality can be obtained, especially when camel milk is used as a raw material for fermentation, the product shows a remarkable potential probiotic effect in the aspects of reducing blood sugar and resisting oxidation, and a new strain and a technical support are provided for development of functional fermented milk products and products for reducing blood sugar and resisting oxidation.

This invention provides a traditional Chinese medicine composition for treating allergic rhinitis, its preparation method, and its application. The effective components of the traditional Chinese medicine composition are made from the following raw materials in parts by weight: Astragalus membranaceus 3-50, Atractylodes macrocephala 3-30, Saposhnikovia divaricata 3-30, Magnolia biondii 3-30, Xanthium sibiricum (fried) 3-30, Ganoderma lucidum 3-50, Platycodon grandiflorus 3-30, calcined dragon bone 5-50, calcined oyster shell 5-50, Terminalia chebula 3-30, Adenophora stricta 3-30, Cordyceps sinensis mycelium powder 3-30, and Dictamnus dasycarpus 3-30. The raw materials of this traditional Chinese medicine composition are common, the preparation method is simple and easy to operate, and it has wide application value. Oral administration of the drug significantly improves nasal sensitivity symptoms in a mouse model of allergic rhinitis, reduces the levels of IgE and histamine in serum and nasal lavage fluid, reduces the level of inflammatory factors in serum, and inhibits the number of inflammatory cells and mast cells in the nasal mucosa, thus effectively treating allergic rhinitis.

Disclosed in the present invention are a PARP inhibitor containing a piperazine structure, a preparation method therefor and pharmaceutical use thereof. Particularly, the present invention relates to novel compounds of general formulas (1), (2), (3), (4) and (5) and / or a pharmaceutically acceptable salt thereof, a composition comprising the compounds of general formulas (1), (2), (3), (4) and (5) and / or the pharmaceutically acceptable salt thereof, a preparation method therefor and use thereof as a PARP inhibitor in the preparation of anti-tumor drugs.

According to etiology and pathogenesis characteristics of smoking harm, 29 traditional Chinese medicines including adenophora tetraphylla, blueberries, mulberry leaves, mint and the like are prepared into preparations of different formulas through the steps of cutting, decocting and the like. The compound substitutional tea drink for oral administration and the plaster externally applied to the Tiantu acupoint, the Danzhong acupoint and the Shuangfeishu acupoint form an integrated combined system preparation for overall conditioning and prevention, and the purposes of relieving the developed symptoms and preventing injuries are achieved through comprehensive overall regulation and intervention by means of the self overall regulation and control mechanism of the five-internal-organ integrated system of the human body. The invention further discloses a preparation method of the compound substitutional tea drink for oral administration and the plaster externally applied to the Tiantu acupoint, the Danzhong acupoint and the Shuangfeishu acupoint. The combined system preparation has the effects of clearing lung and promoting salivation, relieving sore throat and detoxifying, moistening dryness and reducing phlegm, relieving cough and asthma, reinforcing qi and nourishing yin, and promoting blood circulation to remove meridian obstruction, and is used for preventing and treating smoking harm.

The present invention relates to an eye drop composition for treating dry eye syndrome, containing recoflavone. Particularly, the present invention relates to an eye drop composition which, by containing a certain concentration or higher of a main ingredient in the composition and comprising one or more permeation enhancers, so that the active ingredient recoflavone is sufficiently delivered to corneal epithelial cells in vivo to exhibit an effective medicinal effect, can maximize the amelioration of dry eye symptoms.

This utility model discloses a portable essential oil massage device, belonging to the technical field of massage therapy devices, which solves the problems of inconvenient essential oil delivery and limited functionality in existing massage devices. The portable essential oil massage device includes a main body and a replaceable massage head. The bottom center of the main body has an insertion hole with two axial protrusions, and an essential oil chamber inside to hold an essential oil bottle. An oil guide tube passes through the top cap of the essential oil bottle and connects to a miniature solenoid valve. A miniature vibration motor with its axis perpendicular to the bottom surface is fixedly installed inside the main body via a shock-absorbing silicone pad. The top insert of the replaceable massage head has a groove matching the protrusions and an oil guide cavity connecting to the bottom micro-hole. The bottom surface of the main body and the top surface of the massage head are magnetically connected by an annular magnetic clasp. Through the synergistic action of the vibration motor and the magnetic insertion structure, the device achieves rapid massage head replacement, precise essential oil delivery, and multi-dimensional vibration massage functions. The unique effects of aromatic essential oils, combined with massage, accelerate blood circulation, promote skin absorption, and enhance the overall effect.

Disclosed in the present invention are a CLY series compound, a preparation method therefor and the use thereof in the preparation of drugs. The CLY series compound is a compound with a structure of formula I, a tautomer thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof. Animal model experiments show that the CLY series compound, in a chloasma mouse model, can obviously reduce the level oftyrosinase in the skin and blood, reduce the expression of the stem cell factor (SCF) and C-Kit protein in the skin, and inhibit the chromogenesis of chloasma, can obviously promote the healing of a wound on skin and reduce the formation of scars, in a hair loss mouse model, can obviously promote the hair growth and reduce damage to hair follicles, and in a rabbit ear acne model, can obviously reduce the symptoms and reduce pore blockage and acne formation. The CLY series compound can significantly prolong the survival time of acute GVHD mice, and can reduce clinical symptoms, exhibiting a therapeutic effect on acute GVHD; in a pulmonary fibrosis mouse model, same can obviously reduce the levels ofMMP-2 and MMP-9 in the lung tissue, increase the levels of TIMP-1 and VEGF, and simultaneously increase the levels of SOD and CAT enzymes in peripheral blood; and same can also improve the arthritis symptoms ofrheumatoid arthritis mice by means of reducing the level of IL-17 in peripheral blood and increasing inflammatory indexes such as IL-10. The compound can be used alone or in ombination with other drugs, and provides a new drug choice for the treatment of the above diseases.

Compositions and methods use Bifidobacterium longum NCC3001 (ATCC BAA-999) to treat or prevent a depressive symptom. Prolonged anti-depressive effects can continue after administration of the compositions is ended. Non-limiting examples of a depressive symptom which can be treated or prevented include depressed mood; sadness; anxiety; "empty" feelings; loss of interest or pleasure; irritability; restlessness; changes in appetite or weight; sleep disturbances; lack of or decreased energy; feelings of worthlessness; guilt; helplessness; anger and hostility; difficulty in thinking, concentrating, or making decisions; hopelessness; tiredness; fatigue; memory difficulties; tearfulness; brooding; phobias; excessive worry over physical health; sexual dysfunction; persistent physical symptoms that do not respond to treatment; and combinations thereof. These depressive symptoms can be associated with a depressive state or depressive disorder or can be found sub-clinically or not associated with these depressive states / disorders (e.g., not part of a syndrome or psychiatric disorder).

The present application provides a new use of ganciclovir for treating, alleviating and / or relieving non-allergic rhinitis characterized by eosinophilia. The present application research shows that the use of ganciclovir in the treatment of nasal allergic symptoms in NARES patients is obviously relieved, and the originally poor efficacy of anti-allergic drugs can be re-exerted, effectively and durably improving the nasal symptoms of refractory NARES patients, effectively improving the symptoms of rhinitis.

The invention discloses application of fiveleaf gynostemma herb polysaccharide in preparation of medicine for treating ulcerative colitis, the main structure of the fiveleaf gynostemma herb polysaccharide is shown in the specification, research proves that the prepared fiveleaf gynostemma herb polysaccharide has an excellent treatment effect on ulcerative colitis for the first time, activation of NLRP3 inflammasome is inhibited by activating an NRF2 anti-oxidation pathway, and the curative effect of the fiveleaf gynostemma herb polysaccharide on ulcerative colitis is improved. The bacterial flora abundance of bacteroides and thick-walled mycophylum is increased, and the bacterial flora abundance of proteobacteria is reduced, so that the ROS level is reduced, the inflammatory response is reduced, and the intestinal mucosal barrier repair of DSS mice is promoted.

The present application relates to the technical field of planting, in particular to a method for improving seed germination rate and leaf growth of passion fruit. The present application can improve the seed germination rate of passion fruit by soaking passion fruit seeds in ganoderma lucidum solution for a suitable time; by spraying ganoderma lucidum and foliar fertilizer on the leaves of passion fruit plants, the symptoms of viral diseases of the plants can be obviously improved, the use of pesticides can be reduced, the effect of reducing pesticide residues can be achieved, the passion fruit leaves can grow normally, and the leaf growth can be improved.

The present application relates to a squeezing preparation method of the Caesalpinia minax lipid vesicle-like nanoparticles, comprising the following steps: mixing Caesalpinia minax and ultrapure water with a mass ratio of 1:6-1:10 to squeeze juice, then extruding the juice through a 100-200 mesh filter to obtain a Caesalpinia minax raw solution; then, gradient centrifuging the Caesalpinia minax raw solution to obtain a supernatant; finally, centrifuging the supernatant at a relative centrifugal force higher than the highest relative centrifugal force of the gradient centrifuging, then adding a standard phosphate buffer with a mass ratio of 1:8-1:10 to resuspend and precipitate, thereby obtaining the Caesalpinia minax lipid vesicle-like nanoparticles. The present application also provides the Caesalpinia minax lipid vesicle-like nanoparticles obtained by the method and the application of the Caesalpinia minax lipid vesicle-like nanoparticles in the treatment of ulcerative colitis. The present application overcomes the seasonal influence of the preparation of the existing tea lipid vesicle-like nanoparticles, greatly reduces the cost and controls the purity and quality, can solve the intestinal ecological imbalance problems such as mucosal epithelial repair and barrier homeostasis, has good safety and does not produce side effects, and is also a potential treatment for gastrointestinal disease treatment.

The application discloses a traditional Chinese medicine composition for treating Parkinson's disease and a traditional Chinese medicine preparation and application thereof. The traditional Chinese medicine composition comprises, in terms of weight parts, 9-20 parts of Schisandra chinensis, 10-30 parts of Ophiopogon japonicus, 3-15 parts of Radix ginseng rubra, 10-30 parts of Uncaria, 10-30 parts of Cuscuta chinensis, 10-30 parts of Semen ecliptae prostratae, 3-5 parts of ginger and 5-15 parts of Jujube. The application further discloses a preparation of the traditional Chinese medicine composition. The traditional Chinese medicine composition and the preparation thereof can effectively improve the motor function of Parkinson's disease patients, reduce the dosage of Madopa, and thus reduce the related side effects caused by dopamine replacement therapy.

The invention provides semen euryales and fructus alpiniae oxyphyllae paste and a preparation method thereof, and relates to the technical field of traditional Chinese medicine paste preparation. According to the ointment, gordon euryale seeds and fructus alpiniae oxyphyllae are used as core functional raw materials, medicinal and edible auxiliary materials such as Chinese yams, poria cocos, lotus seeds, longans and rhizoma polygonati are matched, honey and rock candy are used as auxiliary materials to regulate the taste, and the ointment is prepared through raw material processing pretreatment, constant-temperature extraction, low-temperature blending, vacuum concentration and sterile filling. The medicine effect is improved by adopting a processing technology of stir-frying gordon euryale seeds and stir-frying fructus alpiniae oxyphyllae with salt, and a plurality of auxiliary materials are matched to realize the synergistic effects of tonifying spleen and clearing damp, reinforcing kidney and boosting essence, warming kidney and reducing urination, warming spleen and stopping diarrhea, and soothing nerves and nourishing heart; low-temperature extraction and vacuum concentration processes are adopted in the whole preparation process, and active ingredients of the raw materials are reserved to the maximum extent. The obtained paste is fine and smooth in texture, mellow in taste, easy in nutrition absorption, free of additives, suitable for being eaten by people with spleen-kidney deficiency, overweight dampness, frequent night urination and weakness of spleen and stomach for a long time, standardized in process and capable of being industrially produced.