46 results about "Stool sample" patented technology

The invention provides an excrement sample microscopic image detection method and system based on morphological prior constraint, and the method comprises the steps: obtaining a global background region and a potential target candidate region through separation, so as to generate a standardized category morphological constraint parameter set; inputting the enhanced candidate region feature map into a preset category constraint double-branch instance segmentation network to generate an initial instance mask set corresponding to each independent visible component; performing closed-loop verification of mask integrity and category consistency on the initial instance mask set, performing iterative optimization correction on a mask region which is verified to be unqualified so as to generate an instance segmentation map, and synchronously performing spatial positioning and attribute marking on each independent mask region in the instance segmentation map; and based on an attribute marking result, performing multi-dimensional feature extraction and subdivision category identification on each independent mask region, and synchronously generating a corresponding excrement sample detection report. According to the invention, the precision, stability and complex scene adaptation capability of excrement microscopic detection can be greatly improved.

The sampler comprises a box body, a fixed inner ring, a movable inner ring, a box cover and a liquid suction pipe, the box body is of a cylinder structure with an opening in the top, the fixed inner ring fixedly connected is arranged on the inner wall of the box body, a plurality of mounting grooves are formed in the circumferential direction of the fixed inner ring, and the movable inner ring is arranged in the mounting grooves. A fixedly connected spring is arranged in each mounting groove, the other end of each spring is fixedly connected with the lower surface of the movable inner ring, and a first thread is arranged on the inner wall of the box body; a second thread is arranged on the side wall of the box cover, and the box body and the box cover form a threaded connection structure through the first thread and the second thread. The box cover is provided with a fixedly connected liquid suction pipe, the top of the liquid suction pipe is provided with a rubber ball, the bottom of the liquid suction pipe is provided with a liquid suction port, and the liquid suction pipe body is further provided with a fixedly connected sampling shovel.

Systems and methods for objective evaluation of a stool sample to determine whether a patient's lower gastrointestinal tract is sufficiently clean to undergo a successful gastrointestinal visualization procedure with favorable visualization. A method includes collecting a stool sample from a patient and assessing the stool sample to determine whether an intestine of the patient is sufficiently clean for the patient to undergo a successful lower gastrointestinal tract visualization procedure.

Inflammatory bowel disease (IBD) in humans and dogs and other companion animals is characterized by infiltration of lymphocytes and macrophages into the mucosa and submucosa and clinical signs of gastrointestinal (Gl) dysfunction (diarrhea, malabsorption, weight loss). Alteration of the gut environment and development of dysbiosis may allow the overgrowth of pathogenic bacteria and induction of intestinal injury and inflammation in IBD. What is needed are novel methods that allow for rapid diagnosis of IBD (and follow-up monitoring) and treatment of the disease. The present disclosure relates to methods for diagnosing and treating inflammatory bowel disease (IBD) or gastrointestinal lymphoma.

The invention relates to a stool sample collection device, a detection rack, and a sampling and detection method, and belongs to the field of medical device technology. The invention includes that after collecting the stool sample, the stool sample is mixed with a diluent in a mixing tube, and then the stool sample collection device is fixed upside down on the detection rack. The raised structure on the inner side of the fixed position of the detection rack squeezes the mixing tube, so that the sample to be tested passes through the filter membrane upward into the detection tube, and the residue is trapped in the mixing tube, thereby effectively separating the sample residue. A data label is attached to the outer wall of the stool sample collection device, and the detection rack can be directly placed in the detection equipment. The detection equipment can read the data label and generate a detection result corresponding to the label information. The invention greatly simplifies the sample liquid collection and detection process, ensures the accuracy of the sample detection results, and the stool sample collection device and detection rack of the invention are simple in structure and low in cost, and its collection and detection method is accurate and simple.

A technique for calculating a risk of mild cognitive impairment for a subject who submitted a stool sample and a questionnaire, and a system for calculating a risk indicator for mild cognitive impairment is presented. The system includes an extraction unit configured to extract, from a first data related to intestinal microbiota data of a user, a second data related to a factor or intestinal microorganisms that is indicated to relate to the mild cognitive impairment; and a calculation unit configured to input the second data into a model for calculating a probability of the user having the mild cognitive impairment, the model having a third data as a variable, the third data being related to one or more intestinal microorganisms that represents a difference between intestinal microbiota of healthy participants and intestinal microbiota of patients with the mild cognitive impairment, and to calculate the risk of the user for the mild cognitive impairment, wherein the risk for the mild cognitive impairment is a probability of developing or having already developed the mild cognitive impairment.

The utility model discloses a disposable excrement sampler, which relates to the field of medical instruments, and comprises a collecting bag, a box body and a sampling bottle, the collecting bag is designed into a shape with a top opening larger than a bottom opening, and the collecting bag is used for guiding and accommodating an excrement sample; the box body is installed at the bottom of the collecting bag, and a top through hole of the box body corresponds to a bottom opening of the collecting bag. A notch is formed in one side arm of the box body, and a drawable cut-off plate is arranged in the notch; the sampling bottle is detachably installed at the bottom of the box body, and a bottle opening of the sampling bottle is communicated with a through hole in the bottom of the box body. Excrement discharged by a patient is contained and collected through the collecting bag, after excrement discharging is completed, by pulling the cut-off plate, an excrement sample can fall into the sampling bottle from the collecting bag through the box body in a controlled mode, and the sampling bottle is used for sampling the excrement. Therefore, the stool sample is sampled without pollution, and the accuracy of inspection is ensured.

A stool resuspension comprising a hemoglobin stabilizing reagent is provided.SOLUTION: In some embodiments, the hemoglobin stabilizing reagent may be an osmolyte, a multivalent cation, a sugar or polysaccharide, and optionally a multivalent cation, a protoporphyrin, or an HRP stabilizing component, and optionally a multivalent cation. Also provided are methods of stabilizing hemoglobin in a stool sample in a solution, and sample collection devices comprising the solution.SELECTED DRAWING: None

The present disclosure concerns a computer-implemented method for transforming stool sample data into a diagnostic code, the method including: a) providing a stool sample from a subject; b) determining, as the stool sample data, expression levels of at least two distinct genes from a plurality of mRNA segments in the stool sample; and c) determining, by a computing system executing a machine-learning model and based on the stool sample data, a diagnostic code, wherein the machine-learning model was trained using stool diagnostic training data including a plurality of stool sample data labeled with at least one of two or more corresponding diagnostic codes.

The present disclosure is directed towards methods for evaluating the presence of a cancer within a subject. Such methods include obtaining a stool sample from the subject, identifying a biological component in the stool sample, wherein the identity of the biological component is indicative of the presence or absence of a cancer. The methods disclosed herein may further include quantifying the amount of the biological component in the stool sample, wherein the quantity of the biological component is indicative of the presence or absence of a cancer. The present disclosure is also directed to devices for evaluating the presence of cancer within a subject, such device include a biological sample pre-conditioner configured to prepare a biological sample for quantification of a biological component in the biological sample, and a biological component detector, configured to identify, and optionally quantify the amount of, the biological component in the biological sample.

The present disclosure relates to methods and compositions for producing a sequencing library from mRNA in a stool sample. The present disclosure further provides methods of detecting the presence of a gene sequence expressed in a gut and methods of treating a patient based on the same. Aspects of the present disclosure further relate to a sequencing library produced by the methods of the present disclosure.

1. The name of the design product: the bottle cap for collecting stool sample. 2. The use of the design product: used with the bottle body and the sampling rod to collect stool sample for occult blood test, parasite examination, intestinal flora analysis, etc. 3. The design points of the design product: the shape. 4. The picture or photo that best shows the design points: the perspective view.

The utility model relates to the field of excrement collection, in particular to a household excrement sample collection structure, which comprises a box body, a collection tube and a lining, sample collection codes are arranged on the box body, a bar code strip I is adhered on the surface of the box body, the collection tube is arranged on the lining, and the lining and the collection tube are arranged inside the box body. The collecting tube comprises a transparent tube body, a screw cap and a spoon, a bar code strip II consistent with the bar code strip I in information is adhered to the surface of the transparent tube body, the spoon is fixed on the lower side in the screw cap, the screw cap is in threaded connection with the transparent tube body, two groups of through holes are symmetrically formed in the screw cap, sealing films are arranged in the through holes, and two groups of sealing covers are rotationally connected to the top of the screw cap; the diameter of the sealing cover is larger than that of the through hole, opening and closing of the corresponding sealing cover and insertion and extraction of the sealing film penetrating through the inner side are controlled, cover opening is not needed in the whole process, peculiar smell emission is reduced, and by means of the collecting structure, the sampling process is simplified, the detection efficiency is improved, timely diagnosis and treatment of a patient are guaranteed, medical resources are optimized, and medical experience is improved.

This utility model relates to a telescopic disposable fecal sampling tube, comprising a container body, a sampling tube, and a sealing cap. The sampling tube has a telescopic structure, which includes a first sleeve, a second sleeve, and a third sampling rod that are slidably inserted in sequence, forming a telescopic sampling tube structure with adjustable length. The top end of the first sleeve is fixedly connected to the sealing cap, and the front end of the third sampling rod is provided with a sampling head. The sealing cap is screwed to the upper opening of the container body. This utility model's sampling tube achieves automatic extension and retraction of the sampling head through a telescopic mechanism, eliminating the manual alignment step and reducing the probability of misoperation, thereby reducing the probability of contact with fecal samples. It is particularly suitable for collecting fecal samples from toilets. The sealing cap prevents sample contamination during transmission and avoids environmental pollution. The groove design of the sampling head increases the number of samples obtained per unit area, improving work efficiency.

The invention provides a personalized health intervention system based on a braingut axis theory, and the specific operation comprises the following steps: S1, household standardized sampling and low-temperature transportation: providing a standardized household sampling suite, enabling a user to collect a feces sample, carrying out compliance storage and transportation, and transporting the sample to a detection point position; s2, performing high-throughput sequencing analysis on the intestinal flora, namely receiving the excrement sample acquired by the household sampling module, performing sequencing analysis on the intestinal microbiome in the sample through a high-throughput sequencing technology, and outputting composition, abundance and function annotation data of the intestinal flora; and S3, user emotion and sleep phenotype data acquisition: acquiring emotion and sleep related phenotype data autonomously reported by the user. According to the invention, convenient collection and stable transportation of intestinal flora samples are realized through the standardized household sampling suite, a user does not need to go to a professional institution, the detection threshold is reduced, and the user participation degree is improved.

The application discloses an intestinal type scoring model for undifferentiated spondyloarthropathy and a construction method and application thereof, and belongs to the technical field of medicines.The 16s rRNA intestinal flora amplicon of 100 uSpA subjects is detected by using high-throughput second-generation sequencing.The intestinal type classification is explored, the intestinal type scoring is constructed, and the clinical characteristics of different intestinal types are researched.The research mainly includes the following four parts:(1) collecting the stool samples and peripheral blood of the uSpA subjects, and detecting the peripheral lymphocytes and cytokines by using flow cytometry (FCM) and CBA method;(2) performing intestinal flora 16s sequencing by using the lllumina high-throughput sequencing technology;(3) analyzing the 16s sequencing data by using the QIIME2 platform;(4) describing the variability of the microbiome data by using the Dirichlet multinomial mixture unsupervised clustering, classifying the intestinal flora of the uSpA, and mining the characteristics of the intestinal flora of the subjects.

The disclosure relates to a tube and automatic system for preparing and analyzing a biologic sample, such as a stool sample. The tube comprises a housing with an upper portion featuring a cone and a sealing element to receive a sample collector stick. A dispensing valve in the lower portion allows fluid exit to facilitate sample dilution and dispensing. Upon insertion of the sample collector stick, the tube enables a pressure differential to control fluid movement. The system includes a mixing mechanism for sample dilution, utilizing an external vibrator and optional solid elements for efficient mixing. The automatic system coordinates preparation and analyte detection, featuring a container housing with chambers for a test cassette and the tube. A controller operates mixing, valve actuation, and image capture of the test cassette, optionally communicating with remote devices. The system is adaptable for multiple diagnostic tests involving analyte concentration detection, with components to align and secure orientations within the automated system. Methods for using these components are disclosed.

1. The name of this design product: Stool sample detector (integrated). 2. Purpose of this design product: Used for qualitative and quantitative detection of fecal occult blood. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 1.

The present invention relates to kits suitable for determining the ratio of succinate-producing bacteria to succinate-consuming bacteria in a stool sample from a subject, in particular the ratio of (Prevotellaceae + Veillonellaceae) / (Odoribacteriaceae + Clostridiaceae), or for determining the level of succinate in a sample of body fluids from a subject. The invention also relates to a method for determining whether a targeted intervention aimed at reducing circulating succinate levels in a subject has been effective. Finally, the invention relates to targeted interventions for use in the prevention and / or treatment of a disease associated with elevated circulating succinate levels in a patient.

The present invention belongs to the technical field of medical devices and discloses a routine stool collection auxiliary device, comprising a mounting seat, the bottom of which is provided with a fixing assembly suitable for toilets and squat toilets, the top of which is slidably connected to a stool collection box and a mounting block, the top of which is rotatably connected to the mounting box, a driven gear rotatably engaged within the mounting box, the driven gear being coaxially provided with a clamping assembly away from the mounting box, the driven gear being transmission-connected to a scooping assembly provided within the mounting box, and a suction assembly being provided on the top of the clamping assembly. The stool sample collection auxiliary device of the present invention is applicable to both toilets and squat toilets, and can also be used to collect stool samples of different types (formed stool, loose stool, watery stool). Stool sample collection is convenient, clean, and hygienic, and can also improve the patient's comfort when using the toilet, reduce the patient's psychological discomfort, and increase the patient's willingness to undergo a stool examination.

1. The name of this design product: feces sampler. 2. Purpose of this design product: used for collecting stool samples. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The present application relates to the technical field of probiotics, in particular to the application of a strain of Streptococcus ruminantium and a modified strain thereof in the preparation of a product for treating ulcerative colitis. The strain of Streptococcus ruminantium provided by the present application is a beneficial bacterium screened through differential analysis of clinical cohort stool samples, and is more in line with the intestinal flora characteristics of patients with ulcerative colitis. The present application modifies the strain of Streptococcus ruminantium through a manganese-iron bimetallic nanoscale enzyme, which can eliminate excess active oxygen in the intestinal environment and improve the treatment effect. In addition, the present application uses C18-PEG-PBA as a connecting agent, the hydrophobic end C18 of which can be inserted into the porous carbon skeleton of the manganese-iron bimetallic nanoscale enzyme through hydrophobic interaction, and the PBA end can undergo a mild esterification reaction with the polysaccharide on the surface of the probiotic bacteria, achieving stable connection without affecting the survival rate of the probiotic bacteria. The hydrophilic polyethylene glycol shell layer improves the biocompatibility, water solubility and stability of the product, and further improves the treatment effect of ulcerative colitis.

The disclosure provides an evaluation of the virome in health and disease of the oral-gut-brain axis, in particular, periodontitis, irritable bowel disease (IBD) and Alzheimer's Disease (AD). For Alzheimer's disease, a striking feature was found via metagenomics of brain autopsy specimens - the presence of parvoviridae (comprised of erythoviruses and erythroparvoviruses) in the brains of individuals diagnosed with Alzheimer's Disease (AD) but not in brains from age-matched healthy individuals without a medical diagnosis of AD. For IBD, For Periodontitis and IBD, an analysis revealed the top 20 most abundant viral and bacterial species in saliva samples from individuals with periodontal disease or with a healthy periodontium and the top viral and bacterial species in stool samples from individuals with irritable bowel syndrome or with gastrointestinal health. Building upon these discoveries, a number of diagnostic methods and materials for AD and IBD are described herein.

The utility model belongs to the technical field of excrement sampling auxiliary devices, in particular to a toilet bowl device convenient for sampling excrement of a patient, which comprises a toilet bowl, a support component is placed at the rear end in the toilet bowl, the support component comprises a support ring, two connecting shafts, a support and a handle rod, and the left side and the right side of the support ring are fixedly connected with the two connecting shafts respectively. The upper portion of the end, different from the supporting ring, of the connecting shaft is fixedly connected with a support, and a handle rod is fixedly connected between the upper ends of the front support and the rear support. According to the toilet bowl, the supporting assembly is placed in the toilet bowl, the disposable excrement collecting box is placed in the supporting assembly to be used, excrement can fall into the disposable excrement collecting box during defecation, and the excrement cannot directly fall into the toilet bowl; urine and water in the closestool cannot be mixed into excrement in the defecation process, so that the accuracy of subsequent excrement detection is ensured, the operation is simple, the use is convenient, and the excrement of a patient can be conveniently sampled and used.

Devices, systems, kits, and methods for stool sample collection, in particular devices that reversibly attach to a toilet to facilitate collecting, preferably at-home collecting, of a stool specimen from a subject, and for holding the specimen during sampling.

This invention discloses a stool sampling box, relating to the field of medical testing equipment technology. The stool sampling box includes a box body, a lid, a pull-out box, and a squeezing device. The box body has a receiving cavity with an open end for holding a stool sample. The lid can be placed on the opening to seal the receiving cavity. The pull-out box is slidably disposed at the bottom of the box body and communicates with the receiving cavity, allowing the stool sample to fall from the receiving cavity into the pull-out box. The squeezing device includes a push rod and a sealing component. The push rod slides vertically through the lid and pushes the stool sample to fall from the receiving cavity into the pull-out box. The sealing component is fitted onto the push rod and seals the push rod against the lid. This stool sampling box, by sealing the opening of the receiving cavity with the lid, reduces the leakage of stool odor. The push rod pushes the stool sample into the pull-out box for convenient sampling. The sealing component between the push rod and the lid ensures the sealing effect of the box body, further reducing the leakage of stool odor.

A technique for calculating a disease evaluation index using intestinal flora is presented. A disease evaluation index calculation method includes a step of inputting one or more diseases that a user wants to be aware of; a step of extracting the user's intestinal flora data, which is a result of analyzing a stool sample of the user in advance, the user's attribute data, and an association model having a plurality of subjects' attribute data, the subjects' intestinal flora data, which is a result of analyzing stool samples of the subjects, and data on the diseases as internal factors, from a database; and a step of calculating a risk of the diseases using the user's intestinal flora data, the user's attribute data, and the association model.

The present application provides a kind of based on morphological priori constraint's fecal sample microscopic image detection method and system, separate and obtain global background area and potential target candidate area, to generate the standardized category morphological constraint parameter set;With enhanced candidate region feature map input preset category constraint double-branch instance segmentation network, to generate the initial instance mask set corresponding to each independent component;Mask integrity and category consistency closed loop check are carried out to initial instance mask set, and the mask area that does not pass the check is iteratively optimized and modified, to generate instance segmentation atlas, simultaneously to each independent mask area in instance segmentation atlas is spatially positioned and attribute marked;Based on the result of attribute marking, each independent mask area is carried out multi-dimensional feature extraction and fine classification identification, and the corresponding fecal sample detection report is generated simultaneously.The present application can greatly improve the precision, stability and complex scene adaptation capability of fecal microscopic detection.

Provided herein are techniques relating to compositions and methods for detecting tissue cell-specific DNA, such as epithelial cell-specific DNA, in blood or blood products from a subject. The techniques also relate to using tissue cell-specific DNA as an internal control for methylation assays. Provided herein are techniques relating to characterizing the presence or absence and / or amount of different kinds of nucleic acids in a sample, e.g., a blood sample, a stool sample, etc., that can be relevant to the health status of a subject. For example, in some embodiments, the techniques relate to detecting and measuring DNA associated with a particular tissue in a sample type that does not normally contain DNA from that tissue. In preferred embodiments, the techniques relate to detecting and / or measuring epithelial cells and / or epithelial cell-specific DNA in a blood or blood product sample.