59 results about "Stool sample" patented technology

The invention provides an excrement sample microscopic image detection method and system based on morphological prior constraint, and the method comprises the steps: obtaining a global background region and a potential target candidate region through separation, so as to generate a standardized category morphological constraint parameter set; inputting the enhanced candidate region feature map into a preset category constraint double-branch instance segmentation network to generate an initial instance mask set corresponding to each independent visible component; performing closed-loop verification of mask integrity and category consistency on the initial instance mask set, performing iterative optimization correction on a mask region which is verified to be unqualified so as to generate an instance segmentation map, and synchronously performing spatial positioning and attribute marking on each independent mask region in the instance segmentation map; and based on an attribute marking result, performing multi-dimensional feature extraction and subdivision category identification on each independent mask region, and synchronously generating a corresponding excrement sample detection report. According to the invention, the precision, stability and complex scene adaptation capability of excrement microscopic detection can be greatly improved.

The sampler comprises a box body, a fixed inner ring, a movable inner ring, a box cover and a liquid suction pipe, the box body is of a cylinder structure with an opening in the top, the fixed inner ring fixedly connected is arranged on the inner wall of the box body, a plurality of mounting grooves are formed in the circumferential direction of the fixed inner ring, and the movable inner ring is arranged in the mounting grooves. A fixedly connected spring is arranged in each mounting groove, the other end of each spring is fixedly connected with the lower surface of the movable inner ring, and a first thread is arranged on the inner wall of the box body; a second thread is arranged on the side wall of the box cover, and the box body and the box cover form a threaded connection structure through the first thread and the second thread. The box cover is provided with a fixedly connected liquid suction pipe, the top of the liquid suction pipe is provided with a rubber ball, the bottom of the liquid suction pipe is provided with a liquid suction port, and the liquid suction pipe body is further provided with a fixedly connected sampling shovel.

Systems and methods for objective evaluation of a stool sample to determine whether a patient's lower gastrointestinal tract is sufficiently clean to undergo a successful gastrointestinal visualization procedure with favorable visualization. A method includes collecting a stool sample from a patient and assessing the stool sample to determine whether an intestine of the patient is sufficiently clean for the patient to undergo a successful lower gastrointestinal tract visualization procedure.

The invention provides application of Pseudomonas capilliformis (Pseudomonas capilliformis) to preparation of a medicine for preventing, treating and / or improving ulcerative colitis, and belongs to the technical field of probiotic preparations. The invention further provides a preparation method of the Pseudomonas capilliformis (Pseudomonas capilliformis) and application of the Pseudomonas capilliformis (Pseudomonas capilliformis (Pseudomonas capilliformis). In the invention, the pseudosciaena hirsuta is a beneficial bacterium screened through difference analysis of excrement samples in a clinical queue (including excrement samples of healthy control, active-stage ulcerative colitis patients and remission-stage ulcerative colitis patients). Existing commercialized probiotics mainly comprise lactobacillus, bifidobacterium and the like and are not designed for patients with ulcerative colitis, but the pseudomonas hirsuta provided by the invention better conforms to intestinal flora characteristics of the patients with ulcerative colitis and is suitable for individualized treatment of the patients with ulcerative colitis.

Inflammatory bowel disease (IBD) in humans and dogs and other companion animals is characterized by infiltration of lymphocytes and macrophages into the mucosa and submucosa and clinical signs of gastrointestinal (Gl) dysfunction (diarrhea, malabsorption, weight loss). Alteration of the gut environment and development of dysbiosis may allow the overgrowth of pathogenic bacteria and induction of intestinal injury and inflammation in IBD. What is needed are novel methods that allow for rapid diagnosis of IBD (and follow-up monitoring) and treatment of the disease. The present disclosure relates to methods for diagnosing and treating inflammatory bowel disease (IBD) or gastrointestinal lymphoma.

The invention relates to a stool sample collection device, a detection rack, and a sampling and detection method, and belongs to the field of medical device technology. The invention includes that after collecting the stool sample, the stool sample is mixed with a diluent in a mixing tube, and then the stool sample collection device is fixed upside down on the detection rack. The raised structure on the inner side of the fixed position of the detection rack squeezes the mixing tube, so that the sample to be tested passes through the filter membrane upward into the detection tube, and the residue is trapped in the mixing tube, thereby effectively separating the sample residue. A data label is attached to the outer wall of the stool sample collection device, and the detection rack can be directly placed in the detection equipment. The detection equipment can read the data label and generate a detection result corresponding to the label information. The invention greatly simplifies the sample liquid collection and detection process, ensures the accuracy of the sample detection results, and the stool sample collection device and detection rack of the invention are simple in structure and low in cost, and its collection and detection method is accurate and simple.

A technique for calculating a risk of mild cognitive impairment for a subject who submitted a stool sample and a questionnaire, and a system for calculating a risk indicator for mild cognitive impairment is presented. The system includes an extraction unit configured to extract, from a first data related to intestinal microbiota data of a user, a second data related to a factor or intestinal microorganisms that is indicated to relate to the mild cognitive impairment; and a calculation unit configured to input the second data into a model for calculating a probability of the user having the mild cognitive impairment, the model having a third data as a variable, the third data being related to one or more intestinal microorganisms that represents a difference between intestinal microbiota of healthy participants and intestinal microbiota of patients with the mild cognitive impairment, and to calculate the risk of the user for the mild cognitive impairment, wherein the risk for the mild cognitive impairment is a probability of developing or having already developed the mild cognitive impairment.

The utility model discloses a disposable excrement sampler, which relates to the field of medical instruments, and comprises a collecting bag, a box body and a sampling bottle, the collecting bag is designed into a shape with a top opening larger than a bottom opening, and the collecting bag is used for guiding and accommodating an excrement sample; the box body is installed at the bottom of the collecting bag, and a top through hole of the box body corresponds to a bottom opening of the collecting bag. A notch is formed in one side arm of the box body, and a drawable cut-off plate is arranged in the notch; the sampling bottle is detachably installed at the bottom of the box body, and a bottle opening of the sampling bottle is communicated with a through hole in the bottom of the box body. Excrement discharged by a patient is contained and collected through the collecting bag, after excrement discharging is completed, by pulling the cut-off plate, an excrement sample can fall into the sampling bottle from the collecting bag through the box body in a controlled mode, and the sampling bottle is used for sampling the excrement. Therefore, the stool sample is sampled without pollution, and the accuracy of inspection is ensured.

A stool resuspension comprising a hemoglobin stabilizing reagent is provided.SOLUTION: In some embodiments, the hemoglobin stabilizing reagent may be an osmolyte, a multivalent cation, a sugar or polysaccharide, and optionally a multivalent cation, a protoporphyrin, or an HRP stabilizing component, and optionally a multivalent cation. Also provided are methods of stabilizing hemoglobin in a stool sample in a solution, and sample collection devices comprising the solution.SELECTED DRAWING: None

The present disclosure concerns a computer-implemented method for transforming stool sample data into a diagnostic code, the method including: a) providing a stool sample from a subject; b) determining, as the stool sample data, expression levels of at least two distinct genes from a plurality of mRNA segments in the stool sample; and c) determining, by a computing system executing a machine-learning model and based on the stool sample data, a diagnostic code, wherein the machine-learning model was trained using stool diagnostic training data including a plurality of stool sample data labeled with at least one of two or more corresponding diagnostic codes.

The present disclosure is directed towards methods for evaluating the presence of a cancer within a subject. Such methods include obtaining a stool sample from the subject, identifying a biological component in the stool sample, wherein the identity of the biological component is indicative of the presence or absence of a cancer. The methods disclosed herein may further include quantifying the amount of the biological component in the stool sample, wherein the quantity of the biological component is indicative of the presence or absence of a cancer. The present disclosure is also directed to devices for evaluating the presence of cancer within a subject, such device include a biological sample pre-conditioner configured to prepare a biological sample for quantification of a biological component in the biological sample, and a biological component detector, configured to identify, and optionally quantify the amount of, the biological component in the biological sample.

The invention relates to the technical field of curative effect monitoring, in particular to a threatened abortion patient drug curative effect monitoring and personalized medication recommendation system, which comprises a data acquisition module for acquiring physiological data and fetal heart rate information of a threatened abortion patient in real time; the microbiome analysis module is used for analyzing the intestinal microbiome composition of the patient, detecting the microflora change of the endocrine system by collecting the excrement sample of the patient, and predicting the metabolic effect of the medicine on the patient; the drug curative effect evaluation module comprehensively analyzes the data from the data acquisition module and the microbiome analysis module, evaluates the curative effect of the threatened abortion patient after using the drug, and evaluates the influence of the drug on the fetus health in combination with the fetal heart rate and the heart rate variability data; the personalized drug use recommendation module is used for providing personalized drug dosage and use scheme recommendation according to an evaluation result of the drug curative effect evaluation module; the treatment scheme is automatically adjusted, and it is ensured that the medicine plays a role in the optimal treatment range, so that the treatment effect is optimized.

The present disclosure relates to methods and compositions for producing a sequencing library from mRNA in a stool sample. The present disclosure further provides methods of detecting the presence of a gene sequence expressed in a gut and methods of treating a patient based on the same. Aspects of the present disclosure further relate to a sequencing library produced by the methods of the present disclosure.

1. The name of the design product: the bottle cap for collecting stool sample. 2. The use of the design product: used with the bottle body and the sampling rod to collect stool sample for occult blood test, parasite examination, intestinal flora analysis, etc. 3. The design points of the design product: the shape. 4. The picture or photo that best shows the design points: the perspective view.

The utility model relates to the field of excrement collection, in particular to a household excrement sample collection structure, which comprises a box body, a collection tube and a lining, sample collection codes are arranged on the box body, a bar code strip I is adhered on the surface of the box body, the collection tube is arranged on the lining, and the lining and the collection tube are arranged inside the box body. The collecting tube comprises a transparent tube body, a screw cap and a spoon, a bar code strip II consistent with the bar code strip I in information is adhered to the surface of the transparent tube body, the spoon is fixed on the lower side in the screw cap, the screw cap is in threaded connection with the transparent tube body, two groups of through holes are symmetrically formed in the screw cap, sealing films are arranged in the through holes, and two groups of sealing covers are rotationally connected to the top of the screw cap; the diameter of the sealing cover is larger than that of the through hole, opening and closing of the corresponding sealing cover and insertion and extraction of the sealing film penetrating through the inner side are controlled, cover opening is not needed in the whole process, peculiar smell emission is reduced, and by means of the collecting structure, the sampling process is simplified, the detection efficiency is improved, timely diagnosis and treatment of a patient are guaranteed, medical resources are optimized, and medical experience is improved.

This utility model relates to a telescopic disposable fecal sampling tube, comprising a container body, a sampling tube, and a sealing cap. The sampling tube has a telescopic structure, which includes a first sleeve, a second sleeve, and a third sampling rod that are slidably inserted in sequence, forming a telescopic sampling tube structure with adjustable length. The top end of the first sleeve is fixedly connected to the sealing cap, and the front end of the third sampling rod is provided with a sampling head. The sealing cap is screwed to the upper opening of the container body. This utility model's sampling tube achieves automatic extension and retraction of the sampling head through a telescopic mechanism, eliminating the manual alignment step and reducing the probability of misoperation, thereby reducing the probability of contact with fecal samples. It is particularly suitable for collecting fecal samples from toilets. The sealing cap prevents sample contamination during transmission and avoids environmental pollution. The groove design of the sampling head increases the number of samples obtained per unit area, improving work efficiency.

The invention provides a personalized health intervention system based on a braingut axis theory, and the specific operation comprises the following steps: S1, household standardized sampling and low-temperature transportation: providing a standardized household sampling suite, enabling a user to collect a feces sample, carrying out compliance storage and transportation, and transporting the sample to a detection point position; s2, performing high-throughput sequencing analysis on the intestinal flora, namely receiving the excrement sample acquired by the household sampling module, performing sequencing analysis on the intestinal microbiome in the sample through a high-throughput sequencing technology, and outputting composition, abundance and function annotation data of the intestinal flora; and S3, user emotion and sleep phenotype data acquisition: acquiring emotion and sleep related phenotype data autonomously reported by the user. According to the invention, convenient collection and stable transportation of intestinal flora samples are realized through the standardized household sampling suite, a user does not need to go to a professional institution, the detection threshold is reduced, and the user participation degree is improved.

The disclosure provides compositions and methods for therapeutic administration of the compositions to treat comorbidities associated with gut dysbiosis. The disclosure also provides compositions and methods for increasing engraftment of administered microbes. The disclosure also provides methods for stool sample collection.

The present invention relates to a bacterial biomarker or to a combination of bacterial biomarkers in intestinal or stool samples which on one hand help in the diagnosis of colorectal cancer, and on the other hand predict the progression of colorectal cancer, as well as the response to treatment of a subject suffering from this disease.

The application discloses an intestinal type scoring model for undifferentiated spondyloarthropathy and a construction method and application thereof, and belongs to the technical field of medicines.The 16s rRNA intestinal flora amplicon of 100 uSpA subjects is detected by using high-throughput second-generation sequencing.The intestinal type classification is explored, the intestinal type scoring is constructed, and the clinical characteristics of different intestinal types are researched.The research mainly includes the following four parts:(1) collecting the stool samples and peripheral blood of the uSpA subjects, and detecting the peripheral lymphocytes and cytokines by using flow cytometry (FCM) and CBA method;(2) performing intestinal flora 16s sequencing by using the lllumina high-throughput sequencing technology;(3) analyzing the 16s sequencing data by using the QIIME2 platform;(4) describing the variability of the microbiome data by using the Dirichlet multinomial mixture unsupervised clustering, classifying the intestinal flora of the uSpA, and mining the characteristics of the intestinal flora of the subjects.

An innovative stool sampling system allows the collection of a stool sample ranging from 100 to 400 milligrams and its immediate immersion in a preservation and conversation buffer of only 2 to 3 millilitres tailored for subsequent analysis. The sampling system provides the advantage that the stool analyte undergoes only a modest dilution, which is perfect for highly sensitive immunoanalytical assays. The device presented gives way to a refined protocol for direct immunological testing and identification of a wide range of proteinaceous analytes in faeces, including those associated with infectious agents such as s such as H. pylori, viruses, bacteria, and various parasitic infestations.

The disclosure relates to a tube and automatic system for preparing and analyzing a biologic sample, such as a stool sample. The tube comprises a housing with an upper portion featuring a cone and a sealing element to receive a sample collector stick. A dispensing valve in the lower portion allows fluid exit to facilitate sample dilution and dispensing. Upon insertion of the sample collector stick, the tube enables a pressure differential to control fluid movement. The system includes a mixing mechanism for sample dilution, utilizing an external vibrator and optional solid elements for efficient mixing. The automatic system coordinates preparation and analyte detection, featuring a container housing with chambers for a test cassette and the tube. A controller operates mixing, valve actuation, and image capture of the test cassette, optionally communicating with remote devices. The system is adaptable for multiple diagnostic tests involving analyte concentration detection, with components to align and secure orientations within the automated system. Methods for using these components are disclosed.

The utility model relates to the technical field of medical instruments, and discloses an excrement sample sampler which comprises a test tube and a cover body, the bottom end of the cover body is fixedly connected with a sampling tube, a mounting groove is formed in the sampling tube, the inner wall of the mounting groove is fixedly connected with a spring, the bottom end of the spring is fixedly connected with a limiting block, and the limiting block is fixedly connected with the bottom end of the test tube. A push rod is fixedly connected to the top end of the limiting block, a sampling hook is fixedly connected to the bottom end of the limiting block, a threaded ring is fixedly connected to the exterior of the test tube, a threaded groove is formed in the inner wall of the outer cover, a sealing ring is fixedly connected to the interior of the cover body, and the interior of the sealing ring abuts against the exterior of the push rod. According to the excrement sampling device, the structures such as the mounting groove and the sampling hook are matched for use, so that the sampling hook can be pushed out to collect excrement, the sampling hook is hidden in the sampling tube through the reset movement of the spring after collection, and the risk of cross contamination can be effectively reduced.

1. The name of this design product: Stool sample detector (integrated). 2. Purpose of this design product: Used for qualitative and quantitative detection of fecal occult blood. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 1.

The present invention relates to kits suitable for determining the ratio of succinate-producing bacteria to succinate-consuming bacteria in a stool sample from a subject, in particular the ratio of (Prevotellaceae + Veillonellaceae) / (Odoribacteriaceae + Clostridiaceae), or for determining the level of succinate in a sample of body fluids from a subject. The invention also relates to a method for determining whether a targeted intervention aimed at reducing circulating succinate levels in a subject has been effective. Finally, the invention relates to targeted interventions for use in the prevention and / or treatment of a disease associated with elevated circulating succinate levels in a patient.

The present invention belongs to the technical field of medical devices and discloses a routine stool collection auxiliary device, comprising a mounting seat, the bottom of which is provided with a fixing assembly suitable for toilets and squat toilets, the top of which is slidably connected to a stool collection box and a mounting block, the top of which is rotatably connected to the mounting box, a driven gear rotatably engaged within the mounting box, the driven gear being coaxially provided with a clamping assembly away from the mounting box, the driven gear being transmission-connected to a scooping assembly provided within the mounting box, and a suction assembly being provided on the top of the clamping assembly. The stool sample collection auxiliary device of the present invention is applicable to both toilets and squat toilets, and can also be used to collect stool samples of different types (formed stool, loose stool, watery stool). Stool sample collection is convenient, clean, and hygienic, and can also improve the patient's comfort when using the toilet, reduce the patient's psychological discomfort, and increase the patient's willingness to undergo a stool examination.

1. The name of this design product: feces sampler. 2. Purpose of this design product: used for collecting stool samples. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The present application relates to the technical field of probiotics, in particular to the application of a strain of Streptococcus ruminantium and a modified strain thereof in the preparation of a product for treating ulcerative colitis. The strain of Streptococcus ruminantium provided by the present application is a beneficial bacterium screened through differential analysis of clinical cohort stool samples, and is more in line with the intestinal flora characteristics of patients with ulcerative colitis. The present application modifies the strain of Streptococcus ruminantium through a manganese-iron bimetallic nanoscale enzyme, which can eliminate excess active oxygen in the intestinal environment and improve the treatment effect. In addition, the present application uses C18-PEG-PBA as a connecting agent, the hydrophobic end C18 of which can be inserted into the porous carbon skeleton of the manganese-iron bimetallic nanoscale enzyme through hydrophobic interaction, and the PBA end can undergo a mild esterification reaction with the polysaccharide on the surface of the probiotic bacteria, achieving stable connection without affecting the survival rate of the probiotic bacteria. The hydrophilic polyethylene glycol shell layer improves the biocompatibility, water solubility and stability of the product, and further improves the treatment effect of ulcerative colitis.

The disclosure provides an evaluation of the virome in health and disease of the oral-gut-brain axis, in particular, periodontitis, irritable bowel disease (IBD) and Alzheimer's Disease (AD). For Alzheimer's disease, a striking feature was found via metagenomics of brain autopsy specimens - the presence of parvoviridae (comprised of erythoviruses and erythroparvoviruses) in the brains of individuals diagnosed with Alzheimer's Disease (AD) but not in brains from age-matched healthy individuals without a medical diagnosis of AD. For IBD, For Periodontitis and IBD, an analysis revealed the top 20 most abundant viral and bacterial species in saliva samples from individuals with periodontal disease or with a healthy periodontium and the top viral and bacterial species in stool samples from individuals with irritable bowel syndrome or with gastrointestinal health. Building upon these discoveries, a number of diagnostic methods and materials for AD and IBD are described herein.