998 results about "Psychiatry" patented technology

The present disclosure provides a method of treating a symptom or preventing a symptom of generalized anxiety disorder comprising administering an orally disintegrating tablet comprising LSD, or a salt thereof, to a subject in need thereof.

The invention discloses an intelligent intervention system for children with autism spectrum disorder based on multi-modal neural feedback, which comprises a multi-modal physiological signal acquisition module for acquiring electroencephalogram signals of a target child in real time and generating an original physiological signal set; the multi-modal fusion analysis module receives the original physiological signal set and generates a comprehensive evaluation signal representing the current neurocognitive state and the emotion awakening level of the child; the self-adaptive decision control module receives the comprehensive evaluation signal and generates a self-adaptive control signal containing a neural feedback parameter adjustment instruction and a game interaction strategy instruction; the neural feedback intervention module receives the neural feedback parameter adjustment instruction and generates an adaptive neural feedback stimulation signal to act on the child; and the intelligent interactive game module receives a game interactive strategy instruction and dynamically adjusts game scene contents. The intelligent intervention system for children with autism spectrum disorder based on multi-modal neural feedback can solve the problems of poor individual adaptation of autism intervention, multi-modal data splitting and lack of dynamic adjustment.

The present disclosure is directed to acetyl-leucine or a pharmaceutically acceptable salt thereof for use in improving cognitive function, mobility, or cognitive function and mobility in a subject, for example, in an elderly subject.

Intranasal dry powder epinephrine compositions are described herein. The compositions include epinephrine or a pharmaceutically acceptable salt thereof, as well as a stabilizing agent and a carrier. The stabilizing agent is operable to include citric acid, or a pharmaceutically acceptable salt derived therefrom. Such intranasal compositions as described herein are useful in the treatment of health conditions which threaten the central nervous system (CNS) and impede the actions of alpha and beta-adrenergic receptors. Such health conditions include anaphylaxis, bronchospasms, respiratory impairment, organophosphate poisoning, and major adverse cardiac events (MACE).

The disclosure relates to methods and kits for detecting tau, e.g., tau that is phosphorylated at amino acid position T181 (pTau181), tau that is phosphorylated at amino acid position T217 (pTau217), and / or total tau. The disclosure further provides methods for distinguishing between individuals whose cognitive condition will remain stable and whose cognitive condition will decline during their lifetime. The disclosure also provides methods for determining the eligibility of individuals for participation in clinical trials for Alzheimer's disease treatments. Also provided are methods for distinguishing between individuals with Alzheimer's disease and non-Alzheimer's dementia, and for monitoring response to treatment for Alzheimer's disease.

The invention provides an intelligent psychological counseling system based on a multi-mode large model and a cognitive behavior therapy, and the system comprises the steps: recognizing voice from a user side through the multi-mode large model, and obtaining text information and emotional state information; analyzing the text information by using a large language model, carrying out conversation with the user side, and extracting psychological state information of the user side from the conversation; a cognitive behavior treatment strategy matched with the user side is determined according to the emotional state information, so that a voice response to the user side is generated according to the matched cognitive behavior treatment strategy by using a multi-mode large model; by combining a multi-modal large model and a large language model, accurate and efficient natural language understanding of a user side is realized, highly anthropomorphic voice response is provided, dependence on professional psychological consultants is reduced, limitation of psychological consultation services on time and regions can be broken through, large-scale consultation service requirements can be met in an all-weather and low-cost manner, and the psychological consultation service experience is improved. The man-machine interaction experience in the consultation process is improved, and high-quality and high-practicability psychological consultation and treatment services are provided.

The invention provides methods of improving sleep in a patient having a variant of the cryptochrome circadian clock 1 (CRY1) genotype associated with a circadian rhythm sleep disorder (CRSD) Delayed Sleep Wake Phase Disorder (DSWPD).

The invention belongs to the technical field of cognitive impairment intervention evaluation, and particularly relates to an evaluation system and method applied to cognitive impairment intervention. According to the method, the cognitive state is evaluated and the training tasks are allocated based on the real data of the user in the natural life scene, so that the one-sidedness of only depending on a laboratory or one-time evaluation is avoided, the training and intervention are closer to the real demand and life situation of the user, and the training efficiency is improved through multi-source data fusion. The influence of single signal noise or accidental fluctuation on judgment is reduced, the robustness and objectivity of evaluation are improved, indexes such as cognitive performance, intervention indexes and deviation degree are numeralized, long-term tracking and transverse comparison of the effects of different intervention measures are facilitated, interpretable quantitative evidences are provided for clinical personnel, and the accuracy of evaluation is improved. Intervention indexes are calculated in real time, intervention measures are automatically adjusted or reselected according to feedback results, and a quick-response closed-loop system is formed, so that the time from problem discovery to effective intervention is shortened, and the intervention conversion rate is increased.

A medical system useful in the determination of future disease progression in a subject. More specifically the present invention applies machine learning techniques to aid prediction of disease pathology and clinical outcomes in subjects presenting with symptoms of cognitive decline and to expedite clinical development of novel therapeutics.

The present disclosure relates to child restraint systems and components of child restraint systems, for example child seats like a toddler seat and an infant seat, support bases of child seats, in particular support bases that are fixable on a vehicle seat and which bases may be an integral part of a child seat or which may be configured such that a child seat is releasably couplable to them.

The present invention relates to methods using trained classifier for assessing potency of a compound to revert the phenotype of a myotube exhibiting features of a neuromuscular disorder of interest into a healthy phenotype, for predicting the ability of a compound to treat a neuromuscular disorder of interest, for monitoring the response to a therapeutic compound of a patient affected with a neuromuscular disorder of interest, for selecting a patient affected with a neuromuscular disorder of interest for a treatment with a therapeutic compound or for determining whether a patient affected with a neuromuscular disorder of interest is susceptible to benefit from a treatment with a therapeutic compound, or for diagnosing a neuromuscular disorder of interest.

The invention relates to the technical field of health data analysis, in particular to a traditional Chinese medicine children physique and pathology analysis system which comprises an electroencephalogram signal sensing module, a phase deviation feature extraction module, a wave band energy delay analysis module, a physique type judgment module and a pathology risk prediction module. According to the method, frequency domain analysis and phase offset calculation are carried out on electroencephalogram signals, accurate quantification of sleep state sign characteristics is achieved, the sequential relation between the phase change trend and wave band energy is captured, a dynamic characteristic combination capable of reflecting the rhythm transfer rule is constructed, the separability of physique differences is enhanced in a nonlinear mapping mode, and the accuracy of the physique differences is improved. A classification process is kept stable in a high-dimensional space, and a multi-factor prediction system is formed by combining indexes such as energy delay and phase anomaly, so that health state assessment has continuity and sensitivity, risk change can be identified in an early stage, and refined judgment of children's pathological tendency and improvement of result robustness are realized.

The invention discloses a premature infant action intention recognition method. The method comprises the following steps: S1, data acquisition; s2, data preprocessing; s3, extracting data features; s4, performing feature time sequence processing; and S5, judging the action intention. The premature infant action intention recognition method has the beneficial effects that the distinction degree of the action intention is improved, the recognition accuracy is improved, the influence of the development level is eliminated, personalized recognition is realized, individual differences of infants are adapted, the requirements of tender skins and free activities of the infants are met, a therapist can be effectively guided to adjust a training scheme in time, and the training efficiency is improved. And parents can be effectively assisted in judging whether training actions reach the standard or not.

The invention is a method for treating levodopa naïve patients with Parkinson's disease by orally administering a controlled release levodopa formulation twice a day to the levodopa naïve patient and the method provides an improvement of a patient's motor state as determined by patient's Parkinson's disease diary, provides a reduction of from about 10%-40% in the patient's tremor, dyskinesia, and / or mobility and / or provides a reduction in the patient's Movement Disorders Society version of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) scores by at least 3 points.

The present disclosure provides a method of treating schizophrenia or a schizophrenia-related disorder in a patient in need thereof. The method comprises orally administering to the patient, twice daily via a titration regimen, an oral pharmaceutical composition comprising a plurality of xanomeline beads containing xanomeline or a salt thereof, and a plurality of trospium chloride beads containing a trospium chloride salt, the titration regimen comprising increasing titration of the xanomeline or a salt thereof and the trospium chloride salt.

Disclosed are a wearable depressive disorder recognition and seizure detection method and device. The method includes the following steps of: acquiring multi-modal data of a target user by using a wearable device; inputting the multi-modal data into a trained depressive disorder recognition model to determine whether the target user is a depression disorder person or a normal person; and inputting the corresponding multi-modal data to a trained depressive disorder seizure detection model to determine whether the target user is in a seizure state in the case of a determined depressive disorder person.

The invention discloses a composition for treating depression and application of the composition. The composition for treating depression is prepared from the following components in parts by weight: 35 to 40 parts of ligustilide, 0.5 to 1.5 parts of atractydin and 0.1 to 1 part of alpha-cyperone. According to the invention, the active components in the Yueju pill, which are targeted to 5-HT1AR and 5-HTT, are compounded for the first time to prepare a new traditional Chinese medicine functional component composition, and in addition, the anti-depression effect of the active components is evaluated by establishing a reserpine mouse depression model, so that the anti-depression effect of the Yueju pill is improved. The result shows that the active component composition screened by the 5-HT1AR and 5-HTT targets can adjust the content of monoamine neurotransmitters in brain tissues in vivo to achieve the anti-depression effect, and in-vivo pharmacological experiments fully prove that the composition has the anti-depression effect.

The invention relates to pediococcus acidilactici, in particular to pediococcus acidilactici TCI550 with the preservation number of DSM34536, and the pediococcus acidilactici TCI550 has the preservation number of DSM34536. In addition, the pediococcus acidilactici TCI550 and / or metabolites thereof can be suitable for preparing a composition for nerve health care and / or cognition improvement.

A method of treating cognitive decline and / or memory deficits in a subject in need thereof includes administering to the subject a therapeutically effective amount of at least one agent that directly or indirectly increases Ptprd activity and / or decreases Aβ induced inhibition of Ptprd activity in the subject.

Methods of treating a subject for a dissociative disorder and methods of screening agents for the ability to modulate dissociative and associative states in a subject are provided. In particular, agents that alter rhythmic neural activity in the posteromedial cortex can be used to modulate dissociative and associative states in a subject.

The invention provides a microbial marker and a prediction model for schizophrenia with social anxiety disorder. The microbial marker is a Bacteroides microorganism in saliva. The relevance between the relative abundance of Bacteroides microorganisms in saliva and social anxiety disorder is found for the first time. A Nomogram clinical prediction mode is formed by taking the specific microbial marker as a microbial marker in combination with a children bad experience scale and 6-hydroxymelatonin and 5-hydroxyindoleacetic acid in serum, so that objective biological indexes can be provided for early diagnosis and monitoring of whether schizophrenia is accompanied by social anxiety disorder or not; errors of subjective evaluation are reduced; moreover, the oral saliva sample has the obvious advantage of being easy to collect for psychiatric patients, the working difficulty of medical staff can be greatly reduced, and revolutionary changes of prediction, diagnosis and treatment of schizophrenia accompanied with social anxiety disorder are expected to be brought.

The invention discloses an AI psychological counseling method and system for generating an emotional map and a differentiation report, and relates to the technical field of artificial intelligence and psychology crossing. The invention discloses an AI psychological counseling method and system for generating an emotional map and a differentiated report. Through interaction of voice and characters, a visual emotional map is generated, personalized action suggestions are generated, and a visitor report or a psychological counselor report is generated. According to the method, a visual emotional map is generated through voice and character analysis, changes in the emotional map can be seen more visually, meanwhile, a proper psychological AI model is adapted, personalized action suggestions and corresponding related reports are generated, fine emotional fluctuations can be effectively captured through the accurate voice and character capturing capacity, and therefore the emotional effect is improved. A multi-dimensional emotion analysis model is arranged in the system, emotion fluctuation is monitored in real time, a detailed emotion change trend chart is generated, and the scientific basis is provided for psychological counseling.

Methods and compositions for treating social function disorders are disclosed. The methods involve administering compound of Formula I

The present inventive concept provides methods of determining whether a subject has cortical or cerebral visual impairment (CVI) as well as determining whether the subject has a traumatic brain injury thereby allowing treatment for these conditions. The present inventive concept also provides a standardized method for assessing pediatric or adolescent visual acuity.

Provided is a medicament for treating a disease related to motor neuron injury. The medicament comprises: a circular RNA having a circBank ID of hsa_circPTPRN2_018, and a proper diagnosis module and a drug carrier. Also provided is use of a circular RNA in preparing a medicament for diagnosing and treating a disease related to motor neuron injury.

A method for predicting early onset of mental health issues in work environments using artificial intelligence (AI) comprising: a) collecting data from two sources: (1) derived from employee survey an