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984 results about "Organophosphate" patented technology

Organophosphates (also known as phosphate esters, or OPEs) are a class of organophosphorus compounds with the general structure O=P(OR)₃. They can be considered as esters of phosphoric acid. Like most functional groups organophosphates occur in a diverse range of forms, with important examples including key biomolecules such as DNA, RNA and ATP, as well as many insecticides, herbicides, nerve agents and flame retardants.

Xylo-LNA analogues

Based on the above and on the remarkable properties of the 2′-O,4′-C-methylene bridged LNA monomers it was decided to synthesise oligonucleotides comprising one or more 2′-O,4′-C-methylene-β-D-xylofuranosyl nucleotide monomer(s) as the first stereoisomer of LNA modified oligonucleotides. Modelling clearly indicated the xylo-LNA monomers to be locked in an N-type furanose conformation. Whereas the parent 2′-deoxy-β-D-xylofuranosyl nucleosides were shown to adopt mainly an N-type furanose conformation, the furanose ring of the 2′-deoxy-β-D-xylofuranosyl monomers present in xylo-DNA were shown by conformational analysis and computer modelling to prefer an S-type conformation thereby minimising steric repulsion between the nucleobase and the 3′-O-phopshate group (Seela, F.; Wömer, Rosemeyer, H. Helv. Chem. Acta 1994, 77, 883). As no report on the hybridisation properties and binding mode of xylo-configurated oligonucleotides in an RNA context was believed to exist, it was the aim to synthesise 2′-O,4′-C-methylene-β-D-xylofuranosyl nucleotide monomer and to study the thermal stability of oligonucleotides comprising this monomer. The results showed that fully modified or almost fully modified Xylo-LNA is useful for high-affinity targeting of complementary nucleic acids. When taking into consideration the inverted stereochemistry at C-3′ this is a surprising fact. It is likely that Xylo-LNA monomers, in a sequence context of Xylo-DNA monomers, should have an affinity-increasing effect.
Owner:QIAGEN GMBH

mRNA cap analogs

Dinucleotide cap analogs are disclosed, modified at different phosphate positions with a boranophosphate group or a phosphoroselenoate group. The analogs are useful as reagents in the preparation of capped mRNAs and have increased stability both in vitro and in vivo. They may be used as inhibitors of cap-dependent translation. Optionally, the boranophosphate or phosphoroselenoate group has a 2′-O or 3′-O-alkyl group, preferably a methyl group, producing analogs called BH3-ARCAs or Se-ARCAs. ARCAs may be modified with α-, β-, or γ-boranophosphate or phosphoroselenoate groups.
Owner:UNIWERSYTET WARSZAWSKI +1

Pharmaceutical co-crystal compositions

A pharmaceutical composition comprising a co-crystal of an API and a co-crystal former; wherein the API has at least one functional group selected from ether, thioether, alcohol, thiol, aldehyde, ketone, thioketone, nitrate ester, phosphate ester, thiophosphate ester, ester, thioester, sulfate ester, carboxylic acid, phosphonic acid, phosphinic acid, sulfonic acid, amide, primary amine, secondary amine, ammonia, tertiary amine, sp2 amine, thiocyanate, cyanamide, oxime, nitrile diazo, organohalide, nitro, s-heterocyclic ring, thiophene, n-heterocyclic ring, pyrrole, o-heterocyclic ring, furan, epoxide, peroxide, hydroxamic acid, imidazole, pyridine and the co-crystal former has at least one functional group selected from amine, amide, pyridine, imidazole, indole, pyrrolidine, carbonyl, carboxyl, hydroxyl, phenol, sulfone, sulfonyl, mercapto and methyl thio, such that the API and co-crystal former are capable of co-crystallizing from a solution phase under crystallization conditions.
Owner:JOHNSON & JOHNSON CONSUMER COPANIES +2

Process for the manufacture of 1, 1, 1, 3, 3-pentachloropropane

A process is provided for the production of 1,1,1,3,3-pentachloropropane. The process comprises: (a) producing a product mixture in a reactor by reacting carbon tetrachloride and vinyl chloride in the presence of a catalyst mixture comprising organophosphate solvent, iron metal and ferric chloride under conditions sufficient to produce 1,1,1,3,3-pentachloropropane; (b) subjecting the 1,1,1,3,3-pentachloropropane containing product mixture from step (a) to evaporation such that a fraction enriched in 1,1,1,3,3-pentachloropropane is separated from the product mixture and a bottoms fraction results which comprises the iron metal / ferric chloride catalyst components and heavy end by-products; and (c) recycling at least a portion of the bottoms fraction from step (b) to the reactor.
Owner:OCCIDENTAL CHEM CORP

Compositions and Methods for Improving Overall Tooth Health and Appearance

Disclosed are oral care compositions comprising selected surface-active organophosphate compounds and methods of use to provide protection of teeth from erosion caused by the action of chemicals, such as harsh abrasives and acids. The surface-active organophosphate compounds are substantive to teeth, the phosphate groups binding the calcium in teeth and thus preventing loss of calcium from dissolution when contacted with acids. The organophosphate compound may also deposit a protective surface coating that prevents contact of teeth with erosive challenges. Selected organophosphate compounds contain one or more phosphate groups and are combined in the oral care composition with one or more of a fluoride ion agent, an antimicrobial agent preferably selected from quaternary ammonium compounds and polyvalent metal salts, an anticalculus agent and additional surfactant, to provide benefits including superior anti-erosion, anticaries, antiplaque and anti-staining as demonstrated by enhanced fluoride uptake, remineralization, resistance to acid demineralization and antimicrobial activities, resulting in improved overall tooth health, structural integrity and appearance.
Owner:THE PROCTER & GAMBLE COMPANY

High-performance halogen-free flame retardant ABS modified resin and preparation method thereof

The invention relates to a high-performance halogen-free flame retardant ABS modified resin and a preparation method thereof. The resin comprises the following components with the content (in parts by weight): 100 ABS resin, 4-30 polyamide, 5-25 phosphate fire retardant, 0.1-0.5 anti-drippage agent, 5-10 toughening agent, 1-5 nano filler, 1-5 compatilizer, 0.2-1 antioxidant, 0.1-0.5 light stabilizer and 1-5 processing agent. Compared with the prior art, the invention has reasonable technique, and overcomes the defects of poor flame retardant property and low impact strength of the existing halogen-free flame retardant ABS; and the invention adopts a novel high-efficiency halogen-free flame retardant compounding synergism technology, a novel polyamide coal-forming agent, the high-efficiency synergism between organic and inorganic fire retardants, and the master batch method processing technique, thus endowing the resin with high fire resistance on the basis of improving the original good performances (especially the impact performance) of the ABS resin, and having wide application prospect.
Owner:SHANGHAI KUMHO SUNNY PLASTICS +1

Highly purified tocopheryl phosphate, process for producing the same, analytical method therefor and cosmetic

Disclosed herein are a highly purified tocopheryl phosphate and / or a salt thereof (tocopheryl phosphates) wherein a P,P'-bistocopheryl hypophosphate and / or a salt thereof (P,P'-bistocopheryl diphoshates) is contained in a proportion of not higher than 3% by weight; a process for producing a highly purified tocopheryl phosphate and / or a salt thereof, which comprises the steps of reacting a tocopherol with an oxyphosphorus trihalide followed by treating with an acid or basic aqueous solution to thereby form tocopheryl phosphates (i) in which P,P'-bistocopheryl diphoshates (ii) formed as by-products are contained, hydrolyzing the P,P'-bistocopheryl diphoshates (ii) under acid condition, and, optionally, rendering the hydrolyzate neutral or basic under basic condition; and a method of analyzing tocopheryl phosphates, comprising analyzing a sample containing components (i) and (ii) with the use of a high-performance liquid chromatograph column packed with a gel of a polymethacrylate having, bonded thereto, long-chain alkyl groups. None or only an extremely minute amount of P,P'-bistocopheryl diphoshates are contained in the highly purified tocopheryl phosphates, so that the highly purified tocopheryl phosphates exhibit antioxidant and blood circulation promoting effects, have excellent water solubility, are powdery so that the handling thereof is extremely easy, are free from cutaneous irritation and allergenecity and ensure dermal safety. Therefore, the highly purified tocopheryl phosphates are useful as cosmetic ingredients. The amounts of components (i) and (ii) can be simply measured with high accuracy by the above method.
Owner:SHOWA DENKO KK

Impact-modified polycarbonate blends

A thermoplastic molding composition having improved flammability rating and mechanical properties is disclosed. The composition contains aromatic polycarbonate having a weight-average molecular weight Mw≧25,000 g / mol., polyalkylene terephthalate, graft (co)polymer characterized in that its grafted phase includes structural units derived from acrylate monomers, an oligomeric organic phosphoric acid ester, and an optional fluorinated polyolefin. In a preferred embodiment the graft (co)polymer is characterized in its core-shell morphology.
Owner:COVESTRO DEUTSCHLAND AG

2'-Fluorine-4'-Substituted-Nucleoside Analogues, Preparation Methods and Uses Thereof

ActiveUS20100234584A1Reduce pressureMore toxic side effectSugar derivativesDigestive systemPhosphateVirus
The present invention provides 2′-fluorine-4′-substituted-nucleoside analogues or their pro-drugs or 5′-phosphate esters (including the pro-drugs of the 5′-phosphate esters), preparation methods and uses thereof. The compounds have the general formula as follows:whereinB=R=CH3, CN, N3, C≡CH;R′=H, F;X=F, OH, NH2;Y=H, CH3, F, OH, NH2 The compounds are used in the synthesis of drugs for the treatment of virus infection, especially for the treatment of HBV, HCV or HIV infection.
Owner:HENAN GENUINE BIOTECH CO LTD

Method for qualitatively screening 242 kinds of compounds by liquid phase chromatography-mass spectra at the same times

The invention discloses a method which can carry out qualitative screening to 242 compounds (drugs or toxicants) simultaneously. A mode of liquid chromatogram-mass spectrometry (LC-MS / MS) multi-reaction monitoring (MRM) is adopted to carry out determinedness to objects by two pairs of parent ion-daughter ion pair and retention time. The 242 drugs or toxicants comprise toxic products such as opioids, amphetamine and cocaines and the like, bromazepam such as benzodiazepines and barbiturates, and common drugs, alkaloid, pesticide (including organophosphates, carbamates, pyrethroid pesticide residues and organochlorine pesticide), weed killer, raticide and the like.
Owner:上海市公安局刑事侦查总队

Detection of analytes

The present invention relates to the field of detection of analytes, and in particular to detection of organophosphates using a liquid crystal assay format and a variety of analytes in stand-off detection formats utilizing liquid crystals as part of reporting system. The present devices find use in detecting cumulative exposure to organophosphates in the aerosol phase.
Owner:PLATYPUS TECH

Use of cannabinoids and terpenes for treatment of organophosphate and carbamate toxicity

Pharmaceutical compositions in which isolated cannabinoid receptor modulators are optionally combined with terpene blends in a pharmaceutically acceptable carrier. Methods for treating or preventing a disease, disorder, dysfunction or condition caused by exposure to an organophosphate or carbamate acetylcholineesterase inhibitor with the inventive compositions are also disclosed.
Owner:KOTZKER CONSULTING

Protected nucleotide analogs

Disclosed herein are nucleotide analogs with protected phosphates, methods of synthesizing nucleotide analogs with protected phosphates and methods of treating diseases and / or conditions such as viral infections, cancer, and / or parasitic diseases with the nucleotide analogs with protected phosphates.
Owner:ALIOS BIOPHARMA INC

Nucleic acid amplification with terminal-phosphate labeled nucleotides

The present invention relates generally to the use of terminal-phosphate-labeled nucleotides having three or more phosphates as substrates for nucleic acid polymerases and their use in DNA amplification. The labels employed are chemiluminescent, fluorescent, electrochemical and chromogenic moieties as well as mass tags and include those that are directly detectable, detectable after enzyme activation or feed into other processes to generate a different signal. The signal generated from the attached dyes may also be used to quantify the amount of amplification. Further provided are stabilizers that enhance the stability of terminal-phosphate labeled nucleoside polyphosphates in aqueous solutions and are useful for reducing non-enzymatic hydrolysis of these nucleotides, hence decrease background.
Owner:GLOBAL LIFE SCI SOLUTIONS USA LLC

4′-C-substituted-2-haloadenosine derivative

The present invention provides a 4′-C-substituted-2-haloadenosine derivative represented by the following formula [I], [II], or [III]:(wherein X represents a halogen atom, R1 represents an ethynyl group or a cyano group, and R2 represents hydrogen, a phosphate residue, or a phosphate derivative residue). The present invention also provides a pharmaceutical composition containing the derivative and a pharmaceutically acceptable carrier therefor. Such derivative is useful as medicine for the treatment of Acquired Immune Deficiency Syndrome (AIDS).
Owner:YAMASA SHOYU CO LTD

Flame-retardant polycarbonate resin composition and its moldings

An object of the invention is to provide a flame-retardant polycarbonate resin composition which can provide a sliding property of a molding product formed of a flame-retardant resin composition obtained by blending a polycarbonate resin and a styrene resin with a phosphate ester compound and having a good flowability without decreasing an appearance of a molding product. The invention relates to a flame-retardant polycarbonate resin composition including 100 parts by weight of a resin composed of (A) from 60 to 99% by weight of a polycarbonate resin and (B) from 40 to 1% by weight of a styrene resin, (C) from 1 to 30 parts by weight of a phosphate ester compound and (D) from 0.3 to 3 parts by weight of a silicone oil having a viscosity of from 1,000 to 20,000 cs.
Owner:IDEMITSU KOSAN CO LTD

Flame retardant electrical wire

An electrical wire comprising conductor and a covering disposed over the conductor. The covering comprises a thermoplastic composition. The thermoplastic composition comprises a poly(arylene ether); a polypropylene, a block copolymer; and an organophosphate ester. The sum of weighted average aryl alkylene content of the block copolymer and the amount of organophosphate ester is greater than or equal to 46.5.
Owner:SABIC INNOVATIVE PLASTICS IP BV

Fluorochemical free aqueous coating compositions and methods of use thereof

Fluorochemical free aqueous coating compositions are disclosed. The compositions comprise a film-forming polymer and an organophosphate surfactant. The compositions exhibit superior wetting and leveling properties compared to fluoroaining sulfur based surfactants. Inventive compositions are particularly suitable for use as floor finishes. Methods of makinge aqueous coating compositions are also described.
Owner:JOHNSONDIVERSEY INC

Water-based epoxy modified phosphorus-containing styrene-acrylic antirust emulsion and synthesis method thereof

InactiveCN102127271ASmall sizeControl particle diameterAnti-corrosive paintsEpoxy resin coatingsWater basedEpoxy
The invention relates to a water-based epoxy modified phosphorus-containing styrene-acrylic antirust emulsion and a synthesis method thereof. The water-based epoxy modified phosphorus-containing styrene-acrylic antirust emulsion is prepared by a conventional emulsion polymerization method, and can be crosslinked with a crosslinking agent and cured at room temperature; and the particle size of thewater-based epoxy modified phosphorus-containing styrene-acrylic antirust emulsion is 80-140nm, the solid content is 40-50%, and the minimum filming temperature is not higher than 35 DEG C. The emulsion is prepared by introducing epoxy-group-containing epoxy resin and phosphate functional monomer with flash-etching-resistant function into the conventional emulsion polymerization process of acrylate. The polymerization technique is simple and practical, almost no gel is generated in the polymerization process, and the storage stability of the emulsion can reach more than 1 year. When the synthesized emulsion is crosslinked with the curing agent to form a film, a three-dimensional network structure is generated, and an efficiently-antirust paint film with high adhesive force can be formed after the emulsion is completely cured. When the water-based epoxy modified phosphorus-containing styrene-acrylic antirust emulsion is used as water-based antirust paint, the adhesive force can reach Level 1, and the water absorptivity is smaller than or equal to 10%; and the water-based epoxy modified phosphorus-containing styrene-acrylic antirust emulsion does not bubble after being soaked in a 3% NaCl solution for 450 hours, and has favorable corrosion resistance.
Owner:DALIAN POLYTECHNIC UNIVERSITY

Preparation method for anti-rust soap-free acrylate emulsion

The invention relates to a preparation method for a base material of an anti-rust coating. The preparation method for an anti-rust soap-free acrylate emulsion is characterized in that a reactive emulsifier is selected, a polymeric monomer comprises (methyl) acrylic acid and an acrylic monomer thereof, a versatic acid vinyl monomer and a crosslinking monomer, a phosphate monomer is taken as a modified monomer, and the emulsion polymerization is carried out through semi-continue process under the action of an initiator, so that the soap-free anti-rust acrylate emulsion adopting water as dispersive medium is synthesized. The preparation method for the anti-rust soap-free acrylate emulsion can not only meet the requirement of environmental protection, but also enhance the rust resistance.
Owner:HUBEI EAST ST SPECIAL COATING TECH

Phosphate derivatives of pharmaceutical products

According to the invention, there is provided a complex of a pharmaceutical compound selected from the group consisting of opioids, hormones, anaethetics and chemotherapeutic agents comprising the reaction product of: (a) one or more phosphate derivatives of one or more opioids, steroid hormones, thyroid hormones, anaesthetics or chemotherapeutic agents having a phenolic, primary alcohol, secondary alcohol or tertiary hydroxyl group; and (b) a complexing agent selected from the group comprising amphoteric surfactants, cationic surfactants, amino acids having nitrogen functional groups and proteins rich in these amino acids.
Owner:VITAL HEALTH SCIENCES PTY LTD

Cyanine derivatives, fluorescent conjugates containing same and use thereof

A subject matter of the invention is cyanine derivatives of formula:in which the dotted lines represent the atoms necessary for the formation of one or two fused aromatic rings, each ring comprising 5 or 6 carbon atoms;R1, R2, R3 and R4 represent, independently of one another: H; substituted or unsubstituted C1-C15 alkyl; C1-C6 alkoxy; (C2-C12)dialkylamino; C1-C6 alkoxycarbonyl; di(C2-C12)alkylamido; a substituted or unsubstituted aryl, arylalkyl or aryloxy group; a halogen atom; a nitro; an L1-W, L2-M, L2-A or L2-G group;R5 and R6 represent, independently of one another: substituted or unsubstituted C1-C15 alkyl; a substituted or unsubstituted aryl or arylalkyl group; an L1-W, L2-M, L2-A or L2-G group;X is chosen from: O, S or CR7R8; Y is chosen from: O, S or CR9R10;R7, R8, R9 and R10 independently represent: substituted or unsubstituted C1-C15 alkyl; substituted or unsubstituted aryl, arylalkyl or aryloxy; an L1-W, L2-M, L2-A or L2-G group;R7 and R8 and / or R9 and R10 can also together form a ring comprising 5 or 6 atoms or a heterocycle comprising 4 to 5 carbon atoms and an oxygen atom;B represents a polymethine bridge comprising 1 to 5 methine groups, said groups being in particular individually unsubstituted or substituted by a substituted or unsubstituted C1-C15 alkyl; a substituted or unsubstituted aryl, arylalkyl or aryloxy group; a nitro group; an L1-W, L2-M, L2-A or L2-G group;L1 and L2 are connecting arms; G is a reactive group; A is a coupling agent; M is a conjugated molecule, W is a phosphate or phosphonate ester (preferably diester), with the proviso that the cyanine derivative comprises at least one L1-W group and at least one L2-A, L2-G or L2-M group.
Owner:CIS BIO INT

Modified Calcium Phosphate Bone Cement

A calcium phosphate bone cement setting to a calcium-deficient hydroxyl apatite is modified by an organic phosphate ester of orthophosphoric acid or a salt of an organic phosphate ester. The base cement contains preferably tricalcium phosphate, dicalcium phosphate (anhydrous), calcium carbonate and precipitated hydroxyl apatite. The organic phosphate ester is added to the base cement in an amount of 0.5 to 5 percent by weight. The bone cement can be modified further by adding mineralized collagen I.
Owner:DRESDEN UNIVERSITY OF TECHNOLOGY

Carrier

There is provided a method for improving the efficacy and / or transdermal transport of topically administered pharmaceuticals and pharmacologically active compounds, said method comprising the step of incorporating the pharmaceutical or pharmacologically active compound in a carrier comprising an effective amount of one or more complexes of a phosphate derivative of a lipophilic pharmaceutically acceptable compound.
Owner:VITAL HEALTH SCIENCES PTY LTD

Preparation method of halogen-free flame retardant high-intensity polyvinyl alcohol fibers

The invention discloses a preparation method of halogen-free flame retardant high-intensity polyvinyl alcohol fibers, which is characterized by comprising the following steps of uniformly mixing 20-45 parts by weight of phosphate ester flame retardant powder with the average particle size no more than 1.0 microns, 1-10 parts by weight of dispersing agent, and 40-79 parts by weight of water to prepare flame retardant suspended slurry, continuously mixing the slurry and polyvinyl alcohol plus boron spinning solution with the polymerization degree of 1700-3000 and the alcoholysis degree more than 99 percent through a mode of spun injection, carrying out spinning with the mixed solution through a polyvinyl alcohol wet method plus a spinning process route, carrying out neutralization, wet-heat drawing, washing and drying on solidified fibers to obtain as-spun fibers, preheating the as-spun fibers to the temperature of 200-230 DEG C, drawing by 2-4 times, and then carrying out heat setting on the fibers at the temperature of 180-210 DEG C for 2-5min to obtain the halogen-free flame retardant high-intensity polyvinyl alcohol fibers. According to different uses, post-treatment steps such as formalization, oiling, curling, cutting and the like can be selectively carried out on the flame-retardant fibers. The flame-retardant fibers prepared through the method has the advantages of low toxicity and high intensity, realizes self-extinguishment after leaving fire, is free of halogen and the dripping phenomenon and is used for aspects of fabric flame retarding, enhancing flame retardant fabrics and the like, and the limited oxygen index can reach 28-30.
Owner:SICHUAN UNIV +2

Low smoke density poly(arylene ether) compositions, methods, and articles

Thermoplastic compositions and methods of making the compositions are disclosed. The thermoplastic compositions include poly(arylene ether), a poly(alkenyl aromatic), an organophosphate ester flame retardant, a functionalized polysiloxane, and an organic acid. The thermoplastic compositions produce surprisingly low smoke density when burned, and they are useful for the fabrication of articles for the transportation and building and construction industries.
Owner:SHPP GLOBAL TECH BV

Phosphorus-containing stabilizers for fluoroolefins

The present disclosure relates to compositions comprising at least one fluoroolefin and an effective amount of a stabilizer comprising at least one phosphorus-containing compound selected from the group consisting of thiophosphates, butylated triphenylphosphorothionates, and organophosphates. The stabilized compositions may be useful in cooling apparatus, such as refrigeration, air-conditioning, chillers and heat pumps, as well as in applications as foam blowing agents, solvents, aerosol propellants, fire extinguishants, and sterilants.
Owner:THE CHEMOURS CO FC LLC

Reactive phosphorus flame retardant containing DOPO and active double bond and preparation method and application thereof

The invention discloses a reactive phosphorus flame retardant containing DOPO and an active double bond and a preparation method and application thereof. Dichloro replaces phosphate to react with polyhydric alcohols or polyhydric phenol acidifying with propylene or partial methyl propene and then with DOPO modified aryl-dihydric phenol and DOPO modified aryl-dihydric alcohol, and a reactive flame retardant monomer molecule capable of being cured and provided with active double bonds and a DOPO flame retardant group are obtained and can be used in various flame retardants of epoxyacrylates and unsaturated polyester resins and the like containing unsaturated double bond polymer resins. The flame retardant overcomes defects that the compatibility between an additive flame retardant and a matrix is poor, the additive flame retardant and the matrix are easy to lose, the water resistance is poor, and the like, and the LOI (limit oxygen index) value of resins can be improved remarkably and the flame-resistant effect is good when the flame retardant is used for flame retarding in the epoxyacrylates and the unsaturated polyester resins.
Owner:苏州安鸿泰新材料有限公司
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