56results about How to "Extended duration of action" patented technology

Methods and compositions for enhancing the activity and / or duration of action of loteprednol etabonate and other soft anti-inflammatory steroids of the haloalkyl 17α-alkoxycarbonyloxy-11β-hydroxyandrost-4-cn-3-one-17β-carboxylate type and the corresponding Δ1,4-compounds are described. The enhancing agents have the formula:wherein Z1 is carbonyl, β-hydroxymethylene or methylene; R2 is H, —OH or —OCOR3 wherein R3 is C1-5 alkyl; Y is —OH, —SH or —OCOR4 wherein R4 is C1-5 alkyl, cyclopentylethyl or diethylaminoethyl; and the dotted line in ring A indicates that the 1,2-linkage is saturated or unsaturated. Ophthalmic administration in the treatment of dry eye is specifically targeted.

Pharmaceutical compositions in which isolated cannabinoid receptor modulators are optionally combined with terpene blends in a pharmaceutically acceptable carrier. Methods for treating or preventing a disease, disorder, dysfunction or condition caused by exposure to an organophosphate or carbamate acetylcholineesterase inhibitor with the inventive compositions are also disclosed.

The invention discloses an aquaculture Chinese herbal medicine water purification agent. According to the invention, cockscomb, houttuynia cordata, polygonum multiflorum, scutellaria baicalensis, albizia flower, common andrographis, indigowoad root, wild chrysanthemum, mulberry leaf, acori graminei, mangnolia officinalis, thyme, herba glechomae, and licorice are scientifically formulated; and antibacterial and disease-suppression active components in the Chinese herbal medicines are extracted through a fermentation process. With the water purification agent, pathogens in aquaculture water can be effectively removed, the immunity of cultured fish and shrimp can be improved, and the occurrences of aquaculture diseases can be avoided or reduced. With a combined process of liquid fermentation and solid fermentation, probiotics such as bacillus subtilis, bacillus licheniformis, EM bacteria, photosynthetic bacteria and nitrifying bacteria with high content and high activity are added into aquaculture water. Through enrichment and metabolism of the probiotics, pollutants can be removed, nutrition can be supplemented, nutrient digestion and absorption can be promoted, and animal growth and development can be promoted. The water purification agent provided by the invention has a relatively low production cost, and is suitable for industrialized productions and large-scale applications. The water purification agent has a good application prospect.

The present invention discloses novel monocarboxilic ester derivative of buprenorphine and dicarboxilic ester derivative of dibuprenorphine, which exhibit ever lasting pain relieving effect than the hydrochloride of buprenorphine. The present invention discloses also the synthesis process of these novel buprenorphine ester derivatives and long-acting pain relieving medicinal composition containing compound selected from buprenorphine alkaloid and these novel buprenorphine ester derivatives.

A method is provided for preparing a polymer derivative of docetaxel provided by an ester linkage between at least one hydroxyl group of docetaxel and a carboxyl group of an aspartic acid side chain of a block copolymer containing polyethylene glycol and polyaspartic acid, which method includes a step of adjusting the ratio and / or the number of docetaxel molecules linked to the block copolymer to thereby control the release rate of docetaxel from the resultant polymer derivative of docetaxel.

The invention relates to a heat accumulating power station and a heat supplying and power generating method thereof. The heat accumulating power station comprises a power supply, an electric heater, a heat supplying device, a power generating device, a phase change heat storage device and a fused salt heat storage device, wherein the phase change heat storage device is connected to the heat supplying device, the power generating device and the fused salt heat storage device, respectively, and a phase change material is heated by the electric heater so as to convert electric energy into heat energy which is stored in the phase change material; the fused salt heat storage device connected to the heat supplying device, the power generating device and the phase change heat storage device comprises a hot salt tank which stores high-temperature fused salt and a cold salt tank which stores low-temperature fused salt; the hot salt tank is heated through the electric heater by the power supply to convert electric energy into heat energy which is stored in the high-temperature fused salt in the hot salt tank; the power generating or heat supplying duration of the heat accumulating power station is prolonged by matched power generation or heat supply of the phase change heat storage device and the fused salt heat storage device, and meanwhile, by virtue of different heat charging and discharging characteristics of the fused salt and the heat storage device, an implementing means for flexibly supplying heat and power is provided according to different users and price structures.

The invention provides a medicament for treating hemorrhage disease of grass carp. The medicament for treating hemorrhage disease of grass carp comprises the following components of baical skullcap root, rhubarb, amur corktree bark, indigowoad root, table salt and xylogen. The medicament for treating hemorrhage disease of grass carp has the characteristics that: the effect is obvious, the medicament can be stored for a long time, has a long action period, and is low in cost, safe and harmless for aquatic animals and environment, and small in acrimony, the raw materials can be easily obtained, and the like.

The invention relates to the technical field of self-repairing of antifouling coatings and discloses sustained-release silicone oil hydrogel and application thereof in marine antifouling coatings. Themonomers for preparing the hydrogel shell comprise acrylamide, N-hydroxymethyl acrylamide, N-isopropyl acrylamide and alkyl propionate or acrylate. The preparation method of the sustained-release silicone oil hydrogel disclosed by the invention is simple, feasible, high in safety and capable of realizing industrial production, and has great development potential. When applied to the marine antifouling coatings, the sustained-release silicone oil hydrogel is capable of improving the compatibility of the methyl silicone oil and other components of the coating, controlling the release rate of the methyl silicone oil in the coating and prolonging the validity of the effect of the methyl silicone oil, and contributes to maintaining the microstructure of the coating having the antifouling function, and the technical defects of the conventional methyl silicone oil application technology are overcome.

The invention discloses a polyurethane material for adsorbing a TGF-B1 growth factor for tissue repair and a preparation method thereof. The preparation method comprises the following steps: (1) reacting the polymer dihydric alcohol, diisocyanate and a catalyst for 0.5-24h at 60-120 DEG C to form a prepolymer; (2) adding an alkynyl chain extender into the prepolymer, reacting for 0.5-24h at 60-120 DEG C, adding water to end the reaction, baking and purifying through a coprecipitation method to obtain the functional polyurethane; and (3) performing click reaction on the nitrine modified HSNGLPL affinity peptide and the functional polyurethane in the mixed solution of the anhydrous cupric sulfate and the sodium ascorbate. The alkynyl chain extender is introduced into the polyurethane and is combined with the HSNGLPL affinity peptide through the click chemistry. The preparation method is simple and convenient, and the obtained product can specifically adsorb the TGF-B1 growth factor.

The plant antifreezing liquid is compounded with purslane as main material and through extraction, and compounding the extracted liquid with ascorbic acid, glucose, cane sugar, algin sodium, glycerin and choline chloride. The present invention as one kind of natural preparation has no toxicity, no harm and no environmental pollution, and may be sprayed to foliage, flower and bud easily to reach effective antifreezing period of 10-20 days.

The invention relates to a natural formaldehyde scavenging agent and its preparation method. Specifically, the invention relates to a formaldehyde-purifying scavenging agent prepared by natural raw materials and its preparation method. The natural formaldehyde scavenging agent is prepared by the following materials by weight: 30-55 parts of magnets, 50-80 parts of a purslane extracting solution, 20-45 parts of a cassia seed extracting solution, and 100-180 parts of distilled water. By adopting extracting solutions of natural herbal medicines, the natural formaldehyde scavenging agent of the invention provides a solution to the problem of secondary pollution caused by harmful substances generated during usage of current formaldehyde scavenging agents, and has no pollution, lasting effectiveness as well as obvious effect.

The invention provides a remediation method for chrome-polluted soil in a coal mine collapse region. Firstly, soil sample collecting is conducted through a grid multi-point method, then the chrome content of collected soil samples is measured, the soil is graded according to soil chrome content measuring results, then the 10-18 cm thick part of the surface layer of the chrome-polluted soil is turned over, a microbial agent and soil improvement particles of corresponding quantities are applied according to the determined soil grades, finally the chrome-polluted soil is irrigated, the irrigation depth is 20 cm or over, the relative humidity of soil reaches 85% or over and is maintained for 10-20 days, and the microbial agent is composed of adsorption carriers and effective viable bacteria adsorbed on the carriers. The method is high in remediation efficiency, low in cost and free of secondary pollution, measures are adjusted to local conditions, the chrome-polluted soil in the coal mine collapse region can be remedied more precisely and rapidly, chrome is effectively prevented from migrating in the soil, nutrient elements are provided for the soil for a long time in the soil remediation process, and the available value of the soil is increased.

The present invention relates to a class of EP2 antagonist azetidines of general formula (I) wherein the variables and substituents are as defined herein, and especially to EP2 antagonist compounds, to their use in medicine, particularly in the treatment of endometriosis and / or uterine fibroids (leiomyomata) and to intermediates useful in their synthesis and to compositions containing them.

The invention relates to a microorganism oil recovery method, in particular to a method of microorganism wax removing and preventing of a high-temperature and high-salinity high-wax-bearing oil well.The method comprises the following steps that (1) a test oil well is screened; (2) a microorganism wax removing and preventing agent is screened; (3) a field construction technology is selected; (4) afield test is conducted; and (5) the effect is evaluated. According to the method of microorganism wax removing and preventing of the high-temperature and high-salinity high-wax-bearing oil well, theproblems that the using amount is high, the cost is high, and the safety and environmental protection performance is poor due to the fact that a traditional chemical wax removing and preventing agentis used can be solved, the method has the advantages that the reliability is high, the application range is wide, and no environmental pollution is generated, and meanwhile the method further has theadvantages that the cost is low, the action period is long, and the economic benefit is high. Thus, the method can be widely applied to microorganism wax removing and preventing of the wax-bearing oil well.

The invention discloses a silt dam and a design method thereof. The silt dam comprises a mounting plate provided with a water permeable net, a transverse water permeable hole set corresponding to themounting plate is formed in a dam body, a vertical mounting groove corresponding to the transverse water permeable hole set is formed in the dam body, two or more pairs of U-shaped mounting grooves are formed in the vertical mounting groove, and a reinforcing structure parallel to the water flow direction is arranged on the downstream face of the dam body. The design method comprises the steps: adesign flood level and a check flood level are obtained based on local basin weather, hydrology, geology and landform and rainstorm data so as to obtain dam body elevation; after permeable holes withdifferent sizes and different distribution modes are determined to be simulated in the dam body, load analysis and seepage analysis are conducted; the size and the distribution mode of the water permeable holes are determined based on load analysis and seepage analysis results; the sizes of the water permeable net and the mounting plate and the distribution mode of the vertical mounting grooves are determined based on the sizes and the distribution mode of the water permeable holes; and the local sediment particle size is obtained, and the grid size of the permeable net is determined based onthe local sediment particle size.

The plant antifreezing liquid is compounded with purslane as main material and through extraction, and compounding the extracted liquid with ascorbic acid, glucose, cane sugar, algin sodium, glycerin and choline chloride. The present invention as one kind of natural preparation has no toxicity, no harm and no environmental pollution, and may be sprayed to foliage, flower and bud easily to reach effective antifreezing period of 10-20 days.

The invention discloses a good-stability long-action-period modified-Chinese-chestnut-protein-coated slow-release fertilizer. The fertilizer is made from the following raw materials, by weight part, 33-36 of cottonseed cake, 7-8 of potassium dihydrogen phosphate, 12-14 of fermented glutinous rice, 3-4 of ferrous chloride, 2-3 of tamarind seed polysaccharide gum, 1.4-1.5 of microcrystalline wax, 78-80 of fresh Chinese chestnuts, 18-20 of fruits of ficus pumila, 1.9-2.1 of a glutamine transaminase preparation and a proper amount of water. Through spraying for two times, the uniformity of coating films of fertilizer particles is greatly improved, so that stability of the fertilizer particles is improved and a slow-release period of the fertilizer in soil is prolonged. The fertilizer itself contains a large number of organic matters and readily-available inorganic nutrients, and can improve the nutrient construction and physical and chemical properties of the soil during a slow-release stage. The fertilization potential of the soil is improved, and crops are prompted to grow fast.

The invention discloses a prescription for treating grass carp hemorrhagic disease. The prescription comprises components including honeysuckle, Picrasma, Radix Isatidis, Forsythia, lignin, photosynthetic bacteria and water. The prescription for treating grass carp hemorrhagic disease has the advantages of remarkable effects, long storage period, long acting period, low cost, and safety to aquatic animals and the environment.

The invention discloses a composite biological stimulant for delaying senescence and death of leaves in middle and late growth stages of peanuts, and belongs to the technical field of agricultural biotechnology. According to the compound biological stimulant for delaying senescence and death of leaves in middle and late growth stages of peanuts, a plant growth regulator melatonin is used in combination with Fe2O3 nanoparticles or ZnO nanoparticles, so that the action period of the growth regulator can be prolonged, and senescence and death of peanuts can be effectively prevented and controlled.

The invention discloses long-acting multi-element leaf microelement fertilizer comprising a microelement fertilizer raw material, an auxiliary material, a synergist, a slow-release binding material and a natural high-molecular material coated material. The microelement fertilizer, the slow-release material and a leaf binding agent are combined, and therefore after being sprayed to leaves, the microelement fertilizer is protected by the slow-release agent and is not prone to oxidation and ineffectiveness; the binding agent increases the rain wash resistance and the wind and sunshine denudation resistance of the microelement fertilizer, the adhesive force of the microelement fertilizer to the leaves is increased, the time for the microelement fertilizer to stay on the leaves is prolonged, and the absorption rate of the fertilizer is increased. The invention further provides a preparation method of the long-acting multi-element leaf microelement fertilizer.

The invention discloses an anion coating solution for air purification. The anion coating solution is prepared from, by weight, anion powder, distilled water, sodium polyacrylate, lauryl glucoside, glycol, 2-imidazolidone, citric acid, zinc oxide, lauryl betaine, tert-butyl acetate and a monoalkoxy-titanates coupling agent; nanoscale tourmaline powder, nanometer titania, sodium silicate, methyl alcohol and 2-alkyl acetamido ethyl imidazoline are added into a high pressure reaction kettle, the mass ratio of the nanoscale tourmaline powder to the nanometer titania, sodium silicate to the sodium silicate to the methyl alcohol to the 2-alkyl acetamido ethyl imidazoline is 1:(3-5):(1.5-2):(2-4):(3-5), and the prepared slurry mixed solution is subjected to a hydrothermal reaction. The anion coating solution can be thoroughly attached to the surfaces of pollutants, no dead corner exists during formaldehyde removal, the using effect is more obvious and more direct, the interfacial effect is larger, the toxic gas adsorption rate is further increased, the adsorptivity is stronger, and a formed nanometer film and the surface of an object are fused more directly.

The invention discloses fertilizer for purifying soil. Through scientific compatibility and application of cockscomb, houttuynia cordata, polygonum multiflorum, scutellaria baicalensis, albizia flower, common andrographis herb, isatis root, wild chrysanthemum flower, mulberry leaf, rhizoma acori graminei, mangnolia officinalis, thyme, lysimachia christinae hance and liquorice root, and through extraction of antibacterial and disease suppressive active components in the traditional Chinese herbal medicines through a fermentation process, pathogenic bacteria in planting water can be effectivelyeliminated, the immunocompetence of breeding fish and shrimps can be improved and occurrence of planting diseases can be avoided or reduced; high-content and high-activity probiotics such as bacillussubtilis, bacillus licheniformis, EM bacteria, photosynthetic bacteria and nitrifying bacteria are added into the planting water through a liquid fermentation and solid fermentation combined process;through enrichment and metabolism of the probiotics, pollutants are eliminated, nutrition is supplemented for the organism, and the digestion and absorption of nutritional substances and the growth and development of animals are promoted; and the process is low in production cost, favorable for industrialized production and large-scale application and wide in application prospect.

The invention discloses a far infrared anion nanometer solution. The far infrared anion nanometer solution is composed of the ingredients of, by weight, 100 parts of anion powder, 400 parts to 600 parts of distilled water, 6 parts to 8 parts of sodium polyacrylate, 12 parts to 15 parts of dodecyl polyglucoside, 4 parts to 6 parts of ethylene glycol, 10 parts to 12 parts of ethyleneurea, 4 parts to 6 parts of citric acid, 6 parts to 8 parts of zirconia, 12 parts to 15 parts of dodecyl dimethyl betaine, 15 parts to 18 parts of tert-butyl acetate, and 10 parts to 15 parts of alkoxy type titanate coupling agent. The ingredients are mixed and soaked for 2 days to 3 days, and then placed into a ball mill to be subjected to low-speed ball milling for 2 hours to 3 hours and high-speed ball milling for 40 minutes to 60 minutes, and the far infrared anion nanometer solution is obtained. According to the far infrared anion nanometer solution, a permanent nanoscale anion film is formed on the surface of a pollution source to decompose formaldehyde before formaldehyde escapes into the air, formaldehyde is prevented from causing harm to human bodies, anion release can be triggered only by slight changes of temperature and pressure without light irradiation under any room temperature states to decompose formaldehyde, and because the far infrared anion nanometer solution is colorless and odorless, the surfaces of furniture are not damaged.

The invention belongs to the technical field of electric power, and discloses a novel bird repellent apparatus which comprises a medicine storage box. An opening is formed in the medicine storage box, and bird repellent medicines are arranged in the medicine storage box. The novel bird repellent apparatus has the advantages that good effects can be realized, birds can be prevented from being damaged, and accordingly the novel bird repellent apparatus is environmentally friendly and is free of pollution.

The invention discloses traditional Chinese medicine used for treating gout, and a preparation method thereof. The traditional Chinese medicine used for treating gout comprises following raw materialsor extracted products of following raw materials: Plantain seed, rhizoma atractylodis, phellodendron, Radix Astragali, pawpaw, clematis root, honeysuckle flower, Radix Gentianae Macrophyllae, radix stephaniae tetrandrae, raw semen coicis, cassia twig, radix paeoniae rubra, herba aristolochiae mollissimae, radix angelicae pubescentis, rehmanniae radix, Lumbricus, Herba Siegesbeckiae, mulberry, Ligusticum wallichii, mustard seed, Aristolochia impressinervis, cyathula root, lycopodium clavatum, millettia speciosa, centipede, gentrin knotweed, rhizoma smilacis glabrae, and agkistrodon. The traditional Chinese medicine contains a plurality of raw materials which are capable of clearing heat and detoxifying, quickening blood and dispelling stasis, and a plurality of raw materials which are capable of dispelling wind and moisture, dredging channels and activating, relieving pain, and preventing inflammatory; combination is cleaver; honey is added for preparing of honey bolus; the traditionalChinese medicine possesses curative effects on gout, hand and foot anaesthesia, cramp, postpartum apoplexy, lumbar disc protrusion, hyperosteogeny, cervical vertebra pain, scapulobumeral periarthritis, sciatica, arthralgia, lumbar muscle strain, internal traumatic injury, rheumatism ostalgia, and numbness; the curative effect is excellent, and is achieved completely; diseases can be treated completely; and no toxic or side effect is caused.

The invention relates to a wheat seed dressing and a preparation method thereof. In parts by weight, the wheat seed dressing is prepared from 20 parts to 30 parts of humic acid, 10 parts to 15 parts of plant ash, 10 parts to 15 parts of medical stone, 20 parts to 30 parts of Chinese medicinal composition, 0.1 part to 0.5 part of agrochemical fertilizer slow release formulation, and 1 part to 3 parts of mepiquat chloride. In parts by weight, the Chinese medicinal composition is prepared from 5 parts to 10 parts of honeysuckle flower, 5 parts to 10 parts of neem bark, 3 parts to 5 parts of folium artemisiae argyi, 3 parts to 5 parts of folium zanthoxyli, 1 part to 3 parts of atractylodis rhizome, 5 parts to 10 parts of isatidis radix, 3 parts to 5 parts of cortex phellodendri and 3 parts to 5 parts of cortex magnoliae officinalis. The wheat seed dressing disclosed by the invention is green and environmental-friendly, overcomes the defects of high pesticide residues, pollution to the environment, easiness for generating drug resistance and the like, accords with the requirement of people for green foods, and has a certain ecological benefits.

The invention discloses an indoor air purification spray agent. A method for preparing the indoor air purification spray agent includes mixing 100 parts of negative ion powder, 400-600 parts of distilled water, 6-8 parts of sodium polyacrylate, 12-15 parts of lauryl glucoside, 4-6 parts of ethylene glycol, 10-12 parts of 2-imidazolidinone, 4-6 parts of malic acid, 6-8 parts of zirconium oxide, 12-15 parts of polyoxyethylated castor oil, 15-18 parts of hydroxybis(lacto)titanium and 10-15 parts of mono-alcoxyl titanate coupling agents with one another to obtain mixtures and soaking the mixtures; placing the mixtures in a ball mill and carrying out ball-milling on the mixtures at a low speed; carrying out ball-milling on the mixtures at a high speed to obtain the indoor air purification spray agent. A method for preparing the negative ion powder includes adding nanometer-sized tourmaline powder, nanometer titanium dioxide powder, sodium silicate, butyl alcohol and 2-alkyl acetylamino ethyl imidazoline into a high-pressure reaction kettle; mixing the nanometer-sized tourmaline powder, the nanometer titanium dioxide powder, the sodium silicate, the butyl alcohol and the 2-alkyl acetylamino ethyl imidazoline with one another to obtain the negative ion powder. The indoor air purification spray agent has the advantages that obvious service effects can be realized by the indoor air purification spray agent, the indoor air purification spray agent is direct, and good interface effects can be realized; the poisonous gas adsorption rate can be further increased, and the indoor air purification spray agent is high in adsorption.

The invention relates to a traditional Chinese medicine health-care medicine and a preparation method. The traditional Chinese medicine health-care medicine is characterized by being prepared from thefollowing raw materials or extract: costus roots, rush, fructus psoraleae, walnut meat, oyster powder, cordate houttuynia, iris ensata thumb, trifle, semen allii tuberose, dogwood, mantis egg-case, earthworms, fructus caryophylli, spongilla, cistanche, polygala tenuifolia, Semen Cuscutae, fructus cnidii, white poria, Clematis hexapetala Pall. Peel, Morinda officinalis, illicium verum, Angelica sinensis, dalbergia wood, dried lacquer, prepared rehmannia root, ossa draconis and gecko. Multiple traditional Chinese medicines which tonify kidney, nourish yin and tonify yang are matched with multiple traditional Chinese medicines which tonify qi and regulate blood to adjust yin and yang of human body, so that the traditional Chinese medicine health-care medicine is scientific and reasonable informula. Being mixed with honey to from pills, effective components in the medicine are kept well, so that the human mechanism can be adjusted fundamentally, and the traditional Chinese medicine health-care medicine tonifies brain, add essence, benefits marrow and promotes the reproductive function, and is in particular obvious in curative effect in symptoms such as quinquagenarian asthenic disease, weakness of the five internal organs, insufficient yuan qi, leg aches and waist pain, lower deficiency-cold, hernia of small intestine.

The invention discloses a modified-Chinese-chestnut-protein-coated slow-release fertilizer special for hawthorn fruits. The fertilizer is made from the raw materials, by weight part, 34-35 of coarse powder of peanut shells, 2.3-2.5 of sodium carboxymethyl starch, 15-16 of sugarcane ash, 3-4 of ammonium polyphosphate, 1.1-1.3 of cobalt sulfate, 4-5 of ammonium chloride, 2-3 of tamarind seed polysaccharide gum, 76-80 of fresh Chinese chestnuts, 18-22 of fruits of ficus pumila, 1.2-1.4 of a glutamine transaminase preparation and a proper amount of water. The fertilizer can be stable in a plough layer of soil for a long time, has adhesion and graininess for improving soil permeability, and improve the water retention ability of the soil. Continuous release of nutrients meets nutrient requirements of hawthorn fruit trees. Acid raw materials, such as ammonium chloride, are used and match organic matters, such as sugarcane ash and coarse powder of peanut shells, for enabling the soil to change into weak acid soil, which is suitable for the hawthorn fruit trees to grow and to be cultured.