45 results about "Traumatic injury" patented technology

Provided herein are pharmaceutical compositions comprising carotenoids, including liposomes that encapsulate carotenoids including ionizable carotenoids such as trans-crocetin. The provided compositions have uses in treating diseases, disorders and conditions associated with, but not limited to, infection, endotoxemia, inflammation, sepsis, ischemia, hypoxia, shock, stroke, lung injury, wound healing, traumatic injury, reperfusion injury, cardiovascular disease, kidney disease, liver disease, inflammatory disease, metabolic disease, pulmonary disorders, blood related disorders and hyperproliferative diseases such as cancer. Methods of making, delivering, and using the pharmaceutical compositions are also provided.

The invention discloses construction and application of an HPLC (High Performance Liquid Chromatography) fingerprint spectrum for integrally controlling a multi-component material basis of a traumatic injury bone-growing capsule, and belongs to the technical field of quality control of traditional Chinese medicine preparations. According to the method, high performance liquid chromatography and mass spectrometry are combined, and neochlorogenic acid, protocatechuic aldehyde, cryptochlorogenic acid, vanillic acid, rosmarinic acid, alkannic acid, berberine hydrochloride and salvianolic acid B are taken as reference substances; the fingerprint spectrum is successfully constructed by detecting different batches of traumatic injury bone-growing capsules. The method is simple and easy to implement, high in precision, good in reproducibility, accurate and reliable, at least eight components can be confirmed at a time under the same chromatographic condition, the detection efficiency is greatly improved, and time and cost are saved; quality monitoring can be carried out on a plurality of characteristic components of the traumatic injury bone-growing capsule accurately, rapidly and simultaneously, and a powerful guarantee is provided for controlling the quality and ensuring the clinical curative effect of the traumatic injury bone-growing capsule.

The invention relates to a traumatic injury pill and a preparation method thereof. The twenty traditional Chinese medicinal materials are selected, the production method is optimized according to different characteristics of the traditional Chinese medicinal materials, the Chinese angelica, the divaricate saposhnikovia root and the cassia twig contain volatile components and cannot be treated at a high temperature, temperature-controlled crushing needs to be performed preferentially, and the fried frankincense, the fried myrrh and the catechu are easy to soften in the crushing process, are adhered to a crusher and are not easy to crush, so that the traditional Chinese medicinal materials are difficult to crush. And finally, the powder is mixed and crushed with other medicinal powder, so that the crushing effect can be effectively improved. The obtained traumatic injury pill has the effects of promoting blood circulation to remove blood stasis, relieving swelling and pain and promoting reunion of fractured tendons and bones, and can be used for traumatic injury, tendon fracture and blood stasis swelling and pain.

The invention relates to medicine, and more particularly to a novel method for the control of stepping movements in patients with traumatic injuries or diseases of the spinal cord and / or the brain using transcutaneous electrical stimulation, which includes continuously stimulating the spinal cord at the level of the C5-C6, T11-T12 and L1-L2 vertebrae and simultaneously creating a synergistic effect to control foot movement by means of spatial-temporal stimulation of the flexor and extensor muscles of the lower leg in the corresponding phases of the gait cycle. This combined spinal and muscular stimulation enables a coordinated, complete gait, in which the patient is able to control the stepping movements, including controlling foot movements.

Liposomal trans-crocetin pharmaceutical compositions, dosing regimens and methods of treating or preventing disorders and conditions associated with, but not limited to, infection, ischemia, hypoxia, ARDS, inflammation, sepsis, shock, stroke, traumatic injury, and proliferative disorders such as cancer are provided. Methods of using the provided trans-crocetin pharmaceutical compositions and dosing regimens to treat cardiovascular, renal, liver, inflammatory, metabolic, pulmonary, neurological, and other disorders and conditions are also provided, as are methods of increasing the delivery of oxygen and increasing the efficacy of a therapeutic agent using the provided compositions and dosing regimens.

The invention discloses all-traditional Chinese medicine traumatic injury medicinal liquor and a preparation method thereof, and belongs to the field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25-35 parts of rubus suavissimus, 35-45 parts of ventilago leiocarpa benth, 25-35 parts of fructus schisandrae chinensis, 12-18 parts of asarum sieboldii, 35-45 parts of semiliquidambar cathayensis, 35-45 parts of entada phaseoloides, 17-23 parts of kadsura pepper stem, 25-35 parts of lindera glauca, 35-45 parts of lysimachia christinae hance, 25-35 parts of angelica sinensis, 25-35 parts of berchemia lineate, 35-45 parts of oxalis, 35-45 parts of radix achyranthis bidentatae, 17-23 parts of artabotrys hexapetalus, 25-35 parts of sappanwood The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 35 to 45 parts of radix notoginseng, 25 to 35 parts of bodhi, 25 to 35 parts of radix aristolochiae fordianae, 17 to 23 parts of crane knee, 30 to 40 parts of caulis sargentodoxae, 20 to 30 parts of cyathea spinulosa wall, 35 to 45 parts of tinospora sinensis merr, 25 to 35 parts of ardisia punctata, 35 to 45 parts of knottedflower knotweed root, 20 to 30 parts of flos carthami, 35 to 45 parts of cynanchum otophyllum, 25 to 35 parts of schizophragma serratum, 25 to 35 parts of radix cynanchi paniculati and 35 to 45 parts of champion bauhinia root. The traditional Chinese medicine is reasonable and unique in compatibility, remarkable in curative effect and comprehensive in efficacy and gives consideration to exterior and interior.

Embodiments of a tourniquet are provided. The tourniquet comprises an elastic layer, an adhesive layer on a first side of the elastic layer and a release layer on a second, opposite side of the elastic layer. In some embodiments, the adhesive layer comprises an antimicrobial agent incorporated into an acrylic adhesive that does not interfere with the function of adhesively securing layers of the tourniquet under tension to their underlying layers. This arrangement is highly beneficial, as the antimicrobial present in the acrylic adhesive portion of the tourniquet will be placed in contact with any underlying wounds, thereby reducing the risk of infection for traumatic injury victims.

Subject matter of the present invention is an angiotensin-receptor-agonist and / or a precursor thereof for use in the treatment of a disease in a subject, • wherein said disease is selected from the group comprising heart failure, chronic heart failure, acute heart failure (AHF), myocardial infarction (MI), stroke, liver failure, burn injuries, traumatic injuries, severe infection (microbial, viral (e.g. AIDS), parasitic diseases (e.g. Malaria)), SIRS or sepsis, cancer, acute kidney injury (AKI), CNS disorders (e.g. seizures, neurodegenerative diseases), autoimmune diseases, vascular diseases, hypotension and shock, and • wherein said subject has an amount of DPP3 protein and / or DPP3 activity in a sample of bodily fluid that is above a predetermined threshold.

This invention discloses a method for preparing and applying a Miao medicine wine for treating bruises and sprains, comprising the following steps: S1, taking and mixing *Ligusticum striatum*, safflower, *Acanthopanax senticosus*, *Smilax china*, *Ligusticum chuanxiong*, *Sargentodoxa cuneata*, *Sargentodoxa cuneata*, and sappanwood evenly; S2, soaking the mixed Chinese medicinal materials from step S1 in alcohol to obtain the medicinal wine. This invention has the effects of clearing the meridians and relieving pain, promoting blood circulation and removing blood stasis, and promoting diuresis and reducing swelling. The treatment course is short, the efficacy is good, the cure rate is high, and recurrence is not common, with an effectiveness rate of over 98%. It has great potential for widespread application. Furthermore, the medicine of this invention is simple to manufacture, convenient to use, and has no toxic side effects, and can significantly alleviate patient suffering.

The invention discloses an external traditional Chinese medicine composition for treating cold-heat mixed type diseases. The external traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 4-5 parts of radix aconiti carmichaeli, 4-5 parts of garden balsam stem, 4-5 parts of radix et rhizoma rhei, 2-3 parts of radix clematidis, 2-3 parts of frankincense, 2-3 parts of myrrh, 2-3 parts of herba asari, 2-3 parts of raw rhizoma arisaematis, 2-3 parts of fresh ginger, 2-3 parts of herba taraxaci and 2-3 parts of loofah sponge. Compared with the prior art, the traditional Chinese medicine composition has the advantages that cold and heat are used together, yin and yang are harmonized, exterior syndromes are treated by tonifying yang to condition roots, softening hardness to dissipate stagnation, promoting blood circulation to remove blood stasis, dispelling wind and relieving pain, necrotic tissue removing and granulation promoting are adopted to condition and recover, a multi-target and broad-spectrum treatment effect is formed, and the traditional Chinese medicine composition is mainly used for treating cold and heat intermingled diseases and can effectively treat or relieve rheumatoid bone diseases, traumatic injuries, scalds, prostatitis and other diseases.

The invention relates to the technical field of traditional Chinese medicine external preparations, provides an external black plaster patch and a preparation method thereof, and solves the problems of poor formula compatibility, single curative effect and inaccurate process parameters of the existing black plaster. The plaster patch is prepared from the following active ingredients in specific parts by weight: unprocessed radix aconiti, unprocessed radix aconiti kusnezoffii, rhizoma arisaematis, frankincense, myrrh, dragon's blood, pseudo-ginseng, rhizoma sparganii, curcuma zedoary, safflower, ground beetle powder, ligusticum wallichii, garden balsam stem, polygonum cuspidatum, teasel root, rhizoma drynariae, radix cyathulae, camphor, borneol and yellow lead. The preparation method comprises the following steps: frying materials, refining oil until water drops into beads, adding plumbum at 270-300 DEG C, removing fire toxin, mixing fine materials at 70-80 DEG C, and spreading for treating traumatic injury, soft tissue swelling pain and rheumatic arthralgia.

A Lisfranc reconstruction device includes a pair of operator grips mechanically linked to a first arm that includes a barrel and a second arm that includes a jaw whereby motion of the grips is mechanically transformed into relative translation of the barrel and the jaw for compression of a portion of a Lisfranc joint complex therebetween. The device includes a retention mechanism, such as a ratchet, to enable retention of the barrel and jaw when the desired position has been reached. The device may be provided in the form of a kit that includes a wire guide sleeve, a pilot wire, and a Lisfranc screw, in particular a cannulated Lisfranc screw that is sized to travel over the wire in a defined trajectory to facilitate proper screw placement. The device may be used for reconstruction of a traumatic injury to the Lisfranc joint complex.

The invention relates to the technical field of traditional Chinese medicine preparations, and discloses a compound herbal external analgesic ointment for wind-cold-dampness arthralgia and traumatic injury. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 3-8 parts of semen brassicae, 3-8 parts of clematis seed, 3-8 parts of fructus polygoni orientalis, 6-12 parts of radix clematidis, 6-12 parts of garden balsam stem, 6-12 parts of safflower, 2-5 parts of raw arisaema consanguineum schott, 0.5-2 parts of datura seed, 6-12 parts of turmeric, 0.5-2 parts of flos rhododendri mollis, 1-3 parts of radix aconiti kusenzoffii and 5-10 parts of rhizoma zingiberis. According to the external compound herbal pain-relieving ointment, through scientific compatibility of various medicinal materials, the synergistic interaction of the effects of warming channels and expelling cold, promoting blood circulation to remove blood stasis, dispelling wind and eliminating dampness and activating meridians to stop pain is achieved, the limitation of a traditional single-effect formula is overcome, the compound diseases of wind-cold-dampness arthralgia and traumatic injuries can be comprehensively treated, and the ointment is high in seepage force, quick in effect and free of toxic and side effects. And through honey beeswax shaping and strict control of the dosage of toxic medicinal materials, high efficiency and safety of clinical use are ensured.

The invention relates to a tendon-stretching pain-relieving plaster, which is prepared by soaking a plurality of Chinese herbal medicines such as Aristolochia delavayi, Chinese actinidia root, herba aristolochiae, kadsura pepper stem, pseudo-ginseng and yellow lead in clear sesame oil and decocting into the plaster for external use, and the tendon-stretching pain-relieving plaster is mainly prepared from traditional Chinese medicines, has the effects of clearing away heat and toxic materials, diminishing inflammation and relieving pain, is low in cost, has the effects of dredging tendons and activating blood, dispelling wind and eliminating dampness, and stretching tendons and relieving pain, and is suitable for rheumatoid arthritis. The traditional Chinese medicine composition is free of side effects and good in curing effect, and can be used for treating osteoarthropathy such as rheumatic arthritis, osteoproliferation and traumatic injury.

The invention provides a traditional Chinese medicine composition for treating traumatic injuries, a traditional Chinese medicine preparation, a preparation method and application, and particularly belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition for treating traumatic injury comprises the following components in parts by weight: 5-6 parts of processed semen strychni, 5-6 parts of tripterygium wilfordii, 8-10 parts of red caltrop root, 8-10 parts of hematoxylon, 8-10 parts of lysimachia christinae hance, 8-10 parts of lysimachia christinae hance, 1-3 parts of lignum dalbergiae odoriferae and According to the traditional Chinese medicine composition, the red caltrop root, the sappan wood, the mosla scabra and the herba lysimachiae are used as main materials, the processed semen strychni and the tripterygium wilfordii are used as auxiliary materials, and the traditional Chinese medicine composition plays a role under the joint cooperation of the lignum dalbergiae odoriferae and the herba asari, so that the traumatic injury affected part can be rapidly recovered, and the pain of a patient is reduced.

The invention discloses a traditional Chinese medicine composition which comprises the following medicinal materials in terms of 50 preparation units: 60-100 parts of pseudo-ginseng, 60-100 parts of vinegar-processed rhizoma corydalis, 20-60 parts of starfish, 20-60 parts of ground beeltle, 5-15 parts of processed semen strychni, 10-30 parts of safflower, 1-20 parts of vinegar-processed frankincense, 1-20 parts of vinegar-processed myrrh, 1-10 parts of borneol and 0.1-1 part of artificial musk. The invention further discloses a preparation method of a tincture of the traditional Chinese medicine composition and application of the traditional Chinese medicine composition in preparation of medicines for treating acute and chronic falling trauma, neck, shoulder, waist and knee pain or arthralgia. The traditional Chinese medicine composition disclosed by the invention has the effects of relaxing muscles and tendons, promoting blood circulation, dredging collaterals, dissipating blood stasis, diminishing swelling and relieving pain. Pharmacodynamic studies show that the traditional Chinese medicine composition disclosed by the invention takes effect quickly and has a good curative effect when being used for treating symptoms such as traumatic injuries, blood stasis swelling and swelling and red and swollen injuries. The traditional Chinese medicine composition disclosed by the invention effectively relieves the injury condition of a tested animal, and is free of irritation and sensitization to the tested animal in a skin medication toxicity test.

The invention relates to a preparation method of a traumatic injury seven-centimeter preparation based on frankincense sterilization mode control, and the traumatic injury seven-centimeter preparation is prepared from the following medicinal raw materials in parts by mass: 0.8 part of artificial musk, 8 parts of pseudo-ginseng, 16 parts of dragon's blood, 48 parts of safflower, 40 parts of cinnabar, 80 parts of wine-processed angelica sinensis, 32 parts of vinegar-processed myrrh, 1.6 parts of borneol, 32 parts of vinegar-processed frankincense and 40 parts of catechu. The preparation method is characterized by comprising the following steps: S1, sterilizing and crushing raw materials, namely crushing and / or sterilizing the medicinal raw materials respectively, and sterilizing the vinegar frankincense by adopting 60Co-gamma ray irradiation; and S2, total mixing and preparation: mixing all the medicinal raw materials and preparing the traumatic injury seven-centimeter preparation. The method disclosed by the invention is suitable for sterilizing the raw powder, and on the premise of not adopting a complex process, the process feasibility can be ensured while the sterilizing effect and the drug bioavailability are ensured only by controlling the frankincense sterilizing mode and corresponding process parameters.

The invention discloses medicinal liquor with effects of diminishing inflammation, relieving pain and treating traumatic injuries, belongs to the technical field of medicinal liquor, and aims to solve the problems that most of existing medicines are long in treatment time, high in finished product medicine cost and very inconvenient to popularize. Comprising 16-24 parts of acer truncatum leaves, 4-6 parts of ligusticum wallichii, 4-6 parts of rabdosia rubescens, 4-6 parts of eucommia ulmoides, 4-6 parts of Chinese prickly ash, 4-6 parts of fructus kochiae and 200-300 parts of baijiu, the acer truncatum leaves, the ligusticum wallichii, the rabdosia rubescens, the eucommia ulmoides, the Chinese prickly ash and the fructus kochiae are adopted as main traditional Chinese medicinal materials and then soaked in the baijiu to form the finished medicinal liquor, the formula is simple, and therefore the product is low in manufacturing cost and suitable for popularization and application. According to the traumatic injury treatment medicine, white spirit is used as a solvent, acer truncatum leaves are used as injection medicine, ligusticum wallichii, rabdosia rubescens, eucommia ulmoides, pepper and fructus kochiae are used as adjuvants, and the traditional Chinese medicines are combined for use according to the characteristics of the traditional Chinese medicines, so that the traumatic injury position can be fully treated from inside to outside during treatment, and the treatment effect is ensured.

The invention provides a bonesetting pill for treating bone injury, and relates to the technical field of traditional Chinese medicines. The bonesetting pill for treating bone fracture is prepared from Chinese angelica, poria, Chinese yam, pseudo-ginseng, lotus seed, ground beetle, elecampane, dragon's blood, prepared rehmannia root, safflower, prepared nutgrass galingale rhizome, drynaria rhizome, immature bitter orange, rhizoma dioscoreae nipponicae, paris polyphylla, natural copper processed with vinegar, prepared frankincense, prepared myrrh, ajuga paniculata, cortex moutan, liquorice and borneol. The bone setting pill has the main effects of dissipating blood stasis and stopping bleeding, relieving swelling and pain, promoting reunion of fractured bones and promoting fracture healing, and can effectively treat various fractures, dislocation, traumatic injuries, joint sprain, soft tissue contusion, blood stasis, swelling and pain and the like.

Apparatuses and methods for reducing or limiting bleeding in an animal by focused ultrasound (FUS) stimulation of the spleen. The apparatuses and methods may be used treat blood disorders such as hemophilia, or to reduce hemorrhage in surgery or due to traumatic injury. The methods may be non-invasively administered to the patient by transcutaneous application of ultrasound energy.

The external medicinal liquor is prepared from the following components in parts by weight: 10 to 28 parts of rhizoma sparganii, 10 to 25 parts of rhizoma curcumae, 10 to 30 parts of sappan wood, 10 to 20 parts of radix dipsaci asperoidis, 10 to 22 parts of native copper, 10 to 26 parts of herba lycopi, 10 to 25 parts of cortex eucommiae, 10 to 27 parts of rhizoma drynariae, 10 to 23 parts of ground beetle, 10 to 32 parts of radix gentianae macrophyllae, 10 to 40 parts of radix notoginseng, 10 to 30 parts of rhizoma chuanxiong, 10 to 22 parts of radix angelicae lateralis preparata, 10 to 25 parts of flos carthami, 10 to 20 parts of amber, 10 to 50 parts of radix achyranthis bidentatae and 10 to 36 parts of dragon's blood. A plurality of traditional Chinese medicinal materials are scientifically combined, and the raw materials form a synergistic effect in a specific weight part range, so that the problem of blood stasis can be improved, and the repair of injured tissues can be promoted; the raw materials are strictly and normatively pretreated in the preparation process, and plant medicinal materials are selected, cleaned and dried at low temperature, so that effective components are prevented from being lost due to high temperature; the traditional Chinese medicine composition can be correspondingly selected for slight sprain, muscle strain, severe blood stasis swelling and pain and joint injury, is externally applied, sprayed or applied and does not need to be orally taken.

The invention provides a preparation method of a pain-relieving and itching-relieving traumatic injury spray, and belongs to the technical field of medicines.The method comprises the steps that orchid, spiny tree seeds and zanthoxylum bungeanum are selected according to the proportion of 1: 0.5: 0.5, dried at the temperature of 20-25 DEG C (preferably 22 DEG C) and the humidity of 30%-40% (preferably 35%), smashed to 80-120 meshes (preferably 100 meshes) and cooked for 4 hours under the pressure of 0.05-0.1 MPa (preferably 0.08 MPa), and then the mixture is filtered and dried to obtain the pain-relieving and itching-relieving traumatic injury spray. And cooling, stirring and mixing with 45% alcohol at a speed of 100-150 revolutions per minute (preferably 120 revolutions per minute), filtering by a filter screen of 150-200 meshes (preferably 180 meshes), and filling. According to the method, through scientific compatibility and precise process control, the problems that an existing spray is low in effective component extraction rate and poor in stability are solved, the prepared spray can rapidly permeate skin, the effects of relieving pain and itching and promoting injury repair are achieved, use is convenient, and quality is controllable.

The invention discloses a novel fire moxibustion seedling medicinal liquor formula which comprises a formula I, a formula II and a formula III, the formula I comprises tinospora sinensis merr and luculia pinceana; the formula II comprises radix inulae, sticktight and prinsepia utilis royle; and the formula III comprises hedera helix (trident maple), caulis spatholobi, lycopodium clavatum, garden balsam stem and blood transforming pills. Compared with the prior art, the traditional Chinese medicine has the advantages that the traditional Chinese medicine can dispel wind and relieve pain, relax tendons and activate collaterals, and is mainly used for treating rheumatic arthralgia, lumbar muscle degeneration and traumatic injuries.

The invention relates to the technical field of plasters, in particular to a traumatic injury plaster which is covered with a preservative film after being smeared on an affected part, so that medicine effect evaporation is avoided, and the application range is wide.

The invention provides application of loganin in preparation of drugs for treating cardiac traumatic diseases, and belongs to the technical field of drugs related to cardiac diseases. Researches on rat models with penetrable heart injury and operative heart injury find that loganin can promote myocardial cell regeneration after cardiac traumatic injury, action target proteins are ephrinB2 and EphB4, and cardiac structural repair is further realized through myocardial cell regeneration.

The invention discloses a traditional Chinese medicine plaster for treating pain and a use method thereof, and belongs to the technical field of traditional Chinese medicine external preparations. The plaster is composed of 10 g of unprocessed radix aconiti lateralis, 10 g of unprocessed rhizoma pinelliae, 10 g of semen brassicae, 10 g of fructus evodiae, 10 g of sulfur and 5 g of borneol, the total weight is 55 g, the plaster can be divided into 55 parts, the raw materials form the unique formula, no other components are added, all the raw materials are natural raw materials in specific production places and specific harvesting time, and the quality and purity are strictly guaranteed. The plaster is in an external application dosage form, and is uniform in texture, firm in application, small in irritation and long in shelf life. During use, after the skin of a painful part is cleaned up, 1 part of the plaster is smeared on sterile gauze and applied to the painful part once a day, seven days are taken as a course of treatment, and the number of courses of treatment is adjusted according to the degree of pains. The plaster can be used for effectively treating various pains such as muscular soreness, arthralgia, traumatic injury pains, rheumatic arthralgia and neuralgia, and is exact in treatment effect and safe and convenient to use.

Provided herein are compositions for preventing or treating muscle conditions such as muscle damage, injury, or atrophy. In some embodiments, the compositions comprise a prostaglandin E2 (PGE2) compound and a myotoxin. In some embodiments, the muscle damage, injury, or atrophy is the result of a nerve injury, a surgical procedure, or a traumatic injury. Methods of promoting muscle regeneration and methods of increasing muscle mass are also provided herein.

The application discloses a composition for treating traumatic injury and a preparation method thereof, and a traumatic oil yarn. The composition for treating traumatic injury comprises black soybean oil and a compound extract mixed with the black soybean oil, wherein the compound extract comprises oil extracts of the following traditional Chinese medicinal materials: pinellia ternate, prepared wujiabaicang, prepared asters, prepared aconite, ginseng, saposhnicovia divaricata, borneol, safflower, dipsacus asper, paris polyphylla, radix paeoniae, salix caprea leaf and radix scrophulariae. The composition for treating traumatic injury is prepared by compounding the oil extracts of the various traditional Chinese medicinal materials with the black soybean oil, so that the black soybean oil and the extracts of the various traditional Chinese medicinal materials play a mutual synergistic effect, the composition for treating traumatic injury is effectively enhanced in the effects of promoting blood circulation to remove blood stasis, relieving swelling and relieving pain on the tibia sprain, and the composition for treating traumatic injury also has the effect of promoting the healing of broken skin.

Provided herein are pharmaceutical compositions comprising carotenoids, including liposomes that encapsulate carotenoids including ionizable carotenoids such as trans-crocetin. The provided compositions have uses in treating diseases, disorders and conditions associated with, but not limited to, infection, endotoxemia, inflammation, sepsis, ischemia, hypoxia, shock, stroke, lung injury, wound healing, traumatic injury, reperfusion injury, cardiovascular disease, kidney disease, liver disease, inflammatory disease, metabolic disease, pulmonary disorders, blood related disorders and hyperproliferative diseases such as cancer. Methods of making, delivering, and using the pharmaceutical compositions are also provided.

A prosthetic liner having a cylindrical or conical body with an open proximal end, a closed distal end, a posterior face, an anterior face, an internal thermoplastic elastomeric layer, and an external fabric layer, with a support material attached to the anterior face and a plurality of interior surface modifications on the internal thermoplastic elastomeric layer with the option of including at least one channel for wicking. The liner may be a locking or cushion liner. Also, the support material may be attached to the distal end of the liner inside of an enclosed pocket or inside of an open pocket attached to the exterior fabric layer. The support material is preferably a foam the foam selected from the group consisting of ethyl vinyl acetate, polyethylene, neoprene, ethylene propylene diene terpolymer, vinyl, silicone, and urethane. These liners allow for a bulbous formation at the distal end of a residual limb to give comfort to a user who may have a traumatic injury, scar tissue buildup, or simply seeking further comfort.