24 results about "Traumatic injury" patented technology

The invention discloses construction and application of an HPLC (High Performance Liquid Chromatography) fingerprint spectrum for integrally controlling a multi-component material basis of a traumatic injury bone-growing capsule, and belongs to the technical field of quality control of traditional Chinese medicine preparations. According to the method, high performance liquid chromatography and mass spectrometry are combined, and neochlorogenic acid, protocatechuic aldehyde, cryptochlorogenic acid, vanillic acid, rosmarinic acid, alkannic acid, berberine hydrochloride and salvianolic acid B are taken as reference substances; the fingerprint spectrum is successfully constructed by detecting different batches of traumatic injury bone-growing capsules. The method is simple and easy to implement, high in precision, good in reproducibility, accurate and reliable, at least eight components can be confirmed at a time under the same chromatographic condition, the detection efficiency is greatly improved, and time and cost are saved; quality monitoring can be carried out on a plurality of characteristic components of the traumatic injury bone-growing capsule accurately, rapidly and simultaneously, and a powerful guarantee is provided for controlling the quality and ensuring the clinical curative effect of the traumatic injury bone-growing capsule.

The invention relates to medicine, and more particularly to a novel method for the control of stepping movements in patients with traumatic injuries or diseases of the spinal cord and / or the brain using transcutaneous electrical stimulation, which includes continuously stimulating the spinal cord at the level of the C5-C6, T11-T12 and L1-L2 vertebrae and simultaneously creating a synergistic effect to control foot movement by means of spatial-temporal stimulation of the flexor and extensor muscles of the lower leg in the corresponding phases of the gait cycle. This combined spinal and muscular stimulation enables a coordinated, complete gait, in which the patient is able to control the stepping movements, including controlling foot movements.

Liposomal trans-crocetin pharmaceutical compositions, dosing regimens and methods of treating or preventing disorders and conditions associated with, but not limited to, infection, ischemia, hypoxia, ARDS, inflammation, sepsis, shock, stroke, traumatic injury, and proliferative disorders such as cancer are provided. Methods of using the provided trans-crocetin pharmaceutical compositions and dosing regimens to treat cardiovascular, renal, liver, inflammatory, metabolic, pulmonary, neurological, and other disorders and conditions are also provided, as are methods of increasing the delivery of oxygen and increasing the efficacy of a therapeutic agent using the provided compositions and dosing regimens.

The invention discloses all-traditional Chinese medicine traumatic injury medicinal liquor and a preparation method thereof, and belongs to the field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25-35 parts of rubus suavissimus, 35-45 parts of ventilago leiocarpa benth, 25-35 parts of fructus schisandrae chinensis, 12-18 parts of asarum sieboldii, 35-45 parts of semiliquidambar cathayensis, 35-45 parts of entada phaseoloides, 17-23 parts of kadsura pepper stem, 25-35 parts of lindera glauca, 35-45 parts of lysimachia christinae hance, 25-35 parts of angelica sinensis, 25-35 parts of berchemia lineate, 35-45 parts of oxalis, 35-45 parts of radix achyranthis bidentatae, 17-23 parts of artabotrys hexapetalus, 25-35 parts of sappanwood The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 35 to 45 parts of radix notoginseng, 25 to 35 parts of bodhi, 25 to 35 parts of radix aristolochiae fordianae, 17 to 23 parts of crane knee, 30 to 40 parts of caulis sargentodoxae, 20 to 30 parts of cyathea spinulosa wall, 35 to 45 parts of tinospora sinensis merr, 25 to 35 parts of ardisia punctata, 35 to 45 parts of knottedflower knotweed root, 20 to 30 parts of flos carthami, 35 to 45 parts of cynanchum otophyllum, 25 to 35 parts of schizophragma serratum, 25 to 35 parts of radix cynanchi paniculati and 35 to 45 parts of champion bauhinia root. The traditional Chinese medicine is reasonable and unique in compatibility, remarkable in curative effect and comprehensive in efficacy and gives consideration to exterior and interior.

Subject matter of the present invention is an angiotensin-receptor-agonist and / or a precursor thereof for use in the treatment of a disease in a subject, • wherein said disease is selected from the group comprising heart failure, chronic heart failure, acute heart failure (AHF), myocardial infarction (MI), stroke, liver failure, burn injuries, traumatic injuries, severe infection (microbial, viral (e.g. AIDS), parasitic diseases (e.g. Malaria)), SIRS or sepsis, cancer, acute kidney injury (AKI), CNS disorders (e.g. seizures, neurodegenerative diseases), autoimmune diseases, vascular diseases, hypotension and shock, and • wherein said subject has an amount of DPP3 protein and / or DPP3 activity in a sample of bodily fluid that is above a predetermined threshold.

This invention discloses a method for preparing and applying a Miao medicine wine for treating bruises and sprains, comprising the following steps: S1, taking and mixing *Ligusticum striatum*, safflower, *Acanthopanax senticosus*, *Smilax china*, *Ligusticum chuanxiong*, *Sargentodoxa cuneata*, *Sargentodoxa cuneata*, and sappanwood evenly; S2, soaking the mixed Chinese medicinal materials from step S1 in alcohol to obtain the medicinal wine. This invention has the effects of clearing the meridians and relieving pain, promoting blood circulation and removing blood stasis, and promoting diuresis and reducing swelling. The treatment course is short, the efficacy is good, the cure rate is high, and recurrence is not common, with an effectiveness rate of over 98%. It has great potential for widespread application. Furthermore, the medicine of this invention is simple to manufacture, convenient to use, and has no toxic side effects, and can significantly alleviate patient suffering.

The invention discloses an external traditional Chinese medicine composition for treating cold-heat mixed type diseases. The external traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 4-5 parts of radix aconiti carmichaeli, 4-5 parts of garden balsam stem, 4-5 parts of radix et rhizoma rhei, 2-3 parts of radix clematidis, 2-3 parts of frankincense, 2-3 parts of myrrh, 2-3 parts of herba asari, 2-3 parts of raw rhizoma arisaematis, 2-3 parts of fresh ginger, 2-3 parts of herba taraxaci and 2-3 parts of loofah sponge. Compared with the prior art, the traditional Chinese medicine composition has the advantages that cold and heat are used together, yin and yang are harmonized, exterior syndromes are treated by tonifying yang to condition roots, softening hardness to dissipate stagnation, promoting blood circulation to remove blood stasis, dispelling wind and relieving pain, necrotic tissue removing and granulation promoting are adopted to condition and recover, a multi-target and broad-spectrum treatment effect is formed, and the traditional Chinese medicine composition is mainly used for treating cold and heat intermingled diseases and can effectively treat or relieve rheumatoid bone diseases, traumatic injuries, scalds, prostatitis and other diseases.

A Lisfranc reconstruction device includes a pair of operator grips mechanically linked to a first arm that includes a barrel and a second arm that includes a jaw whereby motion of the grips is mechanically transformed into relative translation of the barrel and the jaw for compression of a portion of a Lisfranc joint complex therebetween. The device includes a retention mechanism, such as a ratchet, to enable retention of the barrel and jaw when the desired position has been reached. The device may be provided in the form of a kit that includes a wire guide sleeve, a pilot wire, and a Lisfranc screw, in particular a cannulated Lisfranc screw that is sized to travel over the wire in a defined trajectory to facilitate proper screw placement. The device may be used for reconstruction of a traumatic injury to the Lisfranc joint complex.

The invention relates to the technical field of traditional Chinese medicine preparations, and discloses a compound herbal external analgesic ointment for wind-cold-dampness arthralgia and traumatic injury. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 3-8 parts of semen brassicae, 3-8 parts of clematis seed, 3-8 parts of fructus polygoni orientalis, 6-12 parts of radix clematidis, 6-12 parts of garden balsam stem, 6-12 parts of safflower, 2-5 parts of raw arisaema consanguineum schott, 0.5-2 parts of datura seed, 6-12 parts of turmeric, 0.5-2 parts of flos rhododendri mollis, 1-3 parts of radix aconiti kusenzoffii and 5-10 parts of rhizoma zingiberis. According to the external compound herbal pain-relieving ointment, through scientific compatibility of various medicinal materials, the synergistic interaction of the effects of warming channels and expelling cold, promoting blood circulation to remove blood stasis, dispelling wind and eliminating dampness and activating meridians to stop pain is achieved, the limitation of a traditional single-effect formula is overcome, the compound diseases of wind-cold-dampness arthralgia and traumatic injuries can be comprehensively treated, and the ointment is high in seepage force, quick in effect and free of toxic and side effects. And through honey beeswax shaping and strict control of the dosage of toxic medicinal materials, high efficiency and safety of clinical use are ensured.

The invention relates to a tendon-stretching pain-relieving plaster, which is prepared by soaking a plurality of Chinese herbal medicines such as Aristolochia delavayi, Chinese actinidia root, herba aristolochiae, kadsura pepper stem, pseudo-ginseng and yellow lead in clear sesame oil and decocting into the plaster for external use, and the tendon-stretching pain-relieving plaster is mainly prepared from traditional Chinese medicines, has the effects of clearing away heat and toxic materials, diminishing inflammation and relieving pain, is low in cost, has the effects of dredging tendons and activating blood, dispelling wind and eliminating dampness, and stretching tendons and relieving pain, and is suitable for rheumatoid arthritis. The traditional Chinese medicine composition is free of side effects and good in curing effect, and can be used for treating osteoarthropathy such as rheumatic arthritis, osteoproliferation and traumatic injury.

The invention relates to a preparation method of a traumatic injury seven-centimeter preparation based on frankincense sterilization mode control, and the traumatic injury seven-centimeter preparation is prepared from the following medicinal raw materials in parts by mass: 0.8 part of artificial musk, 8 parts of pseudo-ginseng, 16 parts of dragon's blood, 48 parts of safflower, 40 parts of cinnabar, 80 parts of wine-processed angelica sinensis, 32 parts of vinegar-processed myrrh, 1.6 parts of borneol, 32 parts of vinegar-processed frankincense and 40 parts of catechu. The preparation method is characterized by comprising the following steps: S1, sterilizing and crushing raw materials, namely crushing and / or sterilizing the medicinal raw materials respectively, and sterilizing the vinegar frankincense by adopting 60Co-gamma ray irradiation; and S2, total mixing and preparation: mixing all the medicinal raw materials and preparing the traumatic injury seven-centimeter preparation. The method disclosed by the invention is suitable for sterilizing the raw powder, and on the premise of not adopting a complex process, the process feasibility can be ensured while the sterilizing effect and the drug bioavailability are ensured only by controlling the frankincense sterilizing mode and corresponding process parameters.

The invention discloses medicinal liquor with effects of diminishing inflammation, relieving pain and treating traumatic injuries, belongs to the technical field of medicinal liquor, and aims to solve the problems that most of existing medicines are long in treatment time, high in finished product medicine cost and very inconvenient to popularize. Comprising 16-24 parts of acer truncatum leaves, 4-6 parts of ligusticum wallichii, 4-6 parts of rabdosia rubescens, 4-6 parts of eucommia ulmoides, 4-6 parts of Chinese prickly ash, 4-6 parts of fructus kochiae and 200-300 parts of baijiu, the acer truncatum leaves, the ligusticum wallichii, the rabdosia rubescens, the eucommia ulmoides, the Chinese prickly ash and the fructus kochiae are adopted as main traditional Chinese medicinal materials and then soaked in the baijiu to form the finished medicinal liquor, the formula is simple, and therefore the product is low in manufacturing cost and suitable for popularization and application. According to the traumatic injury treatment medicine, white spirit is used as a solvent, acer truncatum leaves are used as injection medicine, ligusticum wallichii, rabdosia rubescens, eucommia ulmoides, pepper and fructus kochiae are used as adjuvants, and the traditional Chinese medicines are combined for use according to the characteristics of the traditional Chinese medicines, so that the traumatic injury position can be fully treated from inside to outside during treatment, and the treatment effect is ensured.

The invention provides a bonesetting pill for treating bone injury, and relates to the technical field of traditional Chinese medicines. The bonesetting pill for treating bone fracture is prepared from Chinese angelica, poria, Chinese yam, pseudo-ginseng, lotus seed, ground beetle, elecampane, dragon's blood, prepared rehmannia root, safflower, prepared nutgrass galingale rhizome, drynaria rhizome, immature bitter orange, rhizoma dioscoreae nipponicae, paris polyphylla, natural copper processed with vinegar, prepared frankincense, prepared myrrh, ajuga paniculata, cortex moutan, liquorice and borneol. The bone setting pill has the main effects of dissipating blood stasis and stopping bleeding, relieving swelling and pain, promoting reunion of fractured bones and promoting fracture healing, and can effectively treat various fractures, dislocation, traumatic injuries, joint sprain, soft tissue contusion, blood stasis, swelling and pain and the like.

Apparatuses and methods for reducing or limiting bleeding in an animal by focused ultrasound (FUS) stimulation of the spleen. The apparatuses and methods may be used treat blood disorders such as hemophilia, or to reduce hemorrhage in surgery or due to traumatic injury. The methods may be non-invasively administered to the patient by transcutaneous application of ultrasound energy.

The invention relates to the technical field of plasters, in particular to a traumatic injury plaster which is covered with a preservative film after being smeared on an affected part, so that medicine effect evaporation is avoided, and the application range is wide.

The invention provides application of loganin in preparation of drugs for treating cardiac traumatic diseases, and belongs to the technical field of drugs related to cardiac diseases. Researches on rat models with penetrable heart injury and operative heart injury find that loganin can promote myocardial cell regeneration after cardiac traumatic injury, action target proteins are ephrinB2 and EphB4, and cardiac structural repair is further realized through myocardial cell regeneration.

The invention discloses a traditional Chinese medicine plaster for treating pain and a use method thereof, and belongs to the technical field of traditional Chinese medicine external preparations. The plaster is composed of 10 g of unprocessed radix aconiti lateralis, 10 g of unprocessed rhizoma pinelliae, 10 g of semen brassicae, 10 g of fructus evodiae, 10 g of sulfur and 5 g of borneol, the total weight is 55 g, the plaster can be divided into 55 parts, the raw materials form the unique formula, no other components are added, all the raw materials are natural raw materials in specific production places and specific harvesting time, and the quality and purity are strictly guaranteed. The plaster is in an external application dosage form, and is uniform in texture, firm in application, small in irritation and long in shelf life. During use, after the skin of a painful part is cleaned up, 1 part of the plaster is smeared on sterile gauze and applied to the painful part once a day, seven days are taken as a course of treatment, and the number of courses of treatment is adjusted according to the degree of pains. The plaster can be used for effectively treating various pains such as muscular soreness, arthralgia, traumatic injury pains, rheumatic arthralgia and neuralgia, and is exact in treatment effect and safe and convenient to use.

Provided herein are compositions for preventing or treating muscle conditions such as muscle damage, injury, or atrophy. In some embodiments, the compositions comprise a prostaglandin E2 (PGE2) compound and a myotoxin. In some embodiments, the muscle damage, injury, or atrophy is the result of a nerve injury, a surgical procedure, or a traumatic injury. Methods of promoting muscle regeneration and methods of increasing muscle mass are also provided herein.

Provided herein are pharmaceutical compositions comprising carotenoids, including liposomes that encapsulate carotenoids including ionizable carotenoids such as trans-crocetin. The provided compositions have uses in treating diseases, disorders and conditions associated with, but not limited to, infection, endotoxemia, inflammation, sepsis, ischemia, hypoxia, shock, stroke, lung injury, wound healing, traumatic injury, reperfusion injury, cardiovascular disease, kidney disease, liver disease, inflammatory disease, metabolic disease, pulmonary disorders, blood related disorders and hyperproliferative diseases such as cancer. Methods of making, delivering, and using the pharmaceutical compositions are also provided.

The invention relates to the technical field of traditional Chinese medicine external health-care preparations, in particular to arthralgia pain and bone penetrating health-care liquid and a preparation process thereof.The arthralgia pain and bone penetrating health-care liquid is prepared from, by weight, 40-60 g of rhizoma chuanxiong, 30-50 g of periploca forrestii schltr, 15-25 g of frankincense, 20-40 g of lysimachia trientaloides, 40-60 g of radix cynanchi paniculati, 40-60 g of roots of procumbent urena, 30-50 g of beautiful millettia roots and 10-30 g of processed centipedes. The preparation method comprises the following steps: S1, treating medicinal materials; s2, ultrasonic extraction; s3, dipping; s4, concentrating and filling; the health-care liquid has the beneficial effects that the health-care liquid is used for relieving wind-cold-dampness arthralgia, traumatic injury and hyperuricemia joint swelling and pain, the dissolution rate and the transdermal efficiency of pharmacodynamic substances are improved by optimizing component compatibility and an alcohol extraction process, the problem of low transdermal absorption rate of a traditional external medicine is solved, and the health-care liquid takes effect quickly, has a good transdermal absorption effect and is safe and reliable. Moreover, the analgesic effect is obviously superior to that of a traditional Chinese medicine preparation, the transdermal rate is higher than that of a chemical medicine, the allergy rate is low, dependence on chemical analgesic components is reduced, and skin irritation and drug resistance caused by long-term use are avoided.

The invention discloses application of a reagent for detecting inosine content in a biological sample in preparation of a lung cancer EGFR-TKI treatment drug resistance evaluation preparation. The drug resistance of a lung cancer patient to an EGFR-TKI drug can be judged through detection of an in-vitro biological sample, traumatic injury to the patient caused by an invasive living body detection mode of secondary biopsy or liquid biopsy is avoided, and individualized precise treatment of the lung cancer patient is facilitated. And a new strategy for non-invasive in-vitro sample detection and evaluation of EGFR-TKI treatment drug resistance is developed.

The invention discloses a cortex phellodendri traumatic injury treating traditional Chinese medicine composition and a preparation method thereof. The golden cypress traumatic injury treating medicine is prepared from golden cypress, vinegar-processed rhizoma corydalis, vinegar-processed rhizoma sparganii, curcuma zedoary, rheum officinale, radix aucklandiae, sargentgloryvine stem, salvia miltiorrhiza, radix angelicae, astragalus membranaceus, fructus kochiae, notopterygium root and radix angelicae pubescentis. The medicinal raw materials selected by the golden cypress for traumatic injury are nontoxic and harmless traditional Chinese medicinal materials, the product has no toxic or side effect, the use method is as follows: the golden cypress is blended into paste with a proper amount of water, the paste is directly applied to an affected part, the drug effect is favorably exerted, and the golden cypress also has the characteristics of low cost, convenience in carrying, suitability for large-scale production and application and the like.

An absorbable bio-network for preventing fibrous adhesions following surgical or traumatic injury to the hand is disclosed. The bio-network comprises a polymer mixture of poly(lactic-co-glycolic acid) (PLGA) and polycaprolactone (PCL) in a ratio of 60-80 wt% PLGA to 20-40 wt% PCL, and includes an inner drug reservoir formed of PLGA microspheres having a diameter of 20-50 μm and loaded with dexamethasone base at 1-5 wt%. The network is produced by electrospinning to obtain a membrane of 100-200 μm thickness, followed by application of a surface coating of hyaluronic acid and chitosan crosslinked with genipin. The construct provides a controlled drug-release profile characterized by a low initial release during the first two weeks and an increasing release thereafter over a period of 6-8 weeks. The system reduces adhesion formation without impairing early wound healing, and encompasses variations in polymer ratios, microsphere preparation, and coating conditions.

The invention relates to the field of traditional Chinese pharmacology, and discloses an external ointment for traumatic injury, fracture and ostealgia and a preparation method thereof. The traditional Chinese medicine composition comprises the following components: herba lycopi, fructus aurantii, sappan wood, rhizoma atractylodis, rheum officinale, rhizoma atractylodis macrocephalae, frankincense, myrrh, rhizoma cyperi, peach kernels, pericarpium citri reticulatae viride, radix linderae, fructus psoraleae, radix paeoniae rubra, polygonum cuspidatum, rhizoma zingiberis, scutellaria baicalensis, safflower carthamus, lumbricus, eucommia ulmoides, radix achyranthis bidentatae, cinnamon, rhizoma sparganii, curcuma zedoary, asarum, cortex phellodendri, fossil fragments, rosa laevigata michx roots, radix curcumae, amber, native copper, pseudo-ginseng, resina draconis, cinnabar, catechu, red halloysite, chingma abutilon seeds, pollen typhae, clove, corydalis tuber and artemisia anomala. , stalactite, cuttlebone, saussurea involucrata and embelia laeta root. The traditional Chinese medicine composition has the effects of relieving swelling and pain, dispelling wind and eliminating dampness on rheumatism ostalgia, arthralgia and lumbocrural pain diseases such as tenosynovitis, frozen shoulder, knee osteoarthritis, cervical spondylosis, lumbar muscle degeneration, lumbar disc herniation and stiff neck; the effects of promoting blood circulation to remove blood stasis and relieving swelling and pain are also achieved on trauma such as traumatic injuries and fractures.