Traditional Chinese medicine composition for relieving pain, promoting blood circulation, diminishing swelling and removing blood stasis, application of traditional Chinese medicine composition and blood stasis dispersing and pain relieving plaster

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for relieving pain, promoting blood circulation, diminishing swelling and removing blood stasis, application thereof and a blood stasis dispersing and pain relieving patch. The invention provides a traditional Chinese medicine composition for relieving pain, activating blood, diminishing swelling and removing stasis. The traditional Chinese medicine composition comprises the following components: lycopodium clavatum, radix clematidis, asarum, gentiana macrophylla, radix angelicae, rheum officinale, notopterygium root, roasted herba epimedii, radix achyranthis bidentatae, peach kernel, radix angelicae pubescentis, vinegar-processed rhizoma corydalis, vinegar-processed rhizoma cyperi, moutan bark, prepared kusnezoff monkshood root, prepared monkshood, vinegar-processed frankincense, Sinkiang lithospermum, vinegar-processed myrrh and sanguisorba officinalis. The blood stasis dispersing and pain relieving patch has the advantages of being good in curative effect, quick in effect taking, convenient to use, safe and reliable, can be used for treating traumatic injuries and pain caused by cervical spondylosis, scapulohumeral periarthritis, lumbar disc herniation, lumbar vertebrae hyperosteogeny, spinal stenosis, sciatica, ankylosing spondylitis, arthritis and other diseases, and can achieve the effect of treating both symptoms and root causes.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for relieving pain, promoting blood circulation, reducing swelling and removing blood stasis, an application thereof, and a blood stasis-removing and analgesic patch. Background Art

[0002] In the field of Traditional Chinese Medicine, pain relief for various injuries, low back pain, and other chronic conditions has long been an important research area. Currently, there are a variety of ointments on the market that promote blood circulation, relieve pain, and reduce swelling, but their efficacy varies, and some ointments suffer from slow onset and inconvenience. Therefore, developing a traditional Chinese medicine topical patch that is effective, fast-acting, easy to use, and safe and reliable for treating injuries, low back pain, and aseptic inflammation of the shoulder and knee has important practical significance and application value. Summary of the Invention

[0003] The purpose of the present invention is to provide a blood stasis-relieving and analgesic patch that has good efficacy, quick effect, easy use, safety and reliability, and can achieve the effect of treating both the symptoms and the root cause of the disease, and can treat injuries caused by falls, as well as pain caused by cervical spondylosis, periarthritis of the shoulder, lumbar disc herniation, lumbar bone hyperplasia, vertebral canal stenosis, sciatica, ankylosing spondylitis, arthritis and other diseases.

[0004] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0005] The invention provides a traditional Chinese medicine composition for relieving pain, promoting blood circulation, and removing swelling and blood stasis. The composition comprises the following components in parts by mass: 10-20 parts of Herba Lycopodii, 5-15 parts of Radix Clematis, 5-10 parts of Asarum, 5-15 parts of Radix Gentianae Macrophyllae, 5-15 parts of Radix Angelicae Dahuricae, 5-15 parts of Radix Rhizoma Rhei, 5-15 parts of Notopterygium Incisi, 5-15 parts of Rhubarb, 5-15 parts of Radix Notopterygii, 5-15 parts of Rhizoma Epimedii, 5-15 parts of Radix Achyranthis Bidentatae, 5-15 parts of Semen Persicae, 5-15 parts of Radix Angelicae Pubescentis, 5-15 parts of Corydalis Vinegar, 5-15 parts of Rhizoma Cyperi Vinegar, 5-15 parts of Cortex Moutan, 5-15 parts of processed Radix Aconiti Kusnezoffii, 5-15 parts of processed Radix Aconiti Chuanwu, 5-15 parts of vinegar frankincense, 5-15 parts of Lithospermum Officinale, 5-15 parts of Vinegar Myrrh, and 5-15 parts of Radix Sanguisorbae.

[0006] Preferably, the composition comprises the following components in parts by mass: 13-17 parts of Herba Lycopodii, 8-12 parts of Radix Clematidis, 7-8 parts of Asarum, 8-12 parts of Radix Gentianae, 8-12 parts of Radix Angelicae Dahuricae, 8-12 parts of Radix Rhizoma Rhei, 8-12 parts of Radix Notopterygii, 8-12 parts of Rhubarb, 8-12 parts of Radix Notopterygii, 8-12 parts of Rhizoma Epimedii, 8-12 parts of Radix Achyranthis Bidentatae, 8-12 parts of Semen Persicae, 8-12 parts of Radix Angelicae Pubescentis, 8-12 parts of Corydalis Vinegar, 8-12 parts of Rhizoma Cyperi Vinegar, 8-12 parts of Cortex Moutan, 8-12 parts of Processed Radix Aconiti Kusnezoffii, 8-12 parts of Processed Radix Aconiti Chuanwu, 8-12 parts of Vinegar Frankincense, 8-12 parts of Lithospermum Officinale, 8-12 parts of Vinegar Myrrh, and 8-12 parts of Radix Sanguisorbae.

[0007] The present invention also provides the use of the traditional Chinese medicine composition in preparing a blood stasis-removing and analgesic patch.

[0008] The present invention also provides a blood stasis-relieving and analgesic patch, which comprises an active ingredient and a carrier;

[0009] The effective ingredients include a traditional Chinese medicine composition, vinegar and honey;

[0010] The Chinese medicine composition is the Chinese medicine composition described above;

[0011] The mass volume ratio of the traditional Chinese medicine composition and vinegar is 9g:15-25ml;

[0012] The mass ratio of the traditional Chinese medicine composition to honey is 9g:1-3g.

[0013] Preferably, the carrier comprises plain woven spunlace fabric.

[0014] The present invention also provides a method for preparing the blood stasis-removing and analgesic patch, comprising the following steps:

[0015] (1) heating the vinegar to 95-110° C. and then cooling to obtain treated vinegar;

[0016] (2) mixing the treated vinegar with the Chinese medicine composition and honey to obtain an effective ingredient;

[0017] (3) Applying the active ingredient on a carrier to obtain a blood stasis-removing and analgesic patch.

[0018] Preferably, in step (2), the mixing is stirring mixing; the mixing temperature is 35 to 45° C.; and the mixing time is 8 to 12 minutes.

[0019] Preferably, in step (3), the mass area ratio of the active ingredient applied on the carrier is 100-110 g: 96 cm 2 .

[0020] Beneficial effects of the present invention:

[0021] The present invention uses processed Chuanwu, processed Caowu, Asarum, Corydalis, and Clematidis as monarch drugs, mainly playing the role of warming the meridians and dredging menstruation and relieving pain; using Herba Lycopodii, Radix Notopterygii, Radix Angelicae Pubescentis, Rhizoma Cyperi, Epimedium, Olibanum, Myrrha, Radix Achyranthis Bidentatae, and Radix Angelicae Dahuricae as ministerial drugs, mainly serving as meridian-inducing drugs, enhancing the effect of dredging the meridians; using Cortex Moutan, Radix Sanguisorbae, Radix Lithospermi, and Radix Gentianae as adjuvant drugs, avoiding the prescription from being too warm and impatient; using Radix Et Rhizoma Rhei and Rhizoma Pruni as enabling drugs, the overall effect of the drugs is to promote blood circulation and relieve pain. The stasis-removing and analgesic patch of the present invention has the characteristics of good efficacy, quick effect, easy to use, safe and reliable, can be used to treat traumatic injuries, as well as the pain caused by the diseases such as cervical spondylosis, periarthritis of the shoulder, herniated lumbar disc, lumbar bone hyperplasia, vertebral canal stenosis, sciatica, ankylosing spondylitis, and arthritis, and can achieve the effect of treating both the principal and secondary symptoms. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 VAS is the visual pain scoring system. DETAILED DESCRIPTION

[0023] The present invention provides a traditional Chinese medicine composition for relieving pain, promoting blood circulation, reducing swelling and removing blood stasis, comprising the following components in parts by weight:

[0024] 10-20 parts of Herba Lycopodii Herba, preferably 13-17 parts, more preferably 15 parts;

[0025] 5-15 parts of Clematis chinensis, preferably 8-12 parts, more preferably 10 parts;

[0026] 5-10 parts of Asarum, preferably 7-8 parts, more preferably 7.5 parts;

[0027] 5-15 parts of Gentiana macrophylla, preferably 8-12 parts, more preferably 10 parts;

[0028] 5-15 parts of Angelica dahurica, preferably 8-12 parts, more preferably 10 parts;

[0029] 5-15 parts of rhubarb, preferably 8-12 parts, more preferably 10 parts;

[0030] 5-15 parts of Notopterygium wilfordii, preferably 8-12 parts, more preferably 10 parts;

[0031] 5-15 parts of roasted epimedium, preferably 8-12 parts, more preferably 10 parts;

[0032] 5-15 parts of Achyranthes bidentata, preferably 8-12 parts, more preferably 10 parts;

[0033] 5-15 parts of peach kernels, preferably 8-12 parts, more preferably 10 parts;

[0034] 5-15 parts of Angelica dahurica, preferably 8-12 parts, more preferably 10 parts;

[0035] 5-15 parts of vinegared Corydalis yanhusuo, preferably 8-12 parts, more preferably 10 parts;

[0036] 5-15 parts of vinegar-cured cyperus rotundus, preferably 8-12 parts, more preferably 10 parts;

[0037] 5-15 parts of Paeonia suffruticosa moutan bark, preferably 8-12 parts, more preferably 10 parts;

[0038] 5-15 parts of processed Aconitum kusnezoffii, preferably 8-12 parts, more preferably 10 parts;

[0039] 5-15 parts of processed Chuanwu, preferably 8-12 parts, more preferably 10 parts;

[0040] 5-15 parts of vinegar frankincense, preferably 8-12 parts, more preferably 10 parts;

[0041] 5-15 parts of Xinjiang Lithospermum officinale, preferably 8-12 parts, more preferably 10 parts;

[0042] 5-15 parts of vinegar myrrh, preferably 8-12 parts, more preferably 10 parts;

[0043] 5 to 15 parts of Sanguisorba officinalis, preferably 8 to 12 parts, more preferably 10 parts.

[0044] In the present invention, the herb has the functions of dispelling rheumatism, relaxing muscles and tendons, and is suitable for treating injuries from falls, numbness of limbs, arthritis caused by wind, cold and dampness, and joint pain.

[0045] Clematis: dispels wind and dampness, dredges meridians and relieves pain, and eliminates bone stagnation. It is used for rheumatic pain, numbness of limbs, muscle spasms, difficulty in flexion and extension, and fishbone stuck in the throat.

[0046] Asarum: dispels wind, dispels cold, promotes water circulation, opens the orifices, treats wind-cold headache, sinusitis, toothache, phlegm and cough, rheumatic pain. Gentiana: dispels rheumatism, dredges the meridians and relieves pain, reduces deficiency fever, and clears damp-heat.

[0047] Angelica dahurica: dispels cold, dispels wind and relieves pain, clears the nasal passages, dries dampness and stops leukorrhea, reduces swelling and discharges pus;

[0048] Rhubarb: Purgative, purgative, heat-clearing, fire-removing, cooling blood, detoxifying, removing blood stasis and promoting menstruation;

[0049] Qiang Huo: dispels cold, dispels wind, removes dampness, and relieves pain. It is used for colds, headaches, rheumatic pain, and shoulder and back pain.

[0050] Roasted Epimedium: nourishes the kidneys and strengthens yang, dispels wind and dampness, and is mainly used to treat impotence, premature ejaculation, and spermatorrhea. It can also treat coronary heart disease, neurasthenia, menopausal hypertension, and strengthen muscles and bones.

[0051] Achyranthes bidentata: promotes blood circulation and menstruation, nourishes the liver and kidneys, strengthens tendons and bones, and promotes urination and relieves stranguria;

[0052] Peach kernel: promotes blood circulation, removes blood stasis, moistens the intestines and promotes bowel movements, relieves cough and asthma;

[0053] Duhuo: dispels wind and dampness, relieves pain and promotes blood circulation. Indications: dispels wind and dampness, relieves numbness and relieves pain, and relieves exterior symptoms. It is used for wind-cold-dampness arthritis, lower limb pain, Shaoyin hidden wind headache, etc.

[0054] Vinegar-coated Corydalis: promotes qi and blood circulation, relieves pain, and is used for chest, flank, and abdominal pain, amenorrhea, dysmenorrhea, postpartum blood stasis, and swelling and pain caused by falls;

[0055] Vinegar-soaked Cyperus: Soothes liver qi and relieves depression, regulates qi and relieves fullness, regulates menstruation and relieves pain. It is used for liver qi stagnation, chest and rib pain, hernia pain, breast pain, spleen and stomach qi stagnation, abdominal distension and fullness, and irregular menstruation.

[0056] Peony bark: clears heat and cools blood, disperses blood stasis and relieves pain;

[0057] Prepared Radix Aconiti Kusnezoffii: dispels wind and dampness, warms the meridians and relieves pain. It is used for wind-cold-dampness arthralgia, joint pain, cold pain in the heart and abdomen, pain caused by cold hernia, and anesthesia and pain relief.

[0058] Processed Chuanwu: dispels wind and dampness, warms the meridians and relieves pain. It is used for wind-cold-dampness arthralgia, cold pain in joints, pain caused by cold hernia, and as anesthesia and pain relief.

[0059] Vinegar frankincense: It can promote blood circulation, relieve pain, reduce swelling and promote tissue regeneration. It can be used for abdominal pain, traumatic injuries, carbuncle, irregular menstruation, dysmenorrhea, amenorrhea, postpartum blood stasis, etc.

[0060] Xinjiang Lithospermum officinale: clears heat and cools blood, activates blood circulation and detoxifies, clears rashes and eliminates spots. It is used for excessive blood heat and toxins, purple-black spots, measles that do not clear up, sores, eczema, and burns caused by water or fire.

[0061] Vinegar Myrrh: Disperses blood stasis, relieves pain, reduces swelling and promotes tissue regeneration. It is used to treat chest pain, heart pain, epigastric pain, dysmenorrhea, amenorrhea, postpartum blood stasis, abdominal pain due to abdominal masses, rheumatic pain, traumatic injuries, carbuncles, ulcers, etc.

[0062] Sanguisorba officinalis: cools blood and stops bleeding, detoxifies and heals sores, suitable for symptoms such as bloody stool, hemorrhoidal bleeding, bloody dysentery, and metrorrhagia.

[0063] The present invention also provides the use of the traditional Chinese medicine composition in preparing a blood stasis-removing and analgesic patch.

[0064] The present invention also provides a blood stasis-relieving and analgesic patch, which comprises an active ingredient and a carrier;

[0065] The effective ingredients include a traditional Chinese medicine composition, vinegar and honey;

[0066] The Chinese medicine composition is the Chinese medicine composition described above;

[0067] The mass volume ratio of the traditional Chinese medicine composition and vinegar is 9g:15-25ml, preferably 9g:18-22ml, and more preferably 9g:20ml;

[0068] The mass ratio of the traditional Chinese medicine composition to honey is 9g:1-3g, preferably 9g:1.5-2.5g, and more preferably 9g:2g.

[0069] In the present invention, the carrier comprises a plain woven spunlace fabric.

[0070] The present invention also provides a method for preparing the blood stasis-removing and analgesic patch, comprising the following steps:

[0071] (1) heating the vinegar to 95-105° C. and then cooling to obtain treated vinegar;

[0072] (2) mixing the treated vinegar with the Chinese medicine composition and honey to obtain an effective ingredient;

[0073] (3) Applying the active ingredient on a carrier to obtain a blood stasis-removing and analgesic patch.

[0074] In the present invention, in step (1), the heating temperature is preferably 98-102°C, more preferably 100°C.

[0075] In the present invention, in step (2), the mixing is stirring mixing; the mixing temperature is 35 to 45° C., preferably 38 to 42° C., more preferably 40° C.; the mixing time is 8 to 12 minutes, preferably 9 to 11 minutes, more preferably 10 minutes;

[0076] Before mixing the treated vinegar with the Chinese medicinal composition and honey, the Chinese medicinal composition needs to be crushed into fine powder; the fine powder is the medicinal powder that all passes through a No. 5 sieve (i.e., an 80-mesh sieve) and contains no less than 95% of the powder that can pass through a No. 6 sieve (i.e., a 100-mesh sieve).

[0077] In the present invention, in step (3), the mass area ratio of the active ingredient applied on the carrier is 100-110 g: 96 cm 2 , preferably 103-107g:96cm 2 , more preferably 105g:96cm 2 .

[0078] In the present invention, the method for using the Huayu Zhitong patch is: stick the Huayu Zhitong patch on the affected area, change it every 1 day, and three patches constitute a course of treatment.

[0079] The technical solutions provided by the present invention are described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0080] Example 1 A blood stasis-relieving and analgesic patch

[0081] (1) heating the vinegar to 100° C. and then cooling it to obtain treated vinegar;

[0082] (2) 15g of Herba Lycopodii, 5g of Radix Clematis, 8g of Asarum, 8g of Radix Gentianae, 12g of Radix Angelicae Dahuricae, 15g of Radix Rhizoma Rhei, 5g of Radix Notopterygii, 7g of roasted Epimedium, 12g of Radix Achyranthis Bidentatae, 8g of Semen Persicae, 15g of Radix Angelicae Pubescentis, 5g of Corydalis Vinegar, 12g of Cyperus Vinegar, 10g of Cortex Moutan, 6g of Radix Aconitum, 14g of Radix Aconiti Kusnezoffii, 5g of Frankincense Vinegar, 10g of Lithospermum Officinale, 12g of Myrrh Vinegar, and 12g of Radix Sanguisorbae were mixed and pulverized into fine powder to obtain Chinese medicine powder; the treated vinegar, Chinese medicine composition, and honey were stirred and mixed at a mass volume ratio of 20ml:9g:2g at 40°C for 10min to obtain the effective ingredient;

[0083] (3) The active ingredient is divided into 96 cm2 by mass ratio of 105 g:96 cm2.2 Apply it on plain woven spunlace cloth to obtain a blood stasis and pain relieving patch.

[0084] Example 2 A blood stasis-relieving and analgesic patch

[0085] (1) heating the vinegar to 95° C. and then cooling it to obtain treated vinegar;

[0086] (2) 10g of Herba Lycopodii, 10g of Radix Clematis, 5g of Asarum, 6g of Radix Gentianae, 15g of Radix Angelicae Dahuricae, 5g of Radix Rhizoma Rhei, 10g of Rhizoma Notopterygii, 5g of Rhizoma Epimedii, 15g of Radix Achyranthis Bidentatae, 10g of Semen Persicae, 12g of Radix Angelicae Pubescentis, 10g of Corydalis Vinegar, 5g of Rhizoma Cyperi Vinegar, 6g of Paeonia Suffruticosae Moutan, 10g of Radix Aconitum, 10g of Radix Aconiti Kusnezoffii, 12g of Rhizoma Osmanthus Fructus, 8g of Lithospermum Officinale, 15g of Rhizoma Myrrha Vinegar, and 8g of Radix Sanguisorbae were mixed and pulverized into fine powder to obtain Chinese medicine powder; the treated vinegar, Chinese medicine composition, and honey were stirred and mixed at a mass volume ratio of 25ml:9g:1g at 45°C for 8min to obtain the effective ingredient;

[0087] (3) The active ingredient is mixed with a mass area ratio of 110g:96cm 2 Apply it on plain woven spunlace cloth to obtain a blood stasis and pain relieving patch.

[0088] Example 3 A blood stasis-relieving and analgesic patch

[0089] (1) heating the vinegar to 105° C. and then cooling it to obtain treated vinegar;

[0090] (2) 8g of Herba Lycopodii, 12g of Radix Clematis, 10g of Asarum, 12g of Radix Gentianae, 5g of Radix Angelicae Dahuricae, 10g of Rhubarb, 15g of Rhizoma Notopterygii, 15g of Rhizoma Epimedii, 5g of Radix Achyranthis Bidentatae, 12g of Semen Persicae, 8g of Radix Angelicae Pubescentis, 15g of Corydalis Vinegar, 10g of Rhizoma Cyperi Vinegar, 15g of Cortex Moutan, 12g of Radix Aconitum, 8g of Radix Aconiti Kusnezoffii, 10g of Rhizoma Lithospermi, 5g of Rhizoma Myrrha Vinegar, and 10g of Radix Sanguisorbae were mixed and pulverized into fine powder to obtain Chinese medicine powder; the treated vinegar, Chinese medicine composition, and honey were stirred and mixed at a mass volume ratio of 15ml:9g:3g at 35°C for 12min to obtain the effective ingredient;

[0091] (3) The active ingredient is placed in a volume area ratio of 100g:96cm 2 Apply it on plain woven spunlace cloth to obtain a blood stasis and pain relieving patch.

[0092] Experimental case clinical trial

[0093] 1.1 How to use the patch: Apply the Huayu Zhitong patch described in Example 1 to the affected area, changing it every 1 day. Three patches constitute a course of treatment.

[0094] 1.2 Subjective pain visual analogue scale

[0095] After treatment with Huayu Zhitong Patch, the subjective pain visual analogue scale (VAS score, such as Figure 1 The local pain intensity is assessed using a scale (shown in Figure 1) with a total score of 0 to 10. The basic method uses a 10-cm-long flexible ruler with 10 scale marks on one side, with 0 at the "0" end and 10 at the "10" end. A score of 0 indicates no pain, and 10 indicates the most severe, unbearable pain.

[0096] 1.3 Rating Results

[0097] 1) Clinical data of patients with various types of traumatic injuries and fractures

[0098] ① Patient information:

[0099] Methods: A total of 241 patients with fractures who received Huayu Zhitong Patch from July 1, 2024, to September 31, 2024, were enrolled in the orthopedic emergency department, trauma center, and orthopedic inpatient department of Tianjin Hospital of Integrated Traditional Chinese and Western Medicine, Nankai Hospital. The patients included 264 patients in total, 23 of whom were lost to follow-up (a loss-to-follow-up rate of 8.7%). Among them, 145 patients were female, aged 26 to 81 years, with an average age of 61.73±13.09 years; and 96 patients were male, aged 32 to 84 years, with an average age of 62.33±13.07 years. The fracture types included thoracic compression fracture, lumbar compression fracture, intertrochanteric fracture, distal radius fracture, femoral neck fracture, and other types of fractures.

[0100] ②Improvement of local pain before and after treatment:

[0101] The patients' VAS scores at different time points before and after using the Huayu Zhitong patch were paired and measured, and a paired T test was performed. The local VAS score before treatment was 6.47±1.38, ranging from 4 to 8 points; the local VAS score after treatment was 3.25±1.53, ranging from 1 to 6 points; the paired T test result was P<0.001 (t=50.48).

[0102] 2) Clinical data of patients with cervical spondylosis

[0103] ① Patient information:

[0104] Methods A total of 95 patients with cervical spondylosis who were admitted to the orthopedic emergency department, orthopedic outpatient department, and orthopedic inpatient department of the Tianjin Hospital of Integrated Traditional Chinese and Western Medicine, Nankai Hospital from July 1 to October 31, 2024, were enrolled in the study (a total of 107 cases, 12 of whom were lost to follow-up, with a loss rate of 11.2%). Among them, 35 were female, aged 34 to 76 years, with an average age of 57.77±11.55 years; 60 were male, aged 26 to 76 years, with an average age of 54.87±11.39 years. The main type of pain was radiculopathy.

[0105] ②Improvement of local pain before and after treatment:

[0106] The patients' VAS scores at different time points before and after using the Huayu Zhitong patch were paired and measured, and a paired T test was performed. The local VAS score before treatment was 5.76±0.88, ranging from 4 to 8 points; the local VAS score after treatment was 2.91±1.46, ranging from 1 to 6 points; the paired T test result was P<0.001 (t=20.32).

[0107] 3) Clinical data of patients with low back pain

[0108] ① Patient information:

[0109] Methods A total of 117 patients with low back pain who were admitted to the orthopedic emergency department, orthopedic outpatient department, and orthopedic inpatient department of the Tianjin Hospital of Integrated Traditional Chinese and Western Medicine, Nankai Hospital, from July 1 to October 31, 2024, were enrolled in the study (a total of 136 patients, 19 of whom were lost to follow-up, with a loss rate of 13.9%). Among them, 43 were female, aged 29 to 73 years, with an average age of 52.84±15.87 years; 74 were male, aged 20 to 73 years, with an average age of 54.62±16.42 years. The types of pain were lumbar disc herniation, lumbar sprain, and lumbar spinal stenosis.

[0110] ②Improvement of local pain before and after treatment

[0111] The patients' VAS scores at different time points before and after using the Huayu Zhitong patch were measured in pairs, and a paired T test was performed. The local VAS score before treatment was 5.35±1.36, ranging from 3 to 7 points; the local VAS score after treatment was 2.46±1.03, ranging from 1 to 6 points; the paired T test result was P<0.001 (t=21.66).

[0112] 4) Clinical data of patients with knee pain

[0113] ① Patient information:

[0114] Methods A total of 117 patients with fractures who received Huayu Zhitong Patch in the orthopedic emergency, orthopedic outpatient department, and orthopedic inpatient department of the Tianjin Hospital of Integrated Traditional Chinese and Western Medicine, Nankai Hospital from July 1 to October 31, 2024 were selected (a total of 174 cases, 57 cases lost to follow-up, and the loss rate was 32.7%). Among them, 71 were female, aged 51 to 84 years, with an average age of 68.55±6.87 years; 46 were male, aged 36 to 83 years, with an average age of 63.07±11.06 years. The types of knee pain were knee osteoarthritis, traumatic swelling pain, and closed-type pain.

[0115] ②Improvement of local pain before and after treatment

[0116] The patients' VAS scores at different time points before and after using the Huayu Zhitong patch were measured in pairs, and a paired T-test was performed. The local VAS score before treatment was 2.22±1.07, ranging from 1 to 5 points; the local VAS score after treatment was 0.74±0.95, ranging from 0 to 4 points. The paired T-test result was P<0.001 (t=16.19).

[0117] 1.4 Criteria for determining efficacy

[0118] Cured means that clinical symptoms disappear; markedly effective means that clinical symptoms basically disappear, but mild symptoms still exist after drug discontinuation; effective means that clinical symptoms are alleviated, but other treatment measures are still needed; ineffective means that symptoms have no significant improvement or worsen;

[0119] 1.5 Clinical efficacy results

[0120] All outpatients, emergency department and inpatients who received clinical treatment (681 cases) were followed up, with a follow-up rate of 83.7%. The follow-up results are shown in Table 1 ;

[0121] Table 1 Improvement of clinical symptoms in patients in each group

[0122] disease Case cure Significantly effective efficient invalid Efficiency Various fracture injuries 241 138 33 39 31 87.1％ cervical spondylosis 95 50 21 10 14 85.2％ Lumbar degenerative disease 117 71 23 13 10 91.4％ knee arthritis 117 82 16 5 14 88.0％

[0123] The follow-up results showed that the effective rate was 87.9% (including cured, markedly effective, and effective).

[0124] To further illustrate the beneficial effects of the present invention, the present invention provides the following typical cases:

[0125] 1. Zhang, male, 38 years old, suffered from a right ankle fracture caused by a car accident, with obvious swelling and pain. After one course of treatment with the present invention, the pain and swelling symptoms were significantly alleviated and the operation was successful.

[0126] 2. Mr. Zhao, male, 58 years old, suffered from cervical spondylosis and frozen shoulder for 15 years. He was treated in many hospitals without obvious results. After one course of treatment with the present invention, his symptoms were alleviated, and were completely relieved after three courses. No recurrence was found during the follow-up one month later.

[0127] 3. Bai Moumou, female, 48 years old, suffered from lumbar disc herniation for 4 years. She sought medical treatment from many places but could not be cured. She was cured after four courses of treatment with the present invention and showed no recurrence after one month of follow-up.

[0128] 4. Dong Moumou, female, 52 years old, suffered from periarthritis of shoulder for more than 3 years, with recurrent symptoms. She used various plasters on her own, but the symptoms were not significantly relieved. After two courses of treatment with the present invention, the symptoms were significantly relieved. After four courses of treatment, the pain, swelling and limited activity basically disappeared, and there was no recurrence after a follow-up of 2 months.

[0129] As can be seen from the above embodiments, the present invention provides a traditional Chinese medicine composition for relieving pain, promoting blood circulation, reducing swelling and removing blood stasis, and its application and a blood-stasis-relieving and analgesic patch. The blood-stasis-relieving and analgesic patch has the characteristics of good efficacy, quick effect, convenience of use, safety and reliability. It can be used to treat traumatic injuries, as well as pain caused by diseases such as cervical spondylosis, periarthritis of the shoulder, lumbar disc herniation, lumbar bone hyperplasia, vertebral canal stenosis, sciatica, ankylosing spondylitis, and arthritis, and can achieve the effect of treating both the symptoms and the root cause.

[0130] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for relieving pain, promoting blood circulation, reducing swelling and removing blood stasis, characterized in that: The invention comprises the following components in parts by mass: 10-20 parts of Herba Lycopodii, 5-15 parts of Radix Clematis, 5-10 parts of Asarum, 5-15 parts of Radix Gentianae Macrophyllae, 5-15 parts of Radix Angelicae Dahuricae, 5-15 parts of Radix Rhizoma Rhei, 5-15 parts of Radix Notopterygii, 5-15 parts of roasted Herba Epimedii, 5-15 parts of Radix Achyranthis Bidentatae, 5-15 parts of Semen Persicae, 5-15 parts of Radix Angelicae Pubescentis, 5-15 parts of Rhizoma Corydalis, 5-15 parts of Vinegar Corydalis, 5-15 parts of Vinegar Cyperus, 5-15 parts of Cortex Moutan, 5-15 parts of processed Radix Aconiti Kusnezoffii, 5-15 parts of processed Radix Aconiti Chuanwu, 5-15 parts of Vinegar Frankincense, 5-15 parts of Lithospermum Officinale, 5-15 parts of Vinegar Myrrh, and 5-15 parts of Radix Sanguisorbae.

2. The Chinese medicine composition according to claim 1, characterized in that The invention comprises the following components in parts by mass: 13-17 parts of Herba Lycopodii, 8-12 parts of Radix Clematidis, 7-8 parts of Asarum, 8-12 parts of Radix Gentianae, 8-12 parts of Radix Angelicae Dahuricae, 8-12 parts of Radix Rhizoma Rhei, 8-12 parts of Radix Notopterygii, 8-12 parts of roasted Herba Epimedii, 8-12 parts of Radix Achyranthis Bidentatae, 8-12 parts of Semen Persicae, 8-12 parts of Radix Angelicae Pubescentis, 8-12 parts of Rhizoma Corydalis, 8-12 parts of Vinegar Corydalis, 8-12 parts of Vinegar Cyperus, 8-12 parts of Cortex Moutan, 8-12 parts of processed Radix Aconiti Kusnezoffii, 8-12 parts of processed Radix Aconiti Chuanwu, 8-12 parts of Vinegar Frankincense, 8-12 parts of Lithospermum Officinale, 8-12 parts of Vinegar Myrrh, and 8-12 parts of Radix Sanguisorbae.

3. Use of the Chinese medicine composition according to claim 1 or 2 in the preparation of a blood stasis-eliminating and analgesic patch.

4. A blood stasis-relieving and analgesic patch, characterized in that: The blood stasis-eliminating and analgesic patch comprises an active ingredient and a carrier; The effective ingredients include a traditional Chinese medicine composition, vinegar and honey; The Chinese medicine composition is the Chinese medicine composition according to claim 1 or 2; The mass volume ratio of the traditional Chinese medicine composition and vinegar is 9g:15-25ml; The mass ratio of the traditional Chinese medicine composition to honey is 9g:1-3g.

5. The blood stasis-relieving and analgesic patch according to claim 4, characterized in that: The carrier comprises a plain woven spunlace fabric.

6. The method for preparing the blood stasis-eliminating and analgesic patch according to claim 4 or 5, characterized in that: The steps include: (1) heating the vinegar to 95-105° C. and then cooling to obtain treated vinegar; (2) mixing the treated vinegar with the Chinese medicine composition and honey to obtain an effective ingredient; (3) Applying the active ingredient on a carrier to obtain a blood stasis-removing and analgesic patch.

7. The preparation method according to claim 6, characterized in that In step (2), the mixing is performed by stirring; the mixing temperature is 35 to 45° C.; and the mixing time is 8 to 12 minutes.

8. The preparation method according to claim 7, characterized in that In step (3), the mass area ratio of the active ingredient applied on the carrier is 100-110 g: 96 cm 2 .

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