39 results about "Prostatitis" patented technology

The invention discloses a stem cell preparation for improving function degeneration of prostatitis and a preparation method and application thereof, and relates to the technical field of stem cells, the stem cell preparation is prepared from mesenchymal stem cells UC-MSCs and ADSCs according to the cell concentration ratio of 1: 2, hyaluronic acid hydrogel is used as a delivery carrier, and the stem cell preparation is prepared from the mesenchymal stem cells UC-MSCs and ADSCs according to the cell concentration ratio of 1: 2. And two key auxiliary components of juniperus formosana extract and mulberry extract are introduced. Wherein the optimal combination of the UC-MSCs and the ADSCs significantly enhances the anti-inflammatory ability and the tissue regeneration effect; the hyaluronic acid hydrogel carrier system effectively improves the targeting delivery efficiency of the stem cells and prolongs the action time; the two natural active components of the juniperus formosana extract and the mulberry extract synergistically improve the local microenvironment of prostate and inhibit inflammatory response and fibrosis process. The stem cell preparation developed through a multi-component synergistic effect mechanism has the characteristics of high targeting property, lasting treatment effect, high safety and the like, and a new strategy is provided for clinical treatment of prostatitis.

A traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 7-13 parts of Acori Tatarinowii Rhizoma, 14-22 parts of Curcuma phaeocaulis, 14-22 parts of Cuscuta chinensis, 11-19 parts of oyster, 18-30 parts of Verbena officinalis, 12-19 parts of Schisandra chinensis, 14-22 parts of Poria cocos, 24-37 parts of Rhizoma Dioscoreae Hypoglaucae, 4-8 parts of licorice, and 4-9 parts of Indigo naturalis. The traditional Chinese medicine composition tonifies the kidney to consolidate the essence, and treats osteoporosis and prostatitis.

The invention provides a traditional Chinese medicine preparation for treating chronic prostatitis, and relates to the technical field of traditional Chinese medicine pharmacy. The traditional Chinese medicine preparation is prepared from black nightshade, hypericum perforatum, yam rhizome, rhizoma sparganii, common sage herb, chingma abutilon seed, polyporus umbellatus, uniflower swisscentaury root, corydalis amabilis, aspongopus, glossy privet fruit, fructus broussonetiae, radix ophiopogonis, tuber fleeceflower stem, day lily and liquorice. The traditional Chinese medicine preparation has the effects of clearing heat and promoting diuresis, promoting blood circulation to remove blood stasis, nourishing yin and soothing nerves and tonifying liver and kidney. The traditional Chinese medicine preparation disclosed by the invention has a remarkable treatment effect on CNP rats, and the prostate pathological injury condition and inflammatory response of the CNP rats are effectively relieved. In addition, the traditional Chinese medicine composition has a good treatment effect on relieving pain, frequent micturition, urgent urination, dysuria and other clinical symptoms and inflammation conditions of patients, and has a high total treatment effective rate on chronic prostatitis. The traditional Chinese medicine preparation provides a new scheme for treating chronic prostate.

The present application relates to the technical field of stem cell medicine, in particular to a mesenchymal stem cell composition for treating prostate diseases and a preparation method and application thereof. The mesenchymal stem cell composition for treating prostate diseases comprises mesenchymal stem cells treated by low oxygen and an anti-inflammatory peptide WYPWMKKHHRRRRRRRRR. The prostate diseases are selected from prostatitis, prostate calcification, sexual function improvement, frequent urination and urgency, etc. The mesenchymal stem cell composition can significantly improve the symptoms of prostate diseases, and the curative effect is remarkable.

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating or improving prostate diseases and stomach diseases, a traditional Chinese medicine preparation and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw materials: Chinese lobelia, tripterygium wilfordii, selfheal, dandelion, lophatherum gracile, hydrocotyle verticillata and liquorice. The traditional Chinese medicine composition disclosed by the invention is reasonable in compatibility and synergistic in efficacy, can treat prostate diseases such as chronic prostatitis and benign prostatic hyperplasia and stomach diseases such as chronic gastritis and gastric ulcer at the same time by taking a treatment method of clearing away heat and toxic materials, promoting diuresis and treating stranguria, regulating qi and harmonizing stomach and removing stasis and diminishing swelling, has the advantages of definite curative effect, high safety, low recurrence rate, convenience in taking and the like, and is suitable for clinical popularization.

This invention relates to the field of pharmaceutical preparation technology, and particularly to a method for preparing a male enhancement tablet for treating prostatitis. The method optimizes the composition and ratio of auxiliary materials other than the raw medicinal materials. To prepare 2 million tablets of this product, only approximately 1.3 kg of silica, 1.3 kg of magnesium stearate, 90 kg of corn starch, 18 kg of microcrystalline cellulose, 600 kg of ethanol, and 15 kg of gastric-soluble film-coating premix are required. The oil extraction process has also been improved, with the water addition reduced from 6 times the amount of raw materials to 0.4-0.6 kg. The method also changed the process of extracting oil from the medicinal materials by dividing them into eight separate pots for oil extraction. This refined dispersion process greatly saved water consumption and improved the quality of the extracted oil. An additional step of stirring the alcohol precipitation solution for one hour was added to improve the quality of the supernatant. The volatile ether extract of the male health tablets produced by the method of this invention was measured, and the average value of volatile ether extract was found to be 0.53%, which is about 60.6% higher than the 0.33% of the original process, demonstrating significant technological progress.

The invention relates to the field of traditional Chinese medicine, and discloses a traditional Chinese medicine composition for treating chronic prostatitis and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 5-15 parts of pericarpium citri reticulatae viride; 5-15 parts of szechwan chinaberry fruit; 5-15 parts of the root of three-nerved spicebush; 5-15 parts of radix angelicae dahuricae; 10-20 parts of herba lycopi; 10 to 20 parts of herba patriniae; 4 to 8 parts of frankincense; 4 to 8 parts of myrrh; 5 to 15 parts of rhizoma corydalis; 10 to 20 parts of caulis spatholobi; 5 to 15 parts of diverse wormwood herb; 10 to 20 parts of cowherb seed; 5-15 parts of radix curcumae; and 4-8 parts of fennel. The traditional Chinese medicine composition can significantly improve the symptoms of chronic prostatitis, regulate the syndromes of traditional Chinese medicine and improve the life quality of patients, and has good safety and patient compliance.

The invention provides a pharmaceutical composition for treating prostatitis and a preparation method thereof. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 20 to 60 parts of palmatine, 20 to 60 parts of paeoniflorin, 10 to 30 parts of formononetin, 20 to 60 parts of astilbin and 10 to 40 parts of stigmasterol. In-vitro cell tests and in-vivo animal experiments prove that the pharmaceutical composition has the effect of relieving the chronic prostatitis reaction.

The current invention is in the field of molecular biology / pharmacology and provides novel 3-oxabicyclo[3.3.1]nonene compounds and derivatives that modulate the effects of the classical estrogen receptors alpha and beta (ERalpha and ERbeta) with little to no biological or physiological effects on the G protein-coupled estrogen receptor GPER (also known as GPR30). These compounds may function as agonists and / or antagonists of one or more of the disclosed classical estrogen receptors. Diseases that are mediated through one or more of these receptors include cancer (including but not limited to breast (particularly endocrine or anti-hormone resistant, and for the prevention / reduction of endocrine or anti-hormone resistance), reproductive and other hormone-dependent cancers, leukemia, colon cancer, prostate cancer), reproductive (genito-urological) including endometritis, prostatitis, polycystic ovarian syndrome, bladder control, hormone-related disorders, hearing disorders, cardiovascular conditions including hot flashes and profuse sweating, hypertension, stroke, obesity, osteoporosis, hematologic diseases, vascular diseases or conditions such as venous thrombosis, atherosclerosis, among numerous others and disorders of the central and peripheral nervous system, including depression, insomnia, anxiety, multiple sclerosis, neuropathy, neurodegenerative disorders (such as Parkinson's disease and Alzheimer's disease), as well as inflammatory bowel disease, Crohn's disease, coeliac (celiac) disease and related disorders of the intestine, among numerous others as described herein. A contraceptive indication to prevent or reduce the likelihood of pregnancy after intercourse is a further aspect of the present invention.

The present application provides the use of the volatile oil of Magnolia biondii in the preparation of a drug for chronic prostatitis. The present application also provides a pharmaceutical composition for treating chronic prostatitis, which comprises the volatile oil of Magnolia biondii and the volatile oil of Lavandula angustifolia; the weight ratio of the volatile oil of Magnolia biondii to the volatile oil of Lavandula angustifolia is 1.5-2.5:0.5-1.5. The present application also provides the preparation method and use of the extract. The present application further develops the medicinal function of the volatile oil of Magnolia biondii and makes a relevant study on the treatment of chronic prostatitis. The combination of the volatile oil of Lavandula angustifolia and the volatile oil of Magnolia biondii can better treat chronic prostatitis. The volatile oil of Lavandula angustifolia and the volatile oil of Magnolia biondii are prepared into a cream preparation, which is applied to the prostate of a rat with chronic prostatitis, and the drug effect is exerted through transdermal administration, thereby avoiding the side effects of the gastrointestinal tract and the prostate barrier, and achieving a synergistic effect of raw materials, which provides a new idea for the administration route for treating chronic prostatitis.

The invention provides application of lactobacillus reuteri to improvement of prostatitis and erectile dysfunction. The bacterial strain is lactobacillus reuteri NHNK-2001, the lactobacillus reuteri NHNK-2001 is preserved in the China Center for Type Culture Collection on April 25, 2024, and the preservation number of the lactobacillus reuteri NHNK-2001 is CCTCC (China Center for Type Culture Collection) NO: M 2024800. The NHNK-2001 has the functions of generating L-citrulline, repairing aged vascular endothelial cells, promoting vasodilation, repairing aged prostate cells and reducing prostatitis, and can be used for preparing products for improving prostatitis and erectile dysfunction.

The invention belongs to the technical field of health-care food and traditional Chinese medicine preparation, and discloses a medicinal and edible drink for treating prostatitis and a preparation method thereof.The drink is prepared by taking houttuynia cordata, dandelion, purslane and endive as monarch drugs, matching lalang grass rhizome, reed stem root, talc and yam rhizome as ministerial drugs, assisting saffron, and supplementing astragalus membranaceus, Chinese yam, fructus lycii and oyster; and meanwhile, lycopene and fucoidan are added. The preparation method comprises the following steps: pretreatment of raw material cleaning, drying and grouped crushing; carrying out low-temperature cold extraction by adopting water or an ethanol-water mixed solvent at 0-10 DEG C; the cold extraction liquid is heated to 80-95 DEG C and kept for 10-30 min, and high-temperature glowing is completed; the obtained liquid is sequentially subjected to rough filtration, fine filtration and vacuum concentration, instant high-temperature sterilization is conducted under the condition of 121 DEG C, and finally a liquid beverage, a concentrated solution or instant powder is prepared. Through combination of a reasonable formula and a specific technology, stable extraction and retention of various effective components are achieved, and the product quality consistency is good.

The invention relates to a construction method of an experimental autoimmune prostatitis rat model. The construction method comprises the following steps: S1, preparing a prostate specific antigen mixture; s2, selecting male SD rats as laboratory rats, and dividing the laboratory rats into a normal saline control group, a low-dose model group and a high-dose model group; s3, continuously injecting for 7 days, allowing the normal saline control group to accept injection of 0.2 ml of normal saline every day, allowing the low-dose model group to accept injection of 0.1 ml of prostate specific antigen mixture every day, and allowing the high-dose model group to accept injection of 0.2 ml of prostate specific antigen mixture every day; and S4, continuously feeding all groups of experimental mice to the 28th day, inducing the experimental mice in the low-dose model group and the high-dose model group by the prostate specific antigen mixture to cause experimental autoimmune prostatitis, and obtaining the experimental autoimmune prostatitis rat model. The use of animals can be reduced, the cost is reduced, and the modeling efficiency and stability can be improved.

The invention relates to the technical field of stem cell medicines, in particular to a mesenchymal stem cell composition for treating prostate diseases as well as a preparation method and application of the mesenchymal stem cell composition. The mesenchymal stem cell composition for treating the prostate diseases, disclosed by the invention, is prepared from mesenchymal stem cells subjected to hypoxia treatment and an anti-inflammatory peptide WYPWMKKHRRRRRRRR. The prostate diseases are selected from prostatitis, prostate calcification, sexual function improvement, frequent micturition, urgent micturition and the like. The mesenchymal stem cell composition disclosed by the invention can be used for remarkably improving symptoms of prostate diseases and is remarkable in curative effect.

The invention discloses an external traditional Chinese medicine composition for treating cold-heat mixed type diseases. The external traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 4-5 parts of radix aconiti carmichaeli, 4-5 parts of garden balsam stem, 4-5 parts of radix et rhizoma rhei, 2-3 parts of radix clematidis, 2-3 parts of frankincense, 2-3 parts of myrrh, 2-3 parts of herba asari, 2-3 parts of raw rhizoma arisaematis, 2-3 parts of fresh ginger, 2-3 parts of herba taraxaci and 2-3 parts of loofah sponge. Compared with the prior art, the traditional Chinese medicine composition has the advantages that cold and heat are used together, yin and yang are harmonized, exterior syndromes are treated by tonifying yang to condition roots, softening hardness to dissipate stagnation, promoting blood circulation to remove blood stasis, dispelling wind and relieving pain, necrotic tissue removing and granulation promoting are adopted to condition and recover, a multi-target and broad-spectrum treatment effect is formed, and the traditional Chinese medicine composition is mainly used for treating cold and heat intermingled diseases and can effectively treat or relieve rheumatoid bone diseases, traumatic injuries, scalds, prostatitis and other diseases.

The invention provides an anus suppository for treating prostatitis and a preparation method thereof, and relates to the technical field of pharmaceutical preparations. The anus suppository for treating prostatitis comprises an outer-layer sleeve and suppository contents, wherein the suppository contents comprise a heat-clearing and inflammation-diminishing layer, a warming, dredging and blood-activating layer and a qi-tonifying and kidney-tonifying layer which are sequentially distributed from outside to an inner core, and at least part of the suppository contents are wrapped by the outer-layer sleeve. The outer-layer sleeve prevents a large amount of medicine from being discharged after being released in a short time by delaying initial dissolution of a suppository matrix, and can contain dissolved suppository contents so as to prevent the dissolved suppository contents from flowing out of a body due to rectum peristalsis, so that the effective action time of the medicine is prolonged, and the curative effect of the suppository is improved. The medicine effect of the suppository content is fully exerted, and the use experience of a patient is improved; the medicine components permeate outwards at a controllable speed through the permeation part, the local effective medicine concentration of the rectum is maintained, the suppository matrix is gradually dissolved under the action of body temperature, and the traditional Chinese medicine composition is continuously released.

The invention provides an astaxanthin composition containing an effective amount of astaxanthin. Furthermore, the invention provides an astaxanthin composition containing an effective amount of astaxanthin and xanthoceras sorbifolia bunge oil. Furthermore, the invention provides an astaxanthin composition containing an effective amount of astaxanthin, xanthoceras sorbifolia bunge oil, DHA algal oil and / or euphausia superba oil. Furthermore, the invention provides an astaxanthin composition containing an effective amount of astaxanthin, xanthoceras sorbifolia bunge oil, DHA algal oil and / or euphausia superba oil, and one or more vitamins. Furthermore, the invention provides application of the astaxanthin composition in the following fields: 1) relieving physical and visual fatigue; 2) improving fundus diseases and other eye symptoms, and promoting eye health; the astaxanthin / xanthoceras sorbifolia bunge oil composition has the advantages that the astaxanthin / xanthoceras sorbifolia bunge oil composition can be used for treating and improving prostatitis and benign prostatic hyperplasia, is beneficial to male health, can be used for promoting the basic metabolism level and realizing non-exercise fat reduction, and has a more remarkable action effect compared with a composition (agent) only containing an astaxanthin active component.

The application relates to a method for constructing an experimental autoimmune prostatitis rat model, which comprises the following steps: S1, preparing a prostate specific antigen mixture; S2, selecting male SD rats as experimental rats and dividing the rats into a physiological saline control group, a low-dose model group and a high-dose model group; S3, continuously injecting for 7 days, wherein the physiological saline control group receives 0.2ml of physiological saline injection every day, the low-dose model group receives 0.1ml of the prostate specific antigen mixture injection every day, and the high-dose model group receives 0.2ml of the prostate specific antigen mixture injection every day; and S4, continuing to feed all the experimental rats in the groups until the 28th day, wherein the experimental rats in the low-dose model group and the high-dose model group are induced by the prostate specific antigen mixture to cause experimental autoimmune prostatitis, and an experimental autoimmune prostatitis rat model is obtained. The method can not only reduce the use of animals and the cost, but also improve the modeling efficiency and stability.

The invention discloses a bispecific antibody-UC-MSCs preparation for targeting prostate diseases as well as preparation and application of the bispecific antibody-UC-MSCs preparation. The preparation comprises a bispecific antibody BsAb-1 and human umbilical cord mesenchymal stem cells (UC-MSCs), the BsAb-1 is formed by connecting an anti-CD105 single-domain antibody, an anti-PSCA single-domain antibody and a flexible peptide linker in series, wherein the amino acid sequence of the BsAb-1 is as shown in SEQ ID NO: 4. According to the preparation, the UC-MSCs are delivered to a prostate focus through the targeting bridge effect of BsAb-1, the focus enrichment amount within 72 hours is increased by 6.3 times compared with that of pure UC-MSCs, and meanwhile retention of non-target organs such as the liver and the spleen is reduced. The preparation can effectively relieve inflammatory response and fibrosis of chronic prostatitis, and the curative effect of the preparation is remarkably superior to that of pure UC-MSCs treatment. Precise targeted treatment of prostate diseases is achieved, the curative effect is remarkably better than that of a traditional stem cell therapy method, and high clinical application value is achieved.

The utility model provides a multi-head vibration massage instrument for male genital organ health care, which comprises a shell, a double-shaft driving motor is arranged in the shell, five massage heads are arranged on the shell, the five massage heads are arranged in an isosceles triangle shape, and the massage heads are connected with the double-shaft driving motor. The massage heads located at the vertex angle position of the isosceles triangle are obliquely arranged and connected with the double-shaft driving motor through a crank connecting rod mechanism, and the massage heads located at the waist and the base angle position of the isosceles triangle are connected with the double-shaft driving motor through an eccentric swing mechanism. The prostate therapeutic instrument is compact in structure, the five massage heads are arranged to conduct vibration massage on the perineum point, the testis root Yinlian point and the penis root respectively, male diseases such as chronic prostatitis are relieved, a medical prostate therapeutic instrument and a household prostate therapeutic instrument are effectively replaced, operation is convenient, use is safe, and the market blank at the present stage is filled up.

The application belongs to the field of biological medicine, and relates to application of a manganese-type high-stability superoxide dismutase with an amino acid sequence as shown in SEQ ID NO: 1 in prevention and treatment of prostatitis. The manganese-type high-stability superoxide dismutase can reduce the symptoms of CP / CPPS, and has good application value.

The invention relates to the technical field of traditional Chinese medicine patches, in particular to a prostate traditional Chinese medicine patch and a preparation method thereof. The gel is prepared from a traditional Chinese medicine composition and a gel matrix, the traditional Chinese medicine composition is prepared from the following medicinal materials: 15-20 parts of radix aconiti carmichaeli, 10-15 parts of radix et rhizoma rhei, 5-10 parts of sulfur, 20-30 parts of radix salviae miltiorrhizae, 15-21 parts of rhizoma chuanxiong, 5-12 parts of cortex phellodendri, 6-10 parts of rhizoma polygoni cuspidati, 3-5 parts of fructus gardeniae, 3-5 parts of rhizoma corydalis, 2-5 parts of semen brassicae, 2-5 parts of herba lycopi, 2-5 parts of radix clematidis, 2-5 parts of borneol, 1-3 parts of fructus foeniculi and The traditional Chinese medicine composition has the characteristics that cold and heat are used together, and purgation and tonification are combined. The traditional Chinese medicine composition is mainly used for treating qi stagnation and blood stasis of chronic prostatitis by warming yang, tonifying kidney and promoting qi to activate blood, has low curative effect and drug resistance risk compared with western medicines with single target, and has better curative effect and safety.

This invention discloses an extract of *Prunus armeniaca* for treating prostatitis, its preparation method, and its application. Specifically, it relates to the fields of natural plant extraction and male urinary system pharmaceuticals. The *Prunus armeniaca* extract is prepared from the dried stem bark of *Prunus armeniaca*. On a dry weight basis, the extract contains at least 8.5% phytosterols and at least 12% fatty acids. This invention significantly improves the purity and extraction rate of phytosterols and fatty acids in the *Prunus armeniaca* extract by optimizing the extraction and purification process. It overcomes the bottlenecks of insufficient dissolution of active ingredients and high levels of impurities in traditional methods. Chromatographic detection ensures precise control and batch-to-batch stability of product quality. This naturally derived extract is highly safe and can be used alone or in combination with *Saw Palmetto* and pumpkin seed extracts. Through synergistic effects, it significantly enhances anti-inflammatory and prostate function-improving effects, providing a highly effective and safe new option for the treatment of prostatitis.

The invention provides application of an LRG1 inhibitor or a miR-145-5p nano-complex in preparation of a medicine for preventing and / or treating prostatitis, and belongs to the technical field of biological medicine manufacturing. The invention discloses application of an LRG1 inhibitor in preparation of a medicine for preventing and / or treating prostatitis. In order to further improve the stability and the delivery efficiency of the miR-145-5p in vivo when the miR-145-5p is used as an LRG1 inhibitor, the invention provides a miR-145-5p nano-composite which is a polymer nano-particle loaded with the miR-145-5p. According to the invention, through targeted down-regulation of LRG1 and regulation and control of a TGF-beta / Smad signal channel, polarization of macrophages from M1 to M2 is remodeled, and oxidative stress of prostate tissues is synchronously relieved, so that mandatory treatment of prostatitis is realized.

This invention relates to the field of in vitro diagnostics, and particularly to a combined diagnostic kit for prostate diseases. The invention provides reagents including pH, peroxidase, elastase, lecithin bodies, citric acid, zinc, and acid phosphatase under mild reaction conditions, enabling rapid differentiation of inflammatory and non-inflammatory prostatitis, benign prostatic hyperplasia, and non-prostatic genital tract infections using a single test card. Through extensive experimentation, this invention has developed a one-step reaction scheme suitable for the dry chemical determination of acid phosphatase and lecithin bodies in seminal plasma. This method eliminates the need for a stop solution, achieving a one-step reaction under mild conditions that will not cause damage to operators or fully automated instruments. The samples used are seminal plasma or semen, allowing for large sample volumes and easy acquisition, significantly improving diagnostic efficiency for doctors and patient comfort.

The invention provides a temperature-sensitive hydrogel for prostate local drug delivery and a preparation method thereof. The core components of the temperature-sensitive hydrogel comprise a temperature-sensitive carrier compounded by a polylactic acid-glycolic acid-polyethylene glycol triblock copolymer and modified chitosan, targeted active components such as abiraterone and the like and a composite bacteriostatic agent, and a biological adhesion and transdermal enhancer is added; the hydrogel is a sol at normal temperature, is convenient for administration, is rapidly gelatinized at 35-37 DEG C to realize local retention, has excellent biological adhesion and antibacterial properties, is stable and long-acting in drug release, and has an accumulative release rate of 86-92% in 96 h. The preparation process is stable and controllable, is suitable for treating diseases such as prostatic cancer and prostatitis, can improve the bioavailability of drugs and reduce side effects, and has important clinical application value.

The invention discloses a traditional Chinese medicine composition for treating prostatitis, frequent urination, urgent urination and anuresis, and belongs to the technical field of traditional Chinese medicines. The composition is prepared from the following raw materials in parts by weight: 3-10 parts of Chinese prickly ash, 4-20 parts of radix clematidis, 2-18 parts of mineral salt, 3-8 parts of calcined escargots and 3-22 parts of sedum sarmentosum. The invention also discloses a preparation method and application of the compound. The traditional Chinese medicine composition is simple in formula, has the effects of warming and activating meridians, softening hardness to dissipate stagnation, clearing heat and promoting diuresis and relieving swelling and pain by being applied to the navel (Shenque acupoint), and is used for treating prostatitis and related urinary system symptoms. The traditional Chinese medicine is quick in effect, short in treatment course, definite in curative effect, green, safe, free of side effects, convenient to use and low in cost, and provides an excellent external treatment choice for patients.

The invention relates to the technical field of medical preparations, in particular to a preparation method of a male health tablet for treating prostatitis, composition and proportion of auxiliary materials except clean medicinal materials are optimized, and the preparation amount of each 2 million male health tablet is increased greatly. Only about 1.3 kg of silicon dioxide, 1.3 kg of magnesium stearate, 90 kg of corn starch, 18 kg of microcrystalline cellulose, 600 kg of ethyl alcohol and 15 kg of gastric soluble film coating premix are needed; an oil extraction treatment process is improved, the amount of water added is 0.4-0.6 time of the amount of medicinal materials instead of 6 times of the amount of the medicinal materials, the medicinal materials are also uniformly divided into 8 pots for oil extraction instead of being put into one pot for centralized oil extraction, and the quality of an oil extraction product is improved while the water consumption is greatly reduced through refined dispersion treatment; the procedure of additionally stirring alcohol precipitation liquid for 1 hour is added, so that the quality of supernate is improved; according to the present invention, the volatile ether extract determination results of the Mankang tablet produced by the preparation method show that the average value of the volatile ether extract is 0.53%, which is increased by about 60.6% compared to the average value of the volatile ether extract of 0.33% of the original process method, such that the significant technical progress is provided.

The application provides a meridian-targeting theory-based traditional Chinese medicine preparation for treating prostatitis and a preparation method thereof. The preparation is composed of eighteen kinds of traditional Chinese medicines, including plantago seed, alisma orientalis, phellodendron, taraxacum, salvia miltiorrhiza, cyathula officinalis, eucommia ulmoides and epimedium etc. The cyathula officinalis, plantago seed and alisma orientalis are used as meridian-leading drugs to guide the active ingredients to flow down along the liver meridian of foot-Jueyin, the kidney meridian of foot-Shaoyin and the bladder meridian of foot-Taiyang, and target the prostate region. The whole preparation has the effects of clearing heat and reducing dampness, promoting blood circulation to remove blood stasis, soothing liver and regulating qi and tonifying kidney and consolidating the foundation, and is suitable for chronic prostatitis and benign prostatic hyperplasia of the type of lower-heat and kidney deficiency and blood stasis. The preparation can be prepared into various dosage forms such as capsules, granules and oral liquid. Experiments show that the preparation can significantly improve the urination symptoms and reduce the inflammation and fibrosis of the prostate, and has the advantages of strong targeting, definite curative effect, high safety and long-term use.

The invention discloses application of casei paracasei in preparation of a product for improving male reproductive health, and belongs to the technical field of microorganisms. The lactobacillus paracasei NHNK-633 is preserved in the China Center for Type Culture Collection on July 7, 2025, and the preservation number of the lactobacillus paracasei NHNK-633 is CCTCC (China Center for Type Culture Collection) NO: M20251542. The NHNK-633 has the functions of generating L-citrulline, repairing aged vascular endothelial cells, promoting vasodilation, repairing aged prostate cells and reducing prostatitis, and can be used for preparing products for improving male reproductive health.