25 results about "Cream preparation" patented technology

The invention discloses a semitransparent skin-nourishing face cream based on a medium-temperature hot pot process and a preparation method and application thereof, belongs to the technical field of cosmetics, and aims at solving the problems that in the prior art, in the face cream preparation process, a high-temperature processing process can destroy the activity of natural extracts; and the technical problem of how to enable the face cream to be semitransparent through formula system combination is solved. The preparation method of the semitransparent skin-care face cream based on the medium-temperature hot pot process comprises the following steps: putting a phase A into an emulsifying pot, and stirring and heating to 80-85 DEG C; adding the phase B into the emulsifying pot, stirring and heating to 80-85 DEG C, and then cooling to 60-65 DEG C; sequentially adding the phase A, the phase B, the phase C and the phase D into an emulsifying pot to enable the materials to be uniform, and cooling the materials to 53-57 DEG C to obtain cream; and filling the cream to obtain the prepared semitransparent skin-nourishing face cream based on the medium-temperature thermal tank process. The semitransparent face cream is prepared by designing a component compounding system.

The present invention provides a fusidic acid cream preparation, comprising an active ingredient fusidic acid, an aqueous phase part and an oil phase part, wherein the aqueous phase part comprises glycerol, a preservative and purified water; the oil phase part comprises an oily base and an emulsifier; further, in order to avoid the increase of impurities caused by the addition of antioxidants to the excipients due to their thermal instability, the cream does not contain antioxidants. After testing, the stability of the fusidic acid cream of the present application is better than that of the commercially available reference preparation, and it can maintain the stability of the paste properties and active ingredients under high temperature, high humidity, low temperature, freeze-thaw and light conditions. The maximum single impurity and total impurity content in the product do not increase significantly, and the quality is controllable. At the same time, the preparation process of the fusidic acid cream disclosed in the present application is simple and easy to industrialize.

The invention discloses a micro-capsule wrapped high-stability active face cream preparation method based on digital simulation driving, and relates to the technical field of face cream preparation, the micro-capsule wrapped high-stability active face cream preparation method comprises the following steps: constructing a multi-physical field coupling simulation model, and importing skin microenvironment parameters, micro-capsule structure parameters and active component parameters; shell degradation, active molecule diffusion and stratum corneum permeation full-chain dynamic behaviors of the microcapsules on the skin surface are simulated through the model, and a release rate-absorption rate matching curve is output; reversely adjusting the capsule material components and the shell crosslinking degree of the microcapsules according to the curve; constructing a capsule material molecular dynamics simulation model, analyzing capsule material molecular chain degradation paths and key sites in different environments, and designing a capsule material molecular structure; and constructing a digital twinborn body, simulating and predicting raw material fluctuation influence, and adjusting preparation parameters. According to the method, the micro-capsule parameters, the capsule material molecular structure and the preparation parameters are regulated and controlled by combining multi-dimensional parameters through the synergistic effect of a multi-physical field coupling simulation system, a capsule material molecular dynamics simulation system and a digital twin three-stage simulation system.

This invention discloses a glycyrrhizic acid monoammonium cream formulation, its preparation method, and its applications. The glycyrrhizic acid monoammonium cream formulation of this invention comprises glycyrrhizic acid monoammonium salt, oil phase raw materials, emulsifiers, and antibacterial agents. The preparation process is simple and easy to operate. The resulting glycyrrhizic acid monoammonium cream exhibits good stability, strong moisturizing properties, and anti-inflammatory and antioxidant effects. The glycyrrhizic acid monoammonium cream of this invention can be used externally in cosmetics or pharmaceuticals, providing excellent skin care and therapeutic effects.

The invention discloses a photothermal stable fluticasone propionate emulsifiable paste preparation and a preparation process thereof, and relates to the technical field of external emulsifiable paste. Comprising the following steps: step 1, (1) adding isopropyl myristate and cetostearyl alcohol into liquid paraffin, mixing, heating and stirring to obtain an oil phase; (2) adding citric acid, sodium citrate, imidazolidinyl urea, a photo-thermal stabilizer and polyethylene glycol hexadecyl-octadecyl ether into deionized water, mixing, heating and stirring to obtain a water phase; (3) adding fluticasone propionate and propylene glycol into deionized water, heating and stirring to obtain a fluticasone propionate solution; and 2, adding the water phase into the oil phase, stirring, adding a fluticasone propionate solution, uniformly mixing, adding propyl hydroxybenzoate and methyl hydroxybenzoate, and standing at room temperature to obtain the fluticasone propionate emulsifiable paste preparation. The fluticasone propionate emulsifiable paste preparation prepared by the invention has good photo-thermal stability and meets the requirements of external emulsifiable paste.

The invention relates to a nadifloxacin emulsifiable paste and a preparation method thereof, the nadifloxacin emulsifiable paste comprises an active component nadifloxacin and pharmaceutic adjuvants, and is a water-in-oil or oil-in-water external emulsifiable paste preparation. The chemical and physical stability of the product is remarkably improved by adopting a buffer type alkaline hydrotropy system formed by sodium hydroxide and diethanol amine in a synergistic manner, an edetate disodium metal chelating agent and a specifically-formed composite oil phase matrix and combining a vacuum emulsification and double homogenization process; and the preparation process parameters are clear, the industrial amplification can be realized, and the technical problems of poor stability, large quality fluctuation, limited curative effect and the like of the existing nadifloxacin external preparation are solved.

The invention discloses high-stability mometasone furoate emulsifiable paste and a processing technology thereof, and relates to the technical field of emulsifiable paste preparations. A double-emulsification-system preparation process is adopted, the stability of the cream is remarkably improved, firstly, main drug active ingredients are prepared into submicron emulsion through dispersion and homogenization to form a first emulsification system (W / O) to play a role in primary protection, secondly, dispersion is added into a water phase to form an oil-in-water particle structure, and then the dispersion and an oil phase are emulsified to form a second emulsification system (O / W / O) to play a role in secondary protection. The mometasone furoate emulsifiable paste with high stability is prepared by adding auxiliary materials such as titanium dioxide and starch aluminum octenylsuccinate, so that the bioavailability of mometasone furoate is improved; by cooperating with excellent oxidation resistance of 4-vinyl guaiacol, gallic acid and glycyrrhizic acid, the oxidation resistance of the cream is remarkably improved, and the long-acting stability of the cream is further ensured.

The application provides an environment-friendly black soldier fly oil-peptide composite system antioxidant antibacterial hand cream preparation method, and relates to the technical field of cosmetics. The hand cream preparation method specifically comprises the following steps: S1. black soldier fly oil extraction, S2. black soldier fly oil purification, S3. black soldier fly antibacterial peptide fermentation preparation, and S4. hand cream compounding. The insect oil extraction rate reaches 87.0%, the antibacterial peptide is prepared by fermentation of insect residues without raw material waste, and the application is in line with the environmental protection concept. The constructed insect oil-antibacterial peptide composite system replaces chemical additives with natural ingredients, the DPPH free radical scavenging rate is 48.5%, and the antibacterial effect on staphylococcus aureus and escherichia coli is remarkable. The product pH is close to the physiological value of the skin, has no irritation, can continuously moisturize for more than 8 hours, and is excellent in heat resistance, cold resistance and light stability, and meets the industry standard. The enzymolysis and fermentation process is mild, there is no organic solvent residue, the process is simple and controllable, is suitable for industrialized mass production, fills the technical blank of the application of the insect oil-peptide composite system in cosmetics, and has the advantages of high safety, high efficiency, low cost, no pollution, no waste, no harm to the human body, and the like.

The present invention relates to a gel or cream formulation for topical use, the formulation comprising beta-D-mannuronic acid or alpha-L-guluronic acid or a mixture of beta-D-mannuronic acid and alpha-L-guluronic acid, their oligomers or their pharmaceutically acceptable salts, where, based on 100 g of the gel or cream formulation, the content of the beta-D-mannuronic acid or alpha-L-guluronic acid or the mixture of beta-D-mannuronic acid and alpha-L-guluronic acid or alpha-L-guluronic acid or alpha-L-guluronic acid or alpha-L-guluronic acid or alpha- the total amount of beta-D-mannuronic acid or alpha-L-guluronic acid or a mixture of beta-D-mannuronic acid and alpha-L-guluronic acid, their oligomers or their pharmaceutically acceptable salts is from 0.5 g to 40 g, said formulation further comprising caffeic acid. Furthermore, the present invention relates to a gel or cream formulation for topical use in a method of treating inflammation and / or any inflammatory response and / or pain, as well as a method of preparing the gel or cream formulation.

The invention discloses a medicinal composition for treating dermatitis and a preparation method and application thereof, and relates to the technical field of medicines.The medicinal composition is cream, the medicinal composition comprises vitamin E and desonide, based on the total weight of the cream, the content of the desonide is 0.0025%-0.045%, preferably 0.025%, and the content of the vitamin E is 0.025%-0.045%, preferably 0.025%. The invention aims to solve the technical problem that a desonide vitamin E compound emulsifiable paste preparation which is specially designed for infant atopic dermatitis and is low in concentration, fixed in proportion and stable in quality is lacked in the prior art.

The present invention relates to a moisturizing, itching relieving, soothing and repairing cream, the cream comprises sea cucumber peptide, sophocarpidine, inositol, a moisturizing agent, an emulsifier, an antioxidant, a preservative, an emollient, a flavoring agent and a solvent, the moisturizing agent is selected from one or more of glycerol, polydimethylsiloxane, lecithin, ceramide EOP and sodium hyaluronate, and the emulsifier is selected from one or more of glycerol, polydimethylsiloxane, lecithin, ceramide EOP and sodium hyaluronate. The emulsifier is selected from one or more of stearic acid, cetyl alcohol and sorbitan oleate. The cream disclosed by the invention takes the sea cucumber peptide, the sophocarpidine and the inositol as active substances, and synergistically exerts the effects of moisturizing, relieving itching, relieving and repairing. The cream is uniform in cream body color, free of layering, fine and smooth in texture and free of sand grain feeling, and the cream preparation technology is suitable for large-scale industrial production.

The application provides a miconazole nitrate cream and a preparation process, and belongs to the technical field of external medicines, and is characterized in that the miconazole nitrate cream comprises the following components in terms of mass fraction: 1.8wt-2.0wt% miconazole nitrate, 0.3wt-2.0wt% allantoin eugenol amide ester penetration enhancer, 3wt%-5wt% medium-chain triglyceride, 5wt%-10wt% glycerol monostearate, 8wt%-15wt% white petrolatum, 6wt-12wt% glycerol, 0.01wt%-0.10wt% bis(hydroxymethyl)imidazole alkyl urea, 6wt%-12wt% octadecanol, 1wt%-3wt% triethanolamine, and the balance is purified water. The preparation process comprises cream preparation, miconazole nitrate emulsion homogenization and miconazole nitrate cream preparation. The application prepares a nano miconazole nitrate cream product with uniform and delicate texture from the aspects of drug particle size optimization and homogenization. The added allantoin eugenol amide ester penetration enhancer is safe and non-irritating, and the use of the miconazole nitrate cream not only promotes the penetration of the cream and accelerates the recovery of the skin, but also has certain antioxidant function and can effectively prevent the cream from yellowing and deteriorating.

The invention discloses a method for simultaneously extracting panax japonicus saponin and polysaccharide, a panax japonicus saponin and polysaccharide extract, cream and a cream preparation method, and is characterized in that the extraction is performed according to the following method: adding panax japonicus powder into a solvent according to a material ratio of 1: 15, carrying out wall breaking treatment in a wall breaking machine for 30 seconds, then carrying out ultrasonic extraction at room temperature for 30 minutes under the ultrasonic power of 120 W, filtering, washing, and drying to obtain the panax japonicus saponin and polysaccharide extract. The solvent is an ethanol aqueous solution, and the volume concentration of ethanol in the ethanol aqueous solution is 15-75%. Or the panax japonicus powder is added into a solvent, the material ratio is 1: 15, ultrasonic extraction is carried out twice at the room temperature, each time is 30 min, the ultrasonic power is 120 W, the solvent is an ethanol aqueous solution, and the volume concentration of ethanol in the ethanol aqueous solution is 15%-75%. The extraction method is simple, saponin and polysaccharide can be extracted at the same time, the free radical scavenging rate of the extract reaches 96.4%, and the in-vitro antioxidant activity of the total extract is 1.36 times that of vitamin E. The anti-oxidation cream has obvious anti-oxidation capability and can be made into cream skin care products with an anti-oxidation effect.

The utility model provides a device for preparing amino acid facial cleanser from plants. The preparation device comprises a tank body, a discharging pipe is installed at the bottom of the tank body, a valve part is installed outside the discharging pipe and used for controlling the discharging pipe to discharge facial cleanser, a feeding pipe, a stirring assembly and a side door assembly are installed at the top of the tank body, and the stirring assembly is connected with the side door assembly. The stirring assembly is connected with a mounting plate, the mounting plate is connected with a cleaning assembly, and the stirring assembly is used for stirring the facial cleanser in the tank body. According to the preparation device for the plant nutrient-released amino acid facial cleanser, under the interaction of components such as a limiting plate, a limiting groove, a limiting block, a torsional spring and a check block, the scraper can be quickly mounted on the mounting plate in the tank body or the scraper can be taken down from the mounting plate and taken out of the tank body when the scraper is not required to be used; and the scraping plate with residues is prevented from staying in the tank body to influence the preparation of the facial cleanser behind the tank body.

The invention discloses a cooling water device for an atomic absorption spectrophotometer, and relates to the technical field of antibacterial cream preparation, the cooling water device comprises the following raw materials: saffron crocus, honeysuckle stem, honeysuckle extract, lithospermum extract, cortex dictamni extract, sophora flavescens extract, aloe extract, golden scorpion extract, centipede extract and zaocys dhumnade extract. The ointment is prepared from acetic ether, vitamin e, borneol, menthol, stearic acid, medical vaseline, camellia oil and the balance of purified water. The preparation method of the high-efficiency antibacterial cream stock solution comprises the following steps: (1) raw material pretreatment; (2) preparing an extract; (3) mixing and preparing; and (4) sterilization treatment. According to the high-efficiency antibacterial cream stock solution and the preparation method thereof, saffron crocus and honeysuckle stem are added into the raw materials and have the effects of promoting blood circulation to remove blood stasis and clearing away heat and toxic materials, and in addition, various traditional Chinese medicine extracts are added, so that the antibacterial cream stock solution prepared by matching the medicines with auxiliary materials has a high-efficiency antibacterial effect.

The invention relates to the technical field of health care cream preparation, in particular to arthralgia health care cream and production equipment thereof.The arthralgia health care cream comprises a soaking and extracting mechanism which comprises an extracting barrel, a soaking barrel fixedly arranged on the top face of the extracting barrel and communicated with the extracting barrel, a lifting disc arranged in the extracting barrel and a stirring shaft arranged in the soaking barrel; a guide edge attached to the side wall of the lifting disc is fixedly arranged on the inner wall of the extraction barrel in the vertical direction, meanwhile, the lifting disc is further spirally sleeved with a screw column arranged in the vertical direction, and the upper end of the screw column penetrates through and extends to the upper portion of the extraction barrel to be embedded in the output end of a first motor; the outer wall of the soaking cylinder is fixedly connected with a plurality of placing cylinders communicated with the interior of the extracting cylinder; and the loading mechanisms are sleeved in the placing cylinder and are used for loading the raw materials, and the extraction temperature of the effective components of the raw materials loaded in the loading mechanisms from bottom to top is increased, so that the production equipment can be used for soaking and extracting the medicinal materials in a targeted manner according to the effective extraction temperature of the medicinal materials, and is convenient and fast in overall operation and good in practicability.

The invention provides a pharmaceutical composition for treating hypertrophic scars and application, and belongs to the technical field of traditional Chinese medicine, the pharmaceutical composition is obtained by screening traditional Chinese medicine centella asiatica and rheum officinale through an immobilized Notch1 receptor chromatography model, and the pharmaceutical composition is added into optimized blank ointment to prepare an anti-hypertrophic scar external cream preparation. A hypertrophic scar animal model is copied to evaluate the drug effect of the traditional Chinese medicine composition, and it is found that the screened traditional Chinese medicine composition has a good hypertrophic scar resisting effect.

The present application relates to a kind of novel anti-freezing anti-cracking hand cream, according to percentage by weight, including, water phase:55~65%, oil phase:28~38%, emulsification-stable system:3~6%, active repair phase:2~4%, buffer-preservation-fragrance:0.3~0.8%;Wherein, water phase includes, bamboo leaf oligosaccharide:5~10%, 1,3-propanediol:8~12%, erythritol:3~6%, purified water: remainder to water phase 100%;Oil phase includes, camellia seed oil:8~12%, mango seed fat:6~10%, coconut oil MCT:4~8%, phytosterol ester:2~4%, rice bran wax microparticle:2~4%;Emulsification-stable system includes, sucrose stearate:2~3.5%, hydrogenated lecithin:1.5~2.5%, sphingomonad fermenting polysaccharide:0.3~0.7%.The present application also relates to a kind of novel anti-freezing anti-cracking hand cream preparation process.The present application gives quantifiable systematic breakthrough to the current hand cream "thick heavy stuff, high temperature inactivation, low temperature failure, poor wash resistance, slow repair, non-environmental protection " six structural pain points: absorption is fast, extrusion force is small, wash resistance is prolonged, and fissured healing is fast.

The invention relates to a preparation method of a minoxidil external preparation. The preparation method comprises the following steps: preparing an extract from raw materials of ginger, purslane, cacumen biotae and polygonum multiflorum; stearic acid, liquid paraffin, glyceryl monostearate and cetostearyl alcohol are mixed and heated to obtain an oil phase; carbomer 940 is dispersed in purified water, glycerin, poloxamer 188 and methylparaben are added, and a water phase is prepared; and adding the oil phase into the water phase, homogenizing and emulsifying to obtain a matrix, adding minoxidil and the extract into the matrix, and treating by a pulsed electric field to obtain the cream preparation. According to the minoxidil emulsifiable paste preparation prepared by the invention, the use of irritant components such as ethanol and propylene glycol is reduced, the emulsifiable paste is excellent in stability, minoxidil is excellently dispersed in the emulsifiable paste and is not agglomerated, the long-term stability of active components is good, and the traditional Chinese medicine active components and minoxidil have a synergistic effect, so that the minoxidil emulsifiable paste preparation has excellent permeability and can be used for preparing the minoxidil emulsifiable paste preparation. The effects of conditioning, relieving and repairing the scalp are jointly improved, the effect on hair follicles is effectively promoted, and the growth period of the hair follicles is prolonged.

The invention discloses a herba asari-containing slow-release transdermal arthralgia-relieving traditional Chinese medicine ointment and a preparation method thereof. The active ingredients of the ointment are prepared by extracting a plurality of traditional Chinese medicines such as clove, asarum, pepper, saffron crocus, ginseng, radix clematidis, eucommia ulmoides, ligusticum wallichii and pseudo-ginseng through a specific process. The auxiliary materials comprise olive oil emulsifying wax, alkyl polyglucoside and purified water. According to the invention, the O / W type cream is prepared through scientific formula compatibility and fusion of a modern cream preparation technology. The ointment has the effects of expelling wind and removing cold, promoting blood circulation to remove blood stasis and activating meridians to stop pain, and can effectively relieve various arthralgia. An adopted auxiliary material system is mild, safe, free of hormones and preservatives and suitable for sensitive skin. The unique cream structure can wrap medicine components, and slow-release transdermal absorption of the medicine is realized by utilizing the permeation enhancing effect of the alkyl polyglucoside, so that the purpose of long-acting analgesia is achieved. The preparation process is stable, the product quality is controllable, and the preparation method has a wide clinical application prospect.

The application belongs to the technical field of cosmetics, and particularly relates to a bare skin cream containing biocompatible polylactic acid and a preparation method thereof. The preparation method realizes emulsification and dissolution of polylactic acid in oil through an alkali modification process, avoids using organic solvents to dissolve polylactic acid, and maximally reduces the residue of organic solvents. The modified polylactic acid is added into the cream preparation, and there is no obvious particle scrubbing feeling, so that the application of polylactic acid in the ordinary water-oil emulsion system is realized. By replacing traditional titanium dioxide, silica and mineral powder raw materials, polylactic acid with better biocompatibility is added into the cream product, so that the filling of facial skin texture is realized, and the biocompatibility and safety of the powder particles are ensured.

The invention belongs to the technical field of cosmetics, and particularly relates to a tone-up cream containing biocompatible polylactic acid and a preparation method of the tone-up cream. According to the preparation method disclosed by the invention, emulsification and dissolution of polylactic acid in grease are realized through an alkali modification process, the polylactic acid is prevented from being dissolved by using an organic solvent, and residues of the organic solvent are reduced to the greatest extent. The modified polylactic acid is added into a face cream preparation, no obvious particle frosted feeling exists, and application of the polylactic acid in a common water-oil emulsification system is achieved. By replacing traditional titanium dioxide, silica and mineral powder raw materials, polylactic acid with better biocompatibility is added into a face cream product, facial skin texture filling is achieved, and meanwhile the biocompatibility and safety of powder particles are guaranteed.

The invention discloses a method for detecting the content of glyceryl monostearate and glyceryl distearate in emulsifiable paste, and relates to the field of substance detection methods, the method comprises a detection method combining high performance liquid chromatography and evaporative light scattering, and the detection method of the high performance liquid chromatography comprises the following steps: by adopting a molecular exclusion chromatographic column, taking an ammonium acetate aqueous solution and acetonitrile as mobile phases, and measuring the content of glyceryl monostearate and glyceryl distearate in the emulsifiable paste. And carrying out gradient elution. According to the method, size exclusion separation is carried out by adopting a molecular exclusion chromatographic column, HPLC-ELSD general detection is carried out, and ammonium acetate-acetonitrile mobile phase gradient elution is carried out, so that glyceryl monostearate and glyceryl distearate are in a single peak shape, and the interference of a cream matrix is eliminated; therefore, the purposes of simplifying the content calculation, remarkably improving the specificity of the method and the durability of the system, avoiding the dependence of a complex mobile phase system and a special detector, ensuring the accuracy, convenience and stability of single-peak quantification and finally realizing the efficient and exclusive detection of the emulsifier in the complex cream preparation are achieved.

The invention provides application of flos magnoliae volatile oil in preparation of a medicine for treating chronic prostatitis. According to the invention, the medicinal function of the magnolia flower volatile oil is further developed, and the treatment of chronic prostatitis by the magnolia flower volatile oil is subjected to related research. The lavender volatile oil and the magnolia flower volatile oil are compatible, so that the chronic prostatitis can be better treated. The lavender volatile oil and the flos magnoliae volatile oil are prepared into a cream preparation, the cream preparation is externally applied to the prostate of a rat with chronic prostatitis, the drug effect is achieved through transdermal administration, the side effects of gastrointestinal tracts and the synergistic interaction of prostate barriers and raw materials are avoided, and a new thought is provided for the administration route for treating chronic prostatitis.

The invention relates to the technical field of oral thick paste preparation, and discloses an oral thick paste preparation device capable of strengthening and enlarging breasts.The oral thick paste preparation device comprises a placing plate and a decocting pot, the top of the placing plate is fixedly connected with the bottom of the decocting pot, and a heat energy conversion mechanism is arranged on the upper surface of the decocting pot. According to the oral thick paste preparation device capable of strengthening and enlarging the breasts, through the linkage design of the perforated balancing weight and the diverter valve, the function of automatically adjusting the flow direction of steam according to pressure changes is achieved, defoaming is preferentially conducted in the normal pressure state, automatic stirring is conducted in the high pressure state, defoaming operation is conducted continuously, it is guaranteed that the decocting process is in the optimal state all the time, and the oral thick paste preparation efficiency is improved. The steam power is converted through the turbine to drive the stirring mechanism, mechanical and automatic stirring is achieved, the energy-saving and environment-friendly effects are remarkable, by means of steam energy, the electric power cost is saved, the problem of loss of electrical components in the high-temperature and high-humidity environment is solved, the service life is longer, and the equipment structure can be popularized and used in reality easily.