59 results about "Miconazole Nitrate" patented technology

The invention discloses a microbial limit detection method of miconazole nitrate suppository. The method comprises dissolving sample with sodium chloride-peptone buffer solution (pH 7.0) containing 10 vol% polysorbate 80 (Tween 80), adding 20ml of isopropyl myristate, and washing with aqueous solution containing 0.1 vol% polysorbate 80 and 0.1 wt% peptone. Membrane filtration method is adopted for bacteria, mildew, yeast, Staphyloccocus aureus and Monilia albican, with recovery rate all above 70%. Culture medium dilution method is adopted to detect Pseudomonas Aeruginosa. The addition of isopropyl myristate can accelerate fat/water layer separation, shorten experiment time, stabilize flow rate, reduce test cost, and achieve strong operability.

Methods for maintaining a low vaginal pH, preventing the propagation of toxic shock syndrome toxin 1 production during menstruation, preventing the shedding and dissemination of a herpesvirus and treating herpes lesions comprising administering to a human a formulation comprising a pharmaceutically effective amount of an insoluble micronized form of cellulose acetate phthalate or a cellulose acetate phthalate film or a cellulose acetate phthalate porous sponge. Also a method of treating Candida albicans infection comprising administering to a human female a pharmaceutically effective amount of a composition comprising micronized cellulose acetate phthalate and miconazole nitrate.

A composite medicine for treating vaginitis is prepared from fossyol, econazole nitrate or miconazole nitrate, and medicinal auxiliary.

The antifungal medicine composition is medicine prepared with the materials including snake oil 50-100 weight portions, Miconazole nitrate 25-50 weight portions, flavescent sophora root 20-50 weight portions, pearl powder 1-10 weight portions, menthol 1-5 weight portions, and borneol 1-5 weight portions. The antifungal medicine composition as one compound Chinese and Western medicine preparation contains effective antifungal components, and components for clearing away heat and toxic material, eliminating swelling, relieving pain, astringing and promoting granulation. It is used in treating tinea corporis, tinea cruris, tinea manuum, tinea pedis, etc caused by mycotic infection, and has stable treating effect and little side effect.

The invention discloses a nano-silver spray for treating skin diseases, and a preparation method thereof, aiming at providing a medicament prepared from nano-silver as a raw material for treating skin disease. The nano-silver spray comprises the following components in mass percent: 0.05-0.1% of nano-silver solution, 0.5-5% of miconazole nitrate, 0.5-1% of azone, 50-80% of alcohol, 0.01-0.05% of essence and purified water. The preparation method comprises the following steps of: adding the miconazole nitrate into a reaction kettle, then adding the alcohol, heating and stirring for reacting for 1-2 hours; adding the azone and the nano-silver solution, stirring for reacting for 1-2 hours; and adding the purified water and the essence, diluting and stirring for 0.5-1 hour, filtering and filling to obtain finished products. The nano-silver spray disclosed by the invention is applied to skin diseases such as tinea pedis, tinea manuum, tinea corporis, tinea cruris, psoriasis, dermatitis and the like, is especially suitable for patients with psoriasis inveterata, and has notable curative effects, convenience in use, safety and no side effects proven by clinical practice.

The invention discloses a preparation method of miconazole nitrate. The method comprises steps as follows: 2,4-dichloro-2'-chlorinated phenethyl alcohol, imidazole and 2,4-dichlorobenzyl are used as raw materials, an ionic liquid is used as a reaction medium, a reaction is conducted at the temperature 10-100 DEG C, a reaction liquid is cooled to the room temperature after the reaction is finished, the pH value of the reaction liquid is adjusted to range from 1 to 3 by the aid of a nitrate aqueous solution with the volume concentration of 15-50%, the reaction liquid is left to stand for layering, the lower layer is taken for recovery of the ionic liquid, the upper layer is taken for pressure reduced concentration until a solid is separated out, a concentrate is taken and cooled to the room temperature, then a recrystallization solvent is added to the concentrate for recrystallization, crystals are taken and dried, and the miconazole nitrate is obtained. According to the method, the ionic liquid is used as the reaction medium, and a one-pot reaction technology is combined; the method has the technical characteristics that the operation is simple and convenient, the reactions are safe, the yield is high, the ionic liquid can be reused continuously after a product is separated out, the method is environment-friendly and the like.

The invention relates to a miconazole nitrate expandable vaginal suppository, and a preparation method and a detection method thereof. The expandable vaginal suppository comprises a drug-containing matrix formed by miconazole nitrate and a matrix, and an expansion carrier. Miconazole nitrate and a specific solid dispersion carrier are prepared into a solid dispersion to improve the stability of the suppository and solubility of active ingredients, and increase bioavailability of the suppository. The outer layer of the expandable vaginal suppository is coated with a film coating to prolong the action time of the suppository on the vagina and improve the stability of the suppository. The miconazole nitrate expandable vaginal suppository provided by the invention employs seven originally created leading technologies, and has the beneficial effects of prevention of outflow liquid, high stability, lasting effect and prevention of secondary infection.

The invention discloses a compound miconazole nitrate emulsifiable paste and a preparation technology thereof. According to the compound emulsifiable paste, miconazole nitrate and clobetasol propionate are adopted as main drug ingredients, a surface active agent and chondroitin sulfate are adopted as functional auxiliary additives, sodium alga acid is adopted as a thickening agent, glycerol is adopted as a lubricating moisture absorption agent, and on the basis of an absorption enhancer, the paste is prepared by grinding, smashing, vacuum mixing, vacuum stirring and refrigeration; the main drugs, the auxiliary additives and the enhancer are good in compatibility, and the external use treatment effect on tinea corporis, tine cruris, tine manuum, tine pedis, tinea versicolor, mycotic paronychia and monilial vaginitis caused by dermatophytes, saccharomycetes and other fungi is good.

The invention discloses a medicine composition for treating vaginitis. The medicine composition is prepared from transdermal EGF and antibacterial drugs which serve as raw materials and carbomer and glycerol which serve as auxiliary materials. The invention further discloses a preparation method of the medicine composition. The preparation method comprises the following steps of preparing the raw materials and the auxiliary materials; compounding a solution matrix; dissolving nano-silver or miconazole nitrate in glycerol; adding triethanolamine to the matrix, and stirring the mixture slowly till the matrix becomes gel; conducting filtration and sterilization on the transdermal EGF; adding a transdermal EGF solution obtained after filtration to the gel matrix, adding deionized water, and conducting sub packaging. The medicine composition obtained through the method can be widely applied to externalia infection such as bacterial vaginitis and acroposthitis, restoration and healing of skin mucous membranes are accelerated in the inflammation treatment process, bacterial superinfection is prevented, and a certain auxiliary effect is achieved for vaginal contraction.

The invention discloses nursing medicine liquid for treating burns and scalds and a method for preparing the nursing medicine liquid. The nursing medicine liquid comprises Chinese and western medicine components including, by weight, 50-80 parts of white sesame oil, 4-10 parts of nacre mother of pearl, 2-12 parts of lithospermum purpurocaeruleum, 2-9 parts of borneol, 5-10 parts of common bletilla pseudobulb, 10-15 parts of sanguisorba officinalis, 20-25 parts of rhubarb, 5-15 parts of angelica sinensis, 8-12 parts of radix sophorae subprostratae, 10-15 parts of rhizoma paridis, 15-20 parts of fructus cnidii, 5-10 parts of fructus kochiae, 12-15 parts of honeysuckle, 5-10 parts of white cinnamon, 5-8 parts of peppermint, 5-10 parts of radix ampelopsis, 5-8 parts of panax notoginseng, 5-8 parts of pearl powder, 0.3-0.5 part of honey, 0.1-0.2 part of chlorhexidine acetate, 0.1-0.2 part of miconazole nitrate, 0.2-0.5 part of amoxicillin, 0.1-0.2 part of cefalexin and 0.2-0.5 part of furazolidone powder. The nursing medicine liquid and the method have the advantages that the nursing medicine liquid can be easily and feasibly prepared and is low in cost; the nursing medicine liquid has few side effects and is inexpensive, and the burns and scalds can be effectively treated by the aid of the nursing medicine liquid.

The invention discloses an anti-infectious medical silicon rubber material and a preparation method thereof. The anti-infectious medical silicon rubber material comprises the following components by mass: 56-73 parts of solid silicone rubber particles, 3-14 parts of butyl oleate, 11-19 parts of polyethylene wax, 2-8 parts of polyvinylpyrrolidone, 5-17 parts of miconazole nitrate, 13-24 parts of tridodecylamine, 5-22 parts of diammonium hydrogen phosphate, and 3-17 parts of an antioxygen. The silicon rubber material, prepared according to the preparation method, has an excellent antibacterial effect, can prevent infection, and has an important function in clinic treatment.

The invention provides a production technology of miconazole nitrate vaginal tablets, and relates to the technical field of a medicine making technology. The production technology of miconazole nitrate vaginal tablets comprises the following steps of performing weighing and blending, performing dry mixing to obtain wet granules, performing drying, performing granule trimming, performing total mixing, performing tabletting, performing packaging, and performing warehousing: performing packaging, performing total inspection, and performing warehousing. The miconazole nitrate vaginal tablets are produced through an assembly line of whole automated equipment, so that the making efficiency of the whole products can be improved, the yield of unit time can be increased, enterprise profits are increased, quality control is performed for products produced through multiple working procedures, the quality of products produced through a single working procedure can be guaranteed, control on the quality of finished products is realized, the content of defectives in the pharmacy process is reduced, and the whole rate of finished products in the whole pharmacy technological process is increased.

The invention discloses miconazole nitrate compound vaginal extended-release effervescent tablets and a preparation method thereof. The effervescent tablets comprise miconazole nitrate, Corydalis tuber, Tricyrtis root, lightyellow Sophora root, cutch, Wilson's passion flower, root of Silene tenuis, root-bark of shaggy-fruited dittany, fleeceflower root, Chinese mugwort leaf, sodium alginate, polyoxyethylene, fumaric acid, sodium carbonate, sodium bicarbonate, lauryl sodium sulfate, powdered sugar, and polysorbate. The preparation method includes: preparing materials, extracting effective ingredients of herbal materials, and performing granulating and tableting. The miconazole nitrate compound vaginal extended-release effervescent tablets are a Chinese and western medicine mixture, the defect that miconazole nitrate is only capable of killing germs and diminishing inflammation is effectively overcome, and the herbs are good in synergistic effect. Hydrophilic gel extended-release material is used as a medicinal auxiliary material, acting time of the tablets and administering interval can be prolonged, and bioavailability of the tablets can be improved; the tablets directly act on an affected part, take effect fast, are good in effect, are convenient to use and allow higher patient compliance.

The invention discloses western medicine combined ointment for treating manus and tinea pedis. The western medicine combined ointment is prepared from the following raw materials in parts by weight: 2 to 5 parts of miconazole nitrate cream, 2 to 5 parts of compound dexamethasone acetate cream, 5 to 10 parts of glycerol, 5 to 8 parts of marine fish oligopeptide, 0.2 to 0.5 part of vitamin E, 2 to 5 parts of loratadine, 2 to 5 parts of amprenavir, 0.01 to 0.05 part of anti-inflammatory preservatives, 1 to 3 parts of glycyrrhizic acid, 0.1 to 0.5 part of borneol, 0.5 to 2 parts of snake oil, 0.01 to 0.05 part of chondroitin sulfate, 1 to 2 parts of terbinafine hydrochloride solution and 10 to 20 parts of honey. The western medicine combined ointment achieves the synergic action through raw material compounding, and has the advantages that the bacteriostasis effect is good; the itching relieving and sterilization effects are achieved; the western medicine combined ointment can be used for effectively treating the manus and tinea pedis; the recurrence cannot easily occur; the medicine dependence is low; the treatment period is short; the thorough and radical cure can be realized; the western medicine combined ointment also has the curative effects of promoting blood circulation to remove blood stasis, relieving pain and inflammation and preventing infection.

The invention discloses a western medicine ointment for treating tinea of feet and hands. The western medicine ointment is prepared from the following raw materials in parts by weight: 2-5 parts of miconazole nitrate cream, 2-5 parts of mometasone furoate gel, 5-10 parts of glycerol, 5-8 parts of ocean fish oligopeptides, 0.2-0.5 parts of vitamin E, 2-5 parts of Loratadine, 2-5 parts of Amprenavir, 0.01-0.05 parts of an anti-inflammation preservative, 1-3 parts of radix glycyrrhizae, 0.1-0.5 parts of flavones, 0.5-2 parts of snake oil, 0.01-0.05 parts of chondroitin sulfate, 1-2 parts of a terbinafine hydrochloride solution, and 10-20 parts of honey. The western medicine ointment achieves a synergistic effect by compounding the raw materials, has good effects of inhibiting bacteria, relieving itching and killing the bacteria, and can effectively treat the tinea of feet and hands; the western medicine ointment has the advantages of difficult relapse, low drug dependence, short treatment course and radical treatment; and the western medicine ointment also has the curative effects of activating blood to remove stasis, diminishing inflammation to relieve pain, and preventing infection.

The invention discloses miconazole nitrate compound vaginal effervescent tablets and a preparation method thereof. The effervescent tablets comprise miconazole nitrate, Corydalis tuber, Tricyrtis root, lightyellow Sophora root, cutch, herb of Wilson Passionflower, radix Silene tenuis, root-bark of shaggy-fruited dittany, fleeceflower root, Chinese mugwort leaf, tartaric acid, sodium carbonate, sodium bicarbonate, lauryl sodium sulfate, dextrin, and polysorbate. The preparation method includes: preparing materials, extracting effective ingredients of herbal materials, and performing granulating and tableting. The miconazole nitrate compound vaginal effervescent tablets are a Chinese and western medicine mixture, the defect that miconazole nitrate is only capable of killing germs and diminishing inflammation is effectively overcome, and the herbs are good in synergistic effect. The tablets directly act on an affected part, take effect fast, are good in effect and are convenient to use; after the effervescent tablets effervesce, a larger contact area between medicine and the human body is provided; drug effect is improved. The tablets are capable of treating both symptoms and root causes of vaginitis, quickly relieving pain and pruritus symptoms of a patient, restoring vaginal secretion and improving patient compliance.

The invention discloses an external medicine for treating skin diseases, which contains coenzyme Q10 and miconazole nitrate as active components, wherein the coenzyme Q10 accounts for 0.01 to 79 percent of the weight of the external medicine, and the miconazole nitrate accounts for 0.01 to 45 percent of the weight of the external medicine. The invention also discloses a corresponding preparation method for the external medicine for treating skin diseases. The implementation of the invention can greatly increase the rate of curing various skin diseases, particularly, for the ringworm of the foot, the cure rate can reach more than 95 percent, and the recurrence rate is less than 10 percent in a year; and moreover, the external medicine also has an excellent effect in treating skin fester caused by burn, scald, cut and the like and promoting the healing of the skin fester.

Provided are liquid gel and a preparation method thereof. The liquid gel is characterized in that the gel is prepared from 0.5-2.5 parts by weight of chitosan, 0.5-5 parts by weight of hydroxypropyl methylcellulose, 0.5-6 parts by weight of polyethylene glycol 6000, 0.1-0.3 part by weight of chlorhexidine acetate, 0.1-3 parts by weight of carbomer, 0.1-2 parts by weight of propylene glycol, 0.1-3 parts by weight of Chinese hawthorn seeds, 0.2-2 parts by weight of hyaluronic acid matter, 0.01-0.5 part by weight of miconazole nitrate and 50-70 parts by weight of purified water, and the pH ranges from 5 to 7.5. The liquid gel has the advantages of being small in side effect, good in treatment effect, not likely to cause genital tract flora unbalance and capable of effectively relieving or curing the disease.

The invention discloses an externally-used medicine for treating stubborn ringworm and a preparation method thereof. The externally-used medicine comprises 2-3% of medicament and 97-98% of emulsifiable paste. The medicament comprises 2-methyl-5-nitroimidazole-1-ethanol, dexamethasone acetate, cyproheptadine hydrochloride, fluocinonide, miconazole nitrate, ketoconazole, clobetasol propionate, borneol and medical starch. Through scientific compatibility and mutual collaboration of the contents and proportions of all the components of the externally-used medicine for treating stubborn ringworm, the dosage is small, fungi can be quickly killed, itching is relived quickly, and stubborn ringworm is subjected to radical treatment; as for slight red and swollen symptoms cause by the fungi, itching is relived in the first day, the red and swollen symptoms disappear in the second day, and the color of the skin is changed; as for stubborn ringworm, such as psoriasis, existing for ages, the red and swollen symptoms are subsided within 3-5 days, after insistent applying for a month, reappearing of stubborn ringworm is avoided, and therefore radical treatment is achieved; and toxicity and irritation are small, dependence is avoided, the reappearing probability is small, the applicable range is wide, and the externally-used medicine can be used by pregnant women and children.