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Miconazole nitrate compound composition for gynecology department

A technology of miconazole nitrate for gynecology and miconazole nitrate, which is applied in the field of gynecological compositions and can solve problems such as poor antibacterial effect

Inactive Publication Date: 2019-03-08
天津凯茵科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Pulsatilla chinensis (Bunge) Regel as a Chinese herbal medicine is the dried root of the Ranunculaceae plant Pulsatilla chinensis (Latin scientific name: Pulsatillachinensis (Bunge) Regel). Shigella, Bacillus subtilis, Bacillus typhi, Salmonella, and some skin fungi have inhibitory effects, but according to prior art reports, in the extract of Pulsatilla pulsatillae, the main antibacterial effect is protopulsatilla, the antibacterial effect of total saponins of Pulsatillae less effective

Method used

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  • Miconazole nitrate compound composition for gynecology department
  • Miconazole nitrate compound composition for gynecology department

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Pharmacological Example 1, Preparation of drug-resistant strains

[0014] Preparation

[0015] 1) Candida albicans (Candida albicans) (Code: ATCC10231) was used as the standard strain, and the standard strain of Candida albicans was continuously transplanted twice on Sabouraud agar (SDA) medium (cultivation temperature 35°C), and cultivated for 24 hours Finally, select 5 bacterial colonies with a diameter greater than 1 cm and shake them in 5 mL sterile normal saline for 15 seconds to make a bacterial suspension. 5×10 5 CFU / mL.

[0016] 2) Detect the minimum inhibitory concentration (MIC) of miconazole nitrate to Candida albicans, carry out according to CLSIM38-2 scheme, quality control strain is Candida parapsilosis (ATCC 22019); MIC result to Candida albicans standard strain and Compared with the negative control group, the minimum concentration that can significantly inhibit the growth of fungi (about 80%) is the minimum inhibitory concentration

[0017] 3) Induc...

preparation Embodiment

[0041] In the preparation examples, the preparation is made into a gel, and the content specification of miconazole nitrate in all gels is unified as 200mg / 5g

[0042] Example 1

[0043] Miconazole nitrate 4g, Pulsatilla saponin B4 2.4g

[0044] Carbomer 9411g, glycerol 6g Tween 80 1g

[0045] Ethylparaben 0.1g sodium hydroxide solution to adjust the pH to 4.0-4.5 Add purified water to 100g

[0046]Preparation method

[0047] 1) Carbomer is soaked overnight with an appropriate amount of purified water, fully stirred until it is completely swollen into a uniform gel-like polymer, then added ethylparaben and the main ingredient and mixed evenly to obtain a mixed solution 1)

[0048] 2) Mix glycerol and Tween 80 and add the mixed solution 1) Stir well, add an appropriate amount of purified water to 80g, adjust the pH to 4-4.5 with triethanolamine, make up the remaining water and stir well to obtain a transparent gel .

Embodiment 2

[0050] Miconazole nitrate 4g, Pulsatilla saponin B4 3.2g

[0051] Carbomer 941 1g, Glycerol 6g Tween 80 1g

[0052] Ethylparaben 0.1g sodium hydroxide solution to adjust the pH to 4.0-4.5 Add purified water to 100g

[0053] Preparation method

[0054] 1) Carbomer is soaked overnight with an appropriate amount of purified water, fully stirred until it is completely swollen into a uniform gel-like polymer, then added ethylparaben and the main ingredient and mixed evenly to obtain a mixed solution 1)

[0055] 2) Mix glycerol and Tween 80 and add the mixed solution 1) Stir well, add an appropriate amount of purified water to 80g, adjust the pH to 4-4.5 with triethanolamine, make up the remaining water and stir well to obtain a transparent gel .

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Abstract

The invention relates to a miconazole nitrate compound composition for gynecology department. The compound composition is prepared from active ingredients of miconazole nitrate and pulchinenoside B4,and at least one auxiliary material used as a vaginal administration preparation, wherein the mass ratio of the miconazole nitrate to the pulchinenoside B4 in the composition is 1:(0.6 to 1.0); the composition can be prepared into a gel; the auxiliary material is selected from one or several kinds of materials from carbomer, humectants, preservatives, surfactants and pH regulators, and the balancewater.

Description

Technical field: [0001] The invention provides a gynecological composition, especially a gynecological medicine containing steroidal terpenoids and miconazole nitrate. Background technique: [0002] Mycotic vaginitis is a common and multiple vulvovaginal inflammatory disease caused by Candida. Candida albicans is an opportunistic pathogen. Generally, the amount of bacteria is small and does not cause symptoms. Only when the systemic and vaginal local immunity declines , especially the decline of local cellular immunity and the proliferation of Candida albicans will cause vaginitis symptoms. Miconazole Nitrate (Miconazole Nitrate, CAS: 22832-87-7) is a kind of antifungal drug, can be used for the treatment of mycotic vaginitis, but due to extensive use, cause Candida albicans to exist relatively to Miconazole Nitrate Strong drug resistance, leading to the gradual deterioration of its therapeutic effect. Therefore, how to improve the bacteriostasis effect of gynecological mi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K31/4174A61K9/06A61K9/02A61P15/02A61P31/10
CPCA61K9/0034A61K9/02A61K9/06A61K31/4174A61K31/704A61K47/32A61P15/02A61P31/10A61K2300/00
Inventor 李景
Owner 天津凯茵科技有限公司
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