159results about "Suppositories delivery" patented technology

The invention relates to a traditional Chinese medicine composition for treating haemorrhoids and a preparation method and application thereof.The traditional Chinese medicine composition is prepared from, by weight, 20-60 parts of sargentgloryvine stem, 15-45 parts of moutan bark, 20-40 parts of dandelion, 20-40 parts of rheum officinale, 20-40 parts of radix paeoniae rubra and 10-30 parts of lithospermum erythrorhizon. The traditional Chinese medicine composition has the effects of cooling blood and detoxifying, promoting blood circulation to remove blood stasis and relieving swelling and pain through combination of all the medicines, can remarkably relieve inflammation and pain of haemorrhoids through test verification, and has the potential of industrial production and popularization.

The present invention provides a compound represented by Formula I or its pharmaceutically acceptable salt, stereoisomer, isotopic derivative, solvate (e.g., hydrate), prodrug, metal chelate, crystalline form, or metabolite, and its use in the pharmaceutical field. The above compound, particularly propafenone, can be used to treat and / or prevent psoriasis-related diseases. The present invention also found that, at the same dosage, topical application of the drug is more effective than injection in treating psoriasis-related diseases. The propafenone ointment of the present invention has a superior effect in treating psoriasis-related diseases compared to flecainide ointment, which has a similar antiarrhythmic effect.

Provided herewith are treatment methods and generally therapeutic applications which make use of a composite that comprises a calcium carbonate-containing material, and an associating moiety being associated with said calcium carbonate-containing material.

Aspects of disclosure relate to a composition and methodology for treating menopause symptoms utilizing a cannabinoid-based nanoplatform composition. The composition includes phytocannabinoids like CBD, CBG, and CBN, alongside isoflavones and polyphenols, all integrated into nanoplatform designed for enhanced bioavailability and controlled release. The formulation is designed to alleviate key menopause-related issues, including vasomotor symptoms (VMS), genitourinary syndrome of menopause (GSM), bone loss, mood disturbances, and sleep disorders, while addressing cardiovascular disease (CVD) risks. The composition combines cannabinoids, such as CBD, with isoflavones and polyphenols, and is incorporated into nanoplatforms for enhanced delivery and efficacy. Additionally, the disclosure includes a kit comprising oral capsules, intravaginal ovules, and instructions for use. The capsules contain a blend of cannabinoids, flavonoids, and polyphenols, while the ovules are composed of CBD and cocoa butter. The kit provides a comprehensive solution for managing menopause symptoms and mitigating cardiovascular risks.

Ganoderma lucidum spore oil and its use in preparing anti-cancer-related fatigue medicine. The Ganoderma lucidum spore oil has a triglyceride content of more than 90% and no Ganoderma lucidum triterpenoid compounds are detected. The Ganoderma lucidum spore oil is obtained by supercritical carbon dioxide extraction, eluting with a mixture of petroleum ether and ethyl acetate through a silica gel column, concentrating under reduced pressure, and drying in vacuum. The Ganoderma lucidum spore oil is found to significantly improve fatigue caused by cancer and has good safety, and therefore can be applied to preparing anti-cancer-related fatigue medicine.

This disclosure relates to a multi-component intravaginal ring (IVR) that improves the release of non-hormonal substances, which is useful in multi-purpose preventive techniques (MPT) that simultaneously prevent unplanned pregnancies, prevent or treat sexually transmitted infections (STIs), and optimize vaginal health.

The invention relates to the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia using a SGLT-2 inhibitor. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses an anti-inflammatory analgesic indometacin long-acting suppository and a preparation method thereof.The suppository is composed of indometacin sustained-release microspheres and a modified fatty matrix; eudragit RS100 / RL100 is used as a compound framework of the sustained-release microspheres, the sustained-release microspheres are prepared through a spherocrystal granulation process, the modified fatty matrix is prepared from a mixed fatty glyceride compound matrix sustained-release aid, a three-dimensional suspending dispersant and the like through melting, pre-crystallization and high-speed homogenization processes, and the three-dimensional suspending dispersant contains modified nano silicon dioxide, glycerin monostearate and beewax. According to the invention, a microsphere-matrix dual controlled release system is constructed, so that burst release of drugs is eliminated, and long-acting stable release is realized; the microspheres are prevented from settling and agglomerating through a physical locking mechanism, and the storage stability of the preparation is improved by matching with a dual anti-oxidation system; meanwhile, rectal mucosa stimulation is reduced, the preparation process is simple, the quality is controllable, and the composition is suitable for anti-inflammation and analgesia of various diseases and has a wide clinical application prospect.

Disclosed herein are aldehyde dehydrogenase (ALDH-2) inhibitor compounds, such as a compounds of Formula (I) or Formula (II), pharmaceutical compositions comprising these inhibitor compounds, and uses of these compounds and compositions, such as in the methods for safely treating chemical dependency on a substance or condition of addiction, such as alcohol, nicotine, cocaine, opiates, amphetamines, and compulsive eating disorder, and / or anxiety disorder, each individually or concurrent.

This specification describes a formulation comprising a homogeneous suspension of a biopolymer(s) for drug delivery of an active molecule. In an embodiment, the biopolymer is selected from chitin, chitosan, cellulose, hemicellulose, lignin, amylose, actin, fibrin, collagen, silk, fibroin, keratin, wool, alginic acid, and mixtures thereof. In an embodiment, the biopolymer is mechanically treated with an API under high shear conditions and / or high mechanical energy. The formulation can find particular use in drug delivery systems that involve the transport and release of compounds or molecules for purposes such as pharmaceuticals, drug substances, cosmetics, and the like.

Described is a rectal suppository. The rectal suppository comprises 6-thioguanine, at least one hard fat, and at least one surfactant. Further or alternatively, the rectal suppository comprises about 1 to 9 mg of 6-thioguanine. Further or alternatively, there is described a method of preventing, treating and / or managing inflammatory bowel disease in a subject. The method comprises administering a rectal suppository to the subject in need thereof. Further or alternatively, there is described a method of manufacturing a rectal suppository. The method comprises the steps of (a) heating a hard fat to become a liquid hard fat, (b) adding at least one surfactant to the liquid hard fat, (c) adding 6-thioguanine to the liquid hard fat, (d) forming the hard fat into a rectal suppository. Step (b) is optionally carried out before step (c) or after step (c).

The invention discloses a medical biological dressing suppository matrix and a preparation method thereof, and relates to the technical field of suppositories, the medical biological dressing suppository matrix is prepared by taking gelatin, glycerol, polyethylene glycol derivatives and chitosan quaternary ammonium salt as raw materials, the biocompatibility of the suppository matrix is good, and stimulation and anaphylactic reaction cannot be generated on a medication cavity; and after the suppository matrix is dissolved in the cavity, a film with good adhesion can be formed on the mucous membrane of the cavity, so that the released medicine is fully contacted with the focus for a long time, the curative effect and bioavailability of the medicine are improved, and the suppository is suitable for preparing suppositories for treating gynecological diseases, anorectal diseases and prostate diseases.

The present invention relates to substituted tetrazole derivatives that are useful in the prevention and / or treatment of several medical conditions, including hyperproliferative disorders and diseases.

The invention relates to the technical field of Mongolian medicine preparations, in particular to a coptis chinensis six-ingredient decoction and a preparation method of a suppository of the coptis chinensis six-ingredient decoction. Three heat-clearing and anti-inflammatory Mongolian medicines are added on the basis of a traditional Mongolian medicine coptis chinensis-six-ingredient decoction, the total content of effective components is larger than or equal to 12% through composite enzymolysis, supercritical CO2 extraction and gradient membrane separation and purification, and then stability is enhanced through composite embedding. According to the suppository, a drug carrying system is constructed through a pH-ROS double-response carrier and magnetic targeting, self-healing hydrogel, a temperature-sensitive composite matrix and micro-fluidic spray forming are combined, and storage stability is guaranteed through intelligent packaging. The preparation disclosed by the invention is high in targeting property, capable of being accurately enriched in an intestinal inflammation area, high in mucous membrane adhesive force, long in residence time, convenient and comfortable to take, capable of meeting the melting change time limit, capable of remarkably improving stability and bioavailability, suitable for treating ulcerative colitis and capable of promoting modernization transformation of Mongolian medicine.

Disclosed herein are compositions and methods of manufacturing, testing, and using a biocompatible and disposable vaginal suppository, comprising chitosan, collagen, carboxymethyl cellulose, and an enzyme, capable of breaking down vaginal mucous and releasing the active ingredients consistently over extended periods of time. Methods disclosed herein may also include the use of these compositions, methods, and devices for treating vaginal diseases, such as vaginitis, genitourinary syndrome, and other conditions, such as vulvar and vaginal cancer, or cervical cancer.

This invention relates to drug-device core-shell microneedle devices containing anti-diabetes and anti-obesity medications, and transdermal delivery of said medications. The microneedle drug-device system comprises: (a) a two-dimensional array of conical bilayer containing an inner layer with the base diameter ranging from about 100 mm to about 500 mm and the height ranging from about 100 mm about 1200 mm capable of accommodating a known amount of anti-diabetes and / or anti-obesity medications, and a suitable, photostable chromophore or a fluorophore whose absorption and / or emission occurring in the range of 400-900 nm; (b) a larger outer layer that adheres to and encapsulates the inner layer, and protects the inner layer, and (c) a two-dimensional array of cylindrical 'cap layer' that aligns with and adheres to the basal surface of core shell bilayer and seals the bilayer to prevent leakage of said medication(s). The apical (i.e., sharp) ends of the conical bilayer array inserts into the skin and are programmed to allow the said medications to effuse out of the bilayer and into the skin in a controlled fashion and to be monitored by photodetection devices.

To provide a d-amphetamine compound, a composition, as well as a process for producing and using the same.SOLUTION: Compositions comprising a d-amphetamine compound, a composition including at least one organic acid covalent bonded to d-amphetamine, salts thereof, derivatives thereof, or combinations thereof are disclosed. Methods for producing and using them are also be disclosed. Organic compounds include heterocyclic nitrogen compounds. Heterocyclic nitrogen compounds are commonly found in nature and are involved in several biological functions in plants and animals. Examples of heterocyclic nitrogen compounds for use in the implementation of the present technology include, but are not limited to, for example, pyridine derivatives, some of which play an important role in the metabolism of nicotinate and tryptophan. In these compounds, one carbon of the phenyl ring is generally replaced by a nitrogen atom.SELECTED DRAWING: None

The invention discloses a postoperative traditional Chinese medicine composition for treating haemorrhoids and a preparation method of the postoperative traditional Chinese medicine composition, and relates to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises 9-11 parts of coptis chinensis, 9-11 parts of golden cypress, 9-11 parts of bear gall, 9-11 parts of rheum officinale, 19-21 parts of carbonized sanguisorba root, 19-21 parts of carbonized schizonepeta, 5-7 parts of gallnut, 20-22 parts of dragon's blood, 19-21 parts of nacre mother of pearl, 19-21 parts of calamine, 9-11 parts of radix angelicae, 5-7 parts of borneol and 1-3 parts of artificial musk. The invention provides a novel traditional Chinese medicine composition for treating postoperative complications of haemorrhoids, the core is to dredge channels and collaterals, promote qi to activate blood and relieve pain, and the three-dimensional treatment goal of clearing away heat and toxic materials, cooling blood and stopping bleeding, and diminishing swelling and promoting tissue regeneration is achieved through a multi-dimensional formula strategy, so that the purpose of treating the postoperative complications of haemorrhoids is achieved.

The present disclosure provides a method for treating post-acute sequelae of severe acute respiratory syndrome (SARS)-CoV-2 infection (PASC) or one or more symptoms associated with said PASC, said method comprising administering to a subject in need thereof or at risk thereof a pharmaceutical composition comprising a therapeutically effective amount of cyclobenzaprine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. The present disclosure provides, in some embodiments, a method and a pharmaceutical composition for treating post-acute sequelae of (SARS)-CoV-2 infection (PASC) or one or more symptoms associated therewith in a subject in need thereof or at risk thereof, wherein said pharmaceutical composition comprises a therapeutically effective amount of cyclobenzaprine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

Disclosed is use of a thiophene [3,2-d] pyrimidine-4-ketone compound represented by general formula (I). Definition of each substituent is as stated in the description and claims, and the compound is used for preparing medicines for treating and / or preventing liver fibrosis and related diseases or preparing a DPP-4 inhibitor, or is used as a DPP-4 inhibitor.

Disclosed herein, inter alia, are acyclic nucleotide analogs and methods of using an acyclic nucleotide analog for treating and / or ameliorating a papillomavirus infection.

The present invention relates to a composition comprising carglumic acid and sodium acetate. The invention further relates to the composition of the invention for treating hyperammonemia, more specifically N-Acetylglutamate synthase deficiency. The invention further relates to the composition comprising carglumic acid and sodium acetate, wherein the composition is formulated for rectal administration.. The invention also relates to the composition comprising carglumic acid and sodium acetate, wherein the rectal formulation is a suppository and wherein the suppository comprises polyethylene glycol (PEG) being a mixture of one or more low-molecular weight PEGs and one or more medium-molecular weight PEGs.

Provided herein are methods for preventing or treating diseases, said methods comprising (i) inhibiting entry of bacteriophages and / or component(s) thereof into microbiota, bodily fluid(s) or tissue(s) of the mammals and / or (ii) inactivating or modifying bacteriophages and / or component(s) thereof present in microbiota, bodily fluid(s) or tissues of the mammals and / or (iii) inactivating or modifying bacteriophages and / or component(s) thereof in one or more of food, drinking water, water for washing, water for air humidification, air, or habitat object of the mammals.

To provide a d-amphetamine compound, a composition, as well as a process for producing and using the same.SOLUTION: Compositions comprising a d-amphetamine compound, a composition including at least one organic acid covalent bonded to d-amphetamine, salts thereof, derivatives thereof, or combinations thereof are disclosed. Methods for producing and using them are also be disclosed. Organic compounds include heterocyclic nitrogen compounds. Heterocyclic nitrogen compounds are commonly found in nature and are involved in several biological functions in plants and animals. Examples of heterocyclic nitrogen compounds for use in the implementation of the present technology include, but are not limited to, for example, pyridine derivatives, some of which play an important role in the metabolism of nicotinate and tryptophan. In these compounds, one carbon of the phenyl ring is generally replaced by a nitrogen atom.SELECTED DRAWING: None

The present invention provides compositions and methods for treating patients. [Solution] The exemplary composition may include a vaginal microbiome composition. The vaginal microbiome composition may include a mixture of bacteria. The bacterial mixture may include Lactobacillus crispatus, Lactobacillus gasseri, Lactobacillus jensenii, and Lactobacillus rhamnosus.

The present invention provides compositions for treating conditions caused by dysfunction of the central nervous system and conditions caused by dysfunction of the peripheral nervous system. [Solution] A composition containing a pharmaceutically effective amount of 5-methoxy-N,N-dimethyltryptamine (5MeODMT) benzoate that is pharmaceutically acceptable.

Disclosed herein are bicyclic compounds, including pharmaceutical compositions that include one or more of such compounds. Also disclosed are methods of making functionalized bicyclic compounds. Also disclosed herein are methods of treating diseases and / or conditions (e.g., inflammation and / or cancer) with the bicyclic compounds disclosed herein.

The invention belongs to the technical field of medicines, and particularly relates to an icaritin rectal suppository as well as a preparation method and application thereof. The suppository is prepared by directly taking the icaritin as a single active ingredient, and animal experiments prove that the icaritin can remarkably reduce the crissum score of rats suffering from hemorrhoids and remarkably reduce the levels of serum IL-6, IL-beta and TNF-alpha. The suppository disclosed by the invention is stable in component, good in administration and absorption, stable in process and good in application prospect.

The invention provides an umbilicus application suppository for treating constipation and a preparation method thereof, and relates to the technical field of medicine.The umbilicus application suppository for treating constipation comprises a suppository body, the suppository body comprises a suppository matrix and a traditional Chinese medicine microcapsule, and the traditional Chinese medicine microcapsule comprises an emulsified oil phase, an emulsified water phase and a traditional Chinese medicine composition; the traditional Chinese medicine composition comprises rheum officinale, fructus cannabis, bunge cherry seeds, astragalus membranaceus, ginseng, immature bitter oranges, mangnolia officinalis, rhizoma atractylodis, radix sophorae flavescentis, golden cypress, fructus cnidii and fructus evodiae. A transdermal promotion mechanism is designed and optimized by adopting a traditional Chinese medicine micro-capsule structure, and a specific traditional Chinese medicine composition and a micro-encapsulation process are combined, so that the transdermal absorption efficiency of the medicine is effectively improved, the skin irritation reaction is reduced, and meanwhile, the stable slow release of the medicine is realized, thereby solving the problems of low transdermal absorption efficiency, large effect fluctuation, poor skin compatibility and the like in the prior art; the preparation has the advantages of high transdermal absorption efficiency, small skin irritation, good drug sustained release performance and the like.

Disclosed herein are bicyclic compounds, including pharmaceutical compositions containing one or more such compounds. Methods of making functionalized bicyclic compounds are also disclosed. Also disclosed herein are methods of treating diseases and / or conditions (e.g., inflammation and / or cancer) with the bicyclic compounds disclosed herein.