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33 results about "Adenylyl cyclase" patented technology
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Adenylyl cyclase (EC 4.6.1.1, also commonly known as adenyl cyclase and adenylate cyclase, abbreviated AC) is an enzyme with key regulatory roles in essentially all cells. It is the most polyphyletic known enzyme: six distinct classes have been described, all catalyzing the same reaction but representing unrelated gene families with no known sequence or structural homology. The best known class of adenylyl cyclases is class III or AC-III (Roman numerals are used for classes). AC-III occurs widely in eukaryotes and has important roles in many human tissues.
Lactococcus lactis recombinant bacterium for expressing cyclic diadenylate and application of lactococcus lactis recombinant bacterium
The invention discloses a lactococcus lactis recombinant bacterium for expressing cyclic diadenylate and application of the lactococcus lactis recombinant bacterium. The recombinant bacterium is obtained by carrying out multi-gene synergistic modification on lactococcus lactis. The method specifically comprises the following steps: carrying a homologous diadenylate cyclase (DAC) gene, overexpressing glycolysis key enzyme phosphofructokinase (PFK), knocking out a phosphodiesterase (PDE) gene for degrading c-di-AMP, and knocking out a lactic dehydrogenase (ldh) gene. Through the synergistic effect of the transformation, the supply of the precursor ATP is remarkably improved, and the degradation of the c-di-AMP and the accumulation of lactic acid byproducts are reduced, so that the efficient expression of the c-di-AMP is realized.
Owner:SHANDONG CANDERAY AGRI SCI & TECH CO LTD +1