8 results about "Inflammatory pain" patented technology

The present invention relates to a synergistic admixture of Gabapentin and Ketoprofen, preferably Ketoprofen Lysine, to a pharmaceutical composition comprising said admixtures and to the use of said admixtures or pharmaceutical compositions in the treatment of acute or chronic pain, in particular in the treatment of neuropathic or inflammatory pain.

The application relates to the technical field of pharmaceutical chemistry, and discloses a flurbiprofen ester enantiomer prodrug compound, a preparation method thereof, a pharmaceutical composition and purposes, the compound is (R)-AF377 or (S)-AF377, is formed by covalently connecting a carboxyl of (R)-flurbiprofen, (S)-flurbiprofen and a phenolic hydroxyl of acetaminophen through an ester bond, corresponding chiral carbons are R configuration and S configuration respectively, and structures are shown in formula (I) and formula (II). The application further provides a preparation method of the compound, a pharmaceutical composition containing the compound and purposes of the compound in pain, inflammation or fever treatment. The compound has high optical purity, releases an active ingredient in the liver, (S)-AF377 has synergistic anti-inflammatory analgesic activity, (R)-AF377 has independent analgesic activity, can reduce side effects of single drug use, improves bioavailability, and provides a new drug selection for treatment of mild to moderate inflammatory pain.

The application discloses an indolone compound and a pharmaceutical composition and application thereof, and has a molecular structure as follows: the indolone compound has double activities of analgesia and antioxidation, can be used as an analgesic with an antioxidation function, and has application potential in inflammatory pain care.

The application relates to the technical field of medicines, and particularly discloses a class of celecoxib derivatives, a preparation method and application thereof. The derivative is formed by connecting celecoxib and straight-chain amino acids through a chemical bond, and the straight-chain amino acids are glycine, gamma-aminobutyric acid and the like. The derivative or a pharmaceutically acceptable salt and a pharmaceutical composition thereof can be used for preparing medicines for preventing and / or treating pain or nervous system diseases. The derivative has excellent water solubility, strong COX-2 inhibitory activity, good analgesic activity and anti-inflammatory activity, has good analgesic effects on inflammatory pain, neuropathic pain and visceral pain and the like, and has a wide application prospect.

The application discloses application of anterior piriform cortex GABAergic neurons as an analgesic target point, and relates to the technical field of neuroscience and pain. GABA The application discloses that the neural loop (APC GABA →MD) from the anterior piriform cortex GABAergic neurons to the thalamic dorsal medial nucleus plays a key role in pain regulation. Experiments prove that the loop can not only relieve acute pain, but also has a significant analgesic effect on the clinical treatment of intractable chronic inflammatory pain and neuropathic pain models, and shows a wide treatment application prospect.

The application discloses a painkilling preparation containing radix scophulariae and radix aconiti and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine. The preparation is a transdermal patch, which is composed of a backing layer, a drug depot layer and an anti-sticking layer. The drug depot layer contains traditional Chinese medicine active ingredients and patch auxiliaries such as pressure-sensitive adhesive and transdermal absorption accelerators. The traditional Chinese medicine active ingredients take radix scophulariae and radix aconiti as the core drug pair, and are supplemented with one or more of the following drugs: qi-regulating analgesic drugs, blood-removing qi-regulating drugs, blood-activating analgesic drugs, blood-stasis-removing analgesic drugs, warm-qi-activating cold-dispelling drugs, wind-dispelling cold-dispelling drugs and external analgesic drugs. The application is a modern traditional Chinese medicine external preparation prepared by a patch technology, and the drug can penetrate the skin and directly reach the lesion, thereby playing a therapeutic role on inflammatory pain, cancer pain and idiopathic pain. The preparation has the characteristics of large drug loading, good transdermal absorption, fast analgesic effect, long-acting effect and avoidance of oral toxicity risk.

The application discloses a new use of sildenafil and its salts in combination with ibuprofen. Through pharmacodynamics and toxicology experiments, the application first proposes and verifies that the combination of sildenafil and its salts (sildenafil citrate) and ibuprofen has a significant synergistic effect in treating inflammatory pain, and can effectively reduce the renal toxicity induced by long-term administration of ibuprofen. The application solves the problem that long-term or large-dose use of ibuprofen can induce significant renal toxicity, which seriously limits the long-term, standard and sufficient clinical application of ibuprofen. The composition provided by the application can enhance the analgesic effect of ibuprofen and reduce the renal toxicity of ibuprofen, and has important clinical conversion value and practical application prospect.

The present application relates to polypeptides, in particular to an animal toxin polypeptide and application thereof. The polypeptide is identified by RNA sequencing of centipede transcriptome, and bioinformatics screening and Motif scanning analysis of translated protein sequence. Experimental results show that SM-8 shows strong analgesic effect in various pain models, including hot plate test, acetic acid writhing test, formalin inflammatory pain model and migraine model, and the analgesic effect is equivalent to that of butorphanol tartrate and sumatriptan. Molecular mechanism research shows that SM-8 can regulate the expression of pain-related genes. Preliminary safety evaluation by mouse open field test shows that the polypeptide does not cause obvious toxic side effects, has good safety, and has good prospects for development into a new polypeptide analgesic drug.