8 results about "Baroreflex" patented technology

This application discloses the application of pyridostigmine in the preparation of drugs for the prevention and treatment of non-alcoholic fatty liver disease (NAFLD). Validation was conducted using animal models of NAFLD induced by three different etiologies: methionine-choline deficiency diet, high-fat diet, and leptin gene knockout. Pyridostigmine significantly improved vagal nerve activity in the model animals (e.g., improving high-frequency and baroreflex sensitivity in heart rate variability), effectively corrected serum lipid metabolism disorders (reducing LDL cholesterol), alleviated hepatocyte damage (reducing ALT and AST), and at the histopathological level, reduced hepatic steatosis, decreased inflammatory cell infiltration, and inhibited collagen deposition, thereby achieving the prevention and treatment of NAFLD.

Systems and methods are provided for delivering closed-loop or partially closed-loop baroreflex activation therapy (BAT) to treat conditions associated with autonomic dysfunction. A pulse generator delivers stimulation while physiological data, such as ECG, heart rate variability, bioimpedance, and physical activity levels, is collected from one or more sensors. The data is analyzed to assess autonomic nervous system activity, and stimulation parameters are dynamically adjusted in response. In some embodiments, adjustments are made on a beat-to-beat basis using ECG input. Artificial intelligence algorithms may be used to predict patient-specific responses, optimize therapy, and evaluate effectiveness. The method may further include integrating patient-reported symptoms, wirelessly transmitting data, or adjusting stimulation duty cycle based on time of day. The system may further incorporate patient-reported symptoms, a clinician dashboard for remote monitoring, and a multi-channel lead. Stimulation may be delivered non-invasively or via an implantable device.

Devices and methods of use for introduction and implantation of an electrode as part of a minimally invasive technique. An implantable baroreflex activation system includes a control system having an implantable housing, an electrical lead, attachable to the control system, and an electrode structure. The electrode structure is near one end of the electrical lead, and includes a monopolar electrode, a backing material having an effective surface area larger than the electrode, and a releasable pivotable interface to mate with an implant tool. The electrode is configured for implantation on an outer surface of a blood vessel and the control system is programmed to deliver a baroreflex therapy via the monopolar electrode to a baroreceptor within a wall of the blood vessel.

Provided herein are methods for measuring baroreflex response, and baroreflex gauge devices and systems. Such methods and devices position and expand an expandable structure at a target site within a patient's vasculature, preferably the aortic arch, and measure the baroreflex response in one or more transverse dimensions of the expandable structure. The baroreflex gauge device can optionally expand the structure to multiple expanded configurations while monitoring the patient's blood pressure to determine optimal dimensions for baroreflex response. These gauge devices and methods aid in assessing a patient's suitability for treatment and in selecting or customizing an implant to be placed within the vasculature for long-term treatment of hypertension. The baroreflex gauge device can also be integrated into an implant delivery system, allowing partial deployment to enable response measurement and full deployment to enable long-term treatment.

Devices and methods described herein may, among other uses, favorably cause the activation and / or deactivation of vascular baroreceptors in order to achieve a desired impact on a physiological condition, such as baroreflex-regulated conditions, hypertension, hypotension, nervous system disorders, metabolic disorders, cardiovascular disease, heart failure, cardiac arrhythmia, renal disease, respiratory disease, diabetes, and insulin resistance. The devices and methods may be used in concert with each other and / or other treatments, medications, interventions, or behavioral regimens. They may also be used in concert with devices and methods that perform or assist with assessing or measuring a mammal's blood pressure, assessing, measuring, or predicting the impact of the described methods and devices on the patient's condition (including blood pressure), and / or protecting the surrounding anatomy from adverse effects.

Devices, systems and methods for non-invasive modulation of the baroreflex system of a patient. In embodiments, the present disclosure may be used to measure and monitor baroreflex function for diagnostic purposes in patients acutely or chronically to inform and guide medical treatment, assess disease severity, or assess morbidity / mortality risk. In embodiments, the present disclosure may be used to provide non-invasive baroreflex activation therapy acutely or chronically to treat a variety of disease conditions through rebalancing of the sympathetic and parasympathetic limbs of the autonomic nervous system and their connections to higher brain centers.

The application discloses a kind of based on multi-modal fingertip monitor's vascular pressure reflex sensitivity dynamic evaluation method, system and equipment, belong to the technical field of autonomous nerve function assessment of computational physiology.The method relies on monitoring equipment and its specific high-fidelity recording mode that can produce time strictly aligned multi-modal raw data stream in hardware level, relies on synchronous data packet with uniform timestamp that is composed of electrophysiological data sub-packet and optical data sub-packet in data level.The core of method includes: receiving and analyzing the time-aligned data packet, detecting the starting point of skin conductance response event from it, and calculating pulse wave conduction time sequence synchronously;With each skin conductance response event starting point as time reference, analyze the dynamic change characteristics of the pulse wave conduction time sequence in the preset time window after it, and quantify the change characteristics as the evaluation index of vascular pressure reflex sensitivity.The present application makes full use of the accurate timing relationship between skin electrical activity surge event and vascular dynamics instantaneous response provided by high-precision hardware synchronization, solves the problem that traditional pressure reflex sensitivity evaluation method is complex, cannot be continuously monitored, and is difficult to capture instantaneous reflex function.

Methods and associated devices for programming a therapy for an implantable baroreflex activation system are described, including for programming the implantable baroreflex stimulation system with operating parameters.