3 results about "Baroreflex" patented technology

This application discloses the application of pyridostigmine in the preparation of drugs for the prevention and treatment of non-alcoholic fatty liver disease (NAFLD). Validation was conducted using animal models of NAFLD induced by three different etiologies: methionine-choline deficiency diet, high-fat diet, and leptin gene knockout. Pyridostigmine significantly improved vagal nerve activity in the model animals (e.g., improving high-frequency and baroreflex sensitivity in heart rate variability), effectively corrected serum lipid metabolism disorders (reducing LDL cholesterol), alleviated hepatocyte damage (reducing ALT and AST), and at the histopathological level, reduced hepatic steatosis, decreased inflammatory cell infiltration, and inhibited collagen deposition, thereby achieving the prevention and treatment of NAFLD.

Systems and methods are provided for delivering closed-loop or partially closed-loop baroreflex activation therapy (BAT) to treat conditions associated with autonomic dysfunction. A pulse generator delivers stimulation while physiological data, such as ECG, heart rate variability, bioimpedance, and physical activity levels, is collected from one or more sensors. The data is analyzed to assess autonomic nervous system activity, and stimulation parameters are dynamically adjusted in response. In some embodiments, adjustments are made on a beat-to-beat basis using ECG input. Artificial intelligence algorithms may be used to predict patient-specific responses, optimize therapy, and evaluate effectiveness. The method may further include integrating patient-reported symptoms, wirelessly transmitting data, or adjusting stimulation duty cycle based on time of day. The system may further incorporate patient-reported symptoms, a clinician dashboard for remote monitoring, and a multi-channel lead. Stimulation may be delivered non-invasively or via an implantable device.

The application discloses a kind of based on multi-modal fingertip monitor's vascular pressure reflex sensitivity dynamic evaluation method, system and equipment, belong to the technical field of autonomous nerve function assessment of computational physiology.The method relies on monitoring equipment and its specific high-fidelity recording mode that can produce time strictly aligned multi-modal raw data stream in hardware level, relies on synchronous data packet with uniform timestamp that is composed of electrophysiological data sub-packet and optical data sub-packet in data level.The core of method includes: receiving and analyzing the time-aligned data packet, detecting the starting point of skin conductance response event from it, and calculating pulse wave conduction time sequence synchronously;With each skin conductance response event starting point as time reference, analyze the dynamic change characteristics of the pulse wave conduction time sequence in the preset time window after it, and quantify the change characteristics as the evaluation index of vascular pressure reflex sensitivity.The present application makes full use of the accurate timing relationship between skin electrical activity surge event and vascular dynamics instantaneous response provided by high-precision hardware synchronization, solves the problem that traditional pressure reflex sensitivity evaluation method is complex, cannot be continuously monitored, and is difficult to capture instantaneous reflex function.