76 results about "Respiration Disorders" patented technology

An intraoral electromuscular stimulation device and method to treat a breathing disorder. The stimulation device includes a first electrode, a first support member that maintains the first electrode in a sublingual location posterior to a frenulum and proximate to one of a first molar, a second molar and a third molar of a patient. A second electrode is maintained in a sublingual position posterior relative to the first electrode by a second support member. A further embodiment of the stimulation device includes a sensor that detects a respiratory parameter of a patient and outputs a signal indicative thereof. A control unit receives the signal from the sensor, distinguishes between inspiration and expiration, and initiates an electrical stimulation at a stimulation time prior to onset of inspiration and continues stimulation through a portion of inspiration at a level sufficient to induce muscle contraction without pain.

Methods and systems involve coordinating therapies used for treating disordered breathing. Disordered breathing therapies may include cardiac electrical stimulation therapy and external respiratory therapy as well as other therapies for treating disordered breathing in a patient. The therapies delivered to the patient may be coordinated to enhance effectiveness of the therapy, to reduce therapy interactions, to improve patient sleep, or to achieve other therapeutic goals.

A pharmaceutical composition and formulations comprise preventative, prophylactic or therapeutic amounts of an oligo(s) anti-sense to a specific gene(s) or its corresponding mRNA(s), and a glucocorticoid and / or non-glucocorticoid steroid or a ubiquinone or their salts. The agents, composition and formulations are used for treatment of ailments associated with impaired respiration, bronchoconstriction, lung allergy(ies) or inflammation, and abnormal levels of adenosine, adenosine receptors, sensitivity to adenosine, lung surfactant and ubiquinone, such as pulmonary fibrosis, vasoconstriction, inflammation, allergies, allergic rhinitis, asthma, impeded respiration, lung pain, cystic fibrosis, bronchoconstriction, COPD, RDS, ARDS, cancer, and others. The present treatment is effectively administered by itself for conditions without known therapies, as a substitute for therapies exhibiting undesirable side effects, or in combination with other treatments, e.g. before, during and after other respiratory system therapies, radiation, chemotherapy, antibody therapy and surgery, among others. Each of the agents of this invention may be administered directly into the respiratory system so that they gain direct access to the lungs, or by other effective routes of administration. A kit comprises a delivery device, the agents and instructions for its use.

A therapy system adapted to treat a patient's ventilatory instability using a ventilatory therapy, a gas modulation therapy, or both. The algorithm implemented by the therapy system monitors the ventilatory instability, such as Cheyne Stokes Respiration (CSR), mixed apneas, CPAP emergent apneas, and complex sleep disordered breathing (CSDB) and treats the ventilatory instability. The algorithm also determine a reference point with respect to the ventilatory instability. The therapy delivery system initiate the treatment based on the reference point.

A pressure support system and method of treating disordered breathing that optimizes the pressure delivered to the patient to treat the disordered breathing while minimizing the delivered pressure for patient comfort. The controller in the pressure support system operates as a set of prioritized control layers, wherein each control layer competes for control of the pressure generating system to implement a unique pressure control process. The pressure support system also controls the pressure provided to the patient based on the variability of the monitored data and a trend analysis of this data, including an indication the skewness of the patient's inspiratory waveform.

An intraoral electromuscular stimulation device and method to treat a breathing disorder. The stimulation device includes a first electrode, a first support member that maintains the first electrode in a sublingual location posterior to a frenulum and proximate to one of a first molar, a second molar and a third molar of a patient. A second electrode is maintained in a sublingual position posterior relative to the first electrode by a second support member. A further embodiment of the stimulation device includes a sensor that detects a respiratory parameter of a patient and outputs a signal indicative thereof. A control unit receives the signal from the sensor, distinguishes between inspiration and expiration, and initiates an electrical stimulation at a stimulation time prior to onset of inspiration and continues stimulation through a portion of inspiration at a level sufficient to induce muscle contraction without pain.

A pressure support system and method of treating disordered breathing that optimizes the pressure delivered to the patient to treat the disordered breathing while minimizing the delivered pressure for patient comfort. The controller in the pressure support system operates as a set of prioritized control layers, wherein each control layer competes for control of the pressure generating system to implement a unique pressure control process. The pressure support system also controls the pressure provided to the patient based on the variability of the monitored data and a trend analysis of this data, including an indication of the skewness of the patient's inspiratory waveform.

An approach to providing disordered breathing therapy involves the use of a plurality of therapy devices to deliver a coordinated disordered breathing therapy regimen to the patient. The plurality of disordered breathing devices includes at least a therapy device that delivers an electrical stimulation therapy modulating a patient's baroreflex response. Other therapy devices may include a cardiac electrical stimulation device, an external respiratory therapy device, and / or other therapy devices used in the treatment of disordered breathing. A therapy controller coordinates the therapies delivered by the plurality of therapy devices.

An approach to providing disordered breathing therapy includes delivering electrical stimulation therapy modifying a patient's baroreflex response. Disordered breathing therapy may be delivered in response to prediction or detection of disordered breathing events. Various conditions affecting the patient may be evaluated and the baroreflex therapy modified. The therapy may be modified to improve therapy efficacy, to reduce an impact to the patient and / or to mitigate therapy interactions.

An apnea / hypopnea detection system and method that monitors a patient's respiratory flow, determines (a) a long term RMS energy based on the flow, (b) a long term threshold determined based on the long term RMS energy, and (c) a short term RMS energy based on the flow. Determining whether the patient is experiencing an apnea / hypopnea is accomplished by comparing the short term RMS energy with the long term threshold. This A / H detection technique is useful in diagnosing a patient for a breathing disorder, such as OSA, and / or for controlling an auto-titration pressure support system.

A system and method are disclosed for the provision of assisted breathing by the delivery of a controlled pressurized Airflow to the pulmonary airway of a user with breathing disorders. The system comprises a source of compressed respiratory gas (112), a user interface unit (115) including at least one Venturi device (120) and a thin flexible tubing (116) connecting between the source of high pressure gas (112) and the Venturi device. The system and method provide a regulated and controlled flow of air to the user (105) in accordance with the user needs. The invention further discloses a novel small light-weight user interface for replacing prior art breathing masks.

Devices and methods for detecting disordered breathing involve determining that the patient is asleep and sensing one or more signals associated with disordered breathing indicative of sleep-disordered breathing while the patient is asleep. Sleep-disordered breathing is detected using the sensed signals associated with disordered breathing. The sensed signals associated with disordered breathing may also be used to acquire a respiration pattern of one or more respiration cycles. Characteristics of the respiration pattern are determined. The respiration pattern is classified as a disordered breathing episode based on the characteristics of the respiration pattern. One or more processes involved in the detection of disordered breathing are performed using an implantable device.

Methods and systems for diagnosing disorders, including, for example, disordered breathing, involve sensing one or more of a blood chemistry parameter and / or an expired gas parameter, such as expired respiratory gas concentration, blood gas concentration, and blood pH. Diagnosis of the disorder may be performed by a medical device, such as a respiratory therapy device or a cardiac therapy device, based on implantably detected blood gas / pH concentration / level or externally detected expired respiratory gas concentration. Cardiac and respiratory therapies for addressing the disorder may be adjusted based on the detected parameters.

Described is a system including an air pressure supply arrangement, a sensor and a titration device. The air pressure supply arrangement provides air pressure to a patient's airways. The sensor detects input data corresponding to a patient's breathing patterns of a plurality of breaths. The titration device receives and analyzes the input data to determine existence of breathing disorder and corresponding characteristics. The titration device generates output data for adjusting the air pressure supplied to the patient as a function of an index of abnormal respiratory events included in the input data.

A system and method for monitoring respiration including sensing a signal that varies with respiration, deriving a respiration parameter, applying criteria for detecting a respiration disturbance and determining one or more respiratory disturbance metrics. The system preferably includes an implantable sensor with an associated implantable medical device such that chronic respiration monitoring is possible. The implantable medical device may execute methods for detecting and measuring respiratory disturbances or may store data to be transferred to an external device for detecting and measuring respiratory disturbances. Respiratory disturbance detection may trigger a responsive action such as physiological data storage, a change in therapy delivery, or a clinician warning. Assessment of cardiac function may be made based on metrics of respiratory disturbances or a measure of circulatory delay time following detection of a respiratory disturbance.

A ventilator for supplying breathable gas to the airway of a patient with a respiratory disorder is provided herein an, in one embodiment, includes a gas flow generator for generating a flow of said breathable gas to the patient, said gas flow generator comprising a gas flow generator chamber provided with a gas inlet opening and a gas outlet opening; a control valve for controlling the flow and / or pressure of the gas distributed to the patient, said control valve comprising a valve body which is rotatably arranged about a rotational axis within a valve chamber. The valve body essentially exhibits the shape of a sector of a circle, in such a way that an arced first flow regulatory surface is formed along the circular arc of said sector, and that second and third essentially straight flow regulatory surfaces, respectively, are formed along the two diverging sides of said sector.

Systems and methods provide a self-contained, intermittent positive airway pressure system for treating sleep apnea, snoring, and other respiratory disorders. The systems and methods provide an air flow director that can be worn in or over the nose of the individual in communication with an upper airway. The systems and methods provide an airflow regulation assembly that can also be worn in its entirety by the individual in communication with the air flow director. The airflow regulation assembly includes a source of positive pressure. The airflow regulation assembly intermittently operates the source of positive pressure to increase positive air pressure in the air flow director sufficient to resist tissue collapse in the upper airway during only a portion of the respiratory cycle less than the entire respiratory cycle.

A device is disclosed that can detect and treat disordered breathing in a patient. The device can include at least one contact adapted to make contact with a portion of an oral cavity of a patient, and a control circuit configured to: in a first mode, detect a presence of disordered breathing in the patient based, at least in part, on a first signal received from the at least one contact; and in a second mode, provide electrical stimulation via the at least one contact to a portion of the patient's upper airway based on a detection of the presence of disordered breathing.

The invention relates the sensing device used to check sleeping state and interference with respiration. The device comprises spring mattress 1, and pressure sensing device. The spring mattress 1 comprises at least two vent longitudinal partition cushion (11, 12, 13, 14), the adjacent side walls (11a, 12a) are near, the bottoms of cushions(11b, 12b) are connected with each other, the sensing device is sealed elastic body(21, 22) with fluid, in the elastic body there is sensing elements(21a, 22a), the output end of sensing elements are connected with data processing device by wires, and the sealed elastic body(21, 22) is installed on the mattress. The invention improves the comfort degree and sensibility.

The invention belongs to the technical field of biological detection and relates to an African swine fever polymerase chain reaction (PCR) detection method and an oligonucleotide primer pair. The method comprises the following steps: designing a pair of specific primers by referring to a complete genome sequence of 23 ASFVP72 protein strains recorded in GenBank, exploring the optimal reaction system and reaction conditions according to the designed primers, performing sensitivity test, specificity test and reproducibility test on the established PCR reaction method, and performing PCR method detection on clinical samples of sows suffered from reproductive disturbance or piglets with respiratory disturbance symptoms and aborted fetuses from 14 pig farms. The test results prove that the established PCR method can sensitively and rapidly detect the African swine fever virus. The PCR detection method established in the research has high applicability and can be used for detecting the African swine fever disease.

The invention relates to a double coptis for injection as a veterinary herbal medicine compound preparation and a preparation technique as well as an application thereof. The compound preparation is made from the following parts of medicines by weight: 1250 portions to 3750 portions of honeysuckle, 1250 portions to 3750 portions of scutellaria and 2500 portions to 7500 portions of forsythia. Sustained release accessories contain 200 portions of hydroxypropyl methylcellulose and 100 portions of sodium carboxymethylcellulose. The containing of sustained release accessories can reduce injection times for large animals and the stress response of large animals. The veterinary herbal injection preparation has the functions of antiviral, antibacterial, anti-inflammatory and antipyretic analgesic effects, as well as improving immunity and the like, and can be applied to epidemic diarrhea, transmissible gastroenteritis, swine paratyphoid, septicemia caused by various diseases, cough, dyspnea, skin cyanosis, arthrocele, lameness, swine reproduction and respiratory disturbance syndrome and cow mastitis caused by streptococcosis, haemophilus parasuis infection, contagious pleuropneumonia, swine lung plague in veterinarian clinical practice.

An approach to providing disordered breathing therapy includes providing cardiac overdrive pacing using rate regularization. Overdrive pacing therapy may be initiated following detection or prediction of disordered breathing. Characteristics of the disordered breathing or other patient conditions may be used to modify the pacing therapy.

The invention provides anintelligent abdominal breathing physical therapy training instrument. The instrument can assist abdominal breathing practice of patients with a respiratory disorder and a congenital respiratory disease through the arrangement of a breathing assisting device and a suction cup so that the patientswith the respiratory disorder and congenital respiratory diseasecan perform deep abdominal breathing to help the patients breathe deeply, which is beneficial to the prevention and treatment of lung and respiratory diseases. Moreover, the instrument is conveniently worn by a userto perform the abdominal breathing practice anytime and anywhere, has an intelligent control system and an intelligent interactive display device to provide reasonable guidance for the user to use, is suitable for respiratory function training programs of the useraccording to an actual situation, achieves the intelligent and efficient respiratory physical therapy training effect, monitors the accuracy of the abdominal breathing practice during the use of the user by setting an abdominal breathing detection device in the chest position of a human body, and avoids the invalid abdominal breathing practice.

The present invention relates to a new Chinese Tibetan medicine-chongcao qingfei capsule with the functions of moistening lung, supplementing qi, relieving cough and asthma for curing pulmonary diseases of acute and chronic bronchitis, pulmonary emphysema, pneumoconiosis, tabacosis pulmonum and pneumosilicosis, etc. Said new type Chinese Tibetan medicine is made up by using 100 traditional Chinese Tibetan medicinal materials of stemona root, bletilla tuber, oyster shell and others through a certain preparation process.

A therapy system adapted to treat a patient's ventilatory instability using a ventilatory therapy, a gas modulation therapy, or both. The algorithm implemented by the therapy system monitors the ventilatory instability, such as Cheyne Stokes Respiration (CSR), mixed apneas, CPAP emergent apneas, and complex sleep disordered breathing (CSDB) and treats the ventilatory instability. The algorithm also determine a reference point with respect to the ventilatory instability. The therapy delivery system initiate the treatment based on the reference point.

The invention discloses a sleep respiratory disorder treatment system. The system comprises a physiological signal acquisition unit, a physiological signal processing unit, an electrical stimulation parameter control unit, an electrical stimulation unit and a treatment effect statistics and display unit, wherein the units are connected wirelessly or wiredly; electric stimulation parameters are automatically adjusted according to individual physiological signal feedback of each user. According to the system, sleep apnea, hypopnea and snoring symptoms can be effectively eliminated or relieved through percutaneous current stimulation under the condition that the sleep state of the users is not disturbed; an accurate medical effect is obtained; the use compliance of patients is improved.

An ambulatory assist ventilation (AAV) apparatus and system are disclosed for the delivery of a respiratory gas to assist the spontaneous breathing effort of a patient with a breathing disorder. The AAV system includes a compressed respiratory gas source, a respiratory assist device for controlling respiratory gas flow to the patient, a patient circuit tubing and a low profile nasal interface device, which does not have a dead space or hollow area where CO2 can collect, for delivering the respiratory gas to the patient, wherein the nasal interface device is fluidly connected to the respiratory assist device via tubing for receiving the respiratory gas therefrom. In some cases, the nasal interface device may be used in combination with other gas sources, such as oxygen concentrators, to provide dual therapy capability suitable for some applications.

The invention provides enantiopure deuterium-enriched pioglitazone, pharmaceutical compositions, and methods of treating neurological disorders, cancer, respiratory disorders, metabolic disorders, and other disorders using enantiopure deuterium-enriched pioglitazone. A preferred aspect of the invention provides methods of treating Alzheimer's disease, non-small cell lung cancer, hepatocellular carcinoma, and chronic obstructive pulmonary disease using enantiopure deuterium-enriched pioglitazone.