Provided are a ventilation control device and breathing mask equipment with the same. The ventilation control device comprises a cavity, a valve assembly and a heat and moisture exchanger; the cavity is provided with a delivery port, the valve assembly is arranged at the delivery port, for the structure of the valve assembly, when expiration is conducted, the pressure in the cavity is kept larger than the atmospheric pressure, a mask vent which is communicated with the delivery port is formed in the heat and moisture exchanger or the cavity, the mask vent is used for being communicated with a breathing mask, and the heat and moisture exchanger is communicated with the delivery port, so that exhaling and inhaling are both conducted through the heat and moisture exchanger. By means of the ventilation control device, the positive pressure function of the expiratory phase is achieved, and the discomfort caused by continuous positive pressure to a patient is avoided; the ventilation control device does not need to be connected with a positive pressure gas supply device, a pipeline and the like in use, and the patient can move conveniently; when the patient goes out, the patent does not need to carry the positive pressure gas supply device. In addition, the ventilation control device is small in size, convenient to carry and low in cost.