4results about How to "Inhibit transfer" patented technology

This invention discloses the application of a branched-chain amino acid (BCAA) restricted diet in the preparation of drugs for treating liver metastases of tumors. Through mouse model experiments, this invention found that restricting the intake of BCAAs (valine, isoleucine, and leucine) in the diet, or using the SCD1 inhibitor A939572, can significantly inhibit liver metastases of tumors, especially pancreatic cancer liver metastases. Experimental results show that a BCAA restricted diet or SCD1 inhibitor can reduce the number and volume of liver metastases and inhibit their growth. This invention also reveals its mechanism of action: BCAA restriction reduces the propionylation modification of SREBP1, downregulates the transcriptional expression of its target gene SCD1, and thus reduces lipid synthesis, thereby exerting an anti-tumor liver metastasis effect. This invention provides a novel dietary intervention strategy and drug target for the treatment of liver metastases of tumors.

This invention discloses carbon nanodots, their preparation method, and their applications, relating to the field of carbon nanomaterials technology. The carbon nanodots are prepared by solvothermal treatment of nicotinamide, urea, and citric acid or its derivatives. The citric acid derivative is selected from citrate, citric acid hydrate, or citrate hydrate. This invention synthesizes carbon nanodots using nicotinamide as a precursor under solvothermal treatment, simultaneously integrating intrinsic bioactivity, efficient photothermal conversion capability, and red fluorescence imaging function. This multifunctional synergistic therapy overcomes the limitations of single-therapy approaches. Furthermore, the carbon nanodots provided by this invention exhibit extremely high biocompatibility.

This invention discloses the preparation and application of radiofrequency thermoresponsive platinum ion crosslinked black phosphorus nanogel. The nanogel has a core-shell structure, comprising a core composed of a radiofrequency thermosensitive agent and chemotherapeutic drugs, and a shell constructed from a thermosensitive nanopolymer. The thermosensitive nanogel BP-Pt@PNA prepared using the above components exhibits radiofrequency thermosensitive properties. Simultaneously, the introduction of the thermosensitive nanopolymer improves the stability of the radiofrequency thermosensitive agent and chemotherapeutic drugs, enabling long-term drug retention and fully leveraging the synergistic effect of non-invasive radiofrequency thermotherapy and chemotherapy. This drug-loaded nanogel can achieve multimodal treatment applications, including non-invasive radiofrequency thermotherapy-chemotherapy synergistic antitumor therapy and invasive radiofrequency ablation-chemotherapy-vascular embolization synergistic antitumor therapy, demonstrating significant clinical translational potential.

This invention belongs to the field of photocatalysis and discloses a hollow Cu 2‑x S@CuCo2S4 core-shell structured materials, their preparation methods, and applications. The above-mentioned hollow Cu... 2‑x S@CuCo2S4 core-shell structure material includes hollow Cu 2‑x S, and through hydrothermal reaction in hollow Cu 2‑x In-situ grown nanoflower CuCo2S4 layers on S. The preparation method includes: ultrasonically dispersing Cu2O in water, then adding Na2S·9H2O, and reacting to obtain Cu2O@Cu. 2‑x S; Cu2O@Cu 2‑x S acid etching yields hollow Cu 2‑x S; hollow Cu 2‑x S is dispersed in water, and cobalt chloride, copper chloride, thiourea, and ethylene glycol are added. After a hydrothermal reaction, hollow Cu is obtained. 2‑ x S@CuCo2S4 core-shell structured material. This core-shell material, when used as a photocatalyst in photocatalytic water splitting for hydrogen production, exhibits high hydrogen production capacity and good cycle stability.