25results about How to "Inhibit transfer" patented technology

The application provides a preparation method of a diphenylfluorene polyether. The method uses diphenylfluorene as a substrate, butylene oxide as an epoxide monomer, toluene as an organic solvent, and under the action of a composite catalyst, reacts at 110-200 DEG C for 2-6 hours to obtain the diphenylfluorene polyether. The composite catalyst is obtained by reacting a porous aromatic skeleton with a bromoalkyl quaternary ammonium salt to obtain a quaternary ammonium salt functionalized porous aromatic skeleton, and finally, a basic catalyst is limitedly encapsulated in the pore channel of the quaternary ammonium salt functionalized porous aromatic skeleton by electrostatic attraction. The catalyst of the method can be recycled and reused, and the yield retention rate is greater than or equal to 92% after the composite catalyst is used for 5 cycles, and the method is suitable for optical display, high-frequency circuit board, semiconductor packaging and other fields.

The present disclosure relates to a pharmaceutical composition for preventing or treating triple-negative breast cancer, comprising an oligonucleotide as an active ingredient.

This invention discloses the application of a branched-chain amino acid (BCAA) restricted diet in the preparation of drugs for treating liver metastases of tumors. Through mouse model experiments, this invention found that restricting the intake of BCAAs (valine, isoleucine, and leucine) in the diet, or using the SCD1 inhibitor A939572, can significantly inhibit liver metastases of tumors, especially pancreatic cancer liver metastases. Experimental results show that a BCAA restricted diet or SCD1 inhibitor can reduce the number and volume of liver metastases and inhibit their growth. This invention also reveals its mechanism of action: BCAA restriction reduces the propionylation modification of SREBP1, downregulates the transcriptional expression of its target gene SCD1, and thus reduces lipid synthesis, thereby exerting an anti-tumor liver metastasis effect. This invention provides a novel dietary intervention strategy and drug target for the treatment of liver metastases of tumors.

The application discloses a method for preparing polyethylene wax by using a carborane bridged rare earth metallocene catalyst, and simultaneously preparing a carborane bridged indenyl rare earth metallocene compound as a main catalyst, loading the prepared main catalyst and a cocatalyst on a magnetic mesoporous Fe3O4@Al2O3 core-shell nanoparticle carrier to obtain a supported rare earth metallocene catalyst; the main catalyst of the application is a carborane bridged indenyl rare earth metallocene compound with a structure shown in formula (I), wherein a bridging group adopts a closed carborane (closed-1,2-dicarbadodecaborane), and the cage-like three-dimensional structure has super-high thermal stability and chemical inertness and does not degrade or rearrange in a high-temperature molten state of 130-200 DEG C. Large-volume substituents such as methyl, tert-butyl, phenyl or 4-tert-butylphenyl are introduced on the indene ring to provide sufficient steric protection and further inhibit chain transfer and side reactions at high temperatures.

The application provides a polypeptide for specifically blocking the combination of ACVR1C and Grem1 and application thereof, and belongs to the technical field of biological medicine. The application finds a new combination of receptors of Grem1 and ACVR1C, and determines the combination sites of the two; then according to the details of the combination of Grem1 and ACVR1C, a specific blocking small molecule polypeptide (ACVR1C peptide) is designed. The small molecule polypeptide can interfere with or block the combination of Grem1 and ACVR1C in an in-vitro experiment; in an in-vivo treatment experiment, the liver metastasis of colon cancer of the treatment group mice is obviously lower than that of the control group, which indicates that the small molecule polypeptide reaches the target of blocking the liver metastasis of colon cancer by interfering with or blocking the combination of Grem1 and ACVR1C, and provides a new drug design and treatment target for relieving the liver metastasis of colon cancer.

This invention discloses carbon nanodots, their preparation method, and their applications, relating to the field of carbon nanomaterials technology. The carbon nanodots are prepared by solvothermal treatment of nicotinamide, urea, and citric acid or its derivatives. The citric acid derivative is selected from citrate, citric acid hydrate, or citrate hydrate. This invention synthesizes carbon nanodots using nicotinamide as a precursor under solvothermal treatment, simultaneously integrating intrinsic bioactivity, efficient photothermal conversion capability, and red fluorescence imaging function. This multifunctional synergistic therapy overcomes the limitations of single-therapy approaches. Furthermore, the carbon nanodots provided by this invention exhibit extremely high biocompatibility.

The invention relates to an application of osimertinib combined with chidamide in treatment of osimertinib drug-resistant lung cancer, and particularly relates to the following aspects: (1) osimertinib is an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), and shows a remarkable curative effect in treatment of non-small cell lung cancer (NSCLC) patients carrying specific EGFR mutation; (2) chidamide is a novel oral HDACi, can induce cell apoptosis, cell cycle arrest and cell growth inhibition, and shows good tolerance and antitumor activity in various cancer types; and (3) chidamide is taken as an epigenetic regulating agent and can be in synergistic effect with osimertinib, so that the capability of killing lung cancer cells is enhanced. The invention belongs to the technical field of medicines, and particularly provides application of osimertinib combined with chidamide in treatment of osimertinib drug-resistant lung cancer.

The present application relates to the application of cereal bran oligopeptide in the preparation of drugs and / or products for preventing and / or treating colorectal cancer metastasis, and belongs to the technical field of medical uses. The amino acid sequence of the cereal bran oligopeptide is shown in SEQ ID NO. 1 or SEQ ID NO. 2. The cereal bran oligopeptide can target and antagonize the activation of integrin alpha v beta 6 and alpha v beta 3 subtypes, effectively block the metastasis of colorectal cancer to distant organs such as liver and lung, significantly weaken the adhesion and invasion ability of colorectal adenocarcinoma cells, reduce the number of organ metastatic nodules, reduce the weight of organs, significantly improve the pathological damage of organ tissues, and has the advantages of high safety, small side effects, good biocompatibility, easy absorption and the like.

The invention belongs to the field of tumor molecular biology, and particularly relates to application of FBXO44 protein as a target in screening of products for diagnosis, treatment and prognosis of gastric cancer, and the amino acid sequence of the FBXO44 protein is shown as SEQ ID NO.2. The expression level of the FBXO44 protein is detected according to pathology and is used as a basis for judging disease progression, prognosis and survival of gastric cancer patients. The invention further provides application of down-regulation of the FBXO44 protein level in preparation of drugs for treating gastric cancer, down-regulation of the FBXO44 can effectively inhibit growth and metastasis of gastric tumors, a new scheme is provided for disease diagnosis and drug development of gastric cancer, and the current situations that the number of targeted therapeutic targets for gastric cancer is small, and available effective drugs are small are solved to a certain extent clinically. The invention provides a new scheme and strategy for the treatment of gastric cancer, and provides possibilities for preparing new targeted drugs and improving the survival and prognosis of patients.

The invention relates to the technical field of biomedical materials, in particular to radio frequency responsive polyion liquid as well as a preparation method and application thereof. The radio frequency responsive polyion liquid comprises a temperature-sensitive block formed by polymerization of N-isopropylacrylamide and a functional block formed by polymerization of a monomer as shown in a formula I; formula I: [cation] X, the cation being selected from the group consisting of 1-vinyl-3-ethylimidazolium, 1-vinyl-3-butylimidazolium, 1-vinyl-3-hexylimidazolium, benzyl ethyl trimethyl ammonium, or methacryloyloxyethyl trimethyl ammonium; x is a halide ion; and in the block copolymer, anions combined with cations in the functional block are combretastatin phosphate ions. Through the innovative design of the block copolymer, temperature sensitivity, radio frequency responsiveness and treatment activity are integrated, and a multifunctional integrated intelligent material platform is successfully constructed.

The invention relates to the technical field of antibody coupling drugs. The invention provides a TM4SF20-targeted antibody coupling medicine as well as a preparation method and application thereof. An antibody comprises VLCDR1, VLCDR2 and VLCDR3 of which the amino acid sequences are shown as SEQ ID NO: 1-3, and VHCDR1, VHCDR2 and VHCDR3 of which the amino acid sequences are shown as SEQ ID NO: 4-6. In-vivo and in-vitro experiments and clinical samples prove that the gene has high specific expression in pancreatic cancer and is related to poor prognosis of pancreatic cancer; a neutralizing antibody alpha-TM4SF20 is designed for a TM4SF20 target spot, and it is verified through a cell internalization experiment that alpha-TM4SF20 can be internalized into cells very well; alpha-TM4SF20 and Dxd are coupled to form an ADC drug, and the effectiveness and safety of the ADC drug are proved through in-vivo and in-vitro experiments.

The invention discloses an ROS responsive antibody nano-drug conjugate as well as a preparation method and application thereof, and belongs to the field of biological medicines. The conjugate comprises a nano-drug carrier, a TIM-3 blocking antibody and a VISTA blocking antibody, wherein the nano-drug carrier is encapsulated with a first chemotherapeutic drug and a second chemotherapeutic drug which can be subjected to cascade reaction, and the TIM-3 blocking antibody and the VISTA blocking antibody are covalently connected to the surface of the carrier through ROS responsive linkers. After reaching a tumor site, the conjugate can respond to a high-level ROS release antibody of a tumor microenvironment, synchronously block TIM-3 and VISTA immune checkpoints, and relieve immunosuppression; the carried chemotherapeutic drug is subjected to cascade reaction in tumor cells to induce immunogenic death and release tumor antigens and danger signals. Tumor cascade killing and antibody effective blocking synergism can effectively remodel an immunosuppression microenvironment, activate and enhance anti-tumor immune response, and realize efficient tumor killing. The conjugate has the advantages of precise targeting, synergistic interaction and good biological safety, and provides a new strategy for tumor immunotherapy.

The application discloses application of paris polyphylla extract in inhibition of melanin transfer and cosmetics, and belongs to the technical field of cosmetics. The paris polyphylla extract contains β-ecdysterone, and the β-ecdysterone can inhibit melanin transfer, thereby achieving a whitening effect. The cosmetics containing the paris polyphylla extract have good whitening effect.

The invention discloses an acetyltransferase ARD1 inhibitor D753-0266 and application of the acetyltransferase ARD1 inhibitor D753-0266 in colorectal cancer treatment, and relates to the technical field of biological medicines. Through molecular dynamics simulation and binding energy calculation, it is found that the binding energy of D753-0266 and NAA10 can reach-68.12 kcal / mol. In-vitro experiments show that D753-0266 can be directly combined with and stabilize ARD1 protein, down-regulate the expression level of the ARD1 protein, inhibit colorectal cancer cell proliferation in a dose-dependent manner, and remarkably inhibit cell migration and clone formation capability at the same time. In-vivo experiments show that the D753-0266 can effectively inhibit tumor growth in a mouse transplantation tumor model and has good tolerance. The inhibitor fills up the research blank in the field of targeting ARD1, can be used for preparing colorectal cancer treatment drugs, and has high specificity and clinical transformation potential.

This invention discloses the preparation and application of radiofrequency thermoresponsive platinum ion crosslinked black phosphorus nanogel. The nanogel has a core-shell structure, comprising a core composed of a radiofrequency thermosensitive agent and chemotherapeutic drugs, and a shell constructed from a thermosensitive nanopolymer. The thermosensitive nanogel BP-Pt@PNA prepared using the above components exhibits radiofrequency thermosensitive properties. Simultaneously, the introduction of the thermosensitive nanopolymer improves the stability of the radiofrequency thermosensitive agent and chemotherapeutic drugs, enabling long-term drug retention and fully leveraging the synergistic effect of non-invasive radiofrequency thermotherapy and chemotherapy. This drug-loaded nanogel can achieve multimodal treatment applications, including non-invasive radiofrequency thermotherapy-chemotherapy synergistic antitumor therapy and invasive radiofrequency ablation-chemotherapy-vascular embolization synergistic antitumor therapy, demonstrating significant clinical translational potential.

A continuously variable differential gear comprising: a pair of rotating bevel gears engaged with one another via a pinion gear, each of the bevel gears including a first operating surface; an actuator, opposing ends thereof having a pair of interconnected fluid reservoirs, the actuator comprising a pair of secondary operating surfaces; the pair of rotating gears and the pinion gear being housed within the actuator such that the first operating surfaces of the bevel gears and the secondary operating surfaces of the actuator are cooperatively engaged, wherein relative rotation between the pair of bevel gears imparts a linear motion to the actuator thereby varying the pressure between the pair of interconnected fluid reservoirs to resist the linear motion of the actuator and thereby variably dampen relative motion of the bevel gears to each other.

The application belongs to the technical field of water treatment agents, and particularly relates to a multifunctional composite water purifying agent and a preparation method thereof, which comprises the following raw materials in parts by weight: multifunctional water purifying powder 90-100 parts, bentonite 8-10 parts, sodium carboxymethyl cellulose 0.5-1.5 parts, sodium percarbonate 0.5-1 part and sodium citrate 0.5-1 part; the multifunctional water purifying powder comprises core layer material and shell layer slurry; the multifunctional water purifying agent of the application takes the multifunctional water purifying powder with a core-shell structure as a core, cooperates with bentonite, sodium carboxymethyl cellulose, sodium percarbonate and sodium citrate, realizes efficient and synchronous removal of heavy metals, organic matters, colority and microorganisms, and has the advantages of wide spectrum, stability and easy recovery.

This invention belongs to the field of photocatalysis and discloses a hollow Cu 2‑x S@CuCo2S4 core-shell structured materials, their preparation methods, and applications. The above-mentioned hollow Cu... 2‑x S@CuCo2S4 core-shell structure material includes hollow Cu 2‑x S, and through hydrothermal reaction in hollow Cu 2‑x In-situ grown nanoflower CuCo2S4 layers on S. The preparation method includes: ultrasonically dispersing Cu2O in water, then adding Na2S·9H2O, and reacting to obtain Cu2O@Cu. 2‑x S; Cu2O@Cu 2‑x S acid etching yields hollow Cu 2‑x S; hollow Cu 2‑x S is dispersed in water, and cobalt chloride, copper chloride, thiourea, and ethylene glycol are added. After a hydrothermal reaction, hollow Cu is obtained. 2‑ x S@CuCo2S4 core-shell structured material. This core-shell material, when used as a photocatalyst in photocatalytic water splitting for hydrogen production, exhibits high hydrogen production capacity and good cycle stability.

The application provides an inconel alloy plate and a surface control method thereof. The surface control method of the inconel alloy plate comprises the following steps: a thinning step, which comprises rolling the incoming material by at least two passes using a first work roll and rolling oil with a first kinematic viscosity, so as to obtain a thinned plate; in the rolling process, the rolling oil between the first work roll and the incoming material forms an oil film with a first thickness; a smoothing step, which comprises rolling the thinned plate by at least one pass using a second work roll and rolling oil with a second kinematic viscosity; in the rolling process, the rolling oil between the second work roll and the thinned plate forms an oil film with a second thickness; the oil film with the second thickness extrudes the surface of the thinned plate to form a plurality of oil pits, so as to obtain the inconel alloy plate. The oil pits obtained by extrusion of the oil film have a small planar area and a shallow depth, and the AOI defect detection rate in the subsequent precise metal mask manufacturing process can be reduced.

The invention belongs to the technical field of medicines, and discloses a liposome for resisting angiogenesis and down-regulating PD-L1 protein as well as a preparation method and application of the liposome. According to the invention, the active targeting liposome which is modified by NGR and is co-loaded with axitinib and siRNAPD-L1 is prepared by a film dispersion method and a lipid co-extrusion method. The method is simple in preparation process, low in cost, good in stability and high in repeatability. On one hand, Axi / siRNAPD-L1-coated NGR-Lipo inhibits tumor microangiogenesis, reshapes a tumor vascular system, normalizes tumor vessels, inhibits tumor metastasis and improves a tumor immunosuppression microenvironment; on the other hand, PD-L1 protein on the surfaces of tumor cells is silenced, tumor immune escape is relieved, and tumor immunotherapy is enhanced. The Axi / siRNAPD-L1 coated NGR-Lipo realizes an enhanced anti-tumor effect by combining an anti-angiogenesis therapy and an immune checkpoint blocking therapy. The preparation process of the liposome is simple and rapid, is easy for large-scale and industrial production, and also has a better development prospect in the aspect of clinical application transformation.

The present application relates to a kind of compound in the preparation for preventing or treating tumor drug purposes.The compound of the present application can significantly inhibit the growth of malignant tumor, metastasis, prolong survival time;The metastatic ability of high metastatic tumor is particularly remarkable;Drug resistance large cell induced by chemotherapy drug has significant killing effect, and has good market application prospect.

The utility model relates to the technical field of circuit board production equipment, and discloses crease-resistant pressing equipment which comprises a feeding mechanism, a pressing mechanism and a discharging mechanism. The feeding mechanism comprises at least one feeding assembly, each feeding assembly comprises two discharging rotating shafts, and the two discharging rotating shafts can enable two rolls of products to enter the pressing mechanism side by side in the mode that the two rolls of products are staggered by a certain distance in the width direction. The feeding mechanism further comprises a first protective film discharging shaft and a second protective film discharging shaft which are used for discharging protective films. Slitting mechanisms are arranged on belt conveying paths of protective films discharged by the first protective film discharging shaft and the second protective film discharging shaft correspondingly and used for slitting the protective films into multiple sections in the belt conveying direction, and the widths of the multiple sections are matched with the width of a product. According to the equipment, the wider protective film can be slit into a plurality of narrower sections through the slitting mechanism, so that wrinkles of the wider protective film due to uneven stress or heating are avoided, the wrinkles are prevented from being transferred to a product, and the yield of the product is improved.

The present application belongs to the technical field of targeted drug research and development, and particularly relates to a neutrophil-targeted delivery nanoparticle, a preparation method thereof and application thereof in postoperative treatment of tumors. The present application designs a neutrophil-targeted delivery nanoparticle which can target neutrophils in situ in blood, and can overcome the complicated neutrophil extraction, drug loading and reinfusion processes of non-in situ targeting. Meanwhile, the acute inflammatory environment of the postoperative site of tumors can recruit a large number of neutrophils to gather, which provides a strong guarantee for efficient targeted drug delivery. On this basis, the combined delivery of the chemotherapeutic drug doxorubicin and the STING agonist SR-717 can play a role in chemotherapy on one hand; on the other hand, the anti-tumor immune response activated by chemotherapy-induced ICD combined with the immune response activated by the STING agonist can effectively inhibit the postoperative recurrence and metastasis of tumors through the immunotherapy pathway.

This invention relates to a selenium-modified gold nanocomplex encapsulated in ginger exosomes, its preparation method, and its applications, belonging to the fields of biomedical technology and nanomedicine formulations. The complex is assembled from L-selenomethylselenocysteine-modified gold nanoparticles as the core and ginger exosomes as the shell. The preparation method includes: first, preparing selenium-modified gold nanoparticles via a one-step reduction method, then mixing and incubating them with ginger exosomes in a specific ratio to obtain the GE-Se-Au complex. This invention's complex directly inhibits tumor cell proliferation by downregulating the p-ERK / c-Myc pathway, while simultaneously inducing macrophage M1 polarization to remodel the immune microenvironment, achieving a synergistic effect between chemotherapy and immunotherapy. In vitro and in vivo experiments show that this complex has a significant inhibitory effect on drug-resistant non-small cell lung cancer, with extremely low toxicity to normal cells and major organs, demonstrating good biocompatibility. This invention features a simple preparation process and strong targeting, providing a new strategy for overcoming drug resistance in lung cancer clinically.

Disclosed are a battery module including a battery cell stack comprising a plurality of stacked pouch-shaped battery cells, a battery module housing configured to receive the battery cell stack, and a heat dissipation member coupled to a portion of the battery module housing, wherein the heat dissipation member has a through-hole formed in a heat dissipation plate disposed so as to face the battery cell stack and a sealing member is added to the through-hole, and a method of manufacturing the heat dissipation member. It is possible to effectively prevent thermal runaway of a battery cell that has caught fire while minimizing an increase in volume of the battery module.