65 results about "Indene" patented technology

Provided are a compound having a 2,3-dihydro-1H-indene or 2,3-dihydrobenzofuran moiety or pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same and a use thereof, where the compound having a 2,3-dihydro-1H-indene or 2,3-dihydrobenzofuran moiety or pharmaceutically acceptable salt thereof has an inhibitory activity against glucosylceramide synthase (GCS), and therefore can be usefully applied for preventing or treating various diseases associated with GCS, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Parkinson's disease, etc.

The application discloses a pinacine alkyl tetrahydrocarbazole fluorescent probe capable of detecting cell lysosome polarity and a preparation method and application thereof. 9-(3-(dimethylamino)propyl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-2,4-bridged methylene carbazole-6-formaldehyde is used as raw material, and condensation reaction is carried out with 1,3-indan dione to obtain compound 2-(2-(9-(3-(dimethylamino)propyl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-2,4-bridged methylene carbazole-6-yl)vinyl)-1-indene-1,3(2H)-dione (TC-AP-ID), and the probe can specifically detect the polarity of cell lysosomes. In a mixed system of 1,4-dioxane and water, with the increase of the polarity of the system, the fluorescence color of the probe gradually changes from orange to red, and the fluorescence intensity significantly decreases. The probe has the advantages of simple synthesis, good selectivity, high sensitivity, good biocompatibility, low toxicity and the like, can be applied to targeted detection of the polarity of cell lysosomes, and has a good application prospect.

The invention provides an asymmetric synthesis method of (R)-5-halo-2, 3-dihydro-1H-indene-2-carboxylic acid, and belongs to the technical field of medicine and organic synthesis.

The invention provides a tetravinyl benzyl indene derivative, a preparation method of the tetravinyl benzyl indene derivative, tetravinyl benzyl indene derivative thermosetting hydrocarbon resin and application of the tetravinyl benzyl indene derivative thermosetting hydrocarbon resin, and relates to the technical field of thermosetting resin. The tetravinyl benzyl indene derivative provided by the invention contains four vinyl groups, the crosslinking density of the thermosetting hydrocarbon resin is high, the dielectric loss tangent and dielectric constant of the tetravinyl benzyl indene derivative thermosetting hydrocarbon resin are remarkably reduced, and the heat resistance of the tetravinyl benzyl indene derivative thermosetting hydrocarbon resin is remarkably improved. Compared with trivinyl benzyl indene hydrocarbon resin and 1, 2-bis (4-vinylphenyl) ethane hydrocarbon resin, the tetravinyl benzyl indene derivative thermosetting hydrocarbon resin provided by the invention has the advantages of lower dielectric loss tangent, higher glass transition temperature, higher thermal stability, higher thermal stability and higher thermal stability. The method has a good application prospect in preparation of high-frequency and high-speed resin, bonding sheets, metal foil-coated plates, insulating substrates, resin-coated metal foils, insulating films, circuit substrates or electronic devices.

The invention relates to the technical field of structural adhesives, in particular to an epoxy composition capable of being used for bonding a camera module support and a preparation method of the epoxy composition, and the epoxy composition comprises the following components in parts by weight: 7-10 parts of epoxy resin; 20-25 parts of flexible epoxy resin; 5-10 parts of a core-shell epoxy resin toughening agent; 20-25 parts of a compound filler; 30 to 31 parts of organic hydrazide; and 8-9 parts of a modified amine adduct. The flexible epoxy resin has at least one structural characteristic of a long-chain polyether structure and an indene structure. The compound filler comprises calcium carbonate and silicon dioxide. The epoxy composition capable of being used for bonding the camera module support has the advantages of low precipitation, low curing shrinkage, high bonding strength, low modulus and excellent falling resistance, the reliability of the camera module support structure can be remarkably improved, and the epoxy composition is suitable for application environments of various miniature high-performance camera modules.

The application relates to a rubber ring for sealing a pump truck piston and a preparation method thereof, and belongs to the technical field of rubber sealing rings. The rubber ring is divided into an inner ring and an outer ring, the outer ring wraps the inner ring, and the preparation raw materials of the outer ring include 62-75 parts of polyurethane particles, 5-10 parts of natural rubber, 2-5 parts of coumarone-indene resin, 7-9 parts of naphthenic oil and 4-12 parts of graphite; the preparation raw materials of the inner ring include 86-95 parts of polyurethane particles, 1-3 parts of tetrafluoroethylene powder and 5-10 parts of elastic microspheres. The rubber ring prepared by adopting the double-layer functional partition design of the outer ring wrapping the inner ring has good support and high-elasticity sealing performance. The inner ring adopts polyurethane+ tetrafluoroethylene powder+ elastic microspheres as a core support layer, relies on the high strength and high tear resistance of polyurethane itself; the outer ring adopts polyurethane+ natural rubber+ graphite-naphthenic oil paste+ coumarone-indene resin as a functional action layer, can be closely attached to a sealing surface and reduce gaps.

The application discloses a method for preparing polyethylene wax by using a carborane bridged rare earth metallocene catalyst, and simultaneously preparing a carborane bridged indenyl rare earth metallocene compound as a main catalyst, loading the prepared main catalyst and a cocatalyst on a magnetic mesoporous Fe3O4@Al2O3 core-shell nanoparticle carrier to obtain a supported rare earth metallocene catalyst; the main catalyst of the application is a carborane bridged indenyl rare earth metallocene compound with a structure shown in formula (I), wherein a bridging group adopts a closed carborane (closed-1,2-dicarbadodecaborane), and the cage-like three-dimensional structure has super-high thermal stability and chemical inertness and does not degrade or rearrange in a high-temperature molten state of 130-200 DEG C. Large-volume substituents such as methyl, tert-butyl, phenyl or 4-tert-butylphenyl are introduced on the indene ring to provide sufficient steric protection and further inhibit chain transfer and side reactions at high temperatures.

The invention provides a newly developed, inexpensive, and bench-stable Cobalt (II)-complexes encompassing phosphine-free N,N-bidentate ligand system. Particularly, the present invention utilizes Co(II)-complexes as catalyzing system for the sole purpose of studying the C-alkylation reaction through borrowing hydrogen strategy. The present invention also provides a catalytic methodology for selective alkylation, alkenylation of fluorene, and inactivated bulky indene utilizing alcohol under mild and benign conditions. In the present invention, fluorene and indene are alkylated using a range of substrates as an alkylating agent, such as primary and secondary aromatic, heteroaromatic, and aliphatic alcohols. The present invention indicates a sophisticated catalytic process with yields that range from high to exceptional yields and excellent regioselectivity of the C3-alkylated indenes.

The invention discloses a composite film-forming agent as well as a preparation method and application thereof, and aims to provide a composite film-forming agent which can remarkably improve the fitting degree and tensile property of base makeup on the skin surface, enhance the glossiness of the makeup surface, improve the hydration degree of the skin, strengthen the moisturizing effect and form a layer of oleophylic makeup-holding film and a moisturizing film with enhanced hydrophilic capacity. Therefore, a dual film forming effect is achieved; according to the technical scheme, the cleaning agent comprises 4-14% of isododecane; the invention relates to a silicone sealant which is prepared from the following components in percentage by weight: 5 to 40 percent of trimethylsiloxane silicate, 5 to 40 percent of hydrogenated (styrene / methyl styrene) indene copolymer, 30 to 40 percent of cyclopentasiloxane (and) PEG / PPG-18 / 18 polydimethylsiloxane, 0 to 12 percent of polyvinyl pyrrolidone, 0 to 1 percent of polyquaternium-51 solution and 10 percent of water, wherein the sum of the components is 100 percent. The invention belongs to the technical field of cosmetics.

Rubber composition for tires, the rubber composition comprising: 100 parts by mass of a diene rubber containing a styrene-butadiene copolymer rubber having a styrene content of 30% by mass or more; 50 to 200 parts by mass of carbon black having a nitrogen adsorption surface area N2SA of 100 to 500 m2 / g and N2SA / IA, which is a ratio of the nitrogen adsorption surface area N2SA (unit: m2 / g) to an iodine adsorption number IA (unit: mg / g), of 0.90 to 1.03; 5 to 50 parts by mass of a styrolated phenol compound represented by the structural formula (1); and 20 to 90 parts by mass of a sticky resin; wherein a mixed quantity of the styrofoamed phenol compound represents 15% by mass or more based on a quantity of the sticky resin: wherein n is 2 or 3;wherein the sticky resin is one or more types selected from the group consisting of a C9 petroleum resin, a phenolic resin, a coumaron indene resin, a terpene resin, a styrene resin, an acrylic resin, a rosin resin and a dicyclopentadiene resin.

This invention provides a method for preparing phenyl-substituted 2-methyl-1H-indene derivatives via Stille coupling reaction, comprising: reacting brominated 2-methyl-1H-indene, trialkylphenyltin, palladium catalyst, and additives in an organic solvent; and after post-treatment following reaction to obtain the phenyl-substituted 2-methyl-1H-indene derivatives; wherein the trialkylphenyltin is at least one of trimethylphenyltin and tributylphenyltin; the palladium catalyst is at least one of Pd(PPh3)4, Pd2(dba)3, and Pd(dba)2; the additive is at least one of lithium chloride, cesium fluoride, and potassium fluoride; and the organic solvent is at least one of DMF, 1,4-dioxane, and NMP. This invention uses brominated 2-methyl-1H-indene and trialkylphenyltin as raw materials, and prepares the target product by reaction in an organic solvent in the presence of a palladium catalyst and additives. It exhibits good substrate adaptability and is simple to operate.

Provided is a curable resin material which contains: a resin (A) containing an indene ring, a vinylbenzyl group, and an arylalkyl group other than the vinylbenzyl group; and a phosphorus atom-containing compound (B).

Disclosed herein is a PET tracer compound (S)-1-(2-(6-[18F]fluoropyridin-3-yl)-4-(trifluoromethyl)phenyl)-N-(pyrimidin-2-yl)-2,3-dihydro-1H-indene-5-sulfonamide and salts thereof, and uses of the same as imaging agents. Also disclosed are precursor compounds, such as (S)-1-(2-(6-nitropyridin-3-yl)-4-(trifluoromethyl)phenyl)-N-(pyrimidin-2-yl)-2,3-dihydro-1H-indene-5-sulfonamide, and salts thereof. Also disclosed are kits comprising the same.

This invention discloses a method for preparing sulindac. The method involves first performing an Arbuzov reaction and a Wittig-Horner reaction sequentially to obtain 6-fluoro-3-(p-methylthiobenzyl)-2-methyl-1H-indene. 6-fluoro-3-(p-methylthiobenzyl)-2-methyl-1H-indene undergoes a condensation dehydration reaction with glyoxylic acid, followed by double bond rearrangement under acidic conditions to obtain (Z)-5-fluoro-2-methyl-1-(p-methylthiobenzyl)-1H-indene-3-acetic acid. Finally, it undergoes a single oxidation reaction with an oxidant to obtain sulindac. The raw materials and excipients used in this invention are readily available, and the entire reaction route is short, the reaction conditions are mild, the operation is safe and simple, the yield is high, the purity is high, the production cost is low, and the emissions of waste are minimal, conforming to green industrial production standards. The total yield of the obtained sulindac product is over 75%, which is conducive to industrial production.

The application provides a non-fused electron acceptor material and a preparation method thereof, and a structural formula of the non-fused electron acceptor material is shown in general formula I; wherein, a core group comprises a benzotri furan unit, end groups comprise halogen-substituted 3-(dicyanomethylene) indene-1-ketone units, and a pi bridge between the end groups and the core group comprises an alkyl-substituted five-membered heterocyclic unit; (I); in formula I, X1 and X2 are each independently selected from fluorine, chlorine or bromine; Y is selected from oxygen, sulfur or selenium; R is selected from C2~C 400 A straight-chain or branched alkyl group. The material realizes conformational locking without an alkoxy substitution by utilizing an oxygen atom effect, stably maintains a low HOMO energy level while ensuring molecular planarity, and thus significantly improves compatibility with various donor materials.

The invention belongs to the technical field of zinc ion batteries, and particularly relates to a hexahydroxy truxene organic positive electrode material for an aqueous zinc ion battery, a preparation method and application. According to the method, 5, 6-dimethoxy indanone is taken as a raw material, p-toluenesulfonic acid is taken as a catalyst, ethylene glycol is taken as a cocatalyst, 2, 3, 7, 8, 12, 13-hexamethoxy truxene is efficiently synthesized through a water diversion reflux reaction, and then a target product 2, 3, 7, 8, 12, 13-hexahydroxy truxene is obtained through a boron tribromide demethylation reaction. According to the method, the defect that a traditional polyphosphate (PPE) catalyst synthesis process is tedious is overcome, meanwhile, the technical problem that a trimerization product cannot be prepared by replacing an acid catalyst is solved, and the prepared hexahydroxy truxene material is of a nanorod-shaped structure, has excellent cycling stability and high specific capacity when serving as an aqueous zinc ion battery positive electrode material and is suitable for being used as a water-based zinc ion battery positive electrode material. The material can adapt to high-rate charge and discharge, and the overall electrochemical performance is excellent.

This disclosure provides compounds, such as compounds of formula I, and their use in treating medical diseases or conditions such as cancer. This disclosure provides pharmaceutical compositions and methods for manufacturing various indene compounds. The compounds are considered to be modulators of Ras (e.g., K-Ras).

Disclosed herein are various cable gel seal arrangements and thermoplastic gels useful therein. The thermoplastic gels are prepared from a composition including a styrene triblock copolymer, a styrene diblock copolymer, an oil extender, and an additive selected from poly(2,6-dimethyl-1,4-phenylene oxide), a C9 resin, poly(alpha-methylstyrene), a coumarone-indene resin, and combinations thereof, wherein the additive has a Tg from about 95° C. to about 200° C. The thermoplastic gels advantageously exhibit low compression set.

Provided herein are an indene compound, e.g., a compound of Formula (I), and a pharmaceutical composition thereof. Also provided herein is a method of their use for treating, preventing, or ameliorating one or more symptoms of a fibrotic disease.

This invention discloses a dispironaphthyl-1,3'-indene-1',2"-pyrrolidone derivative, its synthetic method, and its applications, relating to the field of organic synthesis technology. Its structural formula is shown in Formula I. The series of dispironaphthyl-1,3'-indene-1',2"-pyrrolidone derivatives provided by this invention contain two quaternary carbon centers, exhibiting a novel structure. The naphthalene ring skeleton is connected to an indene ring, which in turn is connected to a pyrrolidone skeleton. The preparation method provided by this invention uses a simple starting compound, readily available raw materials, mild reaction conditions, simple operation, short preparation cycle, and high yield. It exhibits significant inhibitory effects on tumor cells and can be used to prepare antitumor drugs, laying the foundation for the synthesis and application of such chiral drug skeletons and providing new ideas.

The present invention relates to a method for synthesizing pterosin D using an ammonia-based reducing agent, and more specifically, to a method for synthesizing pterosin D by dissolving a 5-(2-hydroxyethyl)-2,2,4,6-tetramethyl-1H-indene-1,3(2H)-dione compound in an ether solvent and then adding an ammonia-based reducing agent thereto. In addition, the method for preparing pterosin D according to the present invention enables the production of pterosin D with high yield and excellent purity, and is suitable for mass production, thereby being useful for drug research and pharmaceutical production based on pterosin D.

The application discloses a novel near-infrared two-region aggregation-induced emission material, a preparation method and application thereof, and has the following general structure: wherein Ar is R1 and R2 are independently selected from -t-Bu, -OC6H 13 The application uses triphenylamine derivative structural units as electron donors of a molecular system, and uses 6,7-diphenyl-[1,2,5]thiadiazole[3,4-g]quinoxaline or indene ketone condensation [1,2,5]thiadiazole[3,4-g]quinoxaline structural units as electron acceptors to construct a novel photothermal material with near-infrared two-region aggregation-induced emission properties. The compound structure of the application is clear, the synthesis method is simple, and biological activity experiments show that the application has a good application prospect in fluorescence-photoacoustic-photothermal imaging guided photothermal-photodynamic synergistic tumor ablation treatment.

This invention provides an indene compound, such as the compound of formula (I), and a pharmaceutical composition thereof. This invention also provides a method for treating, preventing, or alleviating one or more symptoms of fibrosis using the indene compound and the pharmaceutical composition thereof.

The application discloses a preparation method of coal-based ancient malon resin-based high-softening-point pitch, which comprises the following steps: mixing ancient malon-indene resin and refined medium-temperature pitch, and then performing air oxidation to obtain coal-based ancient malon resin-based high-softening-point pitch with uniform components and a high coking value; when the coal-based ancient malon resin-based high-softening-point pitch is used for coating of a negative material of a lithium ion battery, the capacity of the lithium ion battery can be improved; when the coal-based ancient malon resin-based high-softening-point pitch is used as a refractory binder pitch, the strength and oxidation resistance of the refractory material can be improved.

The invention discloses a high-efficiency synthesis method of a 2-aryl-1-indanone compound, which comprises the following steps of: heating an indene compound serving as a raw material and m-chloroperoxybenzoic acid serving as an oxidant in an organic solvent to react, removing the solvent after the reaction is finished, and separating to obtain the 2-aryl-1-indanone compound. The reaction formula of the synthesis method is as follows: in the formula, R1 is selected from hydrogen atom, methyl, chlorine, trifluoromethyl or fluorine; r2 is selected from methyl, ethyl or n-butyl; and R3 is methyl, fluorine, chlorine or tertiary butyl. The oxidant used in the method is low in price, so that the reaction cost is reduced, and the post-treatment steps of the reaction are simplified. The synthesis reaction does not need inert gas protection atmosphere, the operation is simple and convenient, the reaction condition is mild, and the yield is up to 90%.

This invention relates to a method for preparing indene diazine compounds and oxadiazine insecticides, belonging to the field of pesticide technology. The structure of the indene diazine compound is shown in Formula II: where R is methyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, phenyl, or a substituted phenyl group. The indene diazine compound shown in Formula II is used to prepare the oxadiazine insecticide shown in Formula I. This invention avoids the use of high-risk materials such as phosgene, triphosgene, and sodium hydride. After multiple batch verifications, the overall reaction yield is stable and suitable for industrial production.

The present invention relates to a novel method for synthesizing pterosin D and, more specifically, to a method for preparing pterosin D by the steps of: dissolving a 5-(2-hydroxyethyl)-2,2,4,6-tetramethyl-1H-indene-1,3(2H)-dione compound in an ether solvent; adding thereto a boron-based reducing agent dissolved in water, thereby performing reduction; and performing extraction and crystallization therefrom.

The invention discloses a method for preparing indene by copper-catalyzed propargyl ether rearrangement reaction, which is characterized by comprising the following step: in the presence of a copper catalyst, a ligand and di-tert-butyl peroxide, in an organic solvent, heating a compound in a formula (1) and a compound in a formula (2) to react to generate an indene compound in a formula (3) or a formula (4). The invention discloses a method for preparing benzofuran by copper-catalyzed propargyl ether rearrangement reaction, which is characterized by comprising the following steps: in the presence of a copper catalyst and alkali, in an organic solvent, heating a compound in a formula (5) to react to generate a benzofuran compound in a formula (6). The preparation method provided by the invention has the advantages of cheap and easily available reaction raw materials, simple reaction operation, wide application range of reaction substrates, easy amplification of reaction, mild reaction conditions and the like, and can realize industrial production and application.

Provided are a compound having a 2,3-dihydro-1H-indene or 2,3-dihydrobenzofuran moiety or pharmaceutically acceptable salt thereof, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof, where the. The compound having a 2,3-dihydro-1H-indene or 2,3-dihydrobenzofuran moiety or pharmaceutically acceptable salt thereof has an inhibitory activity against glucosylceramide synthase (GCS), and therefore can be usefully applied for preventing or treating various diseases associated with GCS, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Parkinson's disease, etc.