174 results about "Indene" patented technology

The disclosure provides compounds, e.g., compounds of Formulae (I)-(III), and their use in treating medical diseases or disorders, such as cancer. Pharmaceutical compositions and methods of making various indene compounds are provided. The compounds are contemplated to be modulators of Ras (e.g., K-Ras).

Provided is an arylalkyl-modified indene composition comprising a plurality of compounds, each of the compounds having one or more arylalkyl groups on an indene ring and differing from the others in the number of arylalkyl groups in one molecule. The content of the compound or compounds having a single arylalkyl group in one molecule is 1% or less in the composition at the percentage calculated on the basis of the area ratio in a GPC chart. At least one of the arylalkyl groups present in the composition is an arylalkyl group having a polymerizable unsaturated bond-containing group, while at least one of the arylalkyl groups present in the composition is an arylalkyl group having no polymerizable unsaturated bond-containing group.

Provided is an arylalkyl-modified indene composition that contains a plurality of types of compounds having an arylalkyl group on an indene ring, the compounds having different numbers of arylalkyl groups in one molecule, wherein: the content of a compound in which the number of arylalkyl groups in one molecule is 1 is 1% or less as calculated from the area ratio of the GPC chart; at least one of the arylalkyl groups present in the composition has a polymerizable unsaturated bond-containing group; and at least one of the arylalkyl groups present in the composition does not have a polymerizable unsaturated bond-containing group.

This method for producing an aryl-alkylated indene composition involves: adding an arylalkyl group having a polymerizable unsaturated bond-containing group to an indene compound; and adding an arylalkyl group having no polymerizable unsaturated bond-containing group to the indene compound to which the arylalkyl group having a polymerizable unsaturated bond-containing group is added.

The invention relates to the technical field of metal corrosion protection. The invention provides a preparation method of an active self-repairing anticorrosive coating for a vibration sensor in a severe corrosion environment. The preparation method comprises the following steps: (1) preparing mesoporous silica nanoparticles; (2) preparing carboxyl cerium dioxide nanoparticles; (3) preparing an activated carboxyl cerium dioxide nanoparticle mixed solution; (4) preparing a triazindene-accelerant M solution; (5) preparing a mesoporous silica loaded carboxyl cerium dioxide nanoparticle coated indene and accelerant M filler; and (6) uniformly stirring the filler obtained in the step (5) with epoxy resin to obtain the active self-repairing anticorrosive paint. The invention further provides an active self-repairing anticorrosive coating for the vibration sensor in the severe corrosion environment and application of the active self-repairing anticorrosive coating. According to the anticorrosive paint prepared by the invention, the performances of high carrier loading capacity, strong corrosion inhibitor protection effect, high pH reaction rate and the like are improved, and the performance defects of a traditional self-repairing coating are made up.

The present invention relates to an indene derivative of formula D as specified in claim 1, to a liquid crystal medium comprising a compound of formula D and to high- frequency components comprising these media, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, tunable filters, tunable metamaterial structures, and electronic beam steering antennas, e.g. phased array antennas.

The invention discloses a preparation method of bio-based material modified coumarone resin, an obtained product and application. The preparation method comprises the following steps: mixing a mixture containing polymerizable components indene and coumarone, styrene or a derivative thereof and a catalyst; then dropwise adding a mixture containing polymerizable components indene and coumarone and an organic solvent solution of a bio-based material to carry out polymerization reaction; and adding a quenching agent after the reaction, and performing post-treatment to obtain a final product. According to the invention, a bio-based material is adopted as a raw material, and the raw material is derived from natural plants and has the characteristics of environmental friendliness, degradability and the like, so that the cyclic utilization of resources is realized, and the generation of wastes is reduced. The bio-based modified coumarone resin is high in hydroxyl content and narrow in molecular weight distribution, the compatibility of the coumarone resin and polar resin is improved, the use performance and the application range of the coumarone resin are improved, and the bio-based modified coumarone resin has good application prospects in the fields of adhesives, rubber, coatings, ink and the like, and is particularly suitable for tire tread rubber.

Provided are a compound having a 2,3-dihydro-1H-indene or 2,3-dihydrobenzofuran moiety or pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same and a use thereof, where the compound having a 2,3-dihydro-1H-indene or 2,3-dihydrobenzofuran moiety or pharmaceutically acceptable salt thereof has an inhibitory activity against glucosylceramide synthase (GCS), and therefore can be usefully applied for preventing or treating various diseases associated with GCS, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Parkinson's disease, etc.

The invention discloses a synthesis method of an indaziflam intermediate 2, 6-dimethyl-indene amine. In the invention, indanone is reduced by using a cheap reducing reagent to prepare indanol, the indanol and sulfonyl chloride are subjected to an elimination reaction to prepare indene, and finally, the indene and an amination reagent are subjected to addition to prepare the 2, 6-dimethyl-indene amine. The route is good in reaction selectivity and few in side reaction, and the total yield of the 2, 6-dimethyl-indene amine can reach 70% or above. The method is mild in reaction condition, easy to control, less in three wastes, simple in whole process operation and easy to industrialize.

W / O TYPE COMPOSITION COMPRISING INDENE RESIN The present invention relates to a composition, comprising: (a) a continuous fatty phase comprising (a-1) at least one oil, (a-2) at least one wax and (a-3) at least one indene resin; and (b) a plurality of dispersed aqueous phases comprising (b-1) water. The composition according to the present invention can provide a comfortable feeling, with limited transfer of the composition from a keratinous substance, on which the composition has been applied, to another substance which touches the composition on the keratinous substance. Figure for abstract: none

The application discloses a pinacine alkyl tetrahydrocarbazole fluorescent probe capable of detecting cell lysosome polarity and a preparation method and application thereof. 9-(3-(dimethylamino)propyl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-2,4-bridged methylene carbazole-6-formaldehyde is used as raw material, and condensation reaction is carried out with 1,3-indan dione to obtain compound 2-(2-(9-(3-(dimethylamino)propyl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-2,4-bridged methylene carbazole-6-yl)vinyl)-1-indene-1,3(2H)-dione (TC-AP-ID), and the probe can specifically detect the polarity of cell lysosomes. In a mixed system of 1,4-dioxane and water, with the increase of the polarity of the system, the fluorescence color of the probe gradually changes from orange to red, and the fluorescence intensity significantly decreases. The probe has the advantages of simple synthesis, good selectivity, high sensitivity, good biocompatibility, low toxicity and the like, can be applied to targeted detection of the polarity of cell lysosomes, and has a good application prospect.

The present invention provides a polymer composition comprising a polymer that comprises a unit (a) derived from alpha-methyl styrene-based monomers and a unit (b) derived from phenol-based monomers, wherein the content of an indene-based compound derived from two alpha-methyl styrene-based monomers is 5 wt % or less relative to the total weight of the polymer composition, and the content of an indene-based compound derived from three alpha-methyl styrene-based monomers is 0.1 wt % or less relative to the total weight of the polymer composition. A coating film manufactured from the coating composition comprising the polymer composition may have excellent bending resistance, impact resistance, and chemical resistance.

A Metal-containing film forming composition comprising a precursor having the formula: M(=NR1)(OR2)(OR3)mL. Wherein, M=V or Nb or Ta; R1-R3=independently H or C1-C10 alkyl group; L=Substituted or unsubstituted cyclopentadienes, cyclohexadienes, cycloheptadienes, cyclooctadienes, fluorenes, indenes, fused ring systems, propene, butadiene, pentadienes, hexadienes, heptadienes: m=0 or 1.

The present invention belongs to the field of medicine and relates to the use of benzothiazinone vinylidene indene compounds in the preparation of osteoclast differentiation inhibitors. The present invention uses tartrate-resistant acid phosphatase (TRAP) staining and reverse transcription real-time fluorescence quantitative polymerase chain reaction (RT-qPCR) technology to confirm for the first time that this series of compounds can significantly inhibit RANKL-induced osteoclast differentiation and the formation of multinucleated osteoclasts, and are non-cytotoxic at concentrations of 5μM and below. Based on these findings, the benzothiazinone vinylidene indene compounds provided by the present invention can be used as candidate drug molecules for novel osteoclast differentiation inhibitors, for the prevention and / or treatment of bone metabolic diseases caused by excessive activation of osteoclasts, such as osteoporosis, periprosthetic bone dissolution, tumor metastasis bone destruction, and rheumatoid arthritis.

The invention belongs to the technical field of organic synthesis, and particularly relates to a 3-fluoroisoquinoline-4-alcohol compound and a preparation method and application thereof.The preparation method comprises the steps that substituted 2-azido-2-fluoro-2, 3-dihydro-1H-indene-1-ketone reacts with a solvent; adding an extracting agent for extraction, taking an organic phase, drying, filtering and concentrating to obtain a crude product; and purifying to obtain the 3-fluoroisoquinoline-4-alcohol compound. The solvent is prepared from dimethyl sulfoxide, N, N-dimethyl formamide, acetonitrile, isopropanol, tetrahydrofuran, 1, 4-dioxane, dichloromethane and chloroform. Compared with the prior art, the invention solves the problems that the synthesis of isoquinoline compounds in the prior art needs multi-step reaction, the reaction conditions are harsh, and the tolerance of functional groups is poor. According to the scheme, the 3-fluoroisoquinoline-4-alcohol compound is obtained through one-step chemical reaction, and the method has the advantages that raw materials are simple and easy to obtain, the substrate range is wide, the reaction is mild, the yield is high and the like.

The invention provides an asymmetric synthesis method of (R)-5-halo-2, 3-dihydro-1H-indene-2-carboxylic acid, and belongs to the technical field of medicine and organic synthesis.

Disclosed herein are synthetic methods for increasing the solubility of metallocenes, such as metallocenes containing perfluorobenzyl (indene) groups. These methods can include alkylating a perfluoroaromatic ring of a metallocene precursor using a lithium alkylate reagent in a one-pot reaction. In addition, these processes may be employed without changing reaction equipment or conditions, without separating new intermediates, and at the same time, generally retaining the desired catalyst characteristics.

The invention provides an indeno [1, 2-b] pyridine-5-ketone fused oxa corrole compound and a preparation method of the indeno [1, 2-b] pyridine-5-ketone fused oxa corrole compound. The preparation method comprises the following steps: dissolving 3-amino-oxacorrole and 2-(arylmethylene)-1H-indene-1, 3 (2H)-diketone in toluene, adding acetic acid as a catalyst, stirring and reacting at 110 DEG C for 30 minutes, adding chloranil, continuously reacting for 20 minutes, cooling, directly separating by using a chromatographic column, concentrating and drying to obtain a pure product. The method is mild in synthesis condition and simple and safe to operate, and a brand-new synthesis way is provided for the pi-conjugated expanded oxacorrole compound.

The invention relates to the field of waterproof materials, and discloses a composition for a modified asphalt coating material, the modified asphalt coating material, a preparation method of the modified asphalt coating material and a waterproof coiled material, the composition contains a main agent and auxiliaries, and the main agent comprises matrix asphalt, solvent oil with the aromatic hydrocarbon content larger than or equal to 70 wt%, linear SBS, SBR, neodymium iron boron magnetic powder, cobalt boroacylate and styrene-indene resin; based on the total weight of the composition, the content of the matrix asphalt is 40-55 wt%, the content of the solvent oil is 5-10 wt%, the content of the linear SBS is 3-5 wt%, and the content of the SBR is 3-5 wt%. The waterproof coiled material provided by the invention is excellent in heat preservation property, low temperature resistance and deformation resistance and is suitable for metal roofs.

The invention provides a tetravinyl benzyl indene derivative, a preparation method of the tetravinyl benzyl indene derivative, tetravinyl benzyl indene derivative thermosetting hydrocarbon resin and application of the tetravinyl benzyl indene derivative thermosetting hydrocarbon resin, and relates to the technical field of thermosetting resin. The tetravinyl benzyl indene derivative provided by the invention contains four vinyl groups, the crosslinking density of the thermosetting hydrocarbon resin is high, the dielectric loss tangent and dielectric constant of the tetravinyl benzyl indene derivative thermosetting hydrocarbon resin are remarkably reduced, and the heat resistance of the tetravinyl benzyl indene derivative thermosetting hydrocarbon resin is remarkably improved. Compared with trivinyl benzyl indene hydrocarbon resin and 1, 2-bis (4-vinylphenyl) ethane hydrocarbon resin, the tetravinyl benzyl indene derivative thermosetting hydrocarbon resin provided by the invention has the advantages of lower dielectric loss tangent, higher glass transition temperature, higher thermal stability, higher thermal stability and higher thermal stability. The method has a good application prospect in preparation of high-frequency and high-speed resin, bonding sheets, metal foil-coated plates, insulating substrates, resin-coated metal foils, insulating films, circuit substrates or electronic devices.

The present disclosure relates to a composition comprising: (a) a cationic polymerization initiator; and (b) an indene based or cyclopentadiene based resin; wherein the cationic polymerization initiator is selected from the group consisting of (i) an aromatic sulfonium salt-based cationic polymerization initiator; (ii) a phosphonium salt-based cationic polymerization initiator; (iii) a quaternary ammonium salt-based cationic polymerization initiator; (iv) an aluminum complex-based cationic polymerization initiator; (v) an aromatic iodonium salt-based cationic polymerization initiator; (vi) an aromatic diazonium salt-based cationic polymerization initiator; (vii) a pyridinium-based cationic polymerization initiator and (viii) a mixture thereof. Also described are varnishes and coatings formed from said composition.

The application discloses a method for industrial production of sulindac. The method comprises the following steps: condensation reaction of compound 1 (5-fluoro-2-1-(4-methylthio benzyl) indene) and glyoxylic acid under catalysis of an organic base (benzyl trimethyl ammonium hydroxide) to generate compound 2, isomerization reaction of the compound 2 under hydrobromic acid-acetic acid solution to generate compound 3, which greatly improves reaction conversion rate and yield, reduces three waste problems, and finally obtains compound 4 (sulindac crude product) through oxidation of the obtained compound 3 by hydrogen peroxide, and high-purity sulindac is obtained through recrystallization of the crude product by isopropyl alcohol. The raw materials and reagents used in the preparation process of the sulindac are relatively cheap and low in cost, the whole preparation process is mild in reaction condition, simple and safe in operation, and convenient for industrial production.

The invention relates to the technical field of structural adhesives, in particular to an epoxy composition capable of being used for bonding a camera module support and a preparation method of the epoxy composition, and the epoxy composition comprises the following components in parts by weight: 7-10 parts of epoxy resin; 20-25 parts of flexible epoxy resin; 5-10 parts of a core-shell epoxy resin toughening agent; 20-25 parts of a compound filler; 30 to 31 parts of organic hydrazide; and 8-9 parts of a modified amine adduct. The flexible epoxy resin has at least one structural characteristic of a long-chain polyether structure and an indene structure. The compound filler comprises calcium carbonate and silicon dioxide. The epoxy composition capable of being used for bonding the camera module support has the advantages of low precipitation, low curing shrinkage, high bonding strength, low modulus and excellent falling resistance, the reliability of the camera module support structure can be remarkably improved, and the epoxy composition is suitable for application environments of various miniature high-performance camera modules.

The invention discloses a plurality of BVMO or mutants thereof, the BVMO or the mutants thereof can be used for effectively catalyzing 5-chloro-1-oxo-2, 3-dihydro-1H-indene-2-carboxylic acid methyl ester to generate (S)-5-chloro-2, 3-dihydro-2-hydroxy-1-oxo-1H-indene-2-carboxylic acid methyl ester, and the (S)-5-chloro-2, 3-dihydro-2-hydroxy-1-oxo-1H-indene-2-carboxylic acid methyl ester can be used for catalyzing 5-chloro-1-oxo-2, 3-dihydro-1H-indene-2-carboxylic acid methyl ester to generate (S)-5-chloro-2, 3-dihydro-2-hydroxy-1-oxo-1H-indene-2-carboxylic acid methyl ester. The conversion rate and the optical purity of the 2, 3-dihydro-2-hydroxy-1-oxo-1H-indene-2-carboxylic acid methyl ester can reach 99%, and excellent catalytic effect and conversion efficiency are shown. The indoxacarb intermediate is prepared by adopting a biological catalysis method, so that the production cost can be greatly reduced, the problem of environmental pollution can be avoided, and the indoxacarb intermediate has a wide application prospect and a high market value.

The application relates to a rubber ring for sealing a pump truck piston and a preparation method thereof, and belongs to the technical field of rubber sealing rings. The rubber ring is divided into an inner ring and an outer ring, the outer ring wraps the inner ring, and the preparation raw materials of the outer ring include 62-75 parts of polyurethane particles, 5-10 parts of natural rubber, 2-5 parts of coumarone-indene resin, 7-9 parts of naphthenic oil and 4-12 parts of graphite; the preparation raw materials of the inner ring include 86-95 parts of polyurethane particles, 1-3 parts of tetrafluoroethylene powder and 5-10 parts of elastic microspheres. The rubber ring prepared by adopting the double-layer functional partition design of the outer ring wrapping the inner ring has good support and high-elasticity sealing performance. The inner ring adopts polyurethane+ tetrafluoroethylene powder+ elastic microspheres as a core support layer, relies on the high strength and high tear resistance of polyurethane itself; the outer ring adopts polyurethane+ natural rubber+ graphite-naphthenic oil paste+ coumarone-indene resin as a functional action layer, can be closely attached to a sealing surface and reduce gaps.

The application discloses a method for preparing polyethylene wax by using a carborane bridged rare earth metallocene catalyst, and simultaneously preparing a carborane bridged indenyl rare earth metallocene compound as a main catalyst, loading the prepared main catalyst and a cocatalyst on a magnetic mesoporous Fe3O4@Al2O3 core-shell nanoparticle carrier to obtain a supported rare earth metallocene catalyst; the main catalyst of the application is a carborane bridged indenyl rare earth metallocene compound with a structure shown in formula (I), wherein a bridging group adopts a closed carborane (closed-1,2-dicarbadodecaborane), and the cage-like three-dimensional structure has super-high thermal stability and chemical inertness and does not degrade or rearrange in a high-temperature molten state of 130-200 DEG C. Large-volume substituents such as methyl, tert-butyl, phenyl or 4-tert-butylphenyl are introduced on the indene ring to provide sufficient steric protection and further inhibit chain transfer and side reactions at high temperatures.

The invention provides a newly developed, inexpensive, and bench-stable Cobalt (II)-complexes encompassing phosphine-free N,N-bidentate ligand system. Particularly, the present invention utilizes Co(II)-complexes as catalyzing system for the sole purpose of studying the C-alkylation reaction through borrowing hydrogen strategy. The present invention also provides a catalytic methodology for selective alkylation, alkenylation of fluorene, and inactivated bulky indene utilizing alcohol under mild and benign conditions. In the present invention, fluorene and indene are alkylated using a range of substrates as an alkylating agent, such as primary and secondary aromatic, heteroaromatic, and aliphatic alcohols. The present invention indicates a sophisticated catalytic process with yields that range from high to exceptional yields and excellent regioselectivity of the C3-alkylated indenes.

The invention provides a method for colorimetrically detecting amphetamine and methyamphetamine in drugs based on furyl probes. The furyl probes in the method are furan-indanone, furan-indene dicyanide and furan-indene cyanide respectively. Wherein before and after amphetamine or methyl amphetamine is added into the probe furan-indanone, the color of the solution is changed from faint yellow to rose red; before and after amphetamine or methyl amphetamine is added into the probe furan-indene dicyanide, the color of the solution is changed from brown yellow to blue; the color of the solution is changed from yellow to orange before and after amphetamine is added into the probe furan-indene cyanogen, and the color of the solution is changed from yellow to green before and after methylamphetamine is added into the probe furan-indene cyanogen. Rapid colorimetric distinguishing of single amphetamine or methyamphetamine and qualitative detection of a mixture of amphetamine and methyamphetamine are achieved. The method has no special limitation in use, can quickly complete qualitative detection without pretreatment of an object to be detected, is simple to operate, economical, practical, high in specificity and sensitivity, stable and repeatable in result, and can be practically applied and popularized.

The invention discloses a composite film-forming agent as well as a preparation method and application thereof, and aims to provide a composite film-forming agent which can remarkably improve the fitting degree and tensile property of base makeup on the skin surface, enhance the glossiness of the makeup surface, improve the hydration degree of the skin, strengthen the moisturizing effect and form a layer of oleophylic makeup-holding film and a moisturizing film with enhanced hydrophilic capacity. Therefore, a dual film forming effect is achieved; according to the technical scheme, the cleaning agent comprises 4-14% of isododecane; the invention relates to a silicone sealant which is prepared from the following components in percentage by weight: 5 to 40 percent of trimethylsiloxane silicate, 5 to 40 percent of hydrogenated (styrene / methyl styrene) indene copolymer, 30 to 40 percent of cyclopentasiloxane (and) PEG / PPG-18 / 18 polydimethylsiloxane, 0 to 12 percent of polyvinyl pyrrolidone, 0 to 1 percent of polyquaternium-51 solution and 10 percent of water, wherein the sum of the components is 100 percent. The invention belongs to the technical field of cosmetics.