1794results about "Amino compound purification/separation" patented technology

PCT No. PCT/FR97/01452 Sec. 371 Date Jun. 5, 1998 Sec. 102(e) Date Jun. 5, 1998 PCT Filed Aug. 5, 1997 PCT Pub. No. WO98/05314 PCT Pub. Date Feb. 12, 1998Novel stable paracetamol compositions for use in therapeutic chemistry and specifically galenic pharmacy are disclosed. The compositions contain a solution of paracetamol in an aqueous solvent combined with a buffer having a pH of 4 to 8, and a free radical capturing agent. A water-insoluble inert gas is carefully bubbled through the aqueous solvent to remove oxygen from the medium. Said compositions may also be combined with a centrally or peripherally acting analgesic agent, and are provided as injectable compositions for relieving pain.

The present invention relates to agglomerated zeolitic adsorbents based on zeolite X with an Si/Al ratio such that 1.15<Si/Al≦1.5, at least 90% of the exchangeable cationic sites of the zeolite X of which are occupied either by barium ions alone or by barium ions and potassium ions whose Dubinin volume is greater than or equal to 0.240 cm³/g.

They are obtained by agglomerating zeolite powder with a binder, followed by the zeolitization of the binder, the exchange of the ions of the zeolite by barium ions (and potassium ions) and the activation of the adsorbents thus exchanged.

These adsorbents are particularly suited to the adsorption of the para-xylene present in C₈ aromatic hydrocarbon fractions in the liquid phase in processes of simulated moving bed type but also to the separation of sugars, polyhydric alcohols, cresols or substituted toluene isomers.

Disclosed are: a process for producing purified pentamethylenediamine by simple production steps and in high yield; and others. The process for producing purified pentamethylenediamine comprises: a thermal decomposition step of heating pentamethylenediamine carbonate to yield crude pentamethylenediamine and carbon dioxide; and a distillation step of distilling the crude pentamethylenediamine produced in the thermal decomposition step to yield pentamethylenediamine, wherein the concentration of pentamethylenediamine in the crude pentamethylenediamine is 30 mol% or more relative to the total concentration of pentamethylenediamine and pentamethylenediamine carbonate.

A pharmaceutical composition includes a therapeutically effective amount of exo-R-mecamylamine or a pharmaceutically acceptable salt thereof, substantially free of exo-S-mecamylamine in combination with a pharmaceutically acceptable carrier. Preferably the amount is about 0.5 mg to about 20 mg. Medical conditions are treated by administering a therapeutically effective amount of exo-R-mecamylamine or a pharmaceutically acceptable salt thereof, substantially free of its exo-S-mecamylamine, said amount being sufficient to ameliorate the medical condition. The medical conditions include but are not limited to substance addiction (involving nicotine, cocaine, alcohol, amphetamine, opiate, other psychostimulant and a combination thereof), aiding smoking cessation, treating weight gain associated with smoking cessation, hypertension, hypertensive crisis, Tourette's Syndrome and other tremors, cancer (such as small cell lung cancer), atherogenic profile, neuropsychiatric disorders (such as bipolar disorder, depression, an anxiety disorder, schizophrenia, a seizure disorder, Parkinson's disease and attention deficit hyperactivity disorder), chronic fatigue syndrome, Crohn's disease, autonomic dysreflexia, and spasmogenic intestinal disorders.

The invention relates to a method for isolating 1,5-diaminopentane (DAP) from DAP-containing fermentation broths, to a method for the fermentative production of DAP using said isolating method and to a method for producing DAP-comprising polymers by using the DAP isolated or fermatively produced DAPs according to said methods.

The invention provides a process for production of fine spherical particles of a carbonate or a hydroxide of nickel, cobalt or copper which comprises: dissolving a carbonate or a hydroxide of nickel, cobalt or copper having the general formula (I)wherein M represents Ni, Co or Cu, and x and y are numerals satisfying the followings: 0<=x<=2, 0<=y<=2 and x+y=2, in aqueous ammonia, converting the resulting solution to a W/O emulsion containing droplets of the solution in a non-aqueous medium, and then removing volatile components including ammonia from within the droplets, thereby precipitating a basic carbonate or a hydroxide of a metal selected from nickel, cobalt and copperin the droplets.The fine spherical particles of a carbonate or a hydroxide of nickel, cobalt or copper obtained according to the process of the invention are especially useful as a precursor for the manufacture of uniform, fine spherical particles of nickel, copper or cobalt metal, as well as useful as themselves as a catalyst for use in organic synthesis, a carrier, a pigment, a filler or a glaze.

A method of decomposing wastes containing target compounds having one or more of hydrolyzable bonds of ether bond, ester bond, amide bond and isocyanate bond wherein the method comprises continuously supplying the wastes in a molten state or liquid state to a reactor, continuously supplying super-critical water or high pressure/high temperature water to the reactor, bringing the water into contact with the wastes, thereby decomposing the target compounds and then recovering them as raw material compounds or derivatives thereof for the target compounds. Target compounds contained in wastes in chemical plants which could not be utilized but merely incinerated or discarded so far are continuously decomposed into raw material compounds or derivatives thereof for the aimed compound and can be reutilized effectively.

The invention relates to a triethylamine reclaim treatment method and the devices in the production of acesulfame-K, which is characterized in that the method includes the following steps: a. the crude triethylamine containing water is put into a distillation kettle (1), which is heated to the temperature of 38 DEG C to 42 DEG C, the time is about 20 to 40 minutes, the dichloromethane and other impurities with the low boiling points which are contained in the crude triethylamine are firstly evaporated, collected and then are condensed and collected by a condenser (3); b. the heating is carried out continually to about 83 DEG C, the temperature is kept for more than 30 minutes, which ensures that the water and triethylamine are placed still for layer separation, a lower layer is water, an upper layer is triethylamine, and triethylamine of the upper layer can be collected after the water is drained completely from the bottom of a kettle. Finally, the collected triethylamine is dried by the solid potassium hydroxide or a molecular screen, so the water content of triethylamine can be lower than 0.1 percent. The invention has the advantages of simple using equipment, convenient operation, safety, reliability, low cost, improved reclaim ratio of the product and significantly reduced operating cost.

The invention provides a method for controlling an amine solvent regeneration system, belongs to the technical field of amine solvent recovery, and comprises an amine recovery tower. The method is characterized in that a heat supply regulating valve of a tower bottom reboiler is related to system pressure; and a distilled line regulating valve of a tower top product is related to the gas-phase temperature of the tower top. The method can meet the requirement on purification degree of an amine solvent product on the tower bottom only by presetting a system pressure value and a tower top gas-phase temperature vale; and the control system can trace variations of feeding flow rate, feeding quality and feeding temperature to realize automatic regulation and obtain perfect tower bottom products.

A process comprises contacting a product mixture with a base, optionally in the presence of a polyhydric alcohol, to produce a base-treated mixture and distilling the base-treated mixture in which the product mixture comprises an aromatic amine and a phenolic compound.

Disclosed is a process for producing a diamine, comprising the step of purifying a diamine from an aqueous solution containing a diamine salt. Specifically, the process comprises the step of adding an alkaline substance to the aqueous solution and then filtering the aqueous solution through a nanofiltration film to remove the salt and thus to obtain an aqueous diamine solution, whereby a diamine suitable as a starting material for a polyamide can be obtained by a simpler operation than a conventional extraction operation with an organic solvent.

The invention provides sacubitril derivatives and medicine compositions, preparation methods and application thereof and belongs to the fields of medicine compounds and preparation thereof. The sacubitril derivatives comprise sacubitril lithium salt, sacubitril kali salt, sacubitril magnesium salt, sacubitril calcium salt, sacubitril strontium salt, sacubitril zinc salt, sacubitril ferric salt, sacubitril ammonium salt, sacubitril diethylamine salt, sacubitril ethylenediamine salt, sacubitril piperazine salt, sacubitril N-(2-ethoxyl)-pyrrolidine salt, sacubitril choline salt, sacubitril cholamine salt, sacubitril diethanol amine salt, sacubitril triethanolamine salt, sacubitril tromethamine salt, sacubitril meglumine salt, sacubitril diisopropylamine salt, sacubitril tert-butylamine salt, sacubitril N, N'-bis-benzyl ethylenediamine salt, sacubitril L-lysine salt, sacubitril L-arginine salt or sacubitril L-histidine salt.

The invention relates to a process for the isolation of an organic amine from a composition comprising the organic amine and an acid, or a salt of the organic amine and the acid, wherein the process comprises steps wherein ammonia or hydrazine is added to the composition thereby forming a multi-phase system comprising an organic amine-rich phase and an acid-rich phase, the organic amine-rich phase and the acid-rich phase obtained in step (i) are separated, and the organic amine is isolated from the organic amine-rich phase.

In one embodiment, the invention is to a process of producing an ammonium salt composition. The process comprises the step of providing a process stream comprising sulfuric acid and at least one tertiary amine. The process further comprises the step of contacting the process stream with ammonia under conditions effective to form a waste stream and a product stream. The waste stream comprises water, the tertiary amine, and ammonia and the product stream comprises a first amount of ammonium salt. The process further comprises the step of deriving from the waste stream an off gas stream comprising a preliminary amount of ammonia. The process also comprises the step of contacting the off gas stream with an acid under conditions effective to form an ammonium salt stream and a purge stream. The ammonium salt stream comprises a second amount of ammonium salt and the purge stream comprises a reduced amount of ammonia, which is less than the preliminary amount.

The proposed invention relates to a method and a system for the removal of heat stable amine salts from an amine absorbent used in a carbon dioxide (CO₂) capture process, the method comprising: withdrawing amine absorbent containing heat stable amine salts from the CO₂ capture process; subjecting the withdrawn amine absorbent containing heat stable amine salts to a residual CO₂ removal step; subjecting the amine absorbent from the residual CO₂ removal step to a separation step to separate heat stable amine salts from the amine absorbent; and returning the amine absorbent having a reduced concentration of heat stable amine salts to the CO₂ capture process.

The invention discloses a synthetic method for a quaternary ammonium salt, especially to a synthetic method for a high-purity quaternary ammonium salt. The synthetic method comprises the following steps: adding a certain amount of a solvent, tertiary amine and an alkylation reagent into a reaction vessel with reaction temperature being 20 to 105 DEG C and reaction time being 2 to 24 h; and after a reaction is ended, carrying out direct cooling, centrifugation and drying so as to obtain the high-purity quaternary ammonium salt. The solvent used in the method can be used indiscriminately and repeatedly, so production cost is reduced, and the method has a high industrial practical value.

Disclosed is a method for recovering toluene diamine from a fluid, high-boiling tar residue discharged from TDI preparation processes. After free TDI is separated and recovered from the tar residue, the remaining solid residue is pulverized, slurried and hydrolysis-treated in the presence of a catalyst under the condition of the liquid phase region near a critical point of water to produce toluene diamine, and then the resulting toluene diamine is effectively recovered.

The invention provides a refining method of p-phenylenediamine, which combines distillation and melting crystallization, uses the distillation product condensate to directly process melt crystallization for purification and processes fractional crystallization composed of one crystallization at least and one transpiration to obtain high-purity product. The invention combines distillation and melting crystallization to refine p-phenylenediamine and the invention can obtain high-purity and high-qaulity p-phenylenediamine product whose purity can reach 99.99-99.999% via controlling operation parameters, while the product quality can satisfy the quality demand of polymerization level product and the high-quality p-phenylenediamine can not be produced only by distillation. The refining method of p-phenylenediamine has the advantages of high product purity and flexible production set according to different standards, high yield of high-quality product and low cost, while the operation is processed without solvent to reduce pollution.

A composition and method for producing a tertiary amine is disclosed. The tertiary amine is contacted with an inert gas. The inert gas is nitrogen or more preferably argon. The amine composition is useful in producing polyurethane foam with lower levels of chemical emissions particularly lower emissions of toxic chemicals.

The invention discloses a method for purifying ethylenediamine, comprising the following steps: (1) heating extractant, feeding the extractant in to an extracting tower from the upper part of the extracting tower, gasifying 60.0-92.0% water-bearing ethylenediamine, feeding the ethylenediamine into the lower part of the extracting tower, making the ethylenediamine reversely contact the extractant on the upper part of the extracting tower in the extracting tower, discharging water from the top of the extracting tower and separating the mixture of the ethylenediamine and the extractant at the bottom of the extracting tower, wherein the extractant is diethylene glycol monomethyl ether, diethylene glycol dimethyl ether, triethylene glycol dimethyl ether or diethylene glycol monobutyl ether; and (2) heating the mixture of the ethylenediamine and the extractant, feeding the mixture of the ethylenediamine and the extractant to the middle part of the extracting tower, rectifying the mixture ofthe ethylenediamine and the extractant in a rectifying tower, separating the ethylenediamine on the top of the rectifying tower and discharging the extractant from the bottom of the rectifying tower.The method is mainly used for purifying the ethylenediamine.