266 results about "Diethylamine" patented technology

The invention discloses a water body heavy metal ion pollution treatment adsorption filtering membrane and a preparation method thereof, and relates to the technical field of water treatment. When the water body heavy metal ion pollution treatment adsorption filtering membrane is prepared, graphene oxide sequentially reacts with 3-diethylaminopropylamine, tetrabromophenyl porphyrin and N, N-diethyl allylamine, and functionalized graphene oxide is prepared; the preparation method comprises the following steps: reacting cellulose with 4 '-bromo-2, 2': 6 ', 2' '-terpyridyl and maleic anhydride in sequence to prepare modified cellulose; the preparation method comprises the following steps: reacting sodium alginate with propylene oxide to prepare modified sodium alginate; the modified sodium alginate, the modified cellulose, the functionalized graphene oxide, trans, trans-1, 3-butadiene-1, 4-dicarboxylic acid and a photoinitiator are subjected to a reaction, a membrane is prepared, and the water body heavy metal ion pollution treatment adsorption filtering membrane is prepared. The water body heavy metal ion pollution treatment adsorption filtering membrane prepared by the invention has good antibacterial and photocatalytic organic matter degradation capabilities.

The invention relates to a flame-retardant sodium ion electrolyte as well as a preparation method and application thereof, and belongs to the technical field of electrolytes. The flame-retardant sodium ion electrolyte comprises the following components in percentage by mass: 13-15% of sodium salt, 3-10% of a first additive, 1-3% of a second additive and the balance of an organic solvent, and the first additive is pentafluorobenzene dimethyl silicon diethylamine. According to the flame-retardant sodium-ion electrolyte provided by the invention, the specific first additive is selected, and the effect of the flame-retardant sodium-ion electrolyte is comprehensively superior to that of traditional phosphazene and phosphite flame-retardant additives when the flame-retardant sodium-ion electrolyte is used in a sodium-ion battery; according to the present invention, the lithium ion battery electrolyte has the flame retardation effect, the NaF component-rich SEI film can be formed on the negative electrode side so as to easily provide the electrochemical performance, and the Si-N bond in the structure can remove hydrogen fluoride (HF) and phosphorus pentafluoride (PF5), such that the impurities in the electrolyte can be removed, the cycle performance and the stability of the battery can be improved, and the high application value can be provided.

The invention discloses a method for accurately determining the content of trimethylamine, diethylamine and triethylamine in animal-derived traditional Chinese medicinal materials, which comprises the following steps: mixing alkali liquor and n-tetracosane in a headspace bottle, heating to completely dissolve the n-tetracosane, and standing until the n-tetracosane layer is solidified to seal the alkali liquor below the n-tetracosane layer; animal-derived traditional Chinese medicinal materials are crushed, sieved and dispersed in a trichloroacetic acid aqueous solution, centrifugation is performed after homogenization, supernate is collected, volume metering is performed, and a sample extracting solution is obtained; adding the sample extracting solution above the n-tetracosane layer in the headspace bottle, sealing by a gland, placing on an automatic sampler, sucking gas at the upper part of the headspace bottle, analyzing by a gas chromatograph-triple quadrupole mass spectrometer, and obtaining the contents of trimethylamine, diethylamine and triethylamine in the animal-derived traditional Chinese medicinal materials by an external standard method. The method is accurate and reliable in quantitative result, high in sensitivity and high in analysis efficiency, derivation is assisted by the phase change material n-tetracosane, the phenomenon that the quantitative accuracy is poor due to the volatile and escape characteristics of trimethylamine, diethylamine and triethylamine is effectively improved, the false positive phenomenon can be effectively eliminated through headspace sampling and a multi-reaction monitoring mode, and the method is suitable for large-scale popularization and application. The peak appearance of trimethylamine, diethylamine and triethylamine is completed within 6.5 minutes.

The invention relates to the technical field of pesticides and herbicides, in particular to a preparation method of L-refined glufosinate ammonium, which comprises the following steps: firstly, preparing an intermediate from diethylamine, diethyl methylphosphite, a compound # imgabs0 # as shown in a formula III and a second solvent in the presence of an iridium-containing Lewis base catalyst by adopting a one-pot method; and carrying out rearrangement and hydrolysis reaction to obtain the L-refined glufosinate-ammonium. The preparation method of the L-refined glufosinate-ammonium has the advantages of simple process steps, mild reaction conditions, high yield and high ee value.

The invention discloses an application of tiopronin wrapped by ROS (reactive oxygen species) response hydrogel in preparation of a medicine for treating osteoarthritis. The ROS response hydrogel is prepared from the following components: tiopronin; the compound group of lecithin and ketal thiol (TK) is TK-NH22, 2 '-(propane-2, 2-diyl bis (sulfanilamide diyl)) diethylamine (sulfanediyl), and the compound group of lecithin and ketal thiol (TK) is TK-NH22, 2'-(propane-2, 2-diyl bis (sulfanilamide diyl)); 12 wt% of methyl cellulose, Na2HPO4. 12H2O and xylitol; according to the hydrogel, controlled release of tiopronin is achieved through an ROS response group, mitochondrial autophagy is enhanced by up-regulating a Bnip3-Pink1-Parkin signal channel, oxidative stress is inhibited, and the progress of osteoarthritis is delayed; compared with the prior art, the invention has the advantages that: the invention discloses an osteoarthritis treatment medicine with the effects of resisting inflammation, relieving pain and inhibiting cartilage degeneration for the first time, and discloses a knee joint intracavity administration route of tiopronin for the first time. Particularly, the tiopronin targeted activation Bnip3-Pink1-Parkin signal channel provided by the invention has a remarkable effect in the aspect of inhibiting the progress of OA, which proves that the medicine has a strong effect on the treatment of osteoarthritis.

The invention discloses a preparation method of chloroprocaine hydrochloride, and belongs to the technical field of chloroprocaine hydrochloride synthesis. Comprising the following steps: (1) preparing 4-amino-2-chlorobenzoic acid: dissolving 2-chloro-4-nitrobenzoic acid in a solvent, and uniformly stirring; adding a ruthenium catalyst Ru / SNC into the system, and carrying out heat preservation reaction in a hydrogen atmosphere; the 4-amino-2-chlorobenzoic acid is obtained through a reaction; (2) preparation of chloroprocaine hydrochloride: dissolving 4-amino-2-chlorobenzoic acid, 2-chloroethyl diethylamine and a solid base catalyst K / r-GO in a reaction solvent, and carrying out an esterification reaction; the 2-(diethylamino)-2-chlorine-4-nitrobenzoic acid ethyl ester is obtained; and then salifying and drying to obtain the chloroprocaine hydrochloride. The catalyst provided by the invention realizes efficient catalytic reaction at lower temperature and pressure, can be recycled for dozens of times, and is suitable for large-scale industrial production.

To provide a solventless siloxane composition which is solventless, excellent in temporal stability, and has a low refractive index of a cured film.SOLUTION: A solventless siloxane composition includes a siloxane compound having a structural unit derived from formula (1), and a terminal silanol group stopped by at least one selected from the group consisting of hexamethyldisilazane, chlorotrimethylsilane, trimethylsilyl acetate, N-(trimethylsilyl)diethyamine, N-trimethlysilyl acetoamide, and N-(trimethylsilyl)dimethylamine, where the refractive index of a cured film is 1.45 or lower. (In the formula (1), A1 is a univalent organic group having a radical-polymerizable double bond, A2 is an alkyl group or a siloxy group, and R1 is an alkyl group. Plural R1s may be the same or different. a is 0 or 1.)SELECTED DRAWING: None

The invention provides a high-resilience and high-tensile spandex fiber and a preparation method thereof. In the spandex production process, an amine solution formed by mixing ethidene diamine, 2-methyl pentamethylene diamine and diethylamine is used for carrying out chain extension reaction, and meanwhile, the proportion of mixed amine is controlled, so that the crystallization regularity of a hard segment is ensured, the polymerization degree is not influenced, and the spandex fiber has high rebound resilience and good tensile property; meanwhile, by controlling solvent indexes, polymerization process conditions are stable, so that the spandex fibers have high uniformity. The spandex fiber with high resilience and high tensile strength is obtained through the method.

The invention discloses a preparation method of octafluorocyclopentene, which comprises the following two steps of: firstly, reacting 4-cyclopentene-1, 3-diketone with a selective fluorine reagent in acetonitrile under the condition of reflux to generate a crude product second mixture, purifying the second mixture, and putting the purified second mixture into a second-step reaction to obtain the octafluorocyclopentene. Reacting with diethylamino sulfur trifluoride in dichloromethane to generate a third mixture; the method has the advantages of environment-friendly and simple reaction process, no generation of three wastes, low cost, easy obtaining, simple reaction process, mild reaction, no generation of waste gas pollution even if nitrogen protection is needed, easy operation, and suitableness for industrial production.

The invention provides a bio-based reusable light / moisture dual-curing polyurethane hot melt adhesive, which is characterized in that a novel bio-based modifier is synthesized through reaction of bio-based mustard oil and 2, 2 '-dithio-diyl diethylamine, and the bio-based modifier has a double bond, a dynamic disulfide bond and a thiourea bond which can be photo-cured, so that the light / moisture dual-curing polyurethane hot melt adhesive has the advantages that the light / moisture dual-curing polyurethane hot melt adhesive can be used for preparing the light / moisture dual-curing polyurethane hot melt adhesive, and the service life of the light / moisture dual-curing polyurethane hot melt adhesive is prolonged; the hot melt adhesive prepared by adopting the modifier not only has the characteristics of short curing time and high initial adhesion strength, but also has reusability, water resistance and heat resistance, belongs to a high-performance and environment-friendly hot melt adhesive, and has a great application prospect in the fields of electronic devices, precious metals and the like which need to be disassembled and recycled.

The invention relates to the technical field of organic supramolecular chemical materials, in particular to an imine gelator with tri-state red light emission, a three-dimensional network-shaped gel material of the imine gelator, a preparation method and application of the imine gelator. The gel factor is an asymmetric cholesterol-phenoxy-maleonitrile-diethylamino salicyl gel factor, and can be self-assembled in different solvents to form three-dimensional structure gel of a short rod shape, a fiber net shape and a flat strip shape; due to the highly conjugated asymmetric molecular structure, the fluorescent probe presents three-state red fluorescence emission in a solid state, a solution state and a gel state; the gelator shows intuitive colorimetric change and fluorescence'on-off 'double-signal detection performance on Fe < 3 + > and Co < 2 + > in toluene gel, and has colorimetric change, fluorescence'on-off' and gel-to-sol conversion three-signal response on Cu < 2 + >; the gelator has fluorescence'on-off 'detection response to Cu < 2 + > in a solution state, and double-state four-detection response performance to Cu < 2 + > is achieved; the gelator-Cu < 2 + > binary system has fluorescent on-off detection potential on Pb < 2 + >.

The invention discloses preparation and application of an amido-functionalized polyionic liquid catalyst, vinyl imidazole hydrobromide and N-(4-vinyl) benzyl diethylamine are used as monomers, N, N '-methylene bisacrylamide is used as a cross-linking agent, and the amido-functionalized polyionic liquid catalyst is prepared through a free radical copolymerization method. The imidazole / amido functionalized cross-linked PILs with multiple active sites are prepared by one-step synthesis through a hydrothermal polymerization method. The catalyst has catalytic active sites of amido, imidazolyl and Br, so that the catalyst can efficiently catalyze the cycloaddition reaction of CO2 and epoxide at 80 DEG C and normal pressure in the absence of a solvent and a co-catalyst.

The invention discloses a preparation method of N, N-diethyl alkyl amidine, which comprises the following steps: dissolving N-long-chain alkyl methyl acetimidate and diethylamine in an organic solvent, heating the organic solvent to 20-100 DEG C, reacting at normal pressure for 0.1-100 hours, reducing the pressure of the organic solvent to 0.01-0.08 MPa, reacting at 20-120 DEG C for 0.1-24 hours, and stopping the reaction to obtain the N, N-diethyl alkyl amidine. The N, N-diethyl alkyl amidine is obtained by dissolving the N-long-chain alkyl acetimidic acid methyl ester and the diethylamine in the organic solvent to react, the used raw materials are easy to obtain, the preparation method is simple, the reaction steps are few, operation is easy, toxic and harmful reagents are not needed in the reaction process, environment friendliness is achieved, and the obtained N, N-diethyl alkyl amidine is high in yield, good in purity and suitable for industrial production. The method is suitable for large-scale industrial production, has a wide application prospect, and can be used as a surfactant and a drug synthesis intermediate.

The invention relates to the technical field of external use of medicines, and discloses a gel emplastrum for treating arthralgia and a preparation method thereof.The gel emplastrum is prepared by doping lipid nanoparticles containing diclofenac diethylamine and wrapped by a bimolecular layer into a gel matrix, the sustained and controlled drug release effect is achieved, meanwhile, a penetrating agent is doped into the gel matrix, and the effect of treating arthralgia is achieved. The transdermal absorption effect of the medicine is enhanced, the dosage of the medicine is reduced, meanwhile, the surface modifier is used for modifying the paper nanoparticles, the stability of the product is enhanced, and production and storage are facilitated.

Provided is a polyamide resin having a low mass loss at a temperature slightly higher than the melting point. The polyamide resin includes diamine-derived structural units and dicarboxylic acid-derived structural units, and of the diamine-derived structural units, from 70 to 97 mol % are derived from p-benzenediethanamine and from 3 to 30 mol % are derived from a diamine represented by formula (1). 50 mol % or more of the dicarboxylic acid-derived structural units are derived from an aromatic dicarboxylic acid.

The invention belongs to the technical field of pharmaceutical analysis, and particularly relates to a detection method of an evocamide enantiomer, which comprises the following steps: S1, preparing a test solution; s2, preparing a contrast solution; s3, preparing a system applicable solution; s4, carrying out a system applicability test; s5, testing a test sample and a contrast solution; a chromatographic column is a chiral chromatographic column taking a polysaccharide derivative or a cellulose derivative as a filler, and a mixed solution of n-hexane, isopropanol, trifluoroacetic acid and diethylamine is taken as a mobile phase to detect the Evocadum enantiomer. The method has the characteristics of simplicity in operation, high sensitivity and high accuracy, the chromatographic peaks are high in separation degree, do not interfere with one another, the peak shape is good, the result accuracy is guaranteed, the method can be used for detecting enantiomers in the Evocamide and the Evocamide preparation, the level of the enantiomers of the Evocamide is effectively controlled, and the medication safety is guaranteed.

The invention discloses an LC-MS (liquid chromatography-mass spectrometry) detection method for N, N-diethyl-N ', N'-dimethylethylenediamine in chlorpheniramine maleate, and belongs to the technical field of analytical chemistry. The method comprises the following steps: firstly, preparing a test solution and a reference solution for later use; then setting liquid chromatography-mass spectrometry detection conditions, and detecting N, N-diethyl-N ', N'-dimethylethylenediamine in chlorpheniramine maleate by adopting a Shim-pack Scept Diol-HILIC-120 chromatographic column, taking a 0.1% difluoroacetic acid aqueous solution-acetonitrile mixed solution as a mobile phase and taking a 1% diethylamine acetonitrile solution as a solvent. According to the method, a liquid chromatography-mass spectrometry technology is adopted, the problem that N, N-diethyl-N ', N'-dimethyl ethylenediamine has no ultraviolet absorption can be effectively solved, and meanwhile, the method is high in specificity, high in sensitivity and high in efficiency.

The utility model provides a device for crushing a diethylamine hydrochloride raw material from a raw material barrel. In the device, a steel rail is arranged on the ground, one end of the steel rail is provided with an operation table and a hydraulic propelling mechanism, the other end of the steel rail is provided with a crushing mechanism, the steel rail is provided with a rear limiting stopper and a front limiting stopper, a charging basket fixing belt and a hasp are installed on a charging basket frame, and a hook seat is installed on a frame at the end, close to the front limiting stopper, of the charging basket frame. Rollers are installed at the bottom of the charging basket frame and make contact with the steel rail, a fluted disc is installed at the end of the rotating shaft, crushing teeth are fixedly installed on the fluted disc, the other end of the rotating shaft is connected with the speed reducer through a coupler, and the powder box is connected with the hook base in a hung mode through a hook. According to the device, the hydraulic propeller is controlled by the operating platform to push the charging basket frame and the charging basket to slowly move forwards along the steel rails, raw materials bonded in the charging basket are crushed by utilizing the crushing mechanism, the structural design is reasonable, the automation degree is high, the operation is simple and convenient, the working efficiency is improved, and the quality of the crushed raw materials is ensured.

The invention relates to the technical field of chemical synthesis, and particularly discloses a compound with a peculiar smell removing function as well as a preparation method and application thereof. The chemical name of the compound is 2-ethoxy-3-((E)-methoxy-3-oxopropyl-1-alkene-1-yl) phenyl cinnamate, the smell of the compound is extremely light, sulfur-containing and nitrogen-containing compounds causing stink can be captured through a Michael addition reaction, and efficient peculiar smell removal is achieved. The preparation method comprises the following steps: (1) taking cinnamic acid as an initial raw material, and reacting with diethylamino sulfur trifluoride to prepare cinnamic acid acyl fluoride; (2) carrying out an esterification reaction on the cinnamic acid acyl fluoride and 2-methoxy-3-hydroxybenzaldehyde in the presence of 4-dimethylaminopyridine, so as to obtain 2-methoxy-3-formyl phenyl cinnamate; and (3) carrying out Wittig reaction on the 2-methoxy-3-formyl phenyl cinnamate and a phosphorus ylide reagent, so as to obtain the target compound.

This invention provides an ethyl-containing alkoxy-terminated organosilicon polymer, its preparation method, and its applications. The preparation method includes: S1, mixing methylvinylcyclotetrasiloxane, a solvent, and a first catalyst, introducing hydrogen gas, and reacting at 50-70°C until the methylvinylcyclotetrasiloxane content is no higher than 5%, filtering to remove impurities and obtain the product; S2, under nitrogen protection, ring-opening the product obtained in step S1 with acetic anhydride in the presence of a ring-opening catalyst, neutralizing and hydrolyzing, removing impurities, and obtaining the product; S3, under nitrogen protection, reacting the product of step S2 with hexamethyldisilazane at 40-50°C for 1-3 hours, adding N,N-diethylamino-trialkoxysilane, and reacting at 50-60°C for 1-3 hours. The polymer obtained by this invention, as a thermally conductive powder treatment agent, can effectively improve the dispersion performance of powders and enhance the heat resistance of products without reducing their tensile strength.

The application relates to the technical field of wastewater treatment, and discloses an expanded graphite catalyst for degrading chemical pharmaceutical wastewater and a preparation method. In the application, 2,2'-diamino-N-(hydroxypropyl trimethyl ammonium chloride) diethylamine is used to carry out an amidation reaction with carboxyl groups on the surface of oxidized expanded graphite, so as to bond and introduce active functional groups such as amino groups, quaternary ammonium salts and hydroxyl groups on the surface of the expanded graphite; then, through high-temperature hydrothermal reaction, zinc oxide particles are uniformly generated in the expanded graphite, and the expanded graphite catalyst is obtained. The active groups such as the hydroxyl groups of the expanded graphite catalyst form hydrogen bonds and other interactions with tetracycline hydrochloride, so that the adsorption and removal rate of the tetracycline hydrochloride is improved. The zinc oxide particles are uniformly grown in the expanded graphite matrix and are not prone to agglomeration, and a large number of photocatalytic active sites are exposed, so that the expanded graphite catalyst has better photocatalytic degradation performance on the tetracycline hydrochloride.

The invention discloses a high-draw spandex fiber and a preparation method thereof, and belongs to the field of polymer composite materials. The specific preparation method comprises: mixing polytetrahydrofuran ether diol and diphenylmethane-4,4'-diisocyanate to obtain a prepolymer. Then, dimethylacetamide non-protonic polar solvent is added to the prepolymer to obtain a prepolymer solution. Then, ethylenediamine, 1,2-propylenediamine, sodium N-(2-aminoethyl)-2-aminoethanesulfonate, 1,2-cyclohexanediamine and diethylamine are added to carry out chain extension reaction and chain termination reaction to obtain a polyurethaneurea solution. Additives are added to the polyurethaneurea solution to obtain a spandex spinning solution, and then the spandex spinning solution is matured and then the spandex fiber is prepared by dry spinning technology. The spandex fiber obtained by this preparation method has good fracture performance and resilience performance.

The invention relates to the technical field of wastewater treatment, and discloses an expanded graphite catalyst for degrading chemical pharmaceutical wastewater and a preparation method of the expanded graphite catalyst. 2, 2 '-diamido-N-(hydroxypropyl trimethyl ammonium chloride) diethylamine and carboxyl on the surface of oxidized expanded graphite are subjected to an amidation reaction, and the expanded graphite catalyst is prepared. Active functional groups such as amino, quaternary ammonium salt and hydroxyl are bonded and introduced to the surface of the expanded graphite, then zinc oxide particles are uniformly generated in the expanded graphite through a high-temperature hydrothermal reaction, and the expanded graphite catalyst is obtained. Active groups such as hydroxyl of the expanded graphite catalyst and tetracycline hydrochloride form hydrogen bonds and interact with each other, so that the adsorption and removal rate of tetracycline hydrochloride is increased. Zinc oxide particles uniformly grow in an expanded graphite matrix, are not easy to agglomerate, expose a large number of photocatalytic active sites, and have better photocatalytic degradation performance on tetracycline hydrochloride.

The invention discloses a preparation method of a bilastine intermediate, which comprises the following steps: reacting a compound 5 with thionyl chloride under the conditions that dichloromethane is used as a solvent and DMF (Dimethyl Formamide) is used as a catalyst to generate acyl chloride, and then reacting the acyl chloride with diethylamine to prepare a compound 6; taking dichloromethane as a solvent, and carrying out Friedel-Crafts acylation on the compound 6 and ethyl oxalyl chloride under the condition of anhydrous aluminum trichloride to obtain a compound 7; reducing the compound 7 by using sodium borohydride, liquid caustic soda and a water system to prepare a compound 8; taking dichloromethane as a solvent, and reducing the compound 8 by TMDS under the condition of anhydrous aluminum trichloride to prepare a compound 9; hydrolyzing the compound 9 under the hydrochloric acid condition to obtain a compound 10; and under the condition of thionyl chloride, carrying out esterification reaction on the compound 10 and methanol to prepare the bilastine intermediate TM. The preparation method of the bilastine intermediate, provided by the invention, has the advantages of economical and easily available raw materials, mild reaction conditions, efficient reaction and simple operation, and is suitable for industrial application.

The present application belongs to the technical field of pharmaceutical therapy, and particularly relates to an amide-substituted tryptophan ketone derivative, a preparation method and application thereof. The structural formula of the tryptophan ketone derivative is shown in formula (A) or formula (B). In the formula, n=1 or 2, and R is any one of dimethylamine group, diethylamine group, morpholine group, 1-methylpiperazine group, cyclopropylamine group and 4-hydroxypiperidyl group. The compound can selectively inhibit the activity of acetylcholinesterase, and has the potential to develop into a drug for treating Alzheimer's disease due to the abilities of self-aggregation and the like. 1‑42 ​

The application discloses a kind of breathable antibacterial fabric and its preparation process, S1, nylon is used as warp and tension is maintained;S2, spandex is used as weft, and weft and warp are interwoven into grey cloth;S3, the grey cloth is finished by finishing agent, the burr is cut, and the wrinkle is smoothed, to obtain fabric, using hexamethylene diisocyanate, 3-hydroxypropionic acid is reacted to obtain hexamethylene di (carbamate propionic acid), after acyl chloride, and with N-methyl-2,2-diamino diethylamine, benzyl bromide is reacted, to obtain antibacterial finishing agent.It contains a large number of quaternary ammonium salt antibacterial groups, and has inhibitory and killing effect on bacteria such as escherichia coli, and at the same time contains polyamide and urethane structure, and has high affinity and interfacial force between the polyamide molecular chain in the blended fabric and the urethane structure of spandex polyurethane, to improve the firmness of antibacterial finishing agent attached to the surface of fabric and antibacterial time effect.

The invention provides four new salt forms of Elobixibat in a crystalline state, namely, an Elobixibat ammonium salt, a betaine salt, a diethylamine salt and a triethylamine salt, and the crystal form of the Elobixibat is shown in the description. The invention provides crystal forms of all four crystalline-state new salt forms and a preparation method thereof. The salt form provided by the invention has the advantages of good crystal form stability, good solubility and low hygroscopicity, can better resist the problems of non-uniform active ingredient content, purity reduction, impurity increase and the like caused by factors such as environment temperature and humidity in the processes of medicine preparation and / or storage and the like, reduces the curative effect decline and safety risk caused by the problems, and has a good application prospect. Accurate quantification in medicine manufacturing is facilitated, and preparation uniformity and later storage and transportation are improved.

The invention belongs to the field of medicine synthesis, and relates to a preparation method of a raw material medicine, in particular to a preparation method of a nikethamide raw material medicine, which is prepared by four steps of salifying, condensing, neutralizing and washing, and oxidizing and steaming water to decolor. In the production of nikethamide, nikethamide is firstly salified, after the reaction activity of nikethamide is improved, nikethamide is further condensed with diethylamine, the reaction is an exothermic reaction, the reaction temperature is strictly controlled in the reaction process, the reaction rate of condensation is improved, and the yield is also improved; furthermore, through post-treatment such as oxidation, water distillation and decoloration, the produced raw material medicine has good characters and chemical stability, and meets the requirements of Chinese pharmacopoeia 2020 edition on nikethamide. According to the invention, the production process of the nikethamide bulk drug is optimized, the production period is shortened, and the cost is reduced.

The invention discloses an aluminum-based catalyst for producing triethylamine through reaction of coal-based ethanol and diethylamine. The active component is loaded on the carrier; the rod-like morphology is fully utilized, the dispersity of active metal can be effectively improved, the isolation effect of Sn is achieved, after hydrogen reduction, oxidation-state cobalt becomes reduction-state cobalt more easily, distribution of the reduction-state cobalt in rod-like aluminum oxide is more uniform, agglomeration is not prone to occurring in the reaction process, and the reaction efficiency is improved. The diffusion of reactants and products in the catalyst and the improvement of the reaction activity of the catalyst are facilitated; when the catalyst is used for producing triethylamine through reaction of coal-based ethanol and diethylamine, compared with a CoSn / Al2O3 (irregular morphology) catalyst, the selectivity of triethylamine can be obviously improved. The active components are elemental cobalt and elemental tin.

The invention relates to the field of monoethylamine preparation processes, and discloses a monoethylamine production method, which comprises: under the action of an ammonolysis catalyst, uniformly mixing and preheating diethylamine, hydrogen and ammonia gas, allowing diethylamine to pass through an ammonolysis reactor and a deamination tower, carrying out monoethylamine refining, diethylamine refining and triethylamine refining, and preparing monoethylamine, the ammonolysis catalyst comprises a carrier as well as an active component and an auxiliary agent which are loaded on the carrier, and is characterized in that the carrier is aluminum oxide modified by a titanium silicalite molecular sieve, the content of the aluminum oxide exceeds 68wt% of the total mass of the carrier, the active component comprises nickel, the auxiliary agent comprises iridium, and the content of the titanium silicalite molecular sieve is more than 68wt% of the total mass of the carrier. On the basis of the total weight of the ammonolysis catalyst, the content of the nickel element is 15-30 wt%, and the content of the iridium element is 0.2-2 wt%. By adopting the method disclosed by the invention, monoethylamine can be directly produced by taking diethylamine as a raw material.