1104 results about "Diethylamine" patented technology

The invention describes compositions and methods of use for 2,5-dihydroxybenzene sulfonic acid compounds and pharmaceutically acceptable salts thereof. The invention provides methods for (a) treating skin cancer; (b) treating cancer of the organs; (c) treating leukemia; (d) improving the efficacy of chemotherapy, radiation therapy and / or cancer immunotherapy; (e) treating rosacea; and (f) treating psoriasis by administration of a composition comprising at least one 2,5-dihydroxybenzene sulfonic acid compound or a pharmaceutically acceptable salt thereof, and, optionally at least one therapeutic agent. Also disclosed are compositions comprising administration of at least one 2,5-dihydroxybenzene sulfonic acid compound, or a pharmaceutically acceptable salt thereof, and, at least one therapeutic agent. In the invention the 2,5-dihydroxybenzene sulfonic acid compounds or pharmaceutically acceptable salts thereof are 2,5-dihydroxybenzene sulfonic acid, calcium 2,5-dihydroxybenzenesulfonate, potassium 2,5-dihydroxybenzenesulfonate, magnesium 2,5-dihydroxybenzenesulfonate and diethylamine 2,5-dihydroxybenzenesulfonate.

The invention discloses graphene aerogel and a preparation method thereof. The method comprises the following steps: (1) uniformly mixing graphene oxide dispersion liquid with an amine water-soluble compound to obtain graphene oxide mixed liquid, wherein the amine water-soluble compound is selected from one or more of diethylamine, ethidene diamine, propane diamine, butane diamine, diethylene triamine, triethylene tetramine, tetraethylene pentamine, allylamine polymer and N,N'-bis(2-aminoethyl)-1,3-propane diamine; (2) irradiating the graphene oxide mixed liquid by high-energy rays under the anaerobic condition to obtain amino-modified graphene aerogel; (3) performing freeze-drying or supercritical CO2 drying to obtain the graphene aerogel. The graphene aerogel adopts a porous and macroporous structure, is relatively uniform in structure, and can be used for adsorbing an organic solvent; moreover, the preparation method is simple and environment-friendly.

Production of methyl-methyl acrylate from methanal is carried out by reacting methanal with propanal in diethylamine muriate solution at 40-45 degree to obtain methyl-acryl, mixing methyl-acryl with methanol in proportion of 30-50:1, adding them into reactor, adding into 2.0-4.0% catalyst, inducing into oxygen at 40-60 degree and flow 10 ml / min, reacting for 4-6 hrs and synthesizing to obtain final product. The catalyst carrier is styrene-divinylbenzene polymer organic resin, which consists of palladium 2-5 wt%, bismuth 0-3 wt%, lead 0.3-1 wt% and iron 0.3-1 wt%. It's cheap, has friendly reactive environment, better selectivity and conversion rate.

The invention discloses nano biological filler for purifying aquaculture wastewater in a biological filter tank and a preparation method of the nano biological filler. The biological filler comprises an EM rejuvenation solution and an adsorption carrier of the EM rejuvenation solution, wherein the EM rejuvenation solution is a product obtained by performing mixed fermentation on an EM stock solution, molasses and deionized water; the adsorption carrier is obtained by performing mixed pressing on composite nano powder, kaolin powder and modified bentonite; the composite nano powder is a product obtained by performing mixing and high-temperature sintering on nano-level aluminum oxide, titanium dioxide and silicon dioxide; modified bentonite is prepared from sodium diethyldithiocarbamate modified original soil. The preparation method comprises the following steps: pressing adsorption carrier particles; fermenting to obtain the EM rejuvenation solution; dipping the EM rejuvenation solution by using the adsorption carrier to obtain the nano biological filler. The obtained nano biological filler is high in pore volume, high in cell adsorption capacity, large in specific surface area and strong in stability, has a good treatment effect on aquaculture sewage, and can be used for rapidly removing ammonia nitrogen, phosphorus and heavy metal ions in an aquaculture water body.

The invention provides a Cu-SAPO-34 molecular sieve catalyst and a preparation method and application thereof. The method includes the steps of adding pseudo-boehmite to deionized water, stirring, adding fumed silica or silica sol and orthophosphoric acid, uniformly mixing, adding copper sulfate and tetraethylenepentamine, fully stirring, and adding diethylamine, triethylamine or n-propylamine; placing fully stirred gel in a hydrothermal reaction kettle for crystallization, cooling at room temperature, separating a solid crystalline product from the mother liquor, washing to be in neutral, drying, and calcinating in air at the temperature of 600 DEG C to 850 DEG C to obtain the Cu-SAPO-34 molecular sieve catalyst. The Cu-SAPO-34 molecular sieve catalyst prepared through a one-step hydrothermal synthesis method. And the molecular sieve catalyst of good NH3-SCR catalytic activity and hydrothermal stability is obtained by controlling the using amount of copper sulfate, tetraethylenepentamine and fumed silica or silica sol and the calcination temperature.

The invention relates to magnetic silicon dioxide microspheres modified with diethylaminoethyl on the surface and a preparation method and an application thereof; the sol-gel method is adopted to prepare magnetic silicon dioxide microspheres which have ferroferric oxide nanoparticles as cores and silicon source, namely tetraethoxysilane as shells; by adopting the microspheres as template, alkylene oxide coupling agent 3-glycidoxypropyltrimethoxysilane (GPTMS) as activator and diethylaminoethyl hydrochloride as functional group, the magnetic silicon dioxide microspheres modified with diethylaminoethyl (DEAE) on the surface are prepared. The method comprises the preparation of magnetic silicon dioxide microspheres, the epoxidation of magnetic silicon dioxide microspheres and the DEAE surface modification. The method solves the problems that the bindingability between the existing magnetic microspheres and nucleic acid is not high, the preparation processes are complicated and the like. The bindingability between the magnetic microspheres prepared by the method and nucleic acid is high so as to be used to separate nucleic acid from the biological sample.

The invention relates to a preparation method of high purity bulleyaconitine A. The preparation method comprises the following steps: root of radix aconiti feri of Yunnan is crushed, and acid alcoholic solvent or alcohol water solution is used for diacolation, and supersound or thermal refluxing extraction. The extracting solution is decompressed and concentrated to be non-alcoholic at the temperature of 80 to 90 DEG C, cooled down to room temperature, to ensure the relative density to be 1.00 to 1.30; standing is performed for 10 to 20 hours; the extracting solution is filtered; the pH is adjusted to 6.0 to 8.0 with basifier; and then the extracting solution is extracted with ethyl acetate or chloroform. The ethyl acetate or chloroform liquid is contracted, column chromatography is performed to the obtained paste, silica gel or neutral alumina are used as fillers, any one of solvent vapor-acetone-diethylamine, ligarine-acetone-diethylamine or cyclohexane-acetone-diethylamine is used for eluation, the bulleyaconitine A in the collected liquid is constantly checked during the thin layer chromatography, the collected liquid containing the bulleyaconitine A is merged, the solvent is concentrated, carbinol or ethanol is dissolved, filtering is performed, crystallization is performed at room temperature, filtering is performed, the crystal is repeatedly rinsed with carbinol or ethanol, and the final product is obtained. The purity of the obtained product is high, the production cost is low, and the toxicity of the used organic solvent is low.

The invention discloses a preparation method of high-purity ellagic acid; tara powder is taken as raw material, extracted by purified water or 50-percent to 90-percent ethanol or a methanol water solution, hydrolyzed by concentrated sulfuric acid or hydrogen peroxide, purified by using diethylamine or triethylamine and crystallized, thus obtaining the high-purity ellagic acid; the method has simple technique and is suitable for industrialized production.

The invention provides sacubitril derivatives and medicine compositions, preparation methods and application thereof and belongs to the fields of medicine compounds and preparation thereof. The sacubitril derivatives comprise sacubitril lithium salt, sacubitril kali salt, sacubitril magnesium salt, sacubitril calcium salt, sacubitril strontium salt, sacubitril zinc salt, sacubitril ferric salt, sacubitril ammonium salt, sacubitril diethylamine salt, sacubitril ethylenediamine salt, sacubitril piperazine salt, sacubitril N-(2-ethoxyl)-pyrrolidine salt, sacubitril choline salt, sacubitril cholamine salt, sacubitril diethanol amine salt, sacubitril triethanolamine salt, sacubitril tromethamine salt, sacubitril meglumine salt, sacubitril diisopropylamine salt, sacubitril tert-butylamine salt, sacubitril N, N'-bis-benzyl ethylenediamine salt, sacubitril L-lysine salt, sacubitril L-arginine salt or sacubitril L-histidine salt.

The invention provides a dispersant used for wet grinding of heavy calcium carbonate and the preparation method thereof. The dispersant is composed of Alpha and Beta-unsaturated carboxylic acid of 80 to 100 parts by weight, and other monomers of 0 to 20 parts by weight, which are polymerized together, and a neutralizing agent in the polymer is selected from one or two of inorganic base ammonium hydroxide, sodium hydroxide, potassium hydroxide, calcium hydroxide, etc., or organic base diethylamine, triethylamine, mono ethanolamine, diethanolamine, triethanolamine, etc. The dispersant of the invention is used for grinding calcium carbonate pulp with high solid content, low viscosity and good time efficiency and stability.

The present invention relates to one kind of composite ZSM-23 / ZSM-22 molecular sieve and its synthesis. The silicon-aluminum colloid obtained through mixing silicon source, aluminum source, inorganic alkali, water and template agent is mixed with ZSM-23 molecular sieve, and the pH value of the solution is regulated with inorganic acid to obtain the initial colloid with molar ratios of SiO2 / Al2O3 25-1500, R / SiO2 0.05-3, OH- / SiO2 0.05-0.5, M / SiO2 0.1-0.5 and H2O / SiO2 10-65, the ZSM-23 molecular sieve adding amount in 1-60 wt% of SiO2, and template agent being one or several of diethylamine, diethyl triamine, triethyl tetraamine, hexane diamine and octyl diamine. The initial colloid is hydrothermally crystallized to obtain the composite molecular sieve. The composite molecular sieve is used in the isomerization dewaxing of lubricant oil and exhibits excellent catalyzing performance.

An oil-removing compound and its preparation method. The compound is formed by combining 20-50 wt% of epichlorohydrin-amine cationic polymer, 0-1 wt% of polyacrylamide, 10-25 wt% of an inorganic flocculating agent and the balance water. The preparation method of the compound comprises the following steps of: performing a ring-opening polymerisation reaction between dimethylamine or diethylamine and epoxy chloropropane; adding a cross-linking agent into the reaction system to carry out a crosslinking polymerization reaction so as to obtain the epichlorohydrin-amine cationic polymer; mixing theepichlorohydrin-amine cationic polymer, polyacrylamide and the inorganic flocculating agent with stirring; and adding the mixture into water with stirring to obtain the compound. The compound provided by the invention can treat oil-containing sewage and is widely applied; the preparation method has advantages of mild synthesis condition, easy synthesis technology, low cost and no ''three wastes (waste gas, waste water and industrial residue)'' discharge, and conforms with the requirements of environmental protection.

The invention discloses a polyamide hot melt adhesive used for clothing a preparation method thereof. With the protection of nitrogen-gas, an unsaturated fatty acid dimers comprising carbon numbers between 12 and 20, an dicarboxylic acid comprising carbon numbers between 6 and 12, a molecular weight regulator, a diamine, a lactam, water and a stabilizer are subject to lower temperature and pressure and dehydration in reactions, next, an N-diethylamine- propyl-Octadecanamide, a nonyl phenol, condensation products of formaldehyde and tetraethylenepentamine are added in and stirred. After the series of reactions, the polyamide hot melt adhesive is obtained. The polyamide hot melt adhesive of the invention of used for clothing has the advantages of narrow molecular weight range, rapid solidification and excellent performance of water resistance and solvent resistance, etc.; the copolyamide is modified by adding appropriate proportions of condensation products of N-diethylamine propyl-Octadecanamide and mnnnich amide, so as to improve the water resistance and solvent resistance substantially. The loss rate of peeling strength of the products obtained is less than 20 percent after alkaline cleaning above 60 DEG C; the loss rate of peeling strength of the products obtained is less than 10 percent after dry cleaning by tetrachloroethylene.

The invention provides a method for synthesizing SAPO-5 by using diethylamine as template and recovering the template of the SAPO-5. The structural formula of the SAPO-5 is represented by aR x (SixAlyPz)O2, wherein, the x, y and z are a molar fraction of Si, a molar fraction of Al and a molar fraction of P respectively, and meet a relation of x+y+z =1; the R is the template; and the a is the mole number of the template, and a is between 0.5 and 2.5. The invention is characterized in that: the template adopts the diethylamine or mixture of nitrogenous organic substances mainly containing the diethylamine ; and the method comprises the following steps of: weighing the template, a silicon source, an aluminium source, a phosphorus source and water according to the mole amount of H2O on a molecular sieve with meshes between 0 and 500; preparing gel through sufficiently mixing and stirring the materials; crystallizing the gel at a temperature of between 160 and 350 DEG C with a reaction time not shorter than 0.1 hour; filtering, washing and drying after complete crystallization, and performing drying under a temperature of between 25 and 120 DEG C; heating up the gel to a temperature not higher than 250 DEG C after molecular sieve synthesis, and condensing and volatilizing diethylamine template which can be reused. The method has the advantages of simple preparation method, low cost and high product yield.

The invention mainly discloses a processing technique of ethyl difluoroacetate, which mainly comprises the following steps of: preparing an intermediate product dichloroacetyl diethylamine through an amination process; carrying out fluorination with anhydrous potassium fluoride and the dichloroacetyl diethylamine as raw material under the action of a solvent and a phase transfer catalyst to prepare difluoro-acetyl diethylamine; and carrying out esterification to prepare the ethyl difluoroacetate. The processing technique of the ethyl difluoroacetate is characterized in that the solvent in the fluorination is sulfolane, and the esterification is a direction reaction of ethanol and the difluoro-acetyl diethylamine. The processing technique of the ethyl difluoroacetate specifically has the advantages of improving the final yield by changing the solvent during the fluorination and improving the production rate by carrying out the direct esterification after the fluorination.

The invention relates to a method for preparing simplified high-purity bulleyaconitine A, which comprises the following steps of: immersing tuberous root of kusnezoff monkshood root in 1 to 2 percent alkaline solution; crushing the tuberous root; performing heat reflux extraction with gasoline or petroleum ether 6 and the like; loading the extract; eluting the tuberous root with solvent gasoline, ethyl acetate and triethylamine or diethylamine in a volume ratio of 90-95 to 1-10 to 1-5; concentrating the eluent under reduced pressure till the eluent is dry; then thermally dissolving the eluent with the solvent gasoline; standing the obtained solution for 20 to 24 hours at normal temperature; crystallizing, filtering and drying the solution to obtain the crude product of the bulleyaconitine A; fully dissolving the crude product in methanol on a water bath of 45 to 55 DEG C; filtering the obtained solution and preserving the heat for 30 minutes on the water bath of 45 to 55 DEG C; adding pure water or distilled water dropwise to assist in the crystallization; standing the solution for 20 to 24 hours at normal temperature to form a crystal; performing filtration to remove the liquid part; washing the crystal for three times; and pumping the crystal and drying the crystal to obtain the finished product. The process has the advantages of simplified production flow, low cost, no three-waste emission, simple operation, high production safety and high extraction rate of the bulleyaconitine A.

The invention relates to a synthetic improvement method of acryloylmorpholine, and belongs to the field of organic synthesis. The method comprises the following steps: performing Michael addition on diethylamine and methyl acrylate which are taken as raw materials so as to generate 3-methoxy-diethyl methyl propionate; then performing an amidation reaction by adding morpholine so as to generate 3-morpholinyl-diethyl propionamide; and finally performing a catalytic cracking reaction so as to obtain a target product, namely, the acryloylmorpholine. The method is simple and short in process, easy in raw material obtainment, simple in equipment, easy in reaction condition control, moderate in preparation condition and simple in purification refining process. The acryloylmorpholine is stable, easy to separate and is difficult to polymerize.

Provided is a process for synthesizing molecular sieves of SAPO-11 and SAPO-34 with diethyl amine as template agent. Phosphorus source, aluminum source, silica source and the template agent are taken as raw materials, and SAPO-11 and SAPO-34 are prepared by controlling the proportion (0<R / P2O5<=6.0) of the template agent R and the phosphorus source in synthetic gel. When SAPO-11 is prepared, 0<R / P2O5<=0.8, when SAPO-34 is prepared, 0<R / P2O5<=6.0, and when the proportion of R / P2O5 is between 0.8 and 1.5, symbiotic mixture of SAPO-11 and SAPO-34 with different proportions is formed. The molecular sieves synthesized by the process of the invention can be used as catalyst for acid catalytic reaction, such as the reaction of the conversion of methanol to olefins.

The invention describes compositions and methods of use for 2,5-dihydroxybenzene sulfonic acid compounds and pharmaceutically acceptable salts thereof. The invention provides methods for (a) treating skin cancer; (b) treating cancer of the organs; (c) treating leukemia; (d) improving the efficacy of chemotherapy, radiation therapy and / or cancer immunotherapy; (e) treating rosacea; and (f) treating psoriasis by administration of a composition comprising at least one 2,5-dihydroxybenzene sulfonic acid compound or a pharmaceutically acceptable salt thereof, and, optionally at least one therapeutic agent. Also disclosed are compositions comprising administration of at least one 2,5-dihydroxybenzene sulfonic acid compound, or a pharmaceutically acceptable salt thereof, and, at least one therapeutic agent. In the invention the 2,5-dihydroxybenzene sulfonic acid compounds or pharmaceutically acceptable salts thereof are 2,5-dihydroxybenzene sulfonic acid, calcium 2,5-dihydroxybenzenesulfonate, potassium 2,5-dihydroxybenzenesulfonate, magnesium 2,5-dihydroxybenzenesulfonate and diethylamine 2,5-dihydroxybenzenesulfonate.

The invention provides a rabeprazole sodium composition which comprises the active ingredients of rabeprazole, mannitol and ethylene diamine tetraacetic acid, wherein the weight ratio of ethylene diamine tetraacetic acid to rabeprazole sodium is 0.05-0.5:1. The method for preparing the composition into solid powder-needle preparation comprises the following steps: dissolving the ethylene diamine tetraacetic acid solution with the prescription amount into injection water, adding and stirring the rabeprazole sodium with the prescription amount at a temperature of 25-35 DEG C for dissolving, then adding mannitol with the prescription amount, stirring the mannitol for dissolving, cooling to a room temperature, and regulating the pH value of the solution to 11.5-12.5; adding active carbon intothe confected solution, stirring and filtering for decarburization, and freezing and drying the obtained filtrate to obtain the rabeprazole frozen powder needle. The rabeprazole frozen powder needle has full appearance, favorable stability and solubility and little insoluble grains in the injection.

The invention is concerned with the prepare method of capillary for solid phase microextraction. The methacrylic acid glycidyl is function monomer, the ethyleneglycol dimethacrylate is vulcanizing agent, toluene and dodecyl are mixed pore-causing agent, and 2,2'-azobisisobutyronitrile is initiator. Mix and mill the stuff and pour into quartz capillary disposed with ethylene, close and heat to polymerization. After the reaction, use solvent to clean capillary and remove the rudimental monomer, vulcanizing agent and pore-causing agent to get whole capillary with the polymer of methacrylic acid glycidyl and ethyleneglycol dimethacrylate. Use vitriol to clear the whole capillary to get hydroxylation, or clear the capillary with diethylamine and close to heat at 65 to 75 degree to get the capillary with the polymer of methacrylic acid glycidyl and ethyleneglycol dimethacrylate derived from diethylamine. The method is easy and low cost and the extraction agency stuff is fit to set up a credible and high sensitive analysis method.

The invention relates to a novel nano-composite double network hydrogel and a preparation method thereof. The preparation method of the hydrogel comprises the steps of: performing a condensation (polycondensation) reaction of amines and epichlorohydrin or polyalcohol and aldehydes in clay solution to obtain a condensate (polycondensate) / clay composite first; and adding a hydrophilic monomer under the action of an initiator and a cross-linking agent to obtain the nano-composite double network hydrogel through free radical crosslinking polymerization, wherein in the condensation (polycondensation) reaction, the amines are selected from dimethylamine, methylamine, ethylamine, propylamine, diethylamine, quadrol, propylene diamine, diethylenetriamine, triethylenetetamine and tetraethylenepentamine, the polyalcohol is selected from glycol, propanediol, glycerol, butanediol, neopentyl glycol, pentaerythritol, polyvinyl alcohol, polyethylene glycol, glucose, sucrose, sorbierite, soluble starch and chitosan, the aldehydes are selected from formaldehyde, malonaldehyde and glutaraldehyde, clay is selected from laponite, bentonite or hydrophilic modified bentonite, and the hydrophilic monomer is selected from acrylic acid, acrylamide, N-Isopropylacrylamide, methacrylic acid, acrylonitrile and propene sulfonic acid. The novel hydrogel has the excellent mechanical strength under the condition of high moisture content.

The invention provides a method of preparing a metal organic frame compound by using ultrasonic waves. The method comprises the following steps: dissolving copper salt or zinc salt in a way of stirring or ultrasonication in an organic solvent or a mixed solution of water and the organic solvent; dissolving an organic ligand in the organic solvent or the mixed solution of water and the organic solvent to form an organic ligand solution; then, mixing the organic ligand solution and saline liquor, adding a proton removal agent triethylamine or diethylamine, carrying out reaction under an ultrasonic intermittent effect, and repeatedly replacing by using the solvent to obtain the metal organic frame compound. The reaction temperature is reduced by an ultrasonic synthesis method, the crystallization time is shortened, and the yield of the metal organic frame compound is greatly improved. The method has the advantages of simple operation, mild reaction condition, environmental friendliness, low cost, high reaction yield and the like, and can be put into industrial production easily.

A new optical sensing method for detection of analyte vapors down to ppb levels is described. The sensor is based on the use of a visible indicator, such as Bromocresol green, adsorbed onto a high surface area substrate, such as a silica sphere matrix. When the analyte gas is adsorb onto the matrix, the indicator undergoes a color change. The color change in turn is detected with a suitable spectrometer. Sensor performance is demonstrated for an exemplary amine sensor for the aliphatic amines tert-butylamine, diethylamine and triethylamine and also for pyridine and aniline. The microsphere sensor is more sensitive than other prior art optical amine sensor designs. The sensor response varies with temperature, with lower sensitivity and faster response at higher temperatures allowing for adjustment to prioritize sensitivity or speed. The sensor response is also highly reproducible and fully reversible.

The invention provides a bottom coating for processing vacuum aluminum-plated paper and a preparation method and application thereof. The bottom coating comprises, by weight parts, acrylic resin 5 to 30 parts, a neutralizing agent 0.4 to 6 parts, acrylate resin 100 parts, vinyl resin 5 to 20 parts, a leveling agent 0.011 to 0.15 parts, a defoaming agent 0.11 to 0.75 parts, a wear-resisting agent 0 to 1.5 parts, ethanol 0 to 100 parts and water 30 to 650 parts, wherein the neutralizing agent is selected from one or more of diethylamine, triethylamine, diethanolamine or triethanolamine, and the wear-resisting agent is water-soluble wax emulsion. The bottom coating for vacuum aluminum-plated paper treatment can be used for surface treatment of beer label paper. The bottom coating for the vacuum aluminum-plated paper treatment can meet the requirement of high performance and environment protection for vacuum aluminum-plating coating, and has the advantages of water solubility, safety, environment protection, excellent alkali tolerance, high glossiness and good abrasion resistance.

The invention discloses a Fe<3+> molecular fluorescence sensor based on Rhodamine B and a preparation method and application of the Fe<3+> molecular fluorescence sensor. Rhodamine B is taken as a precursor, and a target product N1-(benzene[d] thiazole-2-yl)-N4-(2-(3',6'-bi(diethylin)-3-carbonyl screw[iso-indoline-1,9'-xanthene]-2-yl)ethyl) maleimide is synthesized at two steps. Detection on Fe<3+> by using the target product shows that the target product has a very good detection effect on Fe<3+>; and meanwhile the raw materials of the Fe<3+> molecular fluorescence sensor are easy to obtain, synthesis steps are simple, after-treatment is convenient to implement, and large-scale production can be relatively easily achieved.

Synthesis of water soluble half amide oxide is carried out by taking 1,4-dioxane as solvent at low-temperature, diethylene acid anhydride reacting with dimethylamine, diethylamine, and dipropylamine under pyridine, the products concentrating, chlorhydric acid acidifying, crystallizing precipitating, and annealing purifying in water or alcohol and diethyl ether mixed solvent. Its advantages include good water solubility, high output, and simple process.

The invention belongs to the technical field of zeolite molecular sieve materials, and concretely relates to a nano-polycrystalline SAPO molecular sieve with a high specific surface area, and a preparation method and an application thereof. The nano-polycrystalline SAPO molecular sieve with a high specific surface area is a CHA structure type or RHO structure type or CHA structure and RHO structure eutectic silicoaluminophosphate (SAPO) molecular sieve, is synthesized through a gas and solid phase crystal transformation reaction of a amorphous silica alumina phosphorus oxide dry glue in steam of a water and diethylamine mixed template, and is especially suitable for catalyzing adsorbing separation of micro-molecular gases from low carbon olefins prepared from methanol.

The invention discloses a one-step synthesis method of N, N-diethyl-3-methyl-benzamide with a fixed bed, which comprises the steps that: 3-methyl benzoic acid and diethylamine are stirred under a solvent system for reaction to generate a complex salt compound of the 3-methyl benzoic acid and diethylamine, and then materials are fed to the catalyzing fixed bed continuously under constant temperature and constant pressure, then dehydrated continuously to obtain a crude product; the solvent is recovered by distillation under ordinary pressure; finally the pure product of the N, N-diethyl-3-methyl-benzamide is obtained after rectification under vacuum. The molar ratio of the 3-methyl benzoic acid to the diethylamine to the solvent is 1.0: (1.0-15.0): (0-25.0), the mass velocity is 0.1 h<-1> to 20.0 h<-1>, the reaction temperature of the fixed bed is 60 DEG C to 550 DEG C and the reaction pressure of the fixed bed is 0.1 MPa to 5.0 MPa. The synthesis technology has the advantages of short technological process, high conversion ratio, good selectivity, high yield rate, small amount of waste gas, waste water and waste residues, reproducible and recyclable catalyst and low cost.