The invention belongs to the field of
fine chemical engineering, and discloses a method for synthesizing 2, 3-dimethyl-2-
isopropyl butyronitrile, which comprises the following steps of: adding an organic
amine solvent into a high-pressure reaction kettle, adding
sodium amide,
sodium iodide and a
phase transfer catalyst into the reaction kettle under the protection of
nitrogen and in a stirring state, stirring for a certain period of time, and reacting for 2-3 hours to obtain 2, 3-dimethyl-2-
isopropyl butyronitrile. Dropwise adding a
mixed solution of
propionitrile and 2-bromopropane into the reactor, controlling the dropwise adding speed and the
reaction temperature, continuously reacting for a period of time after the dropwise adding is finished to obtain a reactant solution, cooling the reactant solution, adding water, standing for layering, collecting an organic phase, distilling the organic phase at normal pressure to recover a
solvent, and rectifying at reduced pressure to obtain 2, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3-pentanediol. According to the method, the
sodium iodide, the
phase transfer catalyst and the organic amine have a synergistic effect, so that the reaction time is shortened, and the yield of the product is improved.