50 results about "Chain termination" patented technology

The invention relates to a chemically modified high-strength high-temperature-resistant polyurethane fiber and a preparation method thereof.The preparation method comprises the following steps that 1, oligomer mixed polyol and diisocyanate are subjected to a full prepolymerization reaction, a solvent is added for full dissolution, and a-NCO-terminated prepolymer polyurethane formate solution is obtained; 2) adding hydroxyalkyl silane and a catalyst into the prepared prepolymer, and fully reacting to obtain a modified prepolymer; (3) carrying out chain extension reaction and chain termination reaction on the prepared modified prepolymer to obtain a polyurethane urea solution; (4) adding an antioxidant, an ultraviolet light absorber, an anti-yellowing agent, a delustering agent and a lubricating and releasing agent into the polyurethane urea solution to prepare a polyurethane spinning solution; and (5) preparing the high-strength high-temperature-resistant polyurethane from the prepared polyurethane spinning solution by virtue of a dry spinning system. According to the invention, a polyurethane molecular chain is subjected to functional chemical modification, so that the product has the characteristics of high temperature resistance and high strength.

The invention discloses the field of organic electronic materials, and particularly discloses a chain terminating molecule for straight-chain polyphosphocarbazole and a polymerization terminating method. The chain termination molecule is a carbazole derivative containing boronic acid pinacol ester, the core structure is'carbazole matrix-linking group-diethyl phosphate group ', and the linking group can be a butyl chain or a benzene ring; after a chain termination molecule is synthesized through a three-step reaction, a Suzuki coupling reaction is utilized to completely replace a residual Br site of straight-chain polyphosphocarbazole, and polymerization termination is realized. The bromine residual quantity of the product is less than or equal to 0.01 wt%, the molecular weight is stabilized at 6-7 monomeric units, and the molecular weight change rate is less than or equal to 5% after the product is dried and stored at 25 DEG C for 6 months; when the material is used as a hole transport layer, the laboratory small-area film thickness deviation is less than or equal to 10%, the corresponding perovskite assembly efficiency is greater than or equal to 23%, the 1000-hour attenuation rate is less than or equal to 15%, the defects of self-agglutination, poor stability and device performance fluctuation of the existing material are solved, the process is simple, and industrialization is easy.

The invention relates to a process for preparing a star copolymer of 1,3-diene and ethylene, the copolymer containing more than 50 mole percent ethylene units. The process comprises the polymerization of a monomeric mixture of 1,3-diene and ethylene in the presence of a catalytic system based on at least one neodymocene borohydride metallocene and an organomagnesium cocatalyst, followed by the reaction of tin tetrachloride with the polymerization reaction product, and then a chain-terminating reaction. The invention also relates to a star copolymer obtainable by the process according to the invention.

The present invention pertains to a polycarbonate resin which contains a structural unit (A) derived from a monomer represented by formula (1) and a structural unit (B) derived from a monomer represented by formula (2), and which has a terminal structure containing a structure derived from a chain terminator represented by formula (Z-1), the molar ratio (A: B) of the structural unit (A) to the structural unit (B) being 35: 65-75: 25, and the number of moles a of the structural unit (A), the number of moles b of the structural unit (B), and the number of moles z of the chain terminator represented by formula (Z-1) satisfy the relationship represented by formula (I). 45 < = 2 * (a + b) / z < 80 (I)

Disclosed is a cDNA amplification method capable of comprehensively amplifying mRNA with a high efficiency and a low bias even from a very small amount of cell sample. The method of amplifying a complementary DNA strand of the present invention comprises steps of capturing a target RNA and synthesizing a complementary DNA strand using a reverse transcriptase having terminal transferase activity in a liquid-phase system or a solid-phase system such that bases such as CCC are added to an end of the complementary DNA strand, and thereafter carrying out homopolymer tailing by the TdT reaction in the presence of a chain-terminating nucleotide triphosphate. By combination with a template-switching reaction, the method enables amplification of the complementary DNA strand with a higher efficiency and a lower bias.

The invention discloses an IVB group metal alkyl complex of a monoanion polydentate ligand and application of the IVB group metal alkyl complex, and provides the IVB group metal alkyl complex of the monoanion polydentate ligand with a general formula structure as shown in a formula (I), a formula (II), a formula (III) and a formula (V). The catalyst can show excellent catalytic performance for homopolymerization and copolymerization of olefin, and especially has better catalytic performance for olefin copolymerization; and a polydentate ligand is adopted to stabilize the structure of the catalyst, increase steric hindrance and inhibit chain termination caused by beta-H elimination in the polymerization process, so that the high activity of the catalyst is realized, and a polymer with high molecular weight is obtained.

This invention provides the application of a class of nucleoside compounds that effectively inhibit CCHFV replication, particularly the application of 2'-α-fluoro-2'-β-methyl modified nucleoside compounds in the preparation of drugs for treating CCHF disease. Studies have found that 2'-α-fluoro-2'-β-methyl-CTP can specifically and efficiently inhibit CCHFV L protein polymerase through an immediate chain termination mechanism, but it cannot be incorporated into the L protein polymerases of Lassa virus (LASV) and Rift Valley fever virus (RVFV), which belong to the same order Arenavirales but different families as CCHFV. Further introduction of this modification into ATP, UTP, and GTP also exhibits good immediate chain termination activity. This invention provides a new direction for the preparation of anti-CCHFV nucleoside drugs and demonstrates its feasibility.

The present invention relates to a reactive hot-melt adhesive composition, containing, in relation to the total weight of the composition, a) 3 wt.% to 79.999 wt.% of at least one alpha-silane-terminated organic polymer; b) 20 wt.% to 96.999 wt.% of at least one silane-terminated polyurethane which is not an alpha-silane-terminated polyurethane; c) 0 wt.% to 70 wt.% of at least one filler; d) 0.001 wt.% to 3 wt.% of at least one silane which has a primary or secondary amino group or a blocked amino group which hydrolyses to form the primary or secondary amino group; wherein the at least one silane-terminated polyurethane b), which is not an alpha-silane-terminated polyurethane, can be obtained by a reaction in which at least one polyol (1) reacts with at least one polyisocyanate (2), optionally in the presence of at least one chain terminator (3), such that a polyurethane prepolymer is formed which, in a further reaction, is reacted with at least one secondary aminosilane (4), which is not an alpha-aminosilane, such that the content of free isocyanate is less than 0.1 wt.% in relation to the total weight of the silane-terminated polyurethane b), and wherein the following proportions result in relation to the sum of the reactants (1), (2), (3) and (4): 1) 40 wt.% to 85 wt.% of the at least one polyol; 2) 10 wt.% to 50 wt.% of the at least one polyisocyanate; 3) 0 wt.% to 25 wt.% of the at least one chain terminator; 4) 1 wt.% to 15 wt.% of the at least one secondary aminosilane, which is not an alpha-aminosilane. The invention also relates to methods for the preparation thereof and to a method for laminating surfaces using the composition.

The present application relates to naphthyl methylene quinone compounds, and preparation method and application thereof, the naphthyl methylene quinone compound has the structural formula of formula I, wherein R1 and R2 are each independently H, C 1‑18 Alkyl or C 1‑18 Cycloalkyl; R3 is H, C 1‑3 Alkyl, C 1‑3 Alkoxy, hydroxyl, nitro or carboxyl.The naphthyl methylene quinone compound of the present application has extended electronic delocalization, which is beneficial to disperse free radicals, makes the structure stable, and plays a role in the termination of free radical reaction chain.The polymerization inhibitor composition containing the naphthyl methylene quinone compound provided by the present application has excellent polymerization inhibition performance, and can be used in the industrial device for inhibiting the polymerization of double bond polymerization monomers.

The invention provides an electrolyte additive, an electrolyte and a battery, the electrolyte additive comprises alkynyl, ether bonds and bromine, the viscosity of ether is low, and the ether bonds are helpful for electrolyte flow, promote rapid movement of lithium ions and significantly improve the rate capability of the battery, so that the battery can still maintain good performance during high-rate charging and discharging; according to the present invention, the bromine group is adopted as the efficient flame retardant, such that the bromine group is rapidly dissociated and captures the free radical during the thermal runaway or short circuit of the battery by using the low bond energy of the carbon-bromine single bond and the high chain termination reaction equilibrium constant of the bromine so as to effectively prevent the flame chain reaction so as to substantially improve the safety of the battery; alkynyl groups are polymerized to form a film on the surfaces of a positive electrode and a negative electrode, the polymer film can well buffer volume expansion of the silicon negative electrode, active particle breakage, pole piece pulverization and active substance falling caused by volume change are reduced, and the cycle stability of the battery is improved; the electrolyte additive provided by the invention can obviously improve the safety performance and the high-temperature safety performance of the battery.

This invention relates to a light-blocking spandex and its preparation method. The light-blocking spandex comprises polyurethane-urea and a matting agent, wherein the matting agent accounts for 0.5% to 5% of the mass of the light-blocking spandex; the matting agent comprises a mixture of titanium dioxide, silicon dioxide, and acrylate. The preparation method is as follows: a polymeric polyol and a polyisocyanate are reacted to obtain a polyurethane prepolymer, which is then dissolved in a solvent to obtain a polyurethane prepolymer solution; the obtained polyurethane prepolymer solution, a diamine chain extender, and an amine chain terminator are reacted to obtain a polyurethane-urea solution; the polyurethane-urea solution and the matting agent are mixed in a certain proportion as raw materials; dry spinning is performed to obtain a light-blocking spandex with a cross-sectional shape including at least one of circular, trefoil, and cross-shaped. This product maintains conventional physical properties that are basically consistent with those of products of the same specification, making the fiber light-blocking, easy to dye, and solving the problem of light transmission and poor coverage of lightweight spandex-containing fabrics.

The invention discloses a preparation method of a high molecular weight polylactic acid-glycolic acid copolymer (PLGA). According to the method, PLGA (poly (lactic-co-glycolic acid)) with relatively low molecular weight is taken as a macromolecular initiator, and ring-opening polymerization of glycolide and lactide monomers is initiated under the action of a catalyst. In the preparation process, a programmed cooling control strategy is introduced by combining the kinetic characteristics of the polymerization reaction, so that the temperature field gradient in the reaction process is accurately regulated and controlled. The control strategy effectively inhibits chain termination and thermal degradation side reactions in the later stage of the reaction while ensuring rapid proceeding of the reaction in the initial stage. According to the method disclosed by the invention, the monomer conversion rate is remarkably improved, and the ultra-high molecular weight PLGA material with the intrinsic viscosity of 1.5 or above is successfully prepared.

The present application relates to natural gas hydrate inhibitor technical field, it is a kind of natural gas hydrate dynamics inhibitor containing polycyclic structure and its preparation method, the former raw material includes acryloyl morpholine, maleic anhydride, dimethylaminopropyl acrylamide, isohexyl glycol, initiator, chain transfer agent and chain terminator, obtain as follows: acryloyl morpholine, maleic anhydride and dimethylaminopropyl acrylamide are dissolved in isohexyl glycol solution, occur radical polymerization under the action of initiator, chain transfer agent and chain terminator and get it.In the natural gas injection and gathering and transportation process, add the natural gas hydrate dynamics inhibitor containing polycyclic structure of the present application, it can participate in hydrate crystal structure generation through the unique polycyclic ring, effectively inhibit the growth of hydrate crystal, prevent the generation of large particle hydrate, with the advantages of good inhibiting effect, less dosage, low comprehensive cost.

The application discloses a strong and tough synergic composite modified asphalt for hydraulic panel leveling layer and a preparation method thereof. Raw materials of the composite modified asphalt include base asphalt, composite modifier, rubber oil and vulcanizing agent. Raw materials of the composite modifier include epoxidized castor oil, HDI (hexamethylene diisocyanate), polymerization inhibitor, phthalic anhydride, inhibitor and chain termination agent. The application drops HDI into the epoxidized castor oil with the polymerization inhibitor to generate epoxidized polyurethane. The epoxidized polyurethane, phthalic anhydride and inhibitor are formed into composite glue particles with a certain size by a granulator. The crosslinking network of the long chain of the epoxidized castor oil and the HDI can effectively help the modified asphalt to realize strong and tough synergy, and the control of the crosslinking density can effectively reduce the viscosity of the modified asphalt, so that the material is more suitable for preparing the asphalt concrete for the strong and tough synergic, long service life hydraulic asphalt concrete panel leveling and cementing layer.

The invention discloses a 2 '-alpha-ethynyl-beta-fluoronucleoside compound which has a structure as shown in a formula I, and pharmaceutically acceptable salts or various optical isomers, solvates or prodrugs thereof, and is a compound targeting a new structure of RNA (Ribonucleic Acid) virus polymerase. The invention also discloses a preparation method of the compound, a composition containing the compound and application of the compound in preparation of drugs for treating virus infection diseases. The 2 '-alpha-ethynyl-beta-fluoronucleoside compound obtained by the invention shows a remarkable chain termination intervention effect in a CCHFV polymerase system, an SARS-CoV-2 polymerase system and an EV71 polymerase system. The result of a cellular level inhibition experiment shows that the 2 '-alpha-ethynyl-beta-fluoronucleoside compound has an obvious inhibition effect on CCHFV on an HUVEC cell.

The invention discloses a process for continuously producing multifunctional modified film material polyethylene, which belongs to the technical field of chemical production and comprises a first reaction system, a second reaction system, a third reaction system and a slurry mixing tank, the first reaction system, the second reaction system and the third reaction system are connected in parallel through pipelines and then are connected with the slurry mixing tank through pipelines, and raw materials of the first reaction system comprise a main catalyst I, a catalyst promoter I, a solvent, a chain terminator and an ethylene monomer; the raw materials comprise a main catalyst II, a cocatalyst II, a solvent, a chain terminator, a comonomer and an ethylene monomer, and the third reaction system comprises a main catalyst III, a cocatalyst III, a solvent, a chain terminator, a comonomer and an ethylene monomer.

The invention belongs to the technical field of environmental analytical chemistry and detection, discloses a soil and water polychlorinated naphthalene environment rapid detection method, and aims to solve the problems that an existing polychlorinated naphthalene detection method is complex in sample pretreatment, long in detection period and high in cost, and a rapid detection technology is insufficient in sensitivity, weak in anti-interference capability and the like. The method comprises the following steps: constructing a free radical chain reaction kinetics system consisting of a chain initiator, a signal report molecule, a chain transfer and regeneration bifunctional reagent and a pH buffer system, taking polychlorinated naphthalene as a chain terminator, and determining the fluorescence quenching rate change of the signal report molecule after the polychlorinated naphthalene is introduced by measuring the fluorescence quenching rate change of the signal report molecule. The ultrasensitive quantitative detection of polychlorinated naphthalene in soil and water is realized. By adopting the technical scheme, the method has the advantages of high sensitivity and signal amplification effect, no need of complex sample pretreatment, environment friendliness, quick response, excellent anti-interference performance and the like.

The invention discloses a preparation method of grafted polypropylene wax. The preparation method comprises the following steps: step 1, raw material pretreatment and performance characterization; 2, preparing a pre-activation system; 3, melting and pre-activating polypropylene wax; 4, preparing a composite initiation system; step 5, carrying out segmented grafting reaction; step 6, chain termination and by-product inhibition; 7, purifying a grafted product; and 8, regulating and controlling performance and preparing a finished product. Ninthly, quality detection and finished product acceptance are conducted; according to the preparation method, pre-activation system preparation and high-speed shearing dispersion are combined, so that the dispersion uniformity of a grafting monomer in a polypropylene wax melting system is remarkably improved; the main initiator and the auxiliary initiator are compounded, so that the initiation temperature interval can be widened, monomer self-polymerization is reduced in the low-temperature initiation period, grafting chain growth is promoted in the medium-temperature growth period, the grafting rate is effectively increased, meanwhile, side reactions such as cross-linking and degradation are inhibited, and the performance stability of the product is remarkably enhanced.

The present invention relates to a reactive hot melt adhesive composition, based on the total weight of the composition, comprising: a) 3 wt.% to 79.999 wt.% of at least one alpha-silane-terminated organic polymer; b) 20 wt.% to 96.999 wt.% of at least one silane-terminated polyurethane, which is not an alpha-silane-terminated polyurethane; c) 0 wt.% to 70 wt.% of at least one filler; d) 0.001 wt.% to 3 wt.% of a filler.-% of at least one silane having a primary or secondary amino group or a blocked amino group hydrolyzed to the primary or secondary amino group; wherein the at least one silane-terminated polyurethane b), which is not an alpha-silane-terminated polyurethane, is obtained by a reaction in which at least one polyol (1) reacts with at least one polyisocyanate (2), optionally in the presence of at least one chain terminator (3), to form a polyurethane prepolymer which is further reacted with at least one secondary aminosilane (4), which is not an alpha-aminosilane, such that the free isocyanate content is less than 0.1 wt% based on the total weight of the silane-terminated polyurethane b), and wherein, based on the sum of the reactants (1), (2), (3) and (4), the following proportions are obtained: 1) 40 wt% to 85 wt% of the at least one polyol; 2) 10 wt% to 50 wt% of the polyisocyanate.-% of at least one polyisocyanate; 3) 0 wt.% to 25 wt.% of at least one chain terminator; 4) 1 wt.% to 15 wt.% of at least one secondary aminosilane that is not an alpha-aminosilane. The invention further relates to processes for their preparation and a process for surface lamination using the composition.

Provided herein are products and processes for detecting the presence or absence of minor nucleic acid species in a sample containing a mixture of minor nucleic acid species and one or more major nucleic acid species, where the amount (frequency or copy number) of the minor nucleic acid species is less than that of the major nucleic acid species. Certain methods include amplifying the mixture and extending the resulting amplicons using chain terminating reagents and extension primers that specifically hybridize to the amplicons, where a chain terminating reagent specific for the major nucleic acid species has a concentration that is less than a chain terminating reagent that is specific for a minor nucleic acid species. Skewing the concentrations of the chain terminating reagents in favor of high concentrations of the chain terminating reagents specific for the minor nucleic acid species relative to a chain terminating reagent specific for a major nucleic acid species improves the detection limit (sensitivity) of detecting minor nucleic acid species present at low frequency or copy number in the mixture. In addition, the signals generated from the extension product of the major nucleic acid species amplicon can serve as a positive control and permit quantification of the minor nucleic acid species relative to the major nucleic acid species in the mixture.

The invention relates to an in-situ synthesis method of a nano material modified polyurethane fiber, which comprises the following steps: 1, carrying out full prepolymerization reaction on polyol and diisocyanate, and adding a solvent for full dissolution to obtain a-NCO-terminated prepolymer polyurethane formate solution; 2, carrying out chain extension and chain termination on the prepolymer solution by adopting a mixed amine solution to generate a polyurethane urea stock solution; and 3, adding the nano Tris-LDH and the nano SiO2 into the polyurethane urea solution for curing, and spinning the polyurethane urea solution into the nano modified Tris-LDH / SiO2 / PU polyurethane elastic fiber by virtue of a dry spinning system. According to the method, high-dispersity nano Tris-LDH and nano SiO2 are jointly used as a nano modified material of polyurethane for the first time, the problems that polyurethane is low in breaking strength, poor in high temperature resistance, insufficient in fatigue resistance and the like are solved, and the polyurethane fiber prepared through the method has good thermal stability, mechanical strength and stretchability.

The invention relates to the technical field of TPU materials, in particular to a water-based foaming TPU high and low temperature film and a preparation method thereof.The high and low temperature film comprises a water-based PU coating, a carrier layer and a hot melt adhesive layer, and the water-based PU coating is formed by coating a water-based PU material; the water-based PU material is prepared from the following raw materials in parts by weight: 100 to 150 parts of isocyanate, 200 to 300 parts of polyether polyol, 5 to 10 parts of a compound chain extender, 0.5 to 2 parts of a hydrophobic modifier, 0.2 to 0.5 part of an antioxidant, 0.02 to 0.05 part of a catalyst, 2 to 3 parts of a salt-forming agent and 0.2 to 0.5 part of a chain terminator, wherein the compound chain extender comprises a dihydric alcohol chain extender and a disulfide bond chain extender. By adding the compound chain extender and the hydrophobic modifier, the film has excellent tensile strength, elongation at break, water resistance, air permeability and repair performance, and has the advantages of light weight, soft touch and the like.

The invention provides a temperature-sensitive gel plugging agent as well as a preparation method and application thereof. The temperature-sensitive gel plugging agent is prepared from the following raw materials in specific parts by weight: hydroxyethyl acrylamide, a cross-linking agent, a stabilizer, an initiator, a chain terminator, a cosolvent and water. According to the temperature-sensitive gel plugging agent, the gelling time can be adjusted according to the temperature change, the water invasion resistance and the salt and gypsum invasion resistance are high after gelling, the high pressure-bearing strength of gel after gelling can be guaranteed, and the pressure-bearing capacity of a low-pressure stratum is greatly improved; meanwhile, degradation can be carried out through gel breaking according to needs, the plugging removal effect is achieved, the plugging agent is suitable for high-permeability, fissure and karst cave malignant leakage plugging, and oil, gas and water layers can be effectively separated to meet the site construction requirement.

Modified antisense mucleic acid molecules ending with or without chain terminating bases targeting the HIV-1 viral genomic RNA 3′ LTR region, and uses thereof for inhibiting HIV-1 replication and infection, are disclosed. The antisense mucleic acid molecules more specifically target a sequence corresponding to about nucleotide 9628 to about nucleotide 9642 of HIV-1 clone pNL4-3.

The present disclosure provides constructs and methods for RNA ligation of 3' chain terminating tails and uses for improving nucleic acid stability and protein expression.

The invention relates to a method for manufacturing thermoplastic poly(vinyl alcohol) derivative in a melt state reaction and a product thereof, wherein the method thermoplastic poly(vinyl alcohol) that has been dried is heated and admixed with an organic acid anhydride that has a catenated carbon structure which ends into a vinyl group, such that a mixture is obtained which is above the melting point of the mixture, thereby causing an ester bond forming condensation reaction in a melt state, wherein at least some of the organic acid anhydride reacts with hydroxyl groups of the thermoplastic poly(vinyl alcohol), such that reaction product is formed which contains carboxylic acid residue and thermoplastic poly(vinyl alcohol) derivative which contains ester bonded pendant chains of which at least some end into vinyl groups. The invention further relates to a method for manufacturing a paper substrate and a product thereof, which contains a primer layer that contains the reaction product.

The application provides a quinoline pyridine nickel pre-catalyst and a preparation method and application thereof. The nickel pre-catalyst is 8-(2,6-di(aryl)-3,4,5-trifluorophenyl) imino-5,6,7-trihydroquinoline pyridine. Under the protection of inert gas, a ligand L is prepared by using 5,6,7-trihydroquinoline-8-ketone and synthetic aniline A, and the ligand L is reacted with (DME)NiBr2 to prepare a series of nickel pre-catalysts Ni R ; the nickel pre-catalyst is activated by methylaluminoxane (MAO) and used for ethylene polymerization catalytic performance experiment, the nickel pre-catalyst shows high catalytic activity (3.1×10 6 g mol ‑1 h ‑1 ), and produces controllable polyethylene with chain walking (branching degree = 58-90 / 1000C), chain transfer (polymer M w = 0.7-2.8 kg mol ‑1 ) and chain termination reaction (vinylidene / ethylene = 83.4-93.6%) and the like. It is worth noting that the beta-elimination reaction is the main chain termination mode in the system, so that the obtained polyethylene can change from polyethylene wax to viscous oil with the change of polymerization temperature, and further produce polyethylene with a higher internal double bond ratio.

The invention relates to the technical field of preparation of diesel engine oil antioxidants, and particularly discloses a preparation process of a diesel engine oil composite antioxidant with a long oil change period, which comprises the following steps: S1, pretreating a nano antioxidant, S2, microencapsulating a main antioxidant, S3, pre-dispersing base oil, S4, dispersing and mixing, S5, homogenizing and stabilizing, and S6, post-treating. According to the invention, the phenolic main antioxidant is released in stages under high temperature and shearing conditions after being microencapsulated, and free radical capture and chain termination effects can be continuously provided in the whole service cycle of the oil product. The amine auxiliary antioxidant participates in free radical capture at the initial stage of a linear oxidation chain, and forms a double insurance mechanism with phenol components, so that the initial oxidation rate is reduced. The metal chelating agent can effectively capture transition metal ions in engine oil and combustion products, inhibit generation of free radicals catalyzed by metal, and guarantee the cooperative work efficiency of antioxidants.

The invention discloses a preparation method of a tetrafluoroethylene-hexafluoropropylene copolymer with regular chain segments, and relates to the technical field of fluorine-containing polymer synthesis. According to the method, the conversion efficiency of hexafluoropropylene and tetrafluoroethylene is optimized through constant-pressure continuous feeding, and a low-temperature and low-dosage initiator is adopted to prolong the chain growth stage and reduce the chain termination frequency, so that the copolymer with higher molecular weight and narrower molecular weight distribution is obtained. And the chain segment regularity of the copolymer is effectively improved by using the chain segment regularity accelerant and the specific molecular weight regulator, so that the tensile strength and the thermal deformation temperature are improved. And the performance deviation of different batches is obviously improved. The method has relatively good industrial operability and is suitable for preparing the high-performance fluoropolymer.