96 results about "Cyclic amines" patented technology

The invention provides a polyimide multilayer composite membrane material as well as a preparation method and application thereof, and belongs to the technical field of gas separation. According to the method, through collaborative design of a functional support layer, a gradient MOF layer and an ultrathin selection layer structure, the problems of support layer pore seepage, MOF agglomeration, weak interface bonding and the like in an existing composite membrane material are solved. The preparation method comprises the following steps: firstly, carrying out electrostatic spinning on a polyamide acid glue solution, and synchronously introducing dopamine by adopting a chemical imidization method to prepare a functionalized polyimide fiber membrane containing hydroxyl and amino on the surface, so that the mechanical property of a supporting layer and the MOF anchoring capability are remarkably improved; growing MOF layers with different particle sizes on the surface of the fiber membrane by regulating and controlling the concentration gradient of ligand / metal salt and the reaction time, and passivating through a silane coupling agent after each step of growth so as to avoid heterogeneous nucleation and construct a gradient structure; after the MOF gradient layer is subjected to Ar plasma pretreatment to introduce hydroxyl, the ultrathin polyamide selection layer is formed by utilizing interfacial polymerization of fluorine-containing acyl chloride and a macrocyclic amine monomer, and the ultrathin polyamide selection layer is suitable for gas separation work.

The invention discloses a quick-curing high-temperature-resistant anticorrosive coating for two-component packaging and a preparation method of the quick-curing high-temperature-resistant anticorrosive coating. The component A of the coating is composed of novolac epoxy resin, epoxy resin, a reactive diluent, an auxiliary agent, an anti-rust pigment, a filler, aluminum powder and a solvent; and the component B consists of phenolic aldehyde amine, alicyclic amine and a solvent. Compared with a traditional phenolic epoxy coating, the product has the advantages of being high in single-time film forming thickness, rapid in curing, resistant to abrasion, high in thermal stability, resistant to cold and hot impact, resistant to corrosion and the like.

The invention relates to the technical field of organic dyes, in particular to a novel xanthene dye for blue photoresist color paste and a synthesis method of the novel xanthene dye. The invention relates to a synthesis method of a novel xanthene dye for blue photoresist color paste, which comprises the following steps: 1) taking rigid cyclic amine as a nucleophilic reagent, and carrying out aromatic nucleophilic substitution reaction on a chlorinated xanthene compound to obtain a xanthene intermediate; 2) performing chlorination reaction on the xanthene intermediate by using a chlorination reagent to obtain a chlorinated xanthene intermediate; 3) mixing active amine and the chlorinated xanthene intermediate, and performing substitution reaction under the action of alkali to obtain the novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste.The novel xanthene dye for the blue photoresist color paste has the advantages of being high in solubility, good in thermal stability and high in contrast ratio.

This invention relates to a mixed amine carbon capture absorbent for carbon dioxide capture. The mixed amine carbon capture absorbent comprises, by mass percentage: 10-30% main absorbent, 2-15% co-absorbent, 0-5% additive, and the balance being water. The main absorbent comprises a polyamine and / or a sterically hindered amine. The polyamine has 2-4 amino groups. The amino groups of the polyamine include any one or a combination of at least two of primary, secondary, and tertiary amino groups. A carbon chain exists between the amino sites of the polyamine. The carbon chain has ≥2 carbon atoms. The co-absorbent comprises a cyclic amine with side chains. The mixed amine carbon capture absorbent of this invention has advantages such as high CO2 loading capacity, high absorption rate, and low regeneration energy consumption. It can achieve efficient and low-energy capture of CO2 from mixed gases and has good application prospects.

To provide a rubber composition and a tire excellent in overall performance of hardness and crack growth resistance.SOLUTION: The rubber composition comprises a rubber ingredient containing a butyl-based rubber, a cyclic amine having double bonds in the ring, and carbon black having a 24M4DBP oil absorption of 170ml / 100g or more.SELECTED DRAWING: None

Provided are a compound having serotonin 5-HT2A receptor antagonism and / or inverse agonism, a pharmaceutically acceptable salt thereof, and a composition for serotonin 5-HT2A receptor antagonism and / or inverse agonism comprising them.A compound represented by Formula (I):wherein R1 is substituted or unsubstituted aromatic heterocyclyl or the like; R2 is each independently a hydrogen atom or the like; R3 is each independently a hydrogen atom or the like; n is 1 or the like; a combination of (L1, L2) is (NH, N) or the like; R4 is a group represented by Formula:wherein p and q are each independently 2 or the like; Ra is substituted or unsubstituted alkyl or the like; Xb is each independently CRbRb′; Rb is each independently a hydrogen atom or the like; Rb′ is each independently a hydrogen atom or the like; Xc is each independently CRcRc′; Rc is each independently a hydrogen atom or the like; Rc′ is each independently a hydrogen atom or the like; Xd is CRd or the like; and Rd is a hydrogen atom or the like; R5 and R6 are each independently a hydrogen atom or the like; and R7 is a group represented by Formula:wherein A is CR11 or the like; R9 is substituted or unsubstituted alkyloxy or the like; R10 is a hydrogen atom or the like; and R11 is each independently a hydrogen atom or the like; or a pharmaceutically acceptable salt thereof.

Provided in the present invention are a solid form of a cyclic amine derivative, a preparation method therefor, and a pharmaceutical composition, specifically relating to a solid form of a compound of formula I or a salt thereof, a preparation method therefor, and a pharmaceutical composition. The compound of formula I or the salt thereof provided by the present invention has strong binding ability to apo(a) and high stability, and can be better used in clinical practice.

The application discloses an ether-containing energetic binder, a preparation method and application, and the ether-containing energetic binder comprises an epoxy resin and a curing agent. The epoxy resin comprises a structural resin component and an energetic resin component, the rigid structural unit selected from at least one of a six-membered alicyclic ring and a benzene ring is contained in a molecular main chain of the structural resin component, the ether bond structural unit is contained in a molecular main chain of the energetic resin component, and the molar ratio of the energetic resin component to the structural resin component in the epoxy resin is 1:4-9; the curing agent comprises a structural curing agent component and an energetic curing agent component, the structural curing agent component is at least one selected from at least one of an alicyclic amine and an aromatic amine, and the energetic curing agent component is at least one selected from at least one of a polyether amine. The rigidity structure and the flexible and pyrolysis structure ratio of the crosslinking network are regulated through molecular design, so that the material has high mechanical strength and high efficient combustion performance, and is suitable for the field with comprehensive requirements on structure and energy release.

Disclosed is a method for manufacturing an aluminum precursor formed by mixing 1 to 3 moles of a compound represented by the following Chemical Formula 1 or following Chemical Formula 2 and 1 to 3 moles of a compound represented by the following Chemical Formula 3,wherein X is O or S, and R1 or R2 is each independently selected from an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, and an aryl group having 6 to 12 carbon atoms,wherein X is O or S, n is 1 to 5, and R1 to R4 are each independently selected from a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, and an aryl group having 6 to 12 carbon atoms,wherein R1, R2 and R3 are different from each other, and each independently selected from a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a dialkylamine having 1 to 6 carbon atoms, a cycloamine group having 1 to 6 carbon atoms, or a halogen atom.

The present application relates to self-assembled block copolymers containing cyclic cross-linkable groups and self-correcting directed self-assembly methods. The self-assembled block copolymers contain cyclic cross-linkable groups selected from one or more of the group consisting of fused saturated alicyclic aryl, cyclic amine aryl, cyclic ether, and saturated alicyclic aryl. The self-correcting directed self-assembly methods include a first directed self-assembly using a first self-assembled block copolymer, which is the self-assembled block copolymer containing cyclic cross-linkable groups described above, and cross-linking to obtain a first nanostructure, and using the first nanostructure to direct a second self-assembly of a second block copolymer to obtain a second nanostructure. The self-correcting directed self-assembly methods using the self-assembled block copolymers containing cyclic cross-linkable groups of the present application substantially reduce pattern defects and reduce line edge roughness and line width roughness.

The invention relates to the technical field of coating preparation, in particular to a preparation method of kerosene-resistant antibacterial static conductive coating. The invention relates to a preparation method of a kerosene-resistant antibacterial static conductive coating. The kerosene-resistant antibacterial static conductive coating comprises a component A raw material and a component B raw material, the component A is prepared from the following raw materials: novolac epoxy resin, toughened modified resin, a reactive diluent, an auxiliary agent, polyhexamethylene biguanide, an anti-rust filler and a solvent; and the component B comprises the following raw materials: a toughening phenolic aldehyde amine curing agent and an alicyclic amine curing agent. The preparation method of the kerosene-resistant antibacterial static conductive coating has the advantages that the phenomena of bubbling and shedding are avoided, the coating has a protection effect and stable salt spray resistance and surface resistivity, and the static conductive requirement is met. The antibacterial rate is increased, the surface pollution is effectively inhibited, the green chemical industry standard is met, the adhesive force of the coating is improved, the wear resistance is improved, and high toughness can be kept in a low-temperature state.

The invention relates to an organ selective regulation and control method of an ionizable lipid gene vector, which comprises the following steps: firstly, synthesizing uncoordinated ionizable lipid containing a ligand unit (such as cyclic amine), and forming ionizable lipid with different structural characteristics by selecting different tail chains, so that the ionizable lipid can directionally select liver or spleen; and metal ions are introduced into the non-coordinated ionizable lipid structure for coordination, so that the lung can be directionally selected. According to the method, nucleic acid molecules can be controllably and efficiently delivered to the liver, spleen or lung of a mouse, the method has the advantages of being simple, easy to implement and wide in universality, metal ion-ligand interaction is introduced into an uncoordinated ionizable lipid structure, charge distribution and apparent pKa of lipid nano particles are changed, and therefore the nucleic acid molecules can be efficiently and controllably delivered to the liver, spleen or lung of the mouse. The lipid nanoparticle organ is selectively converted from the liver or spleen to the lung, and ultrahigh nucleic acid molecule delivery efficiency is shown.

To provide novel organic compounds capable of providing highly reliable light-emitting devices. [Solution] An organic compound represented by the following structural formula (G1) is provided. However, in the organic compound represented by the following general formula (G1), R 1 ~R 14 Each of these groups comprises at least one aliphatic cyclic amine, with the remainder independently representing one of the following: hydrogen, deuterium, a C1-C10 alkyl group, a C3-C10 cycloalkyl group, a substituted or unsubstituted C6-C30 monovalent aromatic hydrocarbon group, a substituted or unsubstituted C1-C30 monovalent heteroaromatic group, and an aliphatic cyclic amine. JPEG2026049691000041.jpg50167

The application provides a solvent-free anticorrosive thermal insulation coating and a preparation method thereof, which comprises components A and B, the component A comprises 30-40 parts of bisphenol A epoxy resin, 5-10 parts of butyl glycidyl ether, 1-3 parts of a dispersing agent, 1-3 parts of an antifoaming agent, 0.5-1.5 parts of a leveling agent, 0.5-1.5 parts of a wetting agent, 1-3 parts of a rheological aid, 10-20 parts of hollow glass microbeads and 10-20 parts of hollow ceramic microbeads, wherein the particle size D50 of the hollow glass microbeads is greater than the particle size D50 of the hollow ceramic microbeads, and the component B comprises 15-25 parts of a modified ester amine curing agent. The hollow glass microbeads and the hollow ceramic microbeads are compounded to form a 'big ball-small ball' grading filling structure, which not only constructs a low-thermal-conductivity thermal insulation layer, but also blocks the water vapor permeation channel, and simultaneously considers thermal insulation and corrosion prevention.

Provided is an azacycloalkylcarbonyl cyclic amine compound which is useful as an active ingredient in a pharmaceutical composition for a treatment of a neutrophil associated inflammatory disease. The azacycloalkylcarbonyl cyclic amine compound of the present invention is a compound of Formula (I) or a salt thereof.(in the formula, Ring A represents azacycloalkyl which may have a substituent and may be spiro-fused; Y represents alkyl which may have a substituent, cycloalkyl which may have a substituent, or the like; L represents a nitrogen-containing aromatic heterocycle or the like; Z represents cycloalkyl which may have a substituent, an aromatic hydrocarbon ring which may have a substituent, a non-aromatic heterocycle which may have a substituent, or the like; and m and n each independently represent an integer of 1 or 2.)

The present invention belongs to the technical field of organic complex synthesis, and specifically relates to a metal complex and its preparation method and application. The general formula of the metal complex is L-M, wherein L is a ligand, M is a metal salt, and the ligand is diphenylmethylbenzylamine or diphenylmethylquinuclidine-3-amine. The diphenylmethylbenzylamine is prepared by reacting imine and sodium cyanoborohydride; the diphenylmethylquinuclidine-3-amine is prepared by reacting diphenylmethylbenzylamine and ammonium formate. The preparation method of the metal complex is to dropwise add a metal salt solution to a methanol solution containing the ligand, carry out a coordination reaction, and filter to obtain a target product. The preparation method has the advantages of simple process, mild conditions, low cost, and easy industrialization. The metal complex provided by the present invention can be used to prepare an antibacterial agent, which has the advantages of high efficiency, low toxicity, and environmental protection.

The application belongs to the technical field of organic synthesis, and particularly relates to a preparation method of maropintan and an intermediate thereof. The preparation method comprises the following steps: S1: 3-quinuclidinone or a salt thereof is reacted with benzophenone under the condition of a base, a first solvent, to obtain 2-(diphenyl methylene) quinuclidin-3-one; S2: the obtained 2-(diphenyl methylene) quinuclidin-3-one is reacted with an amine source and hydrogen under the condition of a chiral ruthenium catalyst, an optional additive and a second solvent, to obtain an intermediate (2S, 3S)-2-diphenyl methyl quinuclidin-3-amine; and S3: the obtained (2S, 3S)-2-diphenyl methyl quinuclidin-3-amine is subjected to a condensation reaction with 5-tert-butyl-2-methoxy benzaldehyde (formula V) in the presence of an acid and a third solvent, and is reduced by palladium carbon or platinum carbon and hydrogen to obtain maropintan. The method has the advantages of low-cost and easily-available raw materials, a short synthesis route, high-yield one-step reaction of double chiral centers, good selectivity, simple process, high product yield and low cost.

A method of treating or preventing peripheral neuropathies includes administering a therapeutically effective amount of a cyclic amine derivative represented by general formula (I) or a pharmacologically acceptable salt thereof to a patient who needs treatmentwherein, carbon marked with * is asymmetric carbon; and A represents a group represented by general formulae (IIa), (IIb) or (IIc):wherein R1 represents a methyl group or an ethyl group optionally substituted with a halogen atom, R2 represents a hydrogen atom or an alkylcarbonyl group having 2 to 5 carbon atoms, each R3 independently represents a methyl group or an ethyl group, and n represents 1 or 2.

The invention provides a solvent-free epoxy coating as well as a preparation method and application thereof, the solvent-free epoxy coating comprises a component A and a component B, and the weight ratio of the component A to the component B is 1: (0.18-0.23); the component A is prepared from the following components in parts by weight: 1 part of bisphenol F epoxy resin, 0.4 to 0.5 part of novolac epoxy resin, 0.2 to 0.4 part of reactive diluent, 0.2 to 0.3 part of sericite powder, 0.02 to 0.03 part of carbon nanofiber, 1.4 to 1.7 parts of pigment filler, 0.010 to 0.015 part of defoaming agent, 0.003 to 0.006 part of dispersing agent, 0.005 to 0.010 part of flatting agent and 0.006 to 0.009 part of base material wetting agent; the component B comprises 1 part of an aromatic amine curing agent, 0.4-0.6 part of an alicyclic amine curing agent and 0.02-0.03 part of a tertiary amine curing accelerator. The method is beneficial to shortening the anti-corrosion construction period of petrochemical equipment.

The invention discloses an ether-containing energetic adhesive as well as a preparation method and application thereof. The ether-containing energetic adhesive comprises epoxy resin and a curing agent. The epoxy resin comprises a structural resin component and an energetic resin component, a molecular main chain of the structural resin component comprises at least one rigid structural unit selected from a six-membered alicyclic ring and a benzene ring, a molecular main chain of the energetic resin component comprises an ether bond structural unit, and the molar ratio of the energetic resin component to the structural resin component in the epoxy resin is 1: (4-9); the curing agent comprises a structural curing agent component and an energetic curing agent component, wherein the structural curing agent component is selected from at least one of alicyclic amine and aromatic amine, and the energetic curing agent component is selected from at least one of polyether amine. The proportion of a rigid structure and a flexible easily-pyrolyzed structure of a cross-linked network is regulated and controlled through molecular design, so that the material has high mechanical strength and efficient combustion performance, and is suitable for the field with comprehensive requirements on the structure and energy release.

The application belongs to the field of pharmaceutical chemistry and provides an alpha-hydroxycarboxylic acid derivative with adamantyl, a preparation method and application thereof, stereoisomers or pharmaceutically acceptable salts thereof, and has the following general structure formula I: wherein, when X=O in the general formula, n=0 or 1, and A is a lipophilic group or a hydrophilic group; when X=N in the general formula, n=0-3, and A is one of an alkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, a heteroaryl group, an aryl-heterocyclic group, a heteroaryl-heterocyclic group, a tetrahydropyrrole group, a piperazine group, a piperidine group, a morpholinyl group and other cyclic amines, and a substituted derivative of the above groups. The structural formula is as shown in formula I, and the alpha-hydroxycarboxylic acid derivative with adamantyl has good inhibitory activity on influenza viruses and can be developed into a new generation of M2 inhibitors, thereby laying a good foundation for the development of anti-influenza drugs.

The invention provides a preparation method and an intermediate of a cyclic amine derivative, and particularly relates to a preparation method and an intermediate of a compound shown as a formula I or a salt thereof. The preparation method of the compound as shown in the formula I or the salt thereof has the advantages of simple route, high product quality, high product yield, easiness in industrial production and the like;

The present invention relates to a method for synthesizing a distal amino alcohol compound, comprising the steps of electrolyzing a cyclic amine compound represented by formula (I) to obtain a distal amino alcohol compound represented by formula (II). The present invention adopts an electrochemical method to directly electrolyze cyclic amines and (high) proline peptide compounds to obtain distal amino alcohol compounds, without the need for pre-preparation of reaction precursors, avoiding the use of noble metal catalysts and stoichiometric oxidants, avoiding the generation of chemical waste, and contributing to the realization of atom economy. The method is simple to operate, has high product purity, is easy to purify, has high efficiency and yield, low production cost, mild reaction conditions, and does not require inert gas protection. By using water as a green solvent and a source of hydroxyl groups, the reaction system is greener, more environmentally friendly, safer, more economical, energy-saving and environmentally friendly, and is more conducive to the realization of industrial production.

The invention discloses a method for preparing ring-expanded amine or chain-extended amine from saturated amine, which comprises the following steps: in a glove box filled with nitrogen or inert gas, adding saturated amine, a first solvent, alkyne and a first catalyst into a first reaction container, heating and stirring, and carrying out ring expansion reaction to obtain ring-expanded amine or chain-extended amine; when two ends of alkyne are respectively connected with CO2Me and H, the method further comprises the following steps: adding the obtained ring-extended amine or chain-extended amine, a second solvent and alkali into a second reaction container, and heating and stirring to fully hydrolyze the ring-extended amine or chain-extended amine to obtain corresponding carboxylic acid; and at room temperature, adding the obtained carboxylic acid, a third solvent and a second catalyst into a third reaction container, then putting the third reaction container into a high-pressure kettle, filling hydrogen, and carrying out a stirring reaction to obtain completely reduced amine. The method does not use a transition metal catalyst, is good in chemical selectivity, wide in substrate application range and wide in functional group compatibility, and can be used for later functional group modification of drug molecules.

The invention discloses a high-toughness high-temperature-resistant epoxy resin composition suitable for an RTM (Resin Transfer Molding) process and a preparation method thereof, and relates to the technical field of epoxy resin. The composition comprises a component A and a component B, wherein the component A comprises an epoxy resin mixture, core-shell structure toughening particles and a stabilizer; and the component B is a composite amine curing agent consisting of aromatic amine, alicyclic amine and polyether amine. The epoxy resin mixture is compounded by trifunctional epoxy resin, bisphenol A epoxy resin and alicyclic epoxy resin according to a specific proportion. Through collaborative design of a core-shell particle toughening technology and a composite curing agent system, a cured resin matrix has high toughness and high heat resistance while a super-long process window is maintained, and the technical problem that high toughness, high heat resistance and long operation period are difficult to consider in an RTM process is solved.

A method for processing polynucleic acids is described, comprising: a) providing a solid support containing ligands, wherein at least a portion of the ligands contain a cyclic amine group having more than six ring members; exposing the solid support to polynucleic acid molecules in a buffer having a pH less than 5.5 to bind at least a portion of the polynucleic acid molecules to the ligands; exposing the solid support having the bound polynucleic acid molecules to a pH greater than 6 to release a portion of the bound polynucleic acid molecules from the ligands of the solid support, optionally retaining a portion of the polynucleic acid molecules bound to the solid support; and utilizing the released portion of the bound polynucleic acid molecules and / or the retained portion of the polynucleic acid molecules bound to the solid support, or a suspension thereof. A solid support containing ligands bound to a solid support (e.g., magnetic beads), wherein at least a portion of the ligands contain a cyclic amine group having more than six ring members, and a kit containing such a solid support are also described.

The invention discloses a branched polyaryl cyclic amine anion exchange membrane containing various cationic groups, a preparation method and application thereof. In an acidic catalytic system, an aromatic compound, a highly branched aromatic compound, a carbonyl substance and polycyclic aromatic hydrocarbon are subjected to a condensation polymerization reaction in a dichloromethane medium to form the polyaryl cyclic amine polymeric membrane material with polycation and highly branched structures. The polymer is subjected to quaternization modification treatment to obtain an anion exchange functional group, then the anion exchange functional group is transformed into an OH <-> form in an alkaline solution, and finally a thin film material with multiple types of ion transmission sites is prepared through a thermal evaporation process. According to the process, a synergistic effect mechanism of a multi-cationic group and a highly branched aromatic skeleton is creatively adopted, and a series of anion exchange membrane products suitable for different industrial scene requirements can be prepared by adjusting polymer composition and membrane forming parameters, and the anion exchange membrane has the remarkable characteristics of excellent ionic conduction performance and structural designability.