5 results about "Tropine" patented technology

The invention belongs to the technical field of medicine synthesis, and particularly relates to an oxygen-mediated trospium chloride key intermediate microchannel synthesis method. According to the method, the diphenyl glycolic acid tropine ester is taken as a starting material and passes through the micro-channel reactor to obtain the diphenyl glycolic acid nortropine ester, the technology is simple in preparation, through the continuous flow reaction of the micro-channel reactor, the atom utilization rate can be increased, side reactions are few, and the method is suitable for large-scale production.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of a tofacitinib key intermediate. According to the present invention, the diphenyl glycolic acid tropine ester is adopted as the starting material, and the diphenyl glycolic acid tropine ester is obtained under the action of the photosensitizer and the perchlorate in cooperation with the irradiation of the high-pressure mercury lamp, such that the technology has characteristics of simple preparation, no use of the expensive catalyst, safety, environmental protection, and avoiding of the risk of the standard exceeding of the heavy metal content, and is suitable for the large-scale production.

The embodiment of the present application discloses a preparation method of nor-tropine alcohol. The method comprises the following steps: performing demethylation reaction on tropinone and chloroethyl chloroformate in the presence of a solvent, performing vacuum concentration and evaporation, and obtaining demethyltropinone; performing reduction reaction on the demethyltropinone and lithium tri-t-butoxyaluminum hydride in the presence of a solvent, and obtaining the nor-tropine alcohol. The present application adopts a new type of reducing agent lithium tri-t-butoxyaluminum hydride, which is safe, not sensitive to air and water, and simple in post-treatment, thus avoiding safety hazards from the source. The present application avoids the use of dangerous Raney nickel and does not need to use an autoclave, so that the production capacity is greatly improved. The present application performs the reaction under low-temperature conditions, is low in energy consumption, can effectively reduce production cost, and is moderate in reaction conditions, safe and simple in operation, and is conducive to large-scale industrial production.

The application discloses a nitrogen and phosphorus double active center polyaryl cyclic amine polymer, an anion exchange membrane and a preparation method and application thereof. First, aromatic compounds containing phosphorus elements are reacted with carbonyl compounds and aromatic hydrocarbon compounds in an organic solvent under acidic conditions to prepare nitrogen and phosphorus double cationic group-containing polyaryl piperidine, polyaryl quinine, polyaryl tropine and other phosphorus-containing polyaryl cyclic amine polymers. Through quaternization and quaternary phosphonation, the polymers have anion exchange capacity, are soaked in corresponding ion solutions and obtain specific functional anion exchange membranes. The anion exchange membranes have nitrogen and phosphorus two active centers for ion exchange, have excellent stability, mechanical properties and ion transmission performance and are mainly applied to technical fields of fuel cells, hydrogen production by water electrolysis, flow batteries, metal-air batteries, carbon dioxide electrolytic cells, electrodialysis, water treatment, salt lake lithium extraction and the like.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a synthesis method of a trospium chloride key intermediate. According to the present invention, the diphenyl glycolic acid tropine ester is adopted as the starting material, and the diphenyl glycolic acid tropine ester is obtained under the action of the photosensitizer and the perchlorate in cooperation with the irradiation of the high-pressure mercury lamp, such that the technology has characteristics of simple preparation, no use of the expensive catalyst, safety, environmental protection, and avoiding of the risk of the standard exceeding of the heavy metal content, and is suitable for the large-scale production.