11 results about "Tropine" patented technology

The invention discloses a preparation process of a Baloxavir marboxil and tropine acid eutectic crystal form. The X-ray powder diffraction pattern of the Baloxavir marboxil and tropine acid eutectic crystal form under Cu-Ka radiation has diffraction angle 2theta values of 4.7 + / -0.2 degrees, 9.1 + / -0.2 degrees, 10.0 + / -0.2 degrees, 10.8 + / -0.2 degrees, 11.9 + / -0.2 degrees, 13.4 + / -0.2 degrees, 14.1 + / -0.2 degrees, 15.0 + / -0.2 degrees, 16.4 + / -0.2 degrees, 17.5 + / -0.2 degrees, 18.0 + / -0.2 degrees, 19.1 + / -0.2 degrees, 20.5 + / -0.2 degrees, 21.5 + / -0.2 degrees, 22.5 + / -0.2 degrees, 23.8 + / -0.2 degrees, 24.5 + / the angle is 30.7 + / -0.2 degrees, and the angle is 31.6 + / -0.2 degrees. And characteristic peaks exist at all positions. The Baloxavir marboxil and tropine acid eutectic crystal form provided by the invention has stable physicochemical properties, excellent solid stability and mechanical stability, and can be stably stored for a long time, the preparation method is simple and convenient, the repeatability is good, and the Baloxavir marboxil and tropine acid eutectic crystal form has important application value for the development of the medicine in the future.

The invention belongs to the technical field of medicine synthesis, and particularly relates to an oxygen-mediated trospium chloride key intermediate microchannel synthesis method. According to the method, the diphenyl glycolic acid tropine ester is taken as a starting material and passes through the micro-channel reactor to obtain the diphenyl glycolic acid nortropine ester, the technology is simple in preparation, through the continuous flow reaction of the micro-channel reactor, the atom utilization rate can be increased, side reactions are few, and the method is suitable for large-scale production.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of a tofacitinib key intermediate. According to the present invention, the diphenyl glycolic acid tropine ester is adopted as the starting material, and the diphenyl glycolic acid tropine ester is obtained under the action of the photosensitizer and the perchlorate in cooperation with the irradiation of the high-pressure mercury lamp, such that the technology has characteristics of simple preparation, no use of the expensive catalyst, safety, environmental protection, and avoiding of the risk of the standard exceeding of the heavy metal content, and is suitable for the large-scale production.

The embodiment of the present application discloses a preparation method of nor-tropine alcohol. The method comprises the following steps: performing demethylation reaction on tropinone and chloroethyl chloroformate in the presence of a solvent, performing vacuum concentration and evaporation, and obtaining demethyltropinone; performing reduction reaction on the demethyltropinone and lithium tri-t-butoxyaluminum hydride in the presence of a solvent, and obtaining the nor-tropine alcohol. The present application adopts a new type of reducing agent lithium tri-t-butoxyaluminum hydride, which is safe, not sensitive to air and water, and simple in post-treatment, thus avoiding safety hazards from the source. The present application avoids the use of dangerous Raney nickel and does not need to use an autoclave, so that the production capacity is greatly improved. The present application performs the reaction under low-temperature conditions, is low in energy consumption, can effectively reduce production cost, and is moderate in reaction conditions, safe and simple in operation, and is conducive to large-scale industrial production.

The invention provides a glucose biosensor based on tropine-amino acid ionic liquid and Ag / carbon nanotube modification and a preparation method of the glucose biosensor. The related key components comprise an Ag and multi-walled carbon nanotube compound (Ag / MWCNTs), tropine-amino acid ionic liquid and glucose oxidase (GOx). The tropine-amino acid ionic liquid and Ag / MWCNTs are adopted to modify the glassy carbon electrode, and GOx is loaded to prepare the sensor electrode, so that the limitations of the existing glucose biosensor in the aspects of sensitivity, stability and biocompatibility are improved, and high responsiveness, selectivity and stability of glucose detection are realized. The sensor is simple in preparation process, friendly in process, free of special equipment and easy to popularize and produce on a large scale. Systematic tests prove that the electrochemical sensor has ideal electroactive area, electrochemical behavior, anti-interference capability, reproducibility and repeatability, and has a good actual sample test result, which indicates that the electrochemical sensor has expected application potential in the field of glucose detection.

The application discloses a nitrogen and phosphorus double active center polyaryl cyclic amine polymer, an anion exchange membrane and a preparation method and application thereof. First, aromatic compounds containing phosphorus elements are reacted with carbonyl compounds and aromatic hydrocarbon compounds in an organic solvent under acidic conditions to prepare nitrogen and phosphorus double cationic group-containing polyaryl piperidine, polyaryl quinine, polyaryl tropine and other phosphorus-containing polyaryl cyclic amine polymers. Through quaternization and quaternary phosphonation, the polymers have anion exchange capacity, are soaked in corresponding ion solutions and obtain specific functional anion exchange membranes. The anion exchange membranes have nitrogen and phosphorus two active centers for ion exchange, have excellent stability, mechanical properties and ion transmission performance and are mainly applied to technical fields of fuel cells, hydrogen production by water electrolysis, flow batteries, metal-air batteries, carbon dioxide electrolytic cells, electrodialysis, water treatment, salt lake lithium extraction and the like.

The invention relates to the technical field of electronic atomization, in particular to a composition capable of improving strength, a liquid preparation and a preparation method and application thereof. According to the composition capable of improving the strength, provided by the invention, the composition capable of improving the strength is prepared from trigonelline, magnolol, pepper alcohol and tropine. According to the composition, specific substances are selected as raw material components of the composition capable of improving the strength, under the synergistic effect of the specific substances, the satisfaction of the nicotine-free liquid preparation is improved, and therefore the purpose of physiologically relieving addiction of a user is achieved.

The invention discloses a chiral tropine alkaloid derivative as well as a preparation method and application thereof, and belongs to the technical field of organic synthesis and medicines. The preparation method comprises the following steps: by taking an olefin derivative and benzo cyclic imine ylide as raw materials, adding a catalyst, a solvent and alkali, and reacting at-50 to 50 DEG C for 6 to 36 hours, so as to obtain the chiral tropine alkaloid derivative. According to the method, a transition metal catalyst is not needed, the tropine alkaloid derivative with multiple chiral centers is obtained through one-step efficient synthesis through the cheap and easily-obtained organic catalyst, and the method has the advantages that a reaction system is simple, operation is easy, conditions are green and mild, raw materials are easy to obtain, the price is low, the yield is high, selectivity is high, and application is easy to expand.

The invention discloses a preparation method and application of an alpha-tropine-based non-arylether polyfluorene alkylene polymer and an anion exchange membrane, and belongs to the technical field of organic synthesis and energy conversion. According to the invention, a non-arylether polyfluorene alkylene polymer containing a side chain terminal bromine group is obtained by utilizing a superacid catalyzed Friedel-Crafts alkylation reaction, and further, the terminal bromine of the polymer and steric hindrance cage-shaped alpha-tropine containing a tertiary amine group are subjected to a Moshu reaction to obtain the non-arylether polyfluorene alkylene anion exchange polymer containing cage-shaped tropine quaternary ammonium salt. The position of the cation group of the anion exchange membrane prepared from the polymer is controllable, and the density of the ion group can be improved. Meanwhile, the caged large-steric-hindrance tropine quaternary ammonium salt ensures the chemical stability, and the contained hydrophilic hydroxyl can promote water transmission and ion conduction in the membrane. A hydrophobic polymer skeleton is separated from hydrophilic tropine through a long alkyl side chain linker, so that the polymer has an obvious microphase separation structure, and generation of OH <-> transport ion channels is promoted. The non-aryl ether polymer main chain and the hydroxyl-containing cage sterically hindered cations can ensure that the anion exchange membrane prepared from the polymer has long-term alkali-resistant stability.

A composition capable of boosting throat hit, the composition comprising trigonelline, magnolol, piperonol and tropine. Specific substances are selected as raw material components of the composition capable of boosting throat hit, and, due to the synergistic effect thereof, the stimulation to the human brain can be significantly improved, and the satisfaction provided by zero-nicotine liquid formulations can be improved, thereby achieving the purpose of physiologically reduce the users' addiction. Further provided are a liquid formulation comprising the composition capable of boosting throat hit, a preparation method therefor, and the use thereof.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a synthesis method of a trospium chloride key intermediate. According to the present invention, the diphenyl glycolic acid tropine ester is adopted as the starting material, and the diphenyl glycolic acid tropine ester is obtained under the action of the photosensitizer and the perchlorate in cooperation with the irradiation of the high-pressure mercury lamp, such that the technology has characteristics of simple preparation, no use of the expensive catalyst, safety, environmental protection, and avoiding of the risk of the standard exceeding of the heavy metal content, and is suitable for the large-scale production.