2 results about "Cyanoacetic acid" patented technology

The application discloses a catalyst for preparing malononitrile, a preparation method of the catalyst and a method for preparing malononitrile by using the catalyst. The catalyst is a solid catalyst, which is an acidic catalyst loaded with rare earth metal oxide. The method for preparing malononitrile is that cyanoacetic acid or cyanoacetate or cyanoacetamide and an ammonia source are subjected to ammoniation dehydration reaction in a continuous reactor to prepare malononitrile according to a certain molar ratio. Then, vacuum distillation (20 torr-25 torr) is carried out, and a fraction collected at 110 DEG C-120 DEG C is malononitrile product. The ammonia source can be ammonia gas, ammonia water, ammonium carbonate or urea. The method for preparing malononitrile can reduce production cost, improve production safety, reduce the discharge amount of three wastes in the preparation of malononitrile by using an existing process, and improve product quality, and is a sustainable and green synthesis route.

The application belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of tetrahydrozoline. The tetrahydrozoline is synthesized from trifluoromethylaniline and 2-cyanoacetic acid ethyl ester under the action of an alkaline catalyst, the method has mild conditions, simple and easy-to-operate post-treatment and purification, low energy consumption, short working hours, and is suitable for large-scale production.