116 results about "Dimethyl fumarate" patented technology

The invention provides compositions and methods for treating autoimmune diseases such as multiple sclerosis. The compositions include a combination of an NMDA Receptor antagonist, such as memantine or rimantadine, and a fumarate agent, such as dimethyl fumarate.

Implantable medical devices having anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of certain NF-kappaB inhibitors, particularly certain dialkyl fumarates, are disclosed. Dimethyl fumarate is a particularly preferred dialkyl fumarate. The anti-restenotic medical devices include stents, catheters, micro-particles, probes and vascular grafts. Intravascular stents are preferred medical devices. The medical devices can be coated using any method known in the art including compounding the dialkyl fumarate with a biocompatible polymer prior to applying the coating. Moreover, medical devices composed entirely of biocompatible polymer-dialkyl fumarate blends are disclosed. Additionally, medical devices having a coating comprising at least one dialkyl fumarate in combination with at least one additional therapeutic agent are also disclosed. Furthermore, related methods of using and making the anti-restenotic implantable devices are also disclosed.

Provided herein are compositions containing compounds, or pharmaceutically acceptable salts, that metabolize to monomethyl fumarate with certain pharmacokinetic parameters and methods for treating, prophylaxis, or amelioration of neurodegenerative diseases including multiple sclerosis using such compositions in a subject, wherein if the compositions contain dimethyl fumarate, the total amount of dimethyl fumarate in the compositions ranges from about 43% w / w to about 95% w / w.

The invention features a method of treating a subject in need of treatment for multiple sclerosis. The method involves orally administering to the subject in need thereof a pharmaceutical composition in unit dosage form consisting essentially of (a) from about 120 mg to about 240 mg of dimethylfumarate formulated for delayed release, and (b) one or more pharmaceutically acceptable excipients, wherein following the orally administering of the unit dosage form monomethylfumarate appears in the plasma of the subject upon hydrolysis of dimethylfumarate and the Cmax of the monomethylfumarate in the plasma of the subject is between about 0.4 and about 2 mg / L, and wherein about 480 mg of dimethylfumarate per day is orally administered to the subject.

The invention features a kit. The kit includes: (i) a first unit dosage form consisting essentially of about 120 mg of dimethylfumarate and one or more pharmaceutically acceptable excipients, wherein the dimethylfumarate is formulated for delayed release; and (ii) a second unit dosage form consisting essentially of about 240 mg of dimethylfumarate and one or more pharmaceutically acceptable excipients, wherein the dimethylfumarate is formulated for delayed release.

This invention provides a method of treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome comprising administering to the subject laquinimod as an add-on therapy to or in combination with DMF. This invention also provides a package comprising laquinimod and DMF for treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome. This invention also provides laquinimod for use as an add-on therapy or in combination with DMF in treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome. This invention also provides a pharmaceutical composition comprising laquinimod and DMF for use in treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome. This invention further provides use of laquinimod and DMF in the preparation of a combination for treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome.

The invention discloses dimethyl fumarate enteric-coated pellets and a preparation method thereof. Each enteric-coated pellet comprises a blank pellet core, an active drug layer wrapping the blank pellet core, an isolating layer, an inner layer enteric-coated coating layer and an outer layer enteric-coated coating layer from inside to outside. The enteric-coated pellets are simple in process, complete in release, good in reproducibility, small in gastrointestinal tract irritation, safe and effective.

The invention relates to a dimethyl fumarate-containing enteric slow-release pellet for treating multiple sclerosis. The dimethyl fumarate-containing enteric slow-release pellet is characterized in that the pellet is subjected to coating, one layer gives play to enteric effect, and one layer gives play to slow-release effect, so that the pellet is controlled to slowly release active substances according to a certain rate after arriving at intestinal tracts.

The invention relates to a coumarin functional dye containing a thiophene bridge chain in the field of fine chemical industry and organic photoelectric material applications. The structure of the coumarin functional dye takes coumarin and a derivative thereof as an electron donor, contains a thiophene structure unit capable of adjusting an absorption spectrum and a fluorescence emission spectrum as the bridge chain and is further connected with a cyanoacetic acid electron withdrawing group. Coumarin-thiophene, POCl3 / DMF (dimethyl fumarate) are added into a reaction container by adopting general reaction for reaction so as to get a 5-(7-substiutted-2-carbonyl-2H-benzopyran-3-yl) thiophene-2-formaldehyde intermediate (II) with an aldehyde group; and the intermediate II with the aldehyde group further reacts with cyanoacetic acid to get the coumarin dye connected by the thiophene. As the coumarin is taken as a chromophore, the electron donating capability is good; the thiophene has high electron cloud density and special optical properties and electron transmission capability; and the electron withdrawing group of the cyanoacetic acid is further connected for enabling the dye to have good light, thermal and chemical stability and photoelectric properties. Therefore, the dye can be used as a photosensitive dye for dye-sensitized solar cells.

A gas-phase antiseptic, antimildew and antistaling agent with high safety and effect and broad spectrum for grain tobacco, medicine, vegetables, clothes, etc is prepared from methyl fumarate, dimethyl fumarate, calcium propioate, VC or VE, benzoic acid and nipagin ester through dissolving in alcohol, heating natural cooling while crystallizing, drying in air, pulverizing and packing in sealed mode.

The invention relates to a mildew-inhibiting composition which comprises the components in parts by weight as follows: 10-15 parts of modified nanometer montmorillonite, 5-10 parts of dimethyl fumarate, 2-5 parts of ethyoxyl quin, 20-25 parts of sodium glutamate, 20-30 parts of nucleotide disodium, 10-15 parts of sanguinarine, 15-30 parts of glutathione, 10-15 parts of choline chloride, 15-20 parts of glycine betaine, 10-15 parts of sodium sorbate, 2-5 parts of chitosan, 3-9 parts of gala mannan oligosaccharide, and 1-5 parts of fructo-oligosaccharide. The mildew-inhibiting composition provided by the invention further has the effects of enhancing the immune function of animals, strengthening the detoxifying function by liver and kidney and promoting the feed intake of poultry besides good bacteria-inhibiting and sterilizing effects.

The invention discloses a continuous production process for dimethyl fumarate. The process comprises the following steps of: uniformly filling a strong acid cation exchange resin catalyst into a reaction cylinder, and heating at the temperature of between 60 and 100 DEG C; adding fumaric acid and a methanol solution which serve as reaction raw materials into the reaction cylinder from an inlet of the fixed reaction cylinder, regulating the flow velocity of a flow pump to ensure that the raw materials are kept in the reaction cylinder for 4 to 8 hours, and collecting a reaction product at an outlet; introducing the reaction product into cold water, stirring, and crystallizing a large number of white crystals; filtering, and washing a filter cake by using 8 to 10 percent Na2CO3; and filtering again, washing the filter cake to be neutral by using distilled water, drying at room temperature, and thus obtaining the dimethyl fumarate. In the process, strong acid cation exchange resin is utilized, does not corrode reaction equipment and pollute the environment, can be repeatedly used and is a good environment-friendly catalyst. The catalyst is fixed in the reaction cylinder; the materials are continuously fed and discharged, so that the continuous operation of the reaction can be realized; and the process has simple reaction conditions and makes the operation convenient.

The present invention relates to a pickling agent for pickling raw leather with hair. Its composition contains (by weight portion) 40-50 portions of sodium chloride whose grain size is 1 mm-2 mm and water content is less than 5%, 20-30 portions of sodium sulfate, 1.5-3 portions of dimethyl fumarate, 1.5-3 portions of white alum and 1.5-3 portions of sodium carbonate. The above-mentioned all ingredients are uniformly mixed so as to obtain the invented pickling agent. It can make raw leather with hair be smooth and have elasticity.

The invention provides a tea pulp powder detergent and a preparation method thereof. A composition of tea pulp powder and three anionic surfactants (sodium lauryl alcohol sulfate, sodium tripolyphosphate and sodium dodecyl benzene sulfonate) is used as a raw material, wood meal and kaolin are added as frictional materials, and a mixture of sodium diacetate and dimethyl fumarate is used as a mold preventive. The preparation method comprises the following steps: mechanically stirring and mixing, and carrying out microwave sterilization to obtain the tea pulp powder detergent. The tea pulp powder detergent has very high oil sludge cleaning actions, lowers the chemical surfactant consumption, and reduces the environmental pollution.

The invention discloses a method for preparing fumaric dimethyl ester (DMF). The method comprises the steps of taking maleic anhydride as raw material and subjecting the raw material and methanol to catalytic reaction in the presence of a solid-acid SO4 / Al2O3 catalyst so as to obtain the fumaric dimethyl ester, namely a target product of the invention. The purity of the fumaric dimethyl ester obtained by the preparation method is up to over 98.5 percent, and the yield of the fumaric dimethyl ester is between 85 and 95 percent. Compared with the prior art, the method has the advantages that the method adopts the solid-acid SO4 / Al2O3 catalyst, is safe and convenient in operation, improves environment, reduces corrosion on equipment, can cyclically recycle reaction solvent and the solid-acid catalyst, reduces the three wastes, ensures stable product quality, and is suitable for industrial production.

A dimethyl fumarate (DMF) softgel is composed of the core prepared from DMF particles and the wall layer prepared from refined paraffin wax, animal wax, plant wax, or synthetic high-molecular material. Its advantages are no irritation to people, and high output rate and effect.

The invention discloses high-density dimethyl fumarate enteric-coated granules and a preparation method thereof. The density of the high-density dimethyl fumarate enteric-coated granules is 1.0g / mL or higher, or is 1.3g / mL or higher, or is 1.6g / mL or higher. Preparation size of the high-density dimethyl fumarate enteric-coated granules is small; the high-density dimethyl fumarate enteric-coated granules are convenient for administration, and are especially suitable for patients, elders, and children with swallowing difficulty, and are capable of increasing patient compliance; preparation content uniformity is high; rapid release is realized; stability is high; and the preparation method is simple, and is suitable for industrialized production.

The invention provides a dimethyl fumarate enteric-coated pellet. The dimethyl fumarate enteric-coated pellet comprises a core, an intermediate coating layer and an enteric layer, wherein the coating material of the intermediate coating layer is copovidone; by calculating in percentage by weight with respect to the core, the increased weight of the intermediate coating layer is 4%-40%; the enteric-coated pellet can be further filled with a capsule so as to be prepared into a capsule, or mixed with other auxiliary materials so as to be prepared into a tablet, or mixed with other auxiliary materials so as to be prepared into a suspension. Even the weight of the intermediate coating layer is increased, the medicine in the prepared enteric-coated pellet still can retain a high release rate. The preparation method is simple and feasible, and is suitable for industrial production.

The invention relates to a dry-typed long-term storage method for sweet sorghum stems and belongs to the technical field of agriculture. The storage method crashes the collected sweet sorghum stems into particles by a kneading grinder, evenly mixes dimethyl fumarate or trichloroisocyanuric hydrogen uric acid, dries and places the mixture in drying and ventilation position to carry out long-term storage. The storage method can acquire long-term and effective storage effect; by mixing dimethyl fumarate or trichloroisocyanuric hydrogen uric acid, the loss of effective sugar content of the sweet sorghum in the particles of sweet sorghum stems can be minimized in the process of drying. The storage method has the advantages of good storage effect for sweet sorghum stems, low consumption of production capacity and simple technology, which can provide annual raw material supply for the production of bio-ethanol prepared by sweet sorghum stems.

The present invention discloses a special cherry preservative which is composed of the following components (parts by weight): 22 parts of tea leaves, 23 parts of propolis, 22 parts of dried tangerine peels, 9 parts of chitosans, 20 parts of lotus leaves, 4 parts of butylated hydroxy anisole, 6 parts of benzoic acids, 7 parts of propyl gallate, 7 parts of vitamin E, 8 parts of vanilla amide, 11 parts of rosemary, 10 parts of salvia japonica, 9 parts of sorbitols, 10 parts of maltitols, 4 parts of xylitols, 18 parts of sesame oil, 20 parts of rice bran oil, 3 parts of cephalins, 3 parts of polylysines, 3 parts of cinnamic acids, 3 parts of beta-cyclodextrins, 2 parts of sodium diacetate, 2 parts of sorbic acid, 6 parts of glycerol monocaprylate and 5 parts of dimethyl fumarate. The special cherry preservative can effectively reduce adhesive rate of the preservative to achieve lower residues, at the same time the toxicity of the preservative is much lower than the existing commercial products, and thus the preservative is suitable for the need of a large-scale industrial production.

An auxin containing multi-vitamines for domestic fowl is composed of soybean powder, wheat flour, soybean oil and additive. Said additive consists of 7 components including multi-vitamines, xylanase,proteinase, dimethyl fumarate, etc.. The said multi vitamines comprise 11 active components including VA, beta-carotin, VD, VC, VE, etc..

The present invention provides dimethyl fumarate (DMF) particles and methods of preparing the DMF particles. Also provided is DMF coated particles comprising DMF particles coated with an enteric coating. The invention also provides various dosage forms and methods of treating a disease or disorder (e.g., multiple sclerosis).

The present invention discloses a special onion preservative which is composed of the following materials (parts by weight): 22 parts of tea leaves, 23 parts of propolis, 22 parts of dried tangerine peels, 19 parts of konjac, 19 parts of forsythia suspensa, 9 parts of chitosans, 20 parts of lotus leaves, 4 parts of butylated hydroxy anisole, 7 parts of vitamin E, 8 parts of vanilla amide, 11 parts of rosemary, 10 parts of salvia japonica, 9 parts of sorbitols, 10 parts of maltitols, 4 parts of xylitols, 18 parts of sesame oil, 20 parts of rice bran oil, 3 parts of cephalins, 3 parts of polylysines, 3 parts of cinnamic acids, 3 parts of beta-cyclodextrins, 2 parts of sodium diacetate, 2 parts of sorbic acid, 6 parts of glycerol monocaprylate and 5 parts of dimethyl fumarate. The special onion preservative can effectively reduce adhesive rate of the preservative to achieve lower residues, at the same time the toxicity of the preservative is much lower than the existing commercial products, and thus the preservative is suitable for the need of a large-scale industrial production.

The invention discloses a special antistaling agent for litchi. The special antistaling agent comprises the following components by weight: 22 parts of tea leaf, 23 parts of propolis, 19 parts of fructus forsythia, 9 parts of chitosan, 20 parts of lotus leaf, 4 parts of butylated hydroxyanisole, 6 parts of benzoic acid, 7 parts of propyl gallate, 7 parts of vitamin E, 8 parts of vanilla amide, 11 parts of rosemary, 10 parts of sage, 9 parts of sorbitol, 10 parts of maltitol, 4 parts of xylitol, 18 parts of sesame oil, 20 parts of rice bran oil, 3 parts of cephalin, 3 parts of polylysine, 3 parts of cinnamic acid, 3 parts of beta-cyclodextrin, 2 parts of sodium diacetate, 2 parts of sorbic acid, 6 parts of mono-caprylin glycerate and 5 parts of dimethyl fumarate. The special antistaling agent for litchi provided by the invention has the beneficial effects of capability of effectively reducing the adhesive rate of the antistaling agent, low residue, much lower toxicity compared with conventional commercial products and capacity of meeting the need of large-scale industrial production.

The invention relates to a novel method for enhancing the efficiency of infecting human T cells by slow viruses carrying CAR (chimeric antigene receptor) genes. A CAR-T technology is regarded as a technology for most possibly curing tumors; although the technology has breakthrough, bottleneck problems still existing in the aspect of preparation of CAR-T cells cannot be solved, for example, the innate immune response of T cells can enable the efficiency of infecting the T cells by the slow viruses carrying CAR genes to be low, so that the CAR-T cells are low in preparation efficiency and high in cost. For the problem of improving the efficiency of infecting the T cells by the slow viruses carrying CAR genes, the applicant conducts a series of experiments and improvement and discovers that the infection efficiency of the CAR slow viruses can be remarkably improved when the T cells are treated by DMF (dimethyl fumarate). The novel method has guiding significance and application values inthe aspects of greatly improving the preparation efficiency of the CAR-T cells, shortening the in vitro amplification time of the CAR-T cells, lowering the production cost of a CAR-T therapeutic method and the like.

The invention provides cinnabar coloring paint which is good in adhesion. After a cinnabar painting is colored, the paint can be well attached to the surface of the cinnabar painting and not prone to peeling off. Meanwhile, cured high-aluminum powder, modified nanowhisker materials, dimethyl fumarate, polyurethane resin, polytetrafluoroethylene, zinc stearate, dibutyl phthalate, silicone macromonomer and a white oil component are added. Adhesion of the cinnabar coloring paint is guaranteed, meanwhile, gaps between all colored substances of the cinnabar coloring paint are small, the outer surface of the colored part of the cinnabar painting forms a smooth curved face, and the cinnabar painting looks natural.

The invention discloses a steel derusting / phosphating solution which is prepared from the following raw materials: 80-85 parts of phosphoric acid, 32-35 parts of hydrochloric acid, 12-15 parts of tartaric acid, 8-12 parts of ammonia water, 6-8 parts of carboxylic acid, 5-6 parts of stearic acid, 4-5 parts of ferric oxide, 6-7 parts of aluminum hydroxide, 7-8 parts of zinc powder, 5-6 parts of zinc hydroxide, 2-3 parts of anhydrous cupric sulfate, 5-6 parts of dimethyl fumarate, 3-5 parts of silicon oil, 4-6 parts of formic acid, 5-6 parts of carrageenin, 5-6 parts of glycerol, 3-5 parts of iron powder, 3-6 parts of copperas powder, 5-6 parts of oxalic acid, 3-5 parts of succinic acid, 3-6 parts of thiocarbamide and 3-5 parts of disodium edetate. The steel derusting / phosphating solution has favorable derusting effect, can form an anticorrosive coating on the metal surface, especially can treat the rusty steel surface to remove rust, and forms a smooth and compact phosphate coating on the treated metal surface, thereby achieving the effect of preventing metallic corrosion.

The present invention relates to pharmaceutical compositions containing dimethyl fumarate (DMF), More specifically, the present invention relates to a pharmaceutical composition for oral use in treating hyperproliferative, inflammatory or autoimmune disorders by administering a low daily dosage in the range of 410 mg±5% or 400 mg±5% dimethyl fumarate, wherein the pharmaceutical formulation is in the form of an erosion matrix tablet.

A compound specified by formula (I), in particular dimethylfumarate (trans-1,2-ethylenedicarboxylic acid dimethyl ester) is provided for use in prevention or therapy of gout, acne, pyoderma gangrenosum, Vitiligo, cardiovascular disease, metabolic syndrome, diabetes and / or complications of diabetes. Also provided are a dosage form comprising said compound and a method of treatment comprising administration of said compound to a patient in need thereof.

The invention provides a binary particle retention system suitable for unbleached chemical pulp. According to the technical scheme, aiming at the physical property characteristics of unbleached chemical pulp, the components of a particle retention system are improved. Specifically, the system omprises the following components in parts by weight: 20-25 parts of polyacrylamide, 12-16 parts of kaolin, 8-10 parts of terephthalic acid, 4-6 parts of diatomite, 2-4 parts of sodium carboxymethyl cellulose, 2-4 parts of sodium hyaluronate, 1-3 parts of chitosan, 1-3 parts of monocalcium phosphate, 1-3parts of maleic acid and 1-3 parts of dimethyl fumarate. A conventional formula of a cationic polymer and an inorganic anionic colloid is abandoned, polyacrylamide and kaolin are used as core components, components such as terephthalic acid, diatomite and sodium carboxymethyl cellulose are added, and the particle retention system is constructed in a compounding mode. The system is particularly suitable for unbleached chemical pulp, the retention and drainage effects are remarkably improved, and the system has outstanding technical advantages.