145 results about "Sanguinarine" patented technology

The invention relates to a Chinese herbal medicinal insecticide, and aims to solve the problem of public hazards of the conventional insecticide. The Chinese herbal medicinal insecticide comprises the following Chinese herbal medicines in part by weight: 50 to 110 parts of macleaya cordata, 50 to 110 parts of eucalyptus robusta smith, 40 to 100 parts of betel nut, 40 to 100 parts of pumpkin seed,40 to 100 parts of clematis root, 40 to 100 parts of celastrus angulatus, 30 to 90 parts of stone-like omphalia, 30 to 90 parts of grand torreya seed, 30 to 90 parts of camphor tree, 30 to 90 parts of pomegranate rind, 30 to 90 parts of lightyellow sophora root, 30 to 90 parts of rhododendron molle, 30 to 70 parts of fourstamen stephania root, 30 to 70 parts of sessile stemona root, 30 to 70 parts of hindu datura flower and 30 to 70 parts of liquoric root. The Chinese herbal medicinal insecticide is prepared by the following steps of: performing alcohol precipitation on the Chinese herbal medicines to obtain the original liquid medicine; diluting sodium usnic acid by using a solvent; and adding 0.1 to 0.3 weight percent of diluted sodium usnic acid into the original liquid medicine. The finished Chinese herbal medicinal insecticide comprises 0.5 percent (g/ml) of sanguinarine, is brownish red, has the ph value of 7 to 8 and the density of 1.10g/cm<3>, and has the advantages of effective insecticidal capability, no damage to humans, high adsorbability and durable seepage force.

The invention discloses a phyto-pesticide and a use method thereof. The pesticide is used for controlling aphids, rice planthoppers and cabbage worms. A principle of 'monarch, minister, adjuvant and messenger' for drug formula in philosophy of the traditional Chinese medicament is used in the development of a product of the phyto-pesticide formula. The phyto-pesticide comprises four plant extracts including 0.5 to 10 percent by sanguinarine of macleaya cordata, which plays a main insect killing role and serves as a monarch drug; 2 to 20 percent by nicotinamide of tobacco extract, which is used for improving the insect killing effect of the 'monarch drug' and serves as a 'minister drug'; 5 to 10 percent by teasaponin of tea oil cake, which is used for making a target insect refuse to have food, generates certain gastrointestinal toxicity to reduce the viability of the insect and serves as an 'adjuvant drug'; 0.1 to 0.5 percent by natural borneol(L(-)-Borneol ) of borneol camphor, which can expel the insect and serves as a 'messenger drug'. The formula combines the 'monarch, minister, adjuvant and messenger' composite formula and an additive and a carrier to prepare the pesticide with insect expelling effect. The phyto-pesticide is effective, free from residue and environmentally-friendly.

The invention relates to a preparation method of macleaya cordata extracts, which comprises the following steps: carrying out diacolation on macleaya cordata medical materials by an acid solution; adding alkali into diacolation liquid for regulating the solution to the alkaline solution for carrying out alkali deposition; dissolving precipitates by low-carbon alcohol; adding a proper amount of active carbon for back flowing extraction; adding acid for generating salt after the recovery of partial solvents from extraction liquid, and separating out orange crystalline precipitates; filtering the precipitates; using alcohol to wash remained acid; and obtaining the macleaya cordata extracts after drying. The extracts have the main ingredients of benzophen anthridine alkaloid salt with sanguinarine and chelerythrine as the representatives, and the total content is not lower than 60 percent through being metered by raw alkali, wherein the content of the sanguinarine is not lower than 40 percent, and the content of the chelerythrine is not lower than 18 percent. The preparation of the macleaya cordata extracts of the invention has the advantages of simple method and equipment, stable process, short production period and little environment pollution. The obtained extracts have high yield, low cost and stable product quality.

The invention discloses a foliar fertilizer for controlling various physiological diseases of crops. The foliar fertilizer is prepared by urea, calcium superphosphate, potash fertilizer, zinc sulfate, magnesium sulfate, borax, ferrous sulfate, duck feather, carboxymethylcellulose, 35% of sulfuric acid, lime, celangulin, sanguinarine, Azadirachtin and other materials. The foliar fertilizer has full nutrition, high concentration and obvious fertilizer efficiency. The plants grow vigorously after being applied with the foliar fertilizer, the yield of the crops is obviously increased, the quality is better, and the disease and lodging resistance is greatly improved. In addition, the safe and pollution-free botanical pesticides contained such as celangulin, sanguinarine and Azadirachtin can effectively reduce the insect and diseases of the crops, and do not pollute the environment and crops. The foliar fertilizer can be used for controlling the root rot of sweet potato, heart rot of maize, withered tip of maize leaf, maize stripe mosaic disease, cotton red leaf blight, cotton leaf cast, red leaf and yellow leaf cast of mint, yellow leaf dwarf of beans, rice red blight and the like, and the effect is remarkable.

The invention relates to application of a sanguinarine or a chelerythrine for preventing and curing of schistosomiasis. The invention applies the sanguinarine and the chelerythrine on killing an oncomelania, a snail egg, a Japanese blood fluke cercaria, a schistosome and the prevention and cure of schistosomiasis. The inventor discovers that the sanguinarine or the chelerythrine can kill the oncomelania and the snail egg safely and effectively and can kill the Japanese blood fluke cercaria as well as a schistosomulum and an imago of the schistosome under a lower concentration, which has the functions of preventing and curing the schistosomiasis and does not pollute the environment.

The invention discloses a functional growing-finishing pig pre-mixing feed, which contains the following components per kilogram of the pre-mixing feed: 10-15g of sanguinarine, 300-500g of biochemical fulvic acid, 50-100g of glycine iron, and the balance pre-mixing feed. The pre-mixing feed adopts plant extracts, microbial fermentation products and organic trace elements to realize reasonable compatibility, thus stimulating growth hormone to secrete by endogenesis, increasing the pig protein synthesis speed safely and efficiently and inhibiting the fat synthesis speed. The pre-mixing feed can promote the growth and the proteinosis of growing-finishing pigs effectively and increase the lean meat percentage.

The invention relates to a feed addictive, wherein each 1kg of feed addictive comprises sodium glutamate 10-500g, disodium 5'-guanylate 10-200g, Disodium 5'-guanylate 10-200g, sanguinarine 1-30g, and balancing carrying agent. The carrying agent is white carbon black.

The invention discloses a graphene oxide and sanguinarine compound and a preparation method thereof. The compound includes a graphene oxide carrier and sanguinarine loaded on the surface of the carrier via a non-covalent pi-pi action, the radial size of the graphene oxide carrier is smaller than or equal to 200nm, the thickness of the graphene oxide carrier is smaller than or equal to 1nm, and a six-arm PEG (polyethylene glycol) is further preferably decorated on the surface of the graphene oxide carrier. The preparation method includes steps of treating the surface of graphene oxide; accordingly forming an active linker on the surface of the graphene oxide; connecting the surface of the graphene oxide with high-polymer materials with hydrophobic groups via the active linker to form the graphene oxide carrier; steeping the graphene oxide carrier into organic solvent with the sanguinarine until the graphene oxide carrier absorbs the sanguinarine in a saturation manner; and then obtaining an objective product by means of separation. The graphene oxide and sanguinarine compound has the advantages that solubility and stability of the sanguinarine can be greatly improved, the sanguinarine has targeting property, and the graphene oxide and sanguinarine compound is expectably widely applied as an anticancer preparation with a huge potential.

The invention discloses flavoprotein oxidase genes of macleaya cordata in synthesis of sanguinarine and chelerythrine and application of the flavoprotein oxidase genes. Three flavoprotein oxidase genes joining in synthesis of sanguinarine and chelerythrine are found in a macleaya cordata genome for the first time, including genes Mc20113, Mc6407 and Mc6408. Steps of reaction are respectively verified by using a brewer's yeast system through upstream precursor feeding, and synthesis of sanguinarine and chelerythrine and midbodies can be achieved. The conversion efficiency of same functional genes of macleaya cordata and opium poppy is further compared by using a brewer's yeast heterologous expression system, and the result shows that the conversion rate of the gene of macleaya cordata is remarkably higher than that of opium poppy. The invention further discloses a molecular mechanism of synthesis of sanguinarine in macleaya cordata, and a theoretic basis and molecular assistant breeding targets are provided for breeding of macleaya cordata with high contents of sanguinarine and chelerythrine; and meanwhile, precious experience is provided for in-vitro artificial synthesis of sanguinarine and chelerythrine.

The invention relates to a sanguinarine alcoholate and a chelerythrine alcoholate and a preparation method and application thereof in acaricidal drugs for animals. Livestock and poultry acariasis is an in vitro parasitic disease which can cause serious damage to the animal health, and serious stress response of animals to influence ingestion, feed efficiency and weight gain, even cause death. At present, the control of the animal acariasis mainly relies on drugs for killing ticks and mites, and the ticks and mites can produce resistance to the drugs after the drugs are used for a long time, so that the drugs can cause adverse environmental and ecological effects, and can only drive and kill polypides instead of ova. The sanguinarine alcoholate and the chelerythrine alcoholate are derived from natural compounds-sanguinarine and chelerythrine alcoholate, and exist in the form of free alkaloids in the acaricidal drugs for animals. The sanguinarine alcoholate and the chelerythrine alcoholate have the characteristics of low toxicity, low residue and not easy production of resistance to the drugs of natural drugs, and have remarkable acaricidal activity and good treatment effect on the acariasis of animals when the sanguinarine alcoholate and the chelerythrine alcoholate are applied as the acaricidal drugs for animals.

The invention relates to a mildew-inhibiting composition which comprises the components in parts by weight as follows: 10-15 parts of modified nanometer montmorillonite, 5-10 parts of dimethyl fumarate, 2-5 parts of ethyoxyl quin, 20-25 parts of sodium glutamate, 20-30 parts of nucleotide disodium, 10-15 parts of sanguinarine, 15-30 parts of glutathione, 10-15 parts of choline chloride, 15-20 parts of glycine betaine, 10-15 parts of sodium sorbate, 2-5 parts of chitosan, 3-9 parts of gala mannan oligosaccharide, and 1-5 parts of fructo-oligosaccharide. The mildew-inhibiting composition provided by the invention further has the effects of enhancing the immune function of animals, strengthening the detoxifying function by liver and kidney and promoting the feed intake of poultry besides good bacteria-inhibiting and sterilizing effects.

The invention discloses a sanguinarine/gelatin microspheres-loaded composite hydrogel support and a preparation method and an application thereof. The method comprises the following steps: adding a sanguinarine solution dropwisely into gelatin microspheres, placing the materials over night, performing freeze drying to obtain a sanguinarine/gelatin microspheres compound; then adding the compound in an aldehyde glucan-aminated sodium hyaluronate pre-gel solution, uniformly stirring the materials, standing gel at normal temperature, and performing freeze drying to obtain the product. The water absorption of the composite hydrogel support is 23-25 times, the porosity is 68-88%, the aperture is 50-200 [mu]m, the composite hydrogel support has functions of wide-spectrum anti-microbial, long-acting anti-microbial and slow release of medicine, and can be used in the fields of skin wound healing and wound dressing.

The invention relates to a method for preparing total alkaloid from macleaya cordata and further separating the total alkaloid to obtain high content alkaloid, particularly a preparation method for high content sanguinarine and chelerythrine. The preparation method comprises: atomizing and extracting a macleaya cordata raw material by acid water, adsorbing and eluting an extraction liquid by weakly polar macroporous resin, and recovering a solvent from an eluant and drying the eluant to obtain the total alkaloid, the content of which is not less than 60%; dissolving the total alkaloid in low-degree ethanol, carrying out secondary adsorption by using polar macroporous resin, carrying out stepwise elution by using 60% and 80% ethanol, and recovering a solvent from an eluant and drying the eluant to separately obtain the chelerythrine and the sanguinarine, the contents of which are not less than 90%. The preparation method provided by the invention is simple in process step, short in production period, high in product yield and less in use level of solvent, the environment is slightly polluted, and the obtained product is high in content, stable in quality and low in cost.

The invention relates to the technical field of pesticide, in particular to a pesticide composition containing sanguinarine (macleaya alkaloids). The pesticide composition is prepared from, by weight, 0.1-30% of first pesticide, 0.1-80% of second pesticide, 5-80% of auxiliaries and 14.9-94.8% of a solvent or filler. The first pesticide is sanguinarine. The second pesticide comprises one of amino-oligosaccharin, cnidium lactone, spinosad, santonin, azadirachtin, wilforgine, neochamaejasmin, hyoscyamine and matrine. The auxiliaries comprise one or more of surfactant, a synergistic agent, an emulsifier, an anti-freezing agent, a dispersing agent, a wetting agent, a thickening agent, an ultraviolet protecting agent, a defoaming agent and an adhering agent. The pesticide belongs to plant source compound pesticide, the compound synergistic effect is remarkable, the pesticide composition can be used for preventing and treating various plant diseases, and pollution of chemical pesticide to the environment is reduced.

The invention provides an additive composition used for a piglet feed. The additive composition comprises tannic acid, sanguinarine and an epimedium herb extract, wherein the mass ratio of the tannic acid, the sanguinarine and the epimedium herb extract is (750-1300):50:(300-800). The invention also provides a compound premix containing the additive composition and an antibiotic-free piglet feed containing the additive composition. The additive composition, and the compound premix prepared from the additive composition, and the antibiotic-free piglet feed prepared from the additive composition have a plurality of functions of improving intestinal microflora balance of piglets, raising immunity, and resisting diarrhea. No antibiotic is added, so that the feed has high safety and accords with an ideal amino acid mode. Coordination on the aspects of electrolyte balance and mineral balance is carried out, so that the feed can comprehensively meet nutrient and health demands of piglets, and price performance ratio is taken into account at the same time so as to greatly raise benefits of pig farms.

The present invention discloses compounds for the treatment of cancer and its application. These compounds comprises one of the following compound: Ammonium pyrrolidinedithiocarbamate Bay 11-7085 BIO Brefeldin A (+)-Butaclamol Calcimycin Calmidazoliur chloride Chelerythrine chloride CK2 Inhibitor 2 CGP-74514A hydrochloride CGS-12066A meleate Dequalinium dichloride Dihydroouabain Diphenyleneiodonium chloride Emetine dihydrochloride hydrate GR 127935 hydrochloride Nifedipine 6-Nitroso-1,2-benzopyrone Palmitoyl-DL-Carnitine chloride Parthenolide PD 169316 1,10-Phenanthroline monohydrate 4-Phenyl-3-furoxancarbonitrile Prazosin hydrochloride Protoporphyrin IX disodium Quinacrine dihydrochloride Quabain Retinoic acid p-hydroxyanilide Rottlerin Sanguinarine chloride Tetraethylthium disulfide and SU 9516. The invention also provides new uses of these compounds, compounds such as for the preparation of the treatment of cancer, inhibit cancer cell, cancer stem cell growth and provides a new pharmaceutical composition for treating cancers

The invention provides a biological pesticide having natural phytotoxin and a preparation method thereof. The biological pesticide consists of barbadosnut seed extract, barbadosnut leaf extract and sanguinarine, wherein the barbadosnut seed extract is 50 to 75 percent ethanol solution extract and the barbadosnut leaf extract is 50 to 75 percent ethanol solution extract. The formula of the biological pesticide is simple and the preparation method is simple. When the pesticide is used for killing pesticides in crops, the pest killing effect is high. Meanwhile, the pesticide is also a new plant molluscicide with remarkable molluscacidal effect, and the pesticide causes little environment pollution and can create high economic and social benefit.

The invention belongs to the field of mouth nursing and specifically relates to toothpaste and a preparation method thereof. The toothpaste disclosed by the invention is prepared from the following ingredients in parts by weight: 30 to 40 parts of abrasive, 0.1 to 0.5 part of paeonol, 0.1 to 0.3 part of sanguinarine, 0.01 to 0.05 part of chebulinic acid, 0.01 to 0.03 part of bioactive glass, 1 to 3 parts of hydroxyapatite, 20 to 30 parts of wetting agent, 1 to 3 parts of foaming agent, 0.5 to 1 part of sodium carboxymethyl cellulose, 0.05 to 0.25 part of xylitol, 0.1 to 0.5 part of benzoic acid, 1 to 2 parts of spice and 30 to 40 parts of water. The toothpaste disclosed by the invention is stable to store, can improve remineralization of the surfaces of damaged teeth, eliminate dental plaque, enhance an anticorrosive function of enamel and effectively prevent and repair decayed teeth. Meanwhile, the toothpaste disclosed by the invention further has effects of inhibiting bacteria, diminishing inflammation and whitening skin and can effectively improve oral inflammation of periodontitis, gingival bleeding and the like.

The invention relates to the technical field of veterinary drugs and discloses a fly killing agent containing macleaya cordata and cyromazine. Macleaya cordata and cyromazine are used as active components of the fly killing agent; according to percentage by weight, the weight percentage range of macleaya cordata is 1-5%, and the weight percentage range of cyromazine is 1-10%; in macleaya cordata, the weight percentage of sanguinarine is not less than 1.50%; the total weight percentage of sanguinarine and chelerythrine is not less than 2.25%. Macleaya cordata and cyromazine are matched in use; the cyromazine is used while a certain amount of chelerythrine is added, so that the effects of killing and controlling flies can be improved; the consumption of cyromazine is reduced; the influence on animal organism and environment is reduced; the effects of killing and controlling flies of the fly killing agent are greatly improved; the consumption of cyromazine is effectively reduced; drug pollution and residue can be reduced; the fly killing agent also has the advantages of accelerating parturition, reducing feed conversion ratio, improving animal parturition performance and reducing feeding cost, and has a wide application prospect in the animal farming industry.

The invention belongs to the field of sensitizing drugs for tumor chemotherapy, and relates to a new application of sanguinarine, that is, the application in the preparation of sensitizing drugs for improving the curative effect of cisplatin chemotherapy. The sanguinarine described in the invention can be used to prepare a sensitizing drug for improving the curative effect of cisplatin chemotherapy, and can improve the curative effect of cisplatin chemotherapy for tumor cells at a low concentration without toxic or side effects. After treatment with sanguinarine at a concentration without toxic side effects, when combined with cisplatin chemotherapy, compared with cisplatin chemotherapy alone, the cell death rate increased by 100%, almost doubled.

The invention discloses a method for extracting high-purity sanguinarine and chelerythrine by using a chromatographic technique. The method comprises the following steps: (1) dissolving a macleaya cordata extract and then filtering; (2) preparing a corresponding buffer solution A and a corresponding buffer solution B; (3) injecting a macleaya cordata solution obtained through the filtering into a chromatographic column filled with SP-Sepharose FF fillers for adsorption; (4) flushing the chromatographic column by using the buffer solution A by 1 to 3 column volumes firstly, then eluting impurities in the chromatographic column by using the buffer solution B, and then eluting a target object from the chromatographic column by using the buffer solution B. The method provided by the invention is simple to operate, small in energy consumption, low in cost, and high in purity, and sanguinarine and chelerythrine with the purity above 98 percent can be obtained.

The invention discloses a compound algistat which is prepared from berberine, fangchinoline and sanguinarine hydrate. The invention also discloses a preparation method and application of the compound algistat. The compound algistat is an environment-friendly algistat, through the combination and advantage complementary of multiple typical alkaloid compounds, the multiple algae causing algae blooms can be effectively suppressed at the same time, thereby greatly improving the algicidal efficiency. The compound algistat provided by the invention has an effective inhibition rate of 80% to 92% or more within 96h on three kinds of green algae such as microcystis aeruginosa, chlorella pyrenoidosa and scenedesmusobliqnus.

The invention relates to a plant essential oil composition for replacing antibiotics of piglet feed and a preparation method and application thereof and belongs to the field of feed. The plant essential oil composition replacing the antibiotics of piglet feed comprises cinnamaldehyde, oregano oil, citronella phenol, sanguinarine, citral, menthone, artemisia scoparia ketone and eucalyptus oil. The above components are safe and non-toxic, have better antibacterial and antiviral functions and can improve the feed intake of piglets. The method for preparing the plant essential oil composition comprises mixing the above ingredients of the plant essential oil composition according to a ratio and carrying out encapsulation. The method is simple and fast, uniformly mixes the ingredients, prevents essential oil volatilization and masks the pungent smell. The plant essential oil composition as a feed additive is used in preparation of weaned piglet feed and the weaned piglet feed can significantly improve the daily feed intake of weaned piglets, reduces a feed conversion ratio and the content of harmful microorganisms in the piglet intestine and prevents resistance to drugs and internal residual.

The invention belongs to the technical field of medicine, and particularly relates to valproate and protoberberine compounds, a preparation method and an application. The valproate and protoberberine compounds have the general structural formula represented by the specification, wherein A <+> represents berberine, coptisine, palmatine, jatrorrhizine or sanguinarine. The valproate and protoberberine compounds have high water solubility and low hygroscopicity and facilitate oral absorption and improve bioavailability, berberine and valproate have the anticancer effect, and berberine further has the functions of delaying epileptic seizure time and relieving the degree of epileptic seizure and can cooperate with valproate for synergy and attenuation.

The invention relates to a preparation method and applications of ion-pair compounds of sanguinarine. In the invention, sanguinarine reacts with an organic acid, and the organic acid mainly comprises chlorogenic acid, gallic acid, shikimic acid, oleanolic acid, ursolic acid, benzoic acid, salicylic acid, tartaric acid, lactic acid, sorbic acid, fumaric acid, malic acid, citric acid, maleic acid, glycyrrhizic acid, glycyrrhetinic acid, carnosic acid, hydroxyci amic acid, rosmarinic acid, succinic acid, ferulic acid, protocatechuic acid, cinnamic acid, caffeic acid, chicoric acid or pseudolaricacid B. The ion-pair compounds prepared from sanguinarine and organic acids have the bioactivity of antibiosis. The invention also relates to applications of ion-pair compounds containing sanguinarine in medicaments, veterinary medicines or daily chemicals.