940 results about "Staphyloccocus aureus" patented technology

The invention discloses an antibacterial peptide and application thereof, and belongs to the technical field of biology. The antibacterial peptide with an inhibition effect on various clinically common pathogenic microorganisms is obtained, and the antibacterial peptide comprises gram-negative bacteria such as escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa, acinetobacter baumannii, vibrio parahaemolyticus, salmonella gallinarum, salmonella typhimurium and enterobacter sakazakii, and gram-positive bacteria. The antibacterial peptide provided by the invention can be used as an antibacterial peptide, such as staphylococcus aureus, listeria monocytogenes and bacillus cereus, and the antibacterial peptide provided by the invention is novel in structure and easy to prepare.

The invention belongs to the technical field of medicines, and particularly relates to application of sesquiterpenoids and / or pharmaceutically acceptable salts thereof in preparation of medicines for treating or preventing infectious diseases caused by staphylococcus aureus. The invention relates to the field of medicines, in particular to application in preparation of medicines for treating or preventing infectious diseases caused by drug-sensitive staphylococcus aureus or drug-resistant staphylococcus aureus. The structure of the sesquiterpenoids is shown as a formula I in the specification. The sesquiterpenoids applied in the invention are derived from rattan chrysanthemum, the source is wide, and the production cost is low. The sesquiterpenoids shown in the formula I have a very good activity inhibition effect on staphylococcus aureus for the first time, and the sesquiterpenoids have a very good activity inhibition effect on staphylococcus aureus with drug sensitivity, drug medium or drug resistance.

The invention belongs to the technical field of antibiosis and wound healing promotion, and relates to double-response (near-infrared light and hydrogen peroxide double-response photo-thermal / carbon monoxide therapy) antibacterial hydrogel as well as preparation and application thereof. The invention relates to a double-response antibacterial hydrogel. The antibacterial hydrogel is prepared from the following components: drug-loaded nano particles and a hydrogel matrix. The drug-loaded nano particles are prepared by loading dimanganese decacarbonyl (MnCO) into cavities of hollow mesoporous copper sulphide nano particles (HMCuS NPs) and coating the surfaces of the particles with a polydopamine layer (PDA). According to the invention, CO / PTT synergistic treatment of bacterial infected wounds is realized, and the antibacterial effect is significantly improved. An in-vitro antibacterial experiment result shows that the antibacterial hydrogel shows extremely strong inhibition capability on escherichia coli and staphylococcus aureus, and the problem of drug resistance caused by a bacterial biofilm is effectively solved.

The invention provides a thiazolidinone compound and application thereof in preparation of drugs for resisting staphylococcus aureus infection. The molecular structural formula of the thiazolidinone compound is shown as a formula (1), a formula (2), a formula (3) or a formula (4). The technical scheme of the invention discloses several thiazolidinone compounds, which not only have an excellent bactericidal effect on staphylococcus aureus and can significantly inhibit the formation of a biofilm of staphylococcus aureus, but also have low cytotoxicity and hemolytic activity. According to the technical scheme, a certain foundation is laid for research and development of novel staphylococcus aureus biofilm infection resisting drugs, and the potential of thiazolidone derivatives for developing novel antibacterial agents for staphylococcus aureus related infection can be deeply known possibly.

The invention relates to the technical field of biological medicine, in particular to an antibody aiming at staphylococcus aureus enterotoxin B and application thereof. A heavy chain variable region of the antibody provided by the invention comprises CDR sequences as shown in SEQ ID NO.1-3, and a light chain variable region of the antibody comprises CDR sequences as shown in SEQ ID NO.9-11. The antibody has high affinity, can specifically bind to staphylococcus aureus SEB, can block binding of SEB and MHC II / TCR, significantly inhibits cytokine storm, shows a dose-dependent protection effect in an MRSA systemic infection model, and can be used for preparing an MRSA systemic infection model. The monoclonal antibody can be used for treating, preventing or diagnosing the infection of the staphylococcus aureus, provides a solution of non-antibiotic therapy for SEB poisoning and drug-resistant staphylococcus aureus infection, and has important clinical and public health values.

The invention discloses an antibacterial peptide fragment intercepted from chitinase IDGF4 protein and application of the antibacterial peptide fragment in preparation of antibacterial drugs. According to the invention, short peptide fragments in chitinase IDGF4 protein are screened, three candidate peptides are obtained through chemical synthesis, the antibacterial performance of the candidate peptides is systematically evaluated, and the evaluation result shows that the peptide fragment with the amino acid sequence as shown in SEQ ID No.2 can effectively inhibit the growth of salmonella and staphylococcus aureus under the concentration of 1mg / mL; the antibacterial effect of the compound is confirmed in inhibition zone experiments, enzyme-labeled turbidimetry and growth curve monitoring, and the compound shows stable and remarkable antibacterial activity and can be used as a novel antibacterial molecule; the invention provides a new candidate sequence for developing the antibacterial peptide with high efficiency and low drug resistance risk, and has application potential in the aspect of preparing clinical antibacterial drugs.

The invention provides a kit for rapidly detecting MRSA and drug-resistant gene nucleic acid POCT of the MRSA based on a phage lyase mutant. The kit comprises nucleic acid extraction and purification and triple PCR rapid amplification detection reagents. The staphylococcus aureus bacteriophage lyase mutant nucleic acid release liquid containing the amino acid sequence as shown in SEQ ID NO: 1 is adopted, wall breaking can be rapidly conducted on staphylococcus aureus, and nucleic acid is released. The effect of the nucleic acid release liquid acting for 5 minutes is equivalent to or even better than that of the lysozyme acting for 60 minutes; according to the present invention, with the combination of the MRSA and drug-resistant gene triple PCR rapid amplification detection reagent, the total detection time is only 35 min, the time is saved by 55 min or more than 55 min compared with the lysozyme method, and the MRSA and drug-resistant gene nucleic acid POCT rapid detection can be achieved;

The invention discloses a staphylococcus aureus biosensor based on a nucleic acid aptamer and a preparation method of the staphylococcus aureus biosensor. Three fluorine atoms (F) are introduced into the 5'end, the 3 'end and the middle position of an aptamer 2' F3-(5 '3'm DNA) sequence (SEQ ID NO: 1) for modification, so that the binding force of the aptamer and graphene is remarkably enhanced, the signal stability and the anti-interference capability of the biosensor are remarkably improved, non-specific fluorescence leakage can be effectively blocked, and reliable guarantee is provided for complex sample detection. According to the present invention, with the cooperation of the graphene oxide quenching substrate, the high-sensitivity detection of the staphylococcus aureus is achieved, the detection limit of the sensor within 5 min can achieve 5 cells / mL, the sensitivity is high, the specificity on the complex sample is more than 95.4%, and the sensor is suitable for the food safety rapid screening and the clinical diagnosis.

The invention provides a probiotic composition for preventing and / or inhibiting oral pathogens as well as a derivative product, a preparation method and application of the probiotic composition, and belongs to the technical field of oral care. The probiotic composition comprises the following bacterial strains in parts by mass: 90 to 0.45 part of a lactobacillus rhamnosus bacterial strain A2114, 10 to 0.3 part of a plant lactobacillus bacterial strain A2124, 80 to 0.4 part of a pediococcus pentosaceus bacterial strain A2135, 250 to 0.25 part of a lactobacillus reuteri bacterial strain A21350, and 40 to 0.2 part of a plant lactobacillus bacterial strain A2109. The probiotic composition or the metabolite thereof can effectively inhibit oral pathogens such as streptococcus mutans, porphyromonas gingivalis, helicobacter pylori, escherichia coli and staphylococcus aureus. Therefore, the probiotic composition or the metabolite thereof shows a good application prospect in the aspects of preventing and relieving oral problems such as decayed teeth, periodontitis and ozostomia.

The invention provides a recombinant chicken antibacterial peptide aiming at drug-resistant staphylococcus aureus, and belongs to the technical field of veterinarians. The recombinant chicken antibacterial peptide is expressed through genetic engineering recombinant escherichia coli. Three natural chicken antibacterial peptide active regions are fused, and two disulfide bonds are introduced to stabilize the structure of the recombinant chicken antibacterial peptide and enhance the affinity of the recombinant chicken antibacterial peptide to staphylococcus aureus outer membrane protein. The minimum inhibitory concentration of the recombinant chicken antibacterial peptide to the drug-resistant staphylococcus aureus is obviously lower than that of three natural chicken antibacterial peptides, and the formation of a biomembrane of a USA300 strain of the drug-resistant staphylococcus aureus can be thoroughly inhibited when the minimum inhibitory concentration is 8 mu g / mL. The recombinant chicken antibacterial peptide has a good antibacterial effect on different drug-resistant staphylococcus aureus separated from a chicken house, and can effectively solve the infection problem of the drug-resistant staphylococcus aureus in the chicken house.

The invention belongs to the technical field of antibacterial peptides, and particularly relates to an antibacterial peptide Mh-GC21 as well as a precursor and application thereof. The amino acid sequence of the antibacterial peptide Mh-GC21 provided by the invention is as shown in SEQ ID NO.1, and two cysteines are oxidized to form a pair of intermolecular disulfide bonds; the C tail end of the antibacterial peptide Mh-GC21 is subjected to amidation modification. The antibacterial peptide Mh-GC21 provided by the invention is from microhyla microcarpa, has broad-spectrum antibacterial activity, has relatively good antibacterial and bactericidal effects on standard strains of acinetobacter baumannii, escherichia coli and staphylococcus aureus and clinically sourced drug-resistant strains, and can be used for targeted destruction of cell membranes of bacteria, removal of biological membranes and inhibition of formation of the biological membranes. Moreover, the antibacterial peptide Mh-GC21 has the advantages of good stability, no hemolytic activity and cytotoxicity, and difficulty in inducing strains to generate drug resistance.

The invention discloses marine-derived penicillium as well as a fermentation method and application thereof. The marine source penicillium is named as Penicillium sp.DSF059, and the preservation number of the marine source penicillium is CCTCC (China Center For Type Culture Collection) NO: M 20232310. According to the invention, the culture conditions of the strain are optimized, the culture medium and culture conditions with high yield of antibacterial active compounds are selected for fermentation, more target products can be obtained, the operation is simple, the cost is low, and the method is suitable for industrial production. Meanwhile, the marine-derived penicillium sp. DSF059 can provide an excellent strain for the development of new drugs for resisting plant pathogens such as coffee leaf blight, coffee brown spot, grape gray mold, golden cypress brown spot, citrus black rot, phytophthora capsici, hickory leaf blight and coffee black spot as well as four pathogens separated from coffee leaf diseases and staphylococcus aureus; good application prospects are realized on prevention and treatment of phytopathogen and staphylococcus aureus.

The invention discloses an antibacterial sanitary towel packaging bag and a preparation method thereof. The antibacterial sanitary towel packaging bag comprises a base material layer, an antibacterial layer and a leakage-proof layer. The base material layer is prepared by blending modified polylactic acid, polybutylene adipate and the like and contains a degradation accelerant; the antibacterial layer contains antibacterial peptide-loaded nano montmorillonite, chitosan and the like, and loofah sponge fiber enhances slow release; and the leakage-proof layer is an ethylene-vinyl acetate copolymer and modified silicon dioxide blended film and is provided with breathable micropores. The preparation method comprises the steps of forming the base material layer, coating the antibacterial layer and the like, and process parameters of each layer are accurately controlled. According to the packaging bag, through cooperation of three layers, the bacteriostasis rate of the packaging bag on escherichia coli and staphylococcus aureus in 24 hours is higher than 99%, the degradation rate of the packaging bag in 83 days is higher than 88%, the oxygen permeability is 4.5-5.2 cm < 3 > / (m224h 0.1 MPa), and the packaging bag has the advantages of long-acting antibiosis, air permeability, leakage prevention, environmental protection, degradation and good mechanical properties, and meets the storage and use requirements of sanitary napkins.

The invention belongs to the field of plant endophytic fungus secondary metabolites, particularly relates to a secondary metabolite of fennel endophytic fungus fusarium oxysporum as well as a preparation method and application thereof, and provides a fennel endophytic fungus secondary metabolite with structures as shown in compounds 1-8. Wherein the compound 2 and the compound 7 have inhibitory activity on staphylococcus aureus, escherichia coli, bacillus cereus, bacillus subtilis, candida albicans and shigella, and have a certain inhibitory effect on cervical cancer Hela cell strains.

The invention relates to the technical field of textile fabrics, in particular to an antibacterial composite fabric and a preparation process thereof. Comprising the following steps: S1, treating a fabric for 30 minutes at 100 DEG C by using a NaOH aqueous solution according to a bath ratio of 1: 50, washing the fabric with deionized water, and drying the fabric at 80 DEG C; soaking the fabric in the finishing agent according to a bath ratio of 1: 40, soaking at 40 DEG C for 24 hours, washing with deionized water, and drying at 80 DEG C; s2, 50 g of the fabric obtained in the step S1 is soaked in 150 mL of a curcumin-coated UiO-66-NH2 compound aqueous solution, and soaking is conducted for 24 h at the temperature of 30 DEG C; and then drying to obtain the antibacterial composite fabric. Through low-temperature finishing of natural curcumin-UiO-66-NH2-MOF, the cotton fabric can obtain the antibacterial rate of more than or equal to 96% of escherichia coli and more than or equal to 98% of staphylococcus aureus within the active component range of 20-80 g / L, and the antibacterial retention rate is still more than or equal to 80% after 50 times of industrial washing; the process is mild and does not damage cotton fibers.

The invention relates to a preparation method and application of recombinant canine lactoferrin and peptide thereof, aiming at codon preference of host cells, canine lactoferrin genes are optimized, the full length of canine lactoferrin and the lactoferrin peptide are successfully expressed by virtue of an escherichia coli expression system, and the recombinant canine lactoferrin and the peptide thereof are identified by virtue of a minimum inhibitory concentration experiment. It is proved that the canine lactoferrin and the peptide thereof have the inhibiting capacity on pathogenic bacteria such as staphylococcus aureus, salmonella typhimurium and staphylococcus pseudointermedius, and the antibacterial activity MIC of the canine lactoferrin on the staphylococcus aureus, the salmonella typhimurium and the staphylococcus pseudointermedius is 1.5 mg / mL; the antibacterial activity MIC of the dog lactoferrin peptide to staphylococcus aureus is equal to 0.75 mg / mL, and the dog lactoferrin peptide shows high antibacterial ability.

The invention relates to the technical field of PA resin, and particularly discloses glass fiber modified antibacterial PA resin suitable for children products and a preparation method of the antibacterial PA resin. The invention discloses glass fiber modified antibacterial PA resin suitable for children products. The glass fiber modified antibacterial PA resin comprises PA resin, glass fibers, talcum powder, nano calcium carbonate, a composite antibacterial agent, a compatilizer, an antioxidant and calcium stearate, the composite antibacterial agent comprises chitosan, an antibacterial peptide microcapsule and a porous silver-zinc-loaded antibacterial agent; the antibacterial peptide microcapsules are sodium alginate embedded antibacterial peptides. The antibacterial PA resin obtained in the invention has the highest bacteriostasis rates of 99.97%, 99.74% and 99.95% for staphylococcus aureus, escherichia coli and candida albicans respectively, the antibacterial property of the PA resin is improved, the compressive strength and notch impact strength are 170.6 MPa and 17.3 kJ / m < 2 > respectively, and high mechanical strength is maintained on the basis of high antibacterial property.

The invention relates to an enzyme response antibacterial carbon dot and a preparation method and application thereof.The carbon dot takes a copper-doped carbon dot as a core and is covalently grafted with a hyaluronic acid shell layer through amidation reaction to form a composite nano material Cu-CDs (at) HA, specifically, soluble copper salt and folic acid are subjected to a hydrothermal reaction to obtain the copper-doped carbon dot, carboxyl is activated through EDC / NHS in a buffer system, and the carbon dot is prepared. And performing grafting reaction with hyaluronic acid to obtain a target product. The hyaluronidase-containing antibacterial composition can be specifically degraded and release antibacterial components under the action of hyaluronidase, shows good bacterial responsive bactericidal performance, has the minimum inhibitory concentrations of 8 g / mL and 16 g / mL for staphylococcus aureus and escherichia coli respectively, and has peroxidase-like activity and free radical scavenging capacity. The antibacterial carbon dots can be used for preparing intelligent wound dressings, antibacterial coatings and other biomedical materials, and have the advantages of responsive drug release, efficient antibacterial property and promotion of wound repair.

The invention belongs to the technical field of biology, and particularly relates to a primer probe composition and a kit for detecting lower respiratory tract infection pathogens. The primer probe composition is used for detecting mycobacterium tuberculosis, mycobacterium avium, mycobacterium abscessus, mycobacterium kansasii, pseudomonas aeruginosa, klebsiella pneumoniae, acinetobacter baumannii and haemophilus influenzae, and the primer probe composition is used for detecting mycobacterium tuberculosis, mycobacterium avium, mycobacterium abscessus, mycobacterium kansasii, pseudomonas aeruginosa, klebsiella pneumoniae, acinetobacter baumannii and haemophilus influenzae. The composition is one or more of a composition for detecting staphylococcus aureus, a composition for detecting streptococcus pneumoniae, a composition for detecting escherichia coli, a composition for detecting moraxella catarrhalis, a composition for detecting serratia marcescens, a composition for detecting mycoplasma pneumoniae, a composition for detecting candida albicans or a composition for detecting adenovirus; the RAA-RDB technology has the core advantages of rapidness, high sensitivity, low cost and easy operation, and is especially suitable for multiple pathogen screening and basic medical application.

The invention belongs to the technical field of food packaging materials, and particularly relates to a preparation method and application of a chitosan-gelatin-tea polyphenol composite preservative film. The invention discloses a chitosan / gelatin / tea polyphenol composite membrane which is prepared by taking chitosan and gelatin as matrixes and tea polyphenol as an active additive through a film casting method. When the addition amount of the tea polyphenol is 1.5%, the comprehensive performance of the composite film is optimal, the ultraviolet light transmittance is as low as 0.113%, and the antibacterial rates on escherichia coli and staphylococcus aureus respectively reach 73.34% and 99.78%. When the strawberry preservative is applied to strawberry preservation, the mass loss rate is only 15.27% after 11 days, the sensory quality is well kept, and the shelf life is prolonged by 4 days. The composite film has excellent antibacterial and fresh-keeping performance, the raw materials are natural and degradable, and the composite film has wide application prospects in the field of fruit and vegetable fresh-keeping.

The invention discloses application of swertiflavin in preparation of a medicine for treating infectious pneumonia caused by methicillin-resistant staphylococcus aureus, and relates to the technical field of medicine. It is found for the first time that swertiflavin can significantly reduce the toxicity of staphylococcus aureus by inhibiting the activity of ClpP protein in MRSA. In addition, the swertiflavin shows a remarkable protection effect in the treatment of the MRSA infectious pneumonia. Specifically, the swertiflavin not only can relieve the injury degree of lung tissues, but also can reduce infiltration and aggregation of inflammatory cells in the lung. The discovery shows that the swertiflavin has potential application value in the field of anti-infection treatment. The invention provides a novel treatment strategy, namely, swertiflavin is used as an active ingredient for preparing the medicine for treating the staphylococcus aureus infectious pneumonia.

The invention is applicable to the technical field of biomedical materials, and provides an anti-inflammatory hemostatic composite gel microsphere and a preparation method and application thereof, and the preparation method comprises the following steps: mixing sodium alginate and baicalin, dissolving in deionized water to obtain a mixed solution, spraying the mixed solution into a calcium chloride solution by utilizing electrospinning and electrospraying, and carrying out electrostatic spinning and electrospraying to obtain the anti-inflammatory hemostatic composite gel microsphere. Gel microspheres are formed through ionic crosslinking; washing the gel microspheres with a calcium chloride solution, and soaking the gel microspheres in a chitosan acetic acid solution to obtain chitosan-encapsulated gel microspheres; placing the gel microspheres in a copper sulfate solution, and performing low-temperature calcium-copper ion exchange to obtain baicalin / copper alginate composite gel microspheres; and filtering, washing and freeze-drying the composite gel microspheres. The electrospray technology is combined with ionic crosslinking, the size and morphology of the microspheres are accurately controlled, the antibacterial effect on escherichia coli and staphylococcus aureus is remarkable, the in-vitro blood coagulation time is shortened by 30%, the cytotoxicity is low, and good biocompatibility is achieved.

The invention discloses a copper-based nano antibacterial preparation and a preparation method thereof, and relates to the field of nano antibacterial materials. The copper-based nano-antibacterial preparation with high activity, broad-spectrum antibacterial effect, long acting and safety is designed by using an in-situ reduction strategy, the copper-based nano-antibacterial preparation is composed of NH2-UiO-66 (Zr) as a carrier and copper oxide nano-particles formed through copper source pre-adsorption and reducing agent reduction, then the copper oxide nano-particles are coated and modified by an amphipathic drug auxiliary material, the size is in a range of 50-500nm, and the copper-based nano-antibacterial preparation is prepared by using the amphipathic drug auxiliary material to prepare the copper-based nano-antibacterial preparation. The copper content is 5%-40% wt, the compound shows a remarkable antibacterial effect on six clinical drug-resistant bacteria, and the effective antibacterial concentrations are 20 ppm and 60 ppm respectively. Compared with copper oxide and cuprous oxide with the same molar concentration, the antibacterial effects of the antibacterial preparation on escherichia coli and staphylococcus aureus are improved by 8 times and 13 times or above respectively. The antibacterial preparation provided by the invention solves the problem of high dosage of ion antibiosis, and provides an optional way for prevention and treatment of drug-resistant bacterium infection.

The invention belongs to the technical field of microorganisms, and particularly discloses lactobacillus plantarum CX1-3-2 capable of producing gamma-aminobutyric acid and improving sleep and application of the lactobacillus plantarum CX1-3-2. The preservation number of the lactobacillus plantarum CX1-3-2 strain is CGMCC (China General Microbiological Culture Collection Center) No. 34340. The lactobacillus plantarum CX1-3-2 can achieve the effect of improving sleep by improving the levels of GABA and 5-HT in brain tissues and reducing the levels of glutamic acid Glu, dopamine DA and noradrenaline NE; the scavenging rate of DPPH free radicals of the strain reaches 96.4%, the scavenging rate of ABTS free radicals of the strain reaches 78.3%, and the strain has an excellent anti-oxidation effect; the diameters of inhibition zones of the strain on staphylococcus aureus, bacillus cereus, escherichia coli and pseudomonas fluorescens are all larger than 17 mm, and the strain has an excellent antibacterial effect.

The invention belongs to the technical field of functional textile materials, and discloses a modified spandex-based high-elastic antibacterial knitted fabric and a preparation method thereof.The fabric is of a double-layer composite knitted structure and comprises an inner high-elastic breathable layer and an outer antibacterial compact layer; the inner layer is formed by blending modified spandex yarns and modified viscose fibers, and the outer layer is formed by blending modified spandex yarns and superfine polyester fibers. The modified spandex yarn is prepared by introducing a hydrophilic antibacterial monomer compound into a spandex base material and matching with a cross-linking agent for graft modification, the hydrophilic antibacterial monomer compound is formed by compounding guanidyl acrylate and acryloyloxy eugenol, and stable fixation of antibacterial groups is achieved from the molecular level. Meanwhile, the molecular chain structure is regulated and controlled to keep high elasticity. The elongation at break of the fabric is greater than or equal to 300%, the elastic recovery rate is greater than or equal to 95%, and the antibacterial rate on escherichia coli and staphylococcus aureus is greater than or equal to 99%.

This invention belongs to the field of microbial technology, specifically relating to a strain of *Lactobacillus plantarum* that produces antimicrobial peptides and its applications. The *Lactobacillus plantarum* is specifically *Lactobacillus plantarum* (…). Lactobacillus plants Lactobacillus plantarum AF-6, with accession number CGMCC No. 33716, is a product of this invention. It generates a variety of antimicrobial peptides with broad-spectrum antibacterial activity, inhibiting spoilage bacteria such as Escherichia coli, Bacillus subtilis, Salmonella, Micrococcus luteus, Pseudomonas aeruginosa, Bacillus cereus, and Staphylococcus aureus. This provides a more reliable and effective option for food safety preservation.

The invention discloses a preparation method of a high-toughness transparent plastic cup, and belongs to the technical field of plastic preparation, and the preparation method comprises the following steps: 1, preparing a modified elastomer toughening agent from 16.4-21.9% of an isosorbide-based plasticizer, 2.2-2.6% of polydimethylsiloxane, 1.5-2.2% of citric acid and the balance of polycaprolactone; 2, preparing a cinnamyl aldehyde bamboo pulp antibacterial reinforcing agent from 4.8 to 8.2 percent of cinnamyl aldehyde, 22 to 36 percent of bamboo pulp, 7.5 to 10.6 percent of bio-based 1, 3-propylene glycol (PO3G) and the balance of water; 3, weighing the cinnamyl aldehyde bamboo pulp antibacterial reinforcing agent, the modified elastomer toughening agent and polylactic acid to prepare high-toughness polylactic acid; and 4, preparing the high-toughness transparent plastic cup from the high-toughness polylactic acid. The high-toughness transparent plastic cup is prepared by compounding the modified elastomer flexibilizer, the cinnamyl aldehyde bamboo pulp antibacterial enhancer and the polylactic acid, and has the advantages of high strength, excellent toughness, good staphylococcus aureus inhibition effect, biodegradability and the like.

The invention provides application of lactobacillus rhamnosus GOLDGUT-M520 or a composition of the lactobacillus rhamnosus GOLDGUT-M520 in preparation of a product for enhancing the immunity of an organism. The lactobacillus rhamnosus GOLDGUT-M520 has the function of enhancing the immunity in both a viable form and an inactivated form of the lactobacillus rhamnosus GOLDGUT-M520. The lactobacillus rhamnosus GOLDGUT-M520 has a good antibacterial capability on escherichia coli and staphylococcus aureus which are pathogenic to intestinal tracts, and is beneficial to enhancing a chemical barrier in an innate immune barrier; the strain can improve the phagocytic activity of macrophages and enhance the innate immune response; the strain can improve the T cell proportion, the B cell proportion and the immune globulin level in mesenteric lymph nodes of immunocompromised mice, and can enhance adaptive immune response. The lactobacillus rhamnosus GOLDGUT-M520 can comprehensively play a role in enhancing immunity, and meanwhile, the inherent immune barrier, the inherent immune response and the adaptive immune response are enhanced.

The invention discloses an S-type three-dimensional carbon nitride / copper sulfide nanosphere heterojunction as well as a preparation method and application thereof, and belongs to the field of antibacterial application of nano materials. The three-dimensional porous carbon nitride not only can increase photocatalytic active sites, but also can improve close contact with copper sulfide. The copper sulfide nanospheres and the three-dimensional porous nanosheets construct an S-shaped heterojunction, and efficient separation of photo-induced electrons and hole pairs can be driven under the action of a built-in electric field, band edge bending and coulomb force. The S-type three-dimensional carbon nitride / copper sulfide nanosphere heterojunction can generate more active oxygen species to inactivate bacteria through a photocatalysis-Fenton-like reaction; in addition, the photothermal effect of copper sulphide has a certain auxiliary sterilization effect. Under the conditions of visible light irradiation and trace hydrogen peroxide, the inactivation rates of the S-type three-dimensional carbon nitride / copper sulfide nanosphere heterojunction on staphylococcus aureus and escherichia coli are up to 99.5% and 99.7% respectively, and meanwhile, the S-type three-dimensional carbon nitride / copper sulfide nanosphere heterojunction has a remarkable treatment effect on wounds infected by staphylococcus aureus.

The invention provides a bridged triphenylamine-derived AIE type antibacterial photosensitizer, a preparation method and antibacterial application thereof, the bridged triphenylamine-derived AIE type antibacterial photosensitizer has the following structure: # imgabs0 is subjected to a cyclization reaction to form a bridged structure to limit bond rotation as a novel molecular design, and the photodynamic antibacterial effect of the AIE photosensitizer (PSs) can be effectively improved; and an AIE photosensitizer is combined with a donor-pi-receptor (D-pi-A) structure, so that a smaller singlet-triplet energy level difference (delta EST) is realized, and an intersystem crossing process is promoted. The mutual combination effect of the PSs and bacteria can be influenced by regulating and controlling the charge number of the PSs, so that effective bacteria recognition and selective antibacterial performance are realized. Experiments show that the AIE antibacterial photosensitizer based on bridged triphenylamine has a specific elimination effect on gram-positive bacteria; and the photodynamic antibacterial agent has a good photodynamic antibacterial effect on staphylococcus aureus and methicillin-resistant staphylococcus aureus.