881 results about "Photosens" patented technology

The invention provides a photosensitive resin composition containing an anthracene methyl quaternary ammonium salt photosensitizer and application of the photosensitive resin composition, a structural main body anthracene ring of the photosensitizer is introduced into methylene substituted by a quaternary ammonium group at a position 10 and / or a position 9, and an acid radical or halogen is adopted as an equilibrium anion; compared with a commercially available anthracene photosensitizer, the photosensitizer has excellent fat solubility and good water solubility through introduction of the quaternary ammonium salt on the premise that the photobleaching property is retained, great potential is brought to formula design of the photosensitive composition, and development waste in a later development process can be greatly reduced; the method can be widely applied to the photo-curing fields of dry films, paints, coatings, printing ink, forming materials and the like.

The preparation method comprises the following steps: synthesizing gold nanostars (GNS) by using a seed growth method, coating mesoporous cerium dioxide (mCeO2) by using a template method, and loading a photosensitizer indocyanine green (ICG), so as to form a nano enzyme diagnosis and treatment system with chemical activity, photoactivity and photothermal effects. In the system, the gold nanostars have a good photo-thermal effect due to the multi-branched structure of the gold nanostars; on one hand, the mesoporous cerium dioxide coated on the outer layer has a chemical effect due to the nano-enzyme effect, and on the other hand, the mesoporous structure of the mesoporous cerium dioxide can better load the photosensitizer indocyanine green. All the components have good stability and biological safety, also have peroxidase simulation activity and a drug loading function, can improve the level of reactive oxygen species (ROS) in a tumor microenvironment and load photosensitizer drugs, and have an excellent anti-tumor effect and small side effects.

The invention provides triazole anthracene methyl formate for a photosensitive resin composition, and relates to the field of photopolymerization. The invention also comprises a photosensitive resin composition containing the triazole anthracene methyl formate, a photosensitive dry film containing the triazole anthracene methyl formate, and applications of the photosensitive resin composition and the photosensitive dry film. The triazole formic acid anthracene methyl ester disclosed by the invention has photosensitivity, can be used as a photosensitizer in the photosensitive resin composition, can improve the adhesive force of the photosensitive resin composition on various metal surfaces, and has the characteristic of low migration; the method can be widely applied to the photo-curing fields of dry films, paints, coatings, printing ink, forming materials and the like.

The invention discloses a dual-mechanism antibacterial photosensitizer as well as a preparation method and application thereof, and relates to the technical field of biomedical photoelectric functional materials. The invention relates to a triphenylamine derivative, which can realize fluorescence imaging of bacterial or fungal infection by utilizing fluorescence characteristics, can generate active oxygen under illumination to play a photodynamic therapy role, is suitable for preparing photodynamic therapy preparations and developing antibacterial materials, and can also be applied to the fields of environment and public health and tumor treatment. The problems that an existing photosensitizer is insufficient in broad spectrum, different in fungus drug resistance mechanism, limited in single treatment effect and the like can be effectively solved, and the photosensitizer has wide application prospects.

The invention provides anthracene methylthiosalicylic acid for a photosensitive resin composition, and relates to the field of photopolymerization. The invention also comprises a photosensitive resin composition containing the anthracene methylthio-salicylic acid, a photosensitive dry film containing the anthracene methylthio-salicylic acid, and applications of the photosensitive resin composition and the photosensitive dry film. The anthracene methyl thiosalicylic acid has photosensitivity and can be used as a photosensitizer in the photosensitive resin composition; the migration characteristic is low; the photosensitive resin composition has good solubility in conventional monomers, and the degree of freedom of formula design of the photosensitive resin composition is greatly improved; the developing agent also has very good solubility in alkali liquor, so that developing garbage can be greatly reduced, and the product yield is improved; the adhesive force of the photosensitive resin composition on various metal surfaces can be improved; the method can be widely applied to the photo-curing fields of dry films, paints, coatings, printing ink, forming materials and the like.

The invention discloses an acid responsive nanoprobe as well as preparation and anti-tumor application thereof. The nanoprobe has a core-shell structure, takes a nanoparticle self-assembled by a polycation aggregation-induced emission (AIE) photosensitizer and functional nucleic acid as a core, and takes a hyaluronic acid modified metal polyphenol network as a shell. The nanoprobe utilizes the acid responsiveness and broad-spectrum absorption performance of the metal polyphenol network and the diagnosis and treatment advantages of the polycation AIE photosensitizer to realize the acid responsiveness'switch 'controllable diagnosis and treatment of the tumor nanoprobe. In a neutral environment, the fluorescence is weak, the generation of ROS is less, and the background noise signal of the nanoprobe and the toxicity of non-targeted tissues are reduced; in an acid environment, fluorescence is enhanced, the ROS yield is improved, and the treatment efficiency and the curative effect monitoring accuracy are improved. The nano diagnosis and treatment probe is ingenious in design and simple to prepare, and can realize PDT and gene therapy synergistic anti-tumor, in-situ real-time report of early tumor treatment effect and assistance in precise cancer treatment.

The invention discloses a composite film based on light-biological synergistic gradient degradation and a preparation method thereof, the composite film sequentially comprises a light response layer, a transition layer and a biological response layer from outside to inside, and the light response layer comprises a polycaprolactone matrix, a tetraphenylporphyrin iron photosensitizer and anatase type TiO2 nanorods; the transition layer is a gradient blend of polylactic acid and modified starch; the biological response layer comprises polyhydroxyalkanoate and bacterial cellulose nanofibers; through the design of the three-layer gradient structure and the construction of the bionic microchannel, the synergistic effect of light degradation, hydrolysis and biodegradation is realized; the composite membrane has excellent mechanical properties and environmental adaptability, the degradation period can be accurately regulated and controlled within 30-180 days, and the soil degradation rate within 60 days reaches 91% or above; the preparation method comprises the processes of electrostatic spinning, gradient co-extrusion and bacterial cellulose in-situ culture. The material can be widely applied to the fields of agricultural mulching films, food packaging and the like, and the problems that a traditional degradable film is poor in mechanical property and uncontrollable in degradation are solved.

The invention provides an aza-BODIPY molecule with NIR-II fluorescence emission and I-type photodynamic activity and a preparation method thereof. The aza-BODIPY molecule has good light absorption in a near-infrared (NIR) region, the emission peak of the aza-BODIPY molecule is prolonged to a near-infrared second region (NIR-II), and the aza-BODIPY molecule shows an ultrahigh NIR-II fluorescence quantum yield of 13%. Meanwhile, the photosensitizer prepared by adopting aza-BODIPY molecules can effectively generate I-type active oxygen species, namely superoxide anion free radicals, under the excitation of 808nm laser. On the basis, high-resolution tumor fluorescence imaging can be realized by utilizing NIR-II fluorescence of the aza-fluorine boron fluorescent sensitizer, and the aza-fluorine boron fluorescent sensitizer is used for accurate and efficient NIR-II fluorescence imaging mediated I-type photodynamic therapy of deep tumor tissues.

The invention relates to the technical field of dry films, in particular to a photosensitive resin composition, a photosensitive dry film and a preparation method of the photosensitive dry film. Comprising alkali-soluble resin, a photopolymerizable monomer with at least one vinyl unsaturated group, a photosensitizer and other additives, and the alkali-soluble resin at least comprises a nitrogen-containing heterochain or nitrogen heterocyclic ring monomer chain segment group; the alkali-soluble adhesive resin containing aza-chain or azacyclo-containing monomer chain segment groups is prepared by introducing an aza-chain or azacyclo-containing monomer, such as a monomer containing primary amine, secondary amine, tertiary amine, quaternary ammonium salt, pyridines, imidazoles and other groups, into alkali-soluble resin, and is used for improving the adhesive force and binding force between the resin and the surfaces of metals such as copper and the like; therefore, the resolution and adhesion capability of the photosensitive resin composition or the photosensitive dry film is improved.

Method and kit for topical treatment of a skin infection, in particular of superficial skin infections, caused by Staphylococcus aureus. The method comprises the steps of applying a photosensitizer to at least a part of the skin affected by the infection, and subjecting said part of the skin to first photons with a majority energy between 2.8 eV and 3.5 eV at a first energy level; and second photons with a majority energy between 1.24 eV and 1.65 eV at a second energy level, the ratio between the first and the second energy levels being in the range from about 10:1 to 2:1. By the method efficient treatment of Staphylococcus aureus infections can be achieved without the administration of topical antibiotics.

The invention discloses a multifunctional nano delivery system based on targeted ferritin as well as a preparation method and application of the multifunctional nano delivery system. According to the system, traditional Chinese medicine active ingredients, namely neogambogic acid GNA, a photosensitizer Ce6 and ferritin targeting peptide HKN15 are integrated through a self-assembly technology, a synergistic treatment system integrating photodynamic therapy PDT and ferroptosis induction is constructed, and the treatment effect on non-small cell lung cancer NSCLC can be remarkably enhanced. According to the nano delivery system, precise targeting of a tumor site is achieved through the ferritin targeting peptide HKN15, and a double anti-tumor mechanism is formed by utilizing the photodynamic effect of the photosensitizer Ce6 and the ferroptosis induction effect of GNA. The preparation process is based on a molecular self-assembly principle, and has the advantages of high tumor accumulation efficiency, low system toxicity, remarkable tumor inhibition effect and the like, and an innovative solution is provided for precise treatment of the non-small cell lung cancer.

The invention relates to the technical field of photoinitiators, and provides a triplet-triplet energy transfer (TTET) free radical I type photoinitiation system, a photocuring composition and application thereof. The system comprises a boron dialkylated dipyrromethene free radical I type photoinitiator and a long wave absorption photosensitizer, the photosensitizer is preferably an osmium (II) complex, and the mass ratio of the photosensitizer to the photoinitiator is preferably 1: 5-1: 200. Under the irradiation of a 650-750 nm light source (preferably a 690 nm LED), the photosensitizer enters a triplet state through intersystem crossing and generates TTET to the photoinitiator, so that the photoinitiator is uniformly split in the triplet state to generate free radicals, thereby initiating polymerization / cross-linking curing of monomers such as (methyl) acrylate and the like. The embodiment shows that the double bond conversion rate of the TPGDA can reach more than 80% within 10 minutes under the conditions of LED at 690 nm and 80 mW / cm < 2 >.

The invention relates to the technical field of anti-tumor, in particular to a supramolecular assembly, a preparation method thereof and application of the supramolecular assembly in preparation of anti-tumor drugs. According to the present invention, tetraphenylporphyrin (TPP-Lys and TPP-Gln) modified by lysine and glutamine respectively and fully methylated cyclodextrin (Bio-PMeCD) modified by biotin are adopted as a carrier and a targeting agent to construct an assembly, and the assembly is used for intracellular enzymatic in-situ polymerization reaction, such that the application of the assembly in the aspects of photosensitizer retention time prolonging and photodynamic treatment effect improving is achieved.

The present invention discloses a water-soluble thionaphthalimide photosensitizer, a preparation method thereof and an application thereof, belonging to the field of organic optofunctional materials. The photosensitizer of the present invention uses thionaphthalimide containing an electron-donating effect as a parent body, and at the same time introduces a water-soluble polyethylene glycol (PEG) group at its amide position. In an aqueous solution, the photosensitizer can self-assemble into nanoparticles with a particle size of 147 nm without other nanocarriers, and has good absorption at 570 nm. The method of the present invention has the advantages of easily available raw materials, simple synthesis and easy separation. The prepared photosensitizer has good reactive oxygen generation ability under white light irradiation, good water solubility, and good photo, thermal and chemical stability. The ultraviolet-visible absorption tail peak can reach the near-infrared region. The nanoparticles have good photodynamic killing effect on cancer cells.

The invention provides a photosensitive resin composition, a photosensitive dry film and application thereof. The photosensitive resin composition comprises alkali-soluble resin, a photopolymerization monomer, a photoinitiator and a photosensitizer, the photosensitive resin composition provided by the invention has excellent photosensitive characteristics, can provide excellent resolution and adhesive force, and is uniformly cured during exposure, a formed anti-corrosion pattern port is rectangular, the side wall is flat, an electroplating solution is not easily polluted in an electroplating process, the yield of a product can be remarkably improved, and the service life of the electroplating solution is prolonged.

A method for preparing nanoparticles of triterpenoid small molecules co-assembled with Ce6 and copper ions wrapped in cancer cell membranes and its application. The present invention prepares a pure natural co-assembled nanotransmission system with new morphological characteristics and multiple biological activities - terpenoid compound and photosensitizer co-assembled nanoparticles. In the composite nanoassembly, triterpenoid compounds and photosensitizer Ce6 are assembled into nanoparticles, providing effective and safe chemotherapy and photodynamic therapy. Subsequently, Cu is complexed on the surface of the nanoparticles. 2+ , when Cu is introduced 2+ When activated, the reduced PDT effect caused by excessive glutathione in the tumor consuming reactive oxygen species can be counteracted. Furthermore, it can enhance CDT therapy through a Fenton-like catalytic reaction with overexpressed H₂O₂ at the tumor site. Finally, these molecules are encapsulated by the tumor cell membrane. By constructing CM@OABACe6 / CuNPs with homologous targeting, a triple synergistic platform for cancer treatment using PDT, chemotherapy, and CDT has been created.

The invention discloses a self-assembled PROTAC nano material based on natural product mitochondria targeting, which is a nano particle prepared from mitochondria targeting molecules, a photosensitizer and PROTAC as raw materials through a nano precipitation method. The mitochondrial targeting molecule is berberine, the photosensitizer is hypericin, and the PROTAC is dBET57; the ratio of the amount of substance of the dBET57 to the amount of substance of the berberine is (1-10): (1-10), and the ratio of the amount of substance of the dBET57 to the amount of substance of the hypericin is (1-10): (1-10). The nano material can be used for blocking multiple energy metabolism pathways of tumor cells, including glycolysis and oxidative phosphorylation, meanwhile, mitochondria is damaged, ferroptosis is induced, and the anti-tumor capacity of pharmacodynamic molecules is improved; bRD4 in tumor cells and downstream carcinogenic protein c-Myc of the BRD4 can be efficiently degraded. The invention also discloses an application of the nano material in preparation of antitumor drugs.

The invention belongs to the technical field of photodynamic therapy, and particularly relates to a BODIPY compound, a preparation method and application of the BODIPY compound as a photosensitizer. The invention provides a series of novel-structure small molecule compound photosensitizers which take BODIPY dimers as basic frameworks and are pure I-type photodynamic. Under the combined action of a heavy atom introduced at a specific position, 2, 4, 6-trimethylphenyl and a defined structure R group, the yield of active oxygen is improved, and the regulation and control of the pure I-type photosensitizer are performed by regulating and controlling the energy level. Compared with a common photosensitizer molecule indocyanine green (ICG), the active oxygen yield is about 50 times that of ICG, higher photo-thermal stability is achieved, the applicability of a photodynamic reagent can be remarkably improved, the preparation method is simple, the reaction efficiency is high, the yield is high, and good industrial application prospects are achieved.

Electrically neutral complex compounds of formula I including any stereoisomer or E / Z isomer thereof wherein: M is Fe < 2 + >, Ru < 2 + >, Os < 2 + >, Co < 3 + >, Rh < 2 + >, Rh < 3 + >, Ir < 3 + >, Ni < 2 + >, Pd < 2 + >, Pt < 2 + > or Pt < 4 + >, in particular Ru < 2 + >; t and T'are H or (C1-C3)-alkyl; lig is a bidentate ligand, in particular 2, 2 '-dipyridyl (bpy) or 4, 7-diphenyl-1, 10-phenanthroline (BPhen); and A is an anion from a pharmaceutically acceptable acid, the electrically neutral complex compounds of formula I are useful in human therapy, in particular as photosensitizers (PS) in photodynamic therapy (PDT) of cancer, skin diseases, fungal infections or microbial infections. They are almost non-toxic under dark conditions at therapeutic doses and exhibit good to excellent photoactivity under hypoxic conditions. They can be used for PDT treatment of deep hypoxia tumors by using light within a far-infrared to near-infrared light treatment window.

The invention provides a bridged triphenylamine-derived AIE type antibacterial photosensitizer, a preparation method and antibacterial application thereof, the bridged triphenylamine-derived AIE type antibacterial photosensitizer has the following structure: # imgabs0 is subjected to a cyclization reaction to form a bridged structure to limit bond rotation as a novel molecular design, and the photodynamic antibacterial effect of the AIE photosensitizer (PSs) can be effectively improved; and an AIE photosensitizer is combined with a donor-pi-receptor (D-pi-A) structure, so that a smaller singlet-triplet energy level difference (delta EST) is realized, and an intersystem crossing process is promoted. The mutual combination effect of the PSs and bacteria can be influenced by regulating and controlling the charge number of the PSs, so that effective bacteria recognition and selective antibacterial performance are realized. Experiments show that the AIE antibacterial photosensitizer based on bridged triphenylamine has a specific elimination effect on gram-positive bacteria; and the photodynamic antibacterial agent has a good photodynamic antibacterial effect on staphylococcus aureus and methicillin-resistant staphylococcus aureus.

The present invention discloses a type I semi-cyanine photosensitizer, a type I targeted photosensitizer, and a preparation method and application thereof. The semi-cyanine photosensitizer can rapidly generate a large amount of O2 under light and hypoxic conditions. ·‑ , thereby achieving the effect of photodynamic therapy, and having good biocompatibility and biodegradability, it is an effective type I photosensitizer. In addition, the above-mentioned type I photosensitizer is reacted with phosphorus oxychloride in the presence of water to prepare a type I photosensitizer with tumor targeting. It can specifically target alkaline phosphatase, a biomarker highly expressed in tumors. Under the action of alkaline phosphatase, the photosensitizer can be enriched in the tumor area, thereby achieving precise tumor imaging and photodynamic therapy, which can effectively reduce the side effects of the photosensitizer and improve the inhibitory effect of the photosensitizer on tumors.

The invention discloses an aggregation-induced emission photosensitizer as well as a preparation method and application thereof. A D-A-pi-A-D symmetrical structure is adopted, the spatial effect and the conjugation degree are adjusted through a pi bridge, the molar absorption coefficient is increased, and singlet excitons are increased; and furthermore, a pyridine ring with positive charges is used for accelerating electron transfer, the yield of triplet excitons and ROS is improved, compared with a traditional photosensitizer, the ROS efficiency is improved by 2-3 times, the efficient killing capability of the photosensitizer on pathogens can be ensured, and a guarantee is provided for rapid healing of infectious wounds. A pyridine ring with positive charges is introduced into an MTCNPy molecule, and the targeting property of the photosensitizer to pathogens is enhanced by utilizing the electrostatic interaction between the pyridine ring and a bacterial negative charge cell membrane, so that the damage to surrounding healthy tissues is reduced. The preparation process is simple, the cost is low, and the hydrogel has excellent hydrophilicity and biocompatibility so as to be more suitable for the biological environment.

The invention belongs to the technical field of photosensitive glass, and discloses colored photosensitive microcrystalline glass and a preparation method and application thereof.The preparation method of the colored photosensitive microcrystalline glass comprises the steps that SiO2, Al2O3, B2O3, Li2O, Na2O, MgO, ZnO, ZrO2, CeO2, Ag2O, Sb2O3, F <->, Cl <->, Br <-> and a clarifying agent are mixed to obtain a mixture, the mixture is sequentially melted, clarified and formed, formed glass is obtained, and the colored photosensitive microcrystalline glass is obtained. And carrying out heat treatment on the formed glass to obtain the colored photosensitive microcrystalline glass. According to the preparation method, a'photosensitizer-colorant-nucleating agent 'decoupling doping strategy is innovatively adopted through component gradient design and a multi-stage heat treatment system, so that color development, crystallization and transparency under different heat treatment systems are realized, and the colored photosensitive microcrystalline glass with a color development function and a photosensitive micro-crystallization characteristic can be prepared.

The invention relates to the technical field of antibiosis, in particular to an AIE type cationic conjugated polymer, a preparation method, plasma activated hydrogel and application. The AIE type cationic conjugated polymer has the following structural formula. By combining an FADM photosensitizer with remarkable aggregation-induced emission characteristics and efficient ROS generation capability with a cold atmospheric pressure plasma technology, a hydrogel material with photodynamic and plasma-derived reactive oxygen species synergistic antibacterial functions is constructed, and the problems that RONS in PAW is extremely short in half-life period, low in viscosity and poor in antibacterial effect are solved. The active ingredients are difficult to effectively enrich and maintain at the infected part.

The invention provides anthracene diaminophosphate for a photosensitive resin composition, and relates to the field of photopolymerization. The invention also comprises a photosensitive resin composition containing the anthracene diphosphoramidate, a photosensitive dry film containing the anthracene diphosphoramidate, and applications of the photosensitive resin composition and the photosensitive dry film. The anthracene diaminophosphate provided by the invention has photosensitivity, can be used as a photosensitizer in the photosensitive resin composition, can improve the adhesive force of the photosensitive resin composition on various metal surfaces, and has the characteristic of low migration; the method can be widely applied to the photo-curing fields of dry films, paints, coatings, printing ink, forming materials and the like.

Methods and systems of PFAS destruction in water containing nitrate. The methods and systems include filtering water containing PFAS and nitrate through a membrane selective for PFAS to obtain a membrane reject containing PFAS and nitrate and a filtrate containing nitrate, forming a treatment solution using the membrane reject including diluting the membrane reject and combining the membrane reject with a photosensitizer, a sulfite salt, and a sufficient amount of base such that the treatment solution has a pH of about 10 or more, and irradiating the treatment solution with UV light in a photoreactor to destroy a portion of the PFAS. Before dilution, a concentration of PFAS in the membrane reject may be between about 3 times and about 20 times greater than before the filtering step. Dilution of the membrane reject may include between about a 3 and about a 20 times dilution.

The invention discloses a dual-curing front-line polymer resin system for repairing a fan blade and a preparation method. The dual-curing front-line polymer resin system is prepared from mixed resin and an initiator, the mixed resin comprises the following components in parts by weight: 80-90 parts of epoxy resin, 8-12 parts of polyfunctional acrylate and 2-8 parts of monofunctional acrylate; the initiator comprises a photoinitiator, a photosensitizer and a thermal initiator, and the mass ratio of the photoinitiator to the photosensitizer to the thermal initiator is (4-6): 1: (2-3); according to the dual-curing frontline polymerization resin system disclosed by the invention, through selection of all the raw materials, a form of photo-initiated frontline polymerization can be adopted, reaction heat pushes the movement towards the thickness direction before polymerization while the surface is rapidly cured by ultraviolet light, so that additional heat source equipment is not needed while complete curing of a thick-layer material and a colored system is realized, and the dual-curing frontline polymerization resin system is simple and convenient to operate and green and environment-friendly.

The invention relates to the fields of medicine, organic chemical industry and fine chemical industry, in particular to a method for synthesizing 1, 4-diketone by catalyzing alkenyl amide and alpha-carbonyl oxidized sulfonium ylide through photooxidation reduction. The preparation method comprises the following steps: under the protection of inert gas, reacting alkenyl amide and alpha-carbonyl oxidized sulfonium ylide serving as substrates in an organic solvent by taking a photosensitizer as a catalyst under the action of blue light irradiation and alkali at 30 DEG C for 18 hours to obtain an alkenyl amide alpha-carbonyl alkylate, and then hydrolyzing under an acidic condition to synthesize various asymmetric 1, 4-diketone compounds. The 1, 4-diketone compound is synthesized by a two-step method by taking alkenyl amide and alpha-carbonyl oxidized sulfonium ylide as initial raw materials, and the method has the remarkable advantages of wide substrate raw material sources, simplicity and convenience in operation, mild reaction conditions, high reaction efficiency, good universality, excellent functional group compatibility and the like.

The present invention belongs to the field of biomedicine, and specifically relates to a light-controlled release of ONOO － Compounds and preparation methods and applications thereof. The present invention provides ONOO ‑ The donor is composed of a diphenyl phenothiazine analogue and arginine covalently linked. Its strong conjugation effect makes it extremely photoresponsive. The polymer has near-infrared light emission and excellent reactive oxygen and reactive nitrogen generation capabilities. When L6 is irradiated with a 660nm laser, it will produce superoxide anions and singlet oxygen. Singlet oxygen oxidizes the guanidine group of arginine to produce NO and ·O2 ‑ and NO to form peroxynitrite (ONOO ‑ ), achieving the goal of highly effective tumor cell killing. Therefore, this compound is a potentially highly effective photosensitizer for tumor killing. Compared to conventional photosensitizers, this killing method has stronger oxidative and nitrative cell damage capabilities, and its development cycle is shorter than that of other photosensitizers, thus possessing great potential application value in clinical treatment.

The invention relates to an SR-B1 targeted polypeptide compound and application thereof in preparation of antitumor drugs, and belongs to the technical field of biological drug manufacturing. In order to solve the problems that the existing PDT photosensitizer is insufficient in targeting property and the treatment effect is limited due to the action of intracellular cholesterol, the invention provides an SR-B1 targeting polypeptide compound which is composed of an SR-B1 targeting polypeptide and an AS1411 aptamer. The SR-B1 targeting polypeptide comprises an SR-B1 targeting peptide fragment, a self-assembly peptide fragment, a response enzyme digestion peptide fragment and a photosensitizer TCPP which are connected in sequence. The invention constructs a polypeptide targeting system based on a dual self-assembly strategy, which not only can target SR-B1, inhibit a cholesterol-mediated tumor for a long time to promote a signal channel and interfere the ROS steady state, but also can target TCPP to a cell nucleus, improve the photosensitivity of PDT, and further improve the killing effect on tumor cells by improving the yield of ROS to cause the damage to the cell nucleus.