588 results about "Photosens" patented technology

The invention provides a photosensitive resin composition containing an anthracene methyl quaternary ammonium salt photosensitizer and application of the photosensitive resin composition, a structural main body anthracene ring of the photosensitizer is introduced into methylene substituted by a quaternary ammonium group at a position 10 and / or a position 9, and an acid radical or halogen is adopted as an equilibrium anion; compared with a commercially available anthracene photosensitizer, the photosensitizer has excellent fat solubility and good water solubility through introduction of the quaternary ammonium salt on the premise that the photobleaching property is retained, great potential is brought to formula design of the photosensitive composition, and development waste in a later development process can be greatly reduced; the method can be widely applied to the photo-curing fields of dry films, paints, coatings, printing ink, forming materials and the like.

The invention provides triazole anthracene methyl formate for a photosensitive resin composition, and relates to the field of photopolymerization. The invention also comprises a photosensitive resin composition containing the triazole anthracene methyl formate, a photosensitive dry film containing the triazole anthracene methyl formate, and applications of the photosensitive resin composition and the photosensitive dry film. The triazole formic acid anthracene methyl ester disclosed by the invention has photosensitivity, can be used as a photosensitizer in the photosensitive resin composition, can improve the adhesive force of the photosensitive resin composition on various metal surfaces, and has the characteristic of low migration; the method can be widely applied to the photo-curing fields of dry films, paints, coatings, printing ink, forming materials and the like.

The invention discloses a dual-mechanism antibacterial photosensitizer as well as a preparation method and application thereof, and relates to the technical field of biomedical photoelectric functional materials. The invention relates to a triphenylamine derivative, which can realize fluorescence imaging of bacterial or fungal infection by utilizing fluorescence characteristics, can generate active oxygen under illumination to play a photodynamic therapy role, is suitable for preparing photodynamic therapy preparations and developing antibacterial materials, and can also be applied to the fields of environment and public health and tumor treatment. The problems that an existing photosensitizer is insufficient in broad spectrum, different in fungus drug resistance mechanism, limited in single treatment effect and the like can be effectively solved, and the photosensitizer has wide application prospects.

The invention provides anthracene methylthiosalicylic acid for a photosensitive resin composition, and relates to the field of photopolymerization. The invention also comprises a photosensitive resin composition containing the anthracene methylthio-salicylic acid, a photosensitive dry film containing the anthracene methylthio-salicylic acid, and applications of the photosensitive resin composition and the photosensitive dry film. The anthracene methyl thiosalicylic acid has photosensitivity and can be used as a photosensitizer in the photosensitive resin composition; the migration characteristic is low; the photosensitive resin composition has good solubility in conventional monomers, and the degree of freedom of formula design of the photosensitive resin composition is greatly improved; the developing agent also has very good solubility in alkali liquor, so that developing garbage can be greatly reduced, and the product yield is improved; the adhesive force of the photosensitive resin composition on various metal surfaces can be improved; the method can be widely applied to the photo-curing fields of dry films, paints, coatings, printing ink, forming materials and the like.

The invention relates to the technical field of dry films, in particular to a photosensitive resin composition, a photosensitive dry film and a preparation method of the photosensitive dry film. Comprising alkali-soluble resin, a photopolymerizable monomer with at least one vinyl unsaturated group, a photosensitizer and other additives, and the alkali-soluble resin at least comprises a nitrogen-containing heterochain or nitrogen heterocyclic ring monomer chain segment group; the alkali-soluble adhesive resin containing aza-chain or azacyclo-containing monomer chain segment groups is prepared by introducing an aza-chain or azacyclo-containing monomer, such as a monomer containing primary amine, secondary amine, tertiary amine, quaternary ammonium salt, pyridines, imidazoles and other groups, into alkali-soluble resin, and is used for improving the adhesive force and binding force between the resin and the surfaces of metals such as copper and the like; therefore, the resolution and adhesion capability of the photosensitive resin composition or the photosensitive dry film is improved.

Method and kit for topical treatment of a skin infection, in particular of superficial skin infections, caused by Staphylococcus aureus. The method comprises the steps of applying a photosensitizer to at least a part of the skin affected by the infection, and subjecting said part of the skin to first photons with a majority energy between 2.8 eV and 3.5 eV at a first energy level; and second photons with a majority energy between 1.24 eV and 1.65 eV at a second energy level, the ratio between the first and the second energy levels being in the range from about 10:1 to 2:1. By the method efficient treatment of Staphylococcus aureus infections can be achieved without the administration of topical antibiotics.

The invention discloses a multifunctional nano delivery system based on targeted ferritin as well as a preparation method and application of the multifunctional nano delivery system. According to the system, traditional Chinese medicine active ingredients, namely neogambogic acid GNA, a photosensitizer Ce6 and ferritin targeting peptide HKN15 are integrated through a self-assembly technology, a synergistic treatment system integrating photodynamic therapy PDT and ferroptosis induction is constructed, and the treatment effect on non-small cell lung cancer NSCLC can be remarkably enhanced. According to the nano delivery system, precise targeting of a tumor site is achieved through the ferritin targeting peptide HKN15, and a double anti-tumor mechanism is formed by utilizing the photodynamic effect of the photosensitizer Ce6 and the ferroptosis induction effect of GNA. The preparation process is based on a molecular self-assembly principle, and has the advantages of high tumor accumulation efficiency, low system toxicity, remarkable tumor inhibition effect and the like, and an innovative solution is provided for precise treatment of the non-small cell lung cancer.

The invention relates to the technical field of photoinitiators, and provides a triplet-triplet energy transfer (TTET) free radical I type photoinitiation system, a photocuring composition and application thereof. The system comprises a boron dialkylated dipyrromethene free radical I type photoinitiator and a long wave absorption photosensitizer, the photosensitizer is preferably an osmium (II) complex, and the mass ratio of the photosensitizer to the photoinitiator is preferably 1: 5-1: 200. Under the irradiation of a 650-750 nm light source (preferably a 690 nm LED), the photosensitizer enters a triplet state through intersystem crossing and generates TTET to the photoinitiator, so that the photoinitiator is uniformly split in the triplet state to generate free radicals, thereby initiating polymerization / cross-linking curing of monomers such as (methyl) acrylate and the like. The embodiment shows that the double bond conversion rate of the TPGDA can reach more than 80% within 10 minutes under the conditions of LED at 690 nm and 80 mW / cm < 2 >.

The invention discloses an aggregation-induced emission photosensitizer as well as a preparation method and application thereof. A D-A-pi-A-D symmetrical structure is adopted, the spatial effect and the conjugation degree are adjusted through a pi bridge, the molar absorption coefficient is increased, and singlet excitons are increased; and furthermore, a pyridine ring with positive charges is used for accelerating electron transfer, the yield of triplet excitons and ROS is improved, compared with a traditional photosensitizer, the ROS efficiency is improved by 2-3 times, the efficient killing capability of the photosensitizer on pathogens can be ensured, and a guarantee is provided for rapid healing of infectious wounds. A pyridine ring with positive charges is introduced into an MTCNPy molecule, and the targeting property of the photosensitizer to pathogens is enhanced by utilizing the electrostatic interaction between the pyridine ring and a bacterial negative charge cell membrane, so that the damage to surrounding healthy tissues is reduced. The preparation process is simple, the cost is low, and the hydrogel has excellent hydrophilicity and biocompatibility so as to be more suitable for the biological environment.

The invention belongs to the technical field of photosensitive glass, and discloses colored photosensitive microcrystalline glass and a preparation method and application thereof.The preparation method of the colored photosensitive microcrystalline glass comprises the steps that SiO2, Al2O3, B2O3, Li2O, Na2O, MgO, ZnO, ZrO2, CeO2, Ag2O, Sb2O3, F <->, Cl <->, Br <-> and a clarifying agent are mixed to obtain a mixture, the mixture is sequentially melted, clarified and formed, formed glass is obtained, and the colored photosensitive microcrystalline glass is obtained. And carrying out heat treatment on the formed glass to obtain the colored photosensitive microcrystalline glass. According to the preparation method, a'photosensitizer-colorant-nucleating agent 'decoupling doping strategy is innovatively adopted through component gradient design and a multi-stage heat treatment system, so that color development, crystallization and transparency under different heat treatment systems are realized, and the colored photosensitive microcrystalline glass with a color development function and a photosensitive micro-crystallization characteristic can be prepared.

The invention relates to the technical field of antibiosis, in particular to an AIE type cationic conjugated polymer, a preparation method, plasma activated hydrogel and application. The AIE type cationic conjugated polymer has the following structural formula. By combining an FADM photosensitizer with remarkable aggregation-induced emission characteristics and efficient ROS generation capability with a cold atmospheric pressure plasma technology, a hydrogel material with photodynamic and plasma-derived reactive oxygen species synergistic antibacterial functions is constructed, and the problems that RONS in PAW is extremely short in half-life period, low in viscosity and poor in antibacterial effect are solved. The active ingredients are difficult to effectively enrich and maintain at the infected part.

The invention provides anthracene diaminophosphate for a photosensitive resin composition, and relates to the field of photopolymerization. The invention also comprises a photosensitive resin composition containing the anthracene diphosphoramidate, a photosensitive dry film containing the anthracene diphosphoramidate, and applications of the photosensitive resin composition and the photosensitive dry film. The anthracene diaminophosphate provided by the invention has photosensitivity, can be used as a photosensitizer in the photosensitive resin composition, can improve the adhesive force of the photosensitive resin composition on various metal surfaces, and has the characteristic of low migration; the method can be widely applied to the photo-curing fields of dry films, paints, coatings, printing ink, forming materials and the like.

Methods and systems of PFAS destruction in water containing nitrate. The methods and systems include filtering water containing PFAS and nitrate through a membrane selective for PFAS to obtain a membrane reject containing PFAS and nitrate and a filtrate containing nitrate, forming a treatment solution using the membrane reject including diluting the membrane reject and combining the membrane reject with a photosensitizer, a sulfite salt, and a sufficient amount of base such that the treatment solution has a pH of about 10 or more, and irradiating the treatment solution with UV light in a photoreactor to destroy a portion of the PFAS. Before dilution, a concentration of PFAS in the membrane reject may be between about 3 times and about 20 times greater than before the filtering step. Dilution of the membrane reject may include between about a 3 and about a 20 times dilution.

The invention relates to the fields of medicine, organic chemical industry and fine chemical industry, in particular to a method for synthesizing 1, 4-diketone by catalyzing alkenyl amide and alpha-carbonyl oxidized sulfonium ylide through photooxidation reduction. The preparation method comprises the following steps: under the protection of inert gas, reacting alkenyl amide and alpha-carbonyl oxidized sulfonium ylide serving as substrates in an organic solvent by taking a photosensitizer as a catalyst under the action of blue light irradiation and alkali at 30 DEG C for 18 hours to obtain an alkenyl amide alpha-carbonyl alkylate, and then hydrolyzing under an acidic condition to synthesize various asymmetric 1, 4-diketone compounds. The 1, 4-diketone compound is synthesized by a two-step method by taking alkenyl amide and alpha-carbonyl oxidized sulfonium ylide as initial raw materials, and the method has the remarkable advantages of wide substrate raw material sources, simplicity and convenience in operation, mild reaction conditions, high reaction efficiency, good universality, excellent functional group compatibility and the like.

The application discloses a photosensitizer conjugate for targeted treatment of tongue squamous cell carcinoma and a preparation method and application thereof, and belongs to the technical field of biological medicines. A novel PROTAC-PDT conjugate Gef-PRO-SS-TPE is synthesized, and the compound connects a PROTAC molecule Gef-PRO targeting EGFR and an AIE photosensitizer TPE derivative through a breakable disulfide bond. On one hand, Gef-PRO can specifically degrade EGFR and block tumor cell proliferation signals; on the other hand, the TPE derivative can generate ROS under light conditions and induce cell apoptosis. More importantly, the disulfide bond can be broken in response to high concentrations of glutathione (GSH) in tumor cells, realizing controllable release of Gef-PRO and TPE molecules, so as to exert a synergistic anti-tumor effect.

The application discloses an environment-friendly black liquid photosensitive ink without 907 and 369 photosensitizers, which is composed of the following components in parts by weight: epoxy propylene acid resin 30-50 parts, photosensitizer 205 3-4 parts, photosensitizer 360 6-7 parts, photoinitiator 184 2-4 parts, superfine silicon powder 5-10 parts, superfine barium sulfate 20-30 parts, liquid chelating agent 1-3 parts, modified bentonite 15-30 parts, and organic silicon defoaming agent 5-10 parts. The application introduces long-wave environment-friendly photosensitizers for the first time, changes the structural defects of the traditional black system using 369 and 907 high carcinogenic photosensitizers to only meet short-wave length and insufficient deep curing of the ink, strengthens the deep curing effect of the carbon black photosensitive ink, improves the solder mask bridge manufacturing capacity of the carbon black photosensitive ink from 4 mil to 2 mil, and realizes secondary development. The product is high in efficiency and environmental protection and high in economic benefits, fully meets the European Union standard, and is mainly supplied to the European Union market.

The invention discloses a 4-BrPA / beta-CD supramolecular photosensitizer as well as a preparation method and application thereof, and belongs to the field of biomedical materials. According to the method, beta-cyclodextrin is used as a subject, 4-bromophthalic anhydride is used as an object, and the water-soluble photosensitizer is constructed through a chemically modified supramolecular assembly strategy. The preparation method comprises the following specific steps: reacting beta-cyclodextrin with paratoluensulfonyl chloride to obtain mono-(6-O-paratoluensulfonyl)-beta-cyclodextrin; then carrying out a reaction with ethidene diamine to obtain mono-(6-ethidene diamine-6-deoxy)-beta-cyclodextrin; then reacting with 4-bromophthalic anhydride in N, N-dimethylformamide, and precipitating and purifying through ethyl acetate to obtain a crude product; and finally, carrying out ultrasonic treatment, centrifugal separation and freeze drying to obtain a pure product. The prepared 4-BrPA / beta-CD supramolecular photosensitizer is excellent in water solubility, has at least 7 excitation centers in a visible light region of 400-520 nm, correspondingly generates at least 7 emission centers in a range of 500-780 nm, has a maximum excitation wavelength of about 460 + / -10 nm and a maximum emission wavelength of about 620 + / -10 nm, has an extremely wide visible light response characteristic, and can be used for antibacterial photodynamic therapy.

The application relates to the field of biological nanotechnology, and provides a multimodal diagnosis and treatment integrated AIE carbon nitride composite nano system and a preparation method thereof. The composite nano system takes selenium-doped carbon nitride nanosheets as a core carrier, realizes active targeting of hepatic stellate cells through VA-PEG2000 modification, simultaneously loads a first AIE photosensitizer and a second AIE photosensitizer with near-infrared two-region emission, and forms a double-photosensitizer composite system. The composite nano system has the dual imaging modalities of near-infrared two-region fluorescence imaging and photoacoustic imaging under the excitation of 660nm and / or 808nm laser, simultaneously generates reactive oxygen through a photodynamic effect to play a treatment function. The application further co-loads an anti-fibrosis drug in the nano system, realizes photodynamic-chemical combined treatment under the guidance of imaging, and solves the technical problems of single imaging modality and insufficient functional integration of an existing liver fibrosis nano diagnosis and treatment system, so that multimodal precise positioning and synergistic enhanced treatment integration of liver fibrosis lesions can be realized.

A rinsing solution for photodynamic disinfection, in particular oral disinfection, including, at least one photosensitiser from the group comprising riboflavin 5′-phosphate sodium in a proportion of 0.2 to 0.6 wt. % and a photosensitiser other than riboflavin 5′-phosphate sodium in a proportion of 0.001 to 0.05 wt. %, at least one viscosity modulator from the group comprising glycerol in a proportion of 1.0 to 5.0 wt. % and hyaluronic acid sodium salt in a proportion of 0.01 to 0.3 wt. %, at least one biofilm inhibitor from the group comprising xylitol in a proportion of 7.0 to 25.0 wt. %, L-arginine in a proportion of 0.01 to 0.5 wt. % and urea in a proportion of 0.5 to 3.0 wt. %, with the remainder on a water base.

This invention discloses a homogeneous microsphere based on singlet oxygen self-circulating aggregation-induced emission, its preparation, and a wash-free detection method, which improves the sensitivity and efficiency of wash-free luminescent oxygen channel immunoassay. This invention successfully prepared AIE receptor microspheres by embedding the photosensitizer AIER dye, ultra-bright AIEG dye, and singlet oxygen-responsive dye SO into carboxyl-modified polystyrene nanoparticles. Simultaneously, an antibody-1-labeled AIE receptor microsphere solution, an antigen-containing test solution, and biotinylated antibody-2 were added to a 96-well plate, followed by streptavidin-modified donor microspheres. After wash-free incubation, the fluorescence signal value was measured, and the concentration of antigen in the test solution was obtained according to a standard curve. This platform completes wash-free, highly sensitive detection within 5 minutes, innovatively combining the aggregation-induced emission characteristics of AIEgens and a singlet oxygen cycling strategy, providing an efficient and universal solution for wash-free diagnostics.

The invention relates to the technical field of drug loading systems, and discloses a nanoparticle applied to photodynamic therapy and a preparation method thereof.The nanoparticle is of a core-shell-crown composite structure and sequentially comprises an inner core layer, an outer core layer, an inner shell layer and an outer shell layer from inside to outside, the inner core layer is composed of NaYF4 up-conversion nanoparticles, and the outer core layer is composed of NaYF4 up-conversion nanoparticles; the middle layer is a mesoporous Zr-MOF layer; the shell layer is a pH responsive polymer layer which is formed by connecting a polyethylene glycol-polycaprolactone block copolymer with folic acid through a hydrazone bond; the targeting canopy layer comprises double targeting ligands, and the double targeting ligands are respectively a bicyclo [6.1. 0] nonyne functionalized iRGD peptide and an azide functionalized anti-EGFR (epidermal growth factor receptor) nano antibody 7D12. The nanoparticles have the advantages of high stability, strong targeting property, high photosensitizer loading and the like, and can efficiently generate active oxygen.

The invention relates to the technical field of photoresists, and particularly provides a photoresist and a preparation method thereof.The photoresist is prepared from phenolic resin, a diazonaphthoquinone photosensitizer, phenyl triphenyl phosphate and a solvent, and the stability and definition of an exposed pattern are optimized through the combination of a special polymer, a sensitizer and the solvent. In the embodiment, the sensitivity range of the formula is 55 mJ / cm < 2 > to 120 mJ / cm < 2 >, the resolution ratio reaches 0.05 mu m, and burrs are controlled to be 0.05 mu m or below. The technology can be widely applied to the fields of semiconductor chip manufacturing, microelectronic packaging, display devices and nanotechnology, meets the production requirements of high precision and high efficiency, and has good market prospects and commercial application value.

The invention provides a photosensitive resin composition containing an acridine methylene quaternary ammonium salt photosensitizer and application of the photosensitive resin composition, quaternary ammonium group substituted methylene is introduced to the ninth position of a structural main body acridine ring of the photosensitizer, and acid radical or halogen is adopted as equilibrium anion. According to the photosensitizer, a quaternary ammonium salt group is introduced to the 9 site of an acridine ring, so that the problems that a traditional 9-phenylacridine photosensitizer is poor in compatibility, prone to crystallization and precipitation, insufficient in water solubility, weak in antistatic performance and the like in a formula are effectively solved. The photosensitive resin composition disclosed by the invention shows excellent dispersion stability, high sensitivity and high resolution, and can be used for remarkably reducing precipitates in a developing process and reducing poor lamination caused by static accumulation. The photosensitive dry film prepared based on the composition is suitable for fine pattern manufacturing in the fields of dry films, paints, coatings, printing ink, forming materials and the like, and has high yield and production efficiency.

This invention discloses a lipid assembly loaded with 5-aminolevulinic acid and its preparation method. The lipid assembly is a hollow sphere with a core consisting of a hydrophilic phospholipid-chelating agent conjugate formed by chelation with a reactive phospholipid PEG reagent. The outer layer of the phospholipid-chelating agent conjugate is loaded with 5-aminolevulinic acid via hydrazone bonds, and then combined with a radionuclide as an internal light source excitation photosensitizer. The lipid assembly is loaded with 5-ALA via hydrazone bonds. Utilizing the acid-sensitive bond-breaking characteristics of hydrazone bonds and the prodrug properties of 5-ALA, combined with a radionuclide labeled on the surface of the lipid assembly as an internal light source excitation photosensitizer, this invention can overcome the limitations of external light penetration depth in traditional photodynamic therapy, achieving deep PDT treatment. Combined with chemotherapy drugs, it can minimize the toxic side effects on normal tissues during the combined use of radionuclides and photosensitizers in targeted therapy.

A process for preparing a supramolecular carrier photosensitizer for photodynamic therapy and a formulation thereof is disclosed for prevention, treatment, anti-inflammatory and sterilization of oral dental diseases. Supramolecular carrier consists of refined lignin, glucomannan, cysteine, and sodium benzoate at a mass ratio of 0.1-1.0%: 0.5-3%: 0.1-0.5%: 0.05%, and the balance of water. Aqueous solutions of refined lignin, glucomannan, cysteine and sodium benzoate are prepared, and a pH value of combined solution is adjusted to 6.5, so that dissolved alkali lignin is precipitated to form an efficient and stable three-dimensional polymer network skeleton, and rich hydrogen bonds are facilitated to be formed between the same molecules and different molecules of lignin and glucomannan, thereby forming a supramolecular carrier formulation loaded with the photosensitizer. It ensures long-term storage stability of physicochemical traits of formulation, which is conducive to rapidly promoting application of PDT in anti-inflammatory and sterilization treatment of oral dental diseases.

The present invention relates to the treatment of viral infections using photosensitizers in dairy cattle. The invention also relates to the prevention of transmission of viral infections from dairy cattle infected by virus to the same or other species. The invention is also directed to methods of controlling infectious agents on milking equipment for dairy cattle. The invention is further directed to milking processes including the treatment of viral infections and / or the prevention of transmission of viral infections from dairy cattle infected by virus to the same or other species and / or the methods for controlling infectious agents on milking equipment for dairy cattle.

The invention provides a photodynamic therapy cervical cannula for a cervical canal, a preparation method of the photodynamic therapy cervical cannula and cervical therapy equipment. The cervical cannula for cervical canal photodynamic therapy comprises a medicine application cone and a cannula body. Wherein the medicine applying cone is made of a transparent material and has a conical structure; the medicine application cone is coated with a photosensitizer coating; a light source inlet through which an irradiation light source enters an inner cavity is formed in the sleeve main body; the cannula main body is connected with the medicine applying cone, and the part, connected with the medicine applying cone, of the cannula main body is made of a transparent material, so that the light of the irradiation light source entering the cannula main body through the light source inlet is irradiated to the cervical canal coated with the photosensitizer through the cone in a use state; and endothelial cells of the cervical canal are subjected to photodynamic reaction, so that viruses in the cervical canal are killed.

Holographic photopolymer materials, holographic photosensitive films, holographic optical elements, and display devices are provided. The holographic photopolymer material comprises a polymer matrix, a photopolymerizable monomer, and a photosensitizer. The refractive index of the photopolymerizable monomer is greater than that of the polymer matrix. The molecular structure of the polymer matrix includes a linear structure, the branched chains of the polymer matrix include activating groups, and / or the molecular structure of the polymer matrix includes a crosslinked structure. Because polymer matrices with a crosslinked molecular structure have a high glass transition temperature, holographic photopolymer materials have good heat resistance. Because holographic photopolymer materials with a linear molecular structure include activating groups that can form crosslinked structures, optical elements made from holographic photopolymer materials can have crosslinked structures, i.e., optical elements can have good heat resistance. Holographic photopolymer materials have good heat resistance, or optical elements made from holographic photopolymer materials can have good heat resistance.

The invention discloses a photodynamic therapy device and a control method thereof. The device comprises a supporting assembly, a monitoring assembly, a therapy execution assembly, a control module and a fixing part. Supporting legs are arranged on the lower side of a substrate of the supporting assembly, a strain sensor array is embedded in the substrate, and a light source array and a distance measuring sensor array are arranged on the lower side of the substrate. A control module is arranged on a shell of the supporting assembly and is in communication connection with the monitoring assembly and the treatment executing assembly, and the posture adjusting assembly is arranged on the upper side of the base, at least partially located in the shell and used for adjusting the injection position and the injection angle of an injection needle in the injection assembly. Adjusting a shooting position and a shooting angle of image acquisition equipment in the monitoring assembly; the injection assembly is arranged on the shell and comprises an injection needle penetrating through the shell and the base. When the device is applied, precise and automatic photosensitizer injection and focus irradiation can be achieved, and the automation level, precision and effect of photodynamic therapy are improved.

The invention discloses preparation and application of a degradable nano delivery system with tumor microenvironment responsiveness, and belongs to the technical field of medicines.The nano delivery system is composed of copper ion doped nano enzyme with photothermal conversion capacity, an indissolvable photosensitizer and a ligand capable of turning charges in a weak acid environment, the copper ion doped nano-enzyme with photo-thermal conversion capacity is a high-molecular polymer formed by dopamine oxidation auto-polymerization and chelating auto-assembly with metal copper ions at the same time; the preparation method comprises the following steps: (1) reacting F127, mesitylene, a trihydroxymethyl aminomethane solution, dopamine hydrochloride and CuCl2. 2H2O to prepare copper ion doped mesoporous polydopamine; 2) reacting the copper ion-doped mesoporous polydopamine with a charge-reversible ligand in a weak acid environment in an alkaline environment to obtain a charge-reversible ligand modified nano-enzyme; and 3) co-incubating the nano-enzyme modified by the charge overturning ligand and an insoluble photosensitizer under ultrasonic waves to obtain the nano-delivery system.