1020 results about "Photosens" patented technology

The invention relates to a method for improving the creep resistant performance of an ultra-high molecular weight polyethylene fiber; and the method is characterized by jointly triggering crosslinking by using a photosensitizer and a thermal initiating agent, thereby crosslinking points of the surface and interior of the ultra-high molecular weight polyethylene fiber are increased, the crosslinking efficiency of a cross-linking agent is improved, the relative slippage among molecules of the ultra-high molecular weight polyethylene fiber is effectively impeded and the creep resistant performance of the fiber is increased.

Method and kit for treating microorganisms in the oral cavity. Such microorganisms include those which contribute to periodontal disease and halitosis. The method comprises the steps of applying a photosensitizer to the interior of the mouth within and/or outside of the periodontal pockets, waiting a predetermined period of time; and irradiating the whole interior of the mouth with a non-coherent light having a wavelength spectrum absorbable by the photosensitizer, and at a predetermined light intensity and for a predetermined time period sufficient to deliver a predetermined light dose.

Provided are methods and compositions for the photodynamic therapy (PDT) of ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular age-related macular degeneration. The selectivity and sensitivity of the PDT method can be enhanced by combining the PDT with an anti-angiogenesis factor, for example, angiostatin or endostatin, or with an apoptosis-modulating factor. Furthermore, the selectivity and sensitivity of the PDT may be further enhanced by coupling a targeting moiety to the photosensitizer so as to target the photosensitizer to choroidal neovasculature.

A composition comprising an active ingredient selected from the group of 5-aminolevulinic acid or a pharmaceutically acceptable salt or derivative thereof; and an aqueous carrier comprising at least one absorption enhancer, an anesthetic, hyaluronic acid and at least one acid selected from the group consisting of glycolic acid and lactic acid. The composition is useful in a photodynamic method of treating skin disorders.

The present invention relates to a photodynamic therapy method and uses thereof for treating an individual in need thereof, comprising administering a photosensitizer to an individual and activating the photosensitizer with a chemiluminescent light source, and/or a light-emitting diode light source, wherein the light source is in dermal contact with the individual. The present invention also relates to a device for photodynamic therapy comprising a permeable reservoir, for containing a photosensitizer formulation for skin application, the device is adapted to deliver the photosensitizer to the individual. The present invention also relates to a device for photodynamic therapy, comprising a permeable reservoir for containing a photosensitizer formulation for skin application and a light source. The light source is a chemiluminescent light source or a light-emitting diode light source and the device is adapted to deliver the photosensitizer to the individual and to irradiate a part of an individual to activate the photosensitizer.

The present invention discloses a photoelectric sensor for detection of kinase activity on the basis of local area surface plasma resonance. The biosensor is prepared as follows: a semiconductor material metal oxide is modified onto an indium tin oxide electrode (ITO), then Kemptide, PKA, and a probe are assembled onto the electrode layer by layer, since the probe contains noble metal nanoparticles and photosensitizer tris (bipyridine) ruthenium, under visible light irradiation, the photosensitizer tris (bipyridine) ruthenium captures more photons, local area surface plasma resonance effect of the noble metal nanoparticles occurs under photon excitation, so that more electrons jump onto a semiconductor metal oxide conduction band to produce photocurrent. The biosensor quantitative detection is based on that different concentrations of PKA cause different extents of phosphorylation of Kemptide, so that the amount of the probe connected to the modified electrode is also different, and photocurrent changes are caused. The method has high sensitivity and selectivity, enzyme inhibition experiments also show that the method achieves the purpose of efficient and sensitive detection of the kinase PKA activity.

The invention relates to a wastewater and waste gas pollutant treatment ball loaded with composite modified nanometer TiO2. The wastewater and waste gas pollutant treatment ball comprises an active microporous ball, the composite modified nanometer TiO2 and a plant-extracted photosensitizer or strong oxidant, wherein the composite modified nanometer TiO2 and the plant-extracted photosensitizer orstrong oxidant are sequentially loaded on the active microporous ball. According to the invention, the composite modified nanometer TiO2 and the plant-extracted photosensitizer or strong oxidant are sequentially loaded on the active microporous ball, so an obtained treatment ball has an active group with high energy; the diameter and the stacking layer thickness of the treatment ball can be determined according to the pollutant concentration and variety; during waste gas treatment, waste gas can be placed in a waste gas exhaust channel; and by utilization of the maze principle, pollutants in the waste gas react with active groups with high energy and are finally converted into substances like CO2 and H2O.

The present invention relates to a method of altering the refractive properties of the eye, the method including forming a pocket in a cornea of an eye of a patient so as to gain access to tissue bounding the pocket; after the pocket in the cornea has been formed, applying a photosensitizer inside the pocket so that the photo sensitizer permeates at least a portion of the tissue bounding the pocket, the photosensitizer facilitating cross-linking of the tissue bounding the pocket; inserting a lens implant into the pocket so as to change the refractive properties of the eye; and irradiating the cornea so as to activate cross-linkers in the portion of the tissue bounding the pocket and thereby stiffen the cornea and prevent corneal ectasia of the cornea.

The invention relates to water-soluble fullerene and preparing method thereof, can effectively solve the problems of poor solubility, low photosensitive activity and poor biocompatibility of the conventional fullerene, and adopts the technical scheme that water-soluble polymer polyethylene imine is connected to a fullerene molecule through chemical bonds to obtain water-soluble fullerene; and theweight ratio of polyethylene imine to fullerene is 0.08 to 0.12 : 1. The method comprises the following steps: the fullerene is reacted with an ammoniation reagent to obtain amino fullerene; amino fullerene is reacted with aziridine in such a manner that under the existence of protonated hydrogen ions, aziridine is grafted on amino groups continuously; and finally, the polymer of fullerene and polyethylene imine (namely water-soluble fullerene) is obtained. The water-soluble fullerene prepared according to the invention has the advantages that the characteristics of fullerene are not damaged;the water dispersibility is high; the toxicity is low; the stability is favorable; the preparation method is simple; the cost is low; and the water-soluble fullerene serves as a photosensitizer or a medicine carrier during the preparation of medicines curing cancers.

The invention discloses glycosylated boron dipyrromethene fluorophore derivatives as well as a preparation method and application of the glycosylated boron dipyrromethene fluorophore derivatives. The method comprises the following steps: by taking glucose and glucosides thereof as action targets, connecting covalent bonds of the action targets to boron dipyrromethene fluorophore derivatives for photodynamics therapy, so that a third generation photosensitizer against cancer which can be used for targeted therapy is obtained. The dipyrromethene fluorophore derivatives containing glucose and glucosides are taken as study researches, activity study of in-vitro breast cancer-resistant cells MBA-MD-231 is expanded, a prodrug suitable for molecular targeted therapy is screened, and a foundation is laid for applying the glycosylated boron dipyrromethene fluorophore derivatives to targeted therapy of cancers. Moreover, the compound synthesis method is simple, readily available in raw materials, low in cost, few in side reactions, high in yield and simple in purification, and industrial production is promoted.

The invention relates to a liquid optical adhesive which can be cured through ultraviolet light and is capable of achieving fixed adhesion between glass and touch control sensing screens in the process that a capacitance type touch screen is manufactured, and a preparation method of the liquid optical adhesive. The liquid optical adhesive is prepared from the following raw materials in percentage by weight: 35-48% of a resin oligomer, 50-63% of a reactive diluent, 0.5-1.3% of a photosensitizer, 0.8-1.6% of a photosensitive prompter and 0.4-1.4% of a cross-linking tackifier. The resin oligomer can be prepared by mixing and dissolving urethane acrylate or epoxy acrylate or a mixture of the two acrylic esters, by defoaming in vacuum and by filtering. The resin oligomer has the advantages of sufficient solidification in ultraviolet light, high production efficiency, high adhesion strength, high light permeability, small solidification shrinkage, yellowing resistance, simple manufacturing process, environmental friendliness and the like.

Prodrugs containing lipid moieties attached to drug derivatives, such as anti-cancer drug derivatives, via linkers comprising disulfide groups are described. Also described are nanoparticles coated with a lipid layer containing the prodrugs, formulations comprising the nanoparticles, and the use of the nanoparticles in methods of treating diseases, such as cancer, alone or in combination with additional drug compounds, targeting agents, and/or immunotherapy agents, such as immunosuppression inhibitors that target the CTLA-4, PD-1/PD-L1, IDO, LAG-3, CCR-7 or other pathways, or multiple immunosuppression inhibitors targeting a combination of such pathways. Optionally, the nanoparticles can comprise a photosensitizer or a derivative thereof and can be used in methods involving photodynamic therapy. Synergistic therapeutic effects result from combinations of multiple modalities provided by the disclosed nanoparticles and/or nanoparticle formulations.

The invention discloses a targeted anti-cancer molecule gefitinib phthalocyanine conjugate, and a preparation method and application thereof. The molecular formula of the gefitinib phthalocyanine conjugate is C56+2nH42+4nO5+nClFN12Zn (n=2-8). Gefitinib with an alkoxyl long chain is introduced into the periphery of a metal phthalocyanine large ring, so the amphipathicity and the biocompatibility can be improved, and the targeting property of a photosensitizer is enhanced. The gefitinib phthalocyanine conjugate is difficult to aggregate, so the cellular uptake ratio is increased and the activity of the photosensitizer in photodynamic therapy is also enhanced. The compound has single structure, is not provided with an isomer, and is easy to purify. A synthesis method is simple, little in side reaction, high in yield, easily available in raw materials, low in cost and favorable for industrialized production.

The invention provides a reduction-sensitive-type water-soluble molecularly-targeted photosensitizer. The photosensitizer is a conjugate which is formed by sequentially connecting meso-tetrahydroxy phenyl chlorine (mTHPC) with a folic acid group through a carbonic ester bond, a disulfide bond and a PEG chain. The invention further provides a chlorine intermediate and a folic acid PEG cysteine amide intermediate which are used for preparing the photosensitizer and a preparation method of the targeted photosensitizer. According to the photosensitizer which has the good tumor targeting performance, the photodynamic activity and water solubility, by introducing the disulfide bond and the carbonic ester bond into the molecular structure, the targeted photosensitizer can generate an exchange reaction of a sulfydryl and the disulfide bond and a nucleophilic substitution reaction in molecules in a strong reducing environment of a tumor cell after entering the cell, therefore, the mTHPC is completely released, and it is guaranteed that the photodynamic activity of the mTHPC cannot be reduced due to the structural change.

The present invention involves the use of photosensitizers to provide antibacterial surfaces on consumer and industrial items. This approach avoids the used of chemicals and solutions that may be toxic. The inventions also avoids the use of chemical compositions that might form degradation products which may be unacceptable to healthy persons or irritating to persons who may have allergies or are otherwise sensitized. According to the invention, photosensitizers with specific properties and specific design features are selected to make practical use of photosensitizers in the consumer and industrial market place. It is important to select a photosensitizer with an activation spectrum that is matched to the environmental conditions under which the surface to be protected is required to exhibit its antimicrobial properties. This means that the illumination energy and intensity levels expected need to yield enough singlet oxygen to destroy the targeted microbes. It is also possible to select photosensitizers that are activated only by wavelengths prominently present in certain illumination lamps, such as those lamps commonly present in a laboratories, medical offices, pharmacies and food service areas, thereby making the surfaces antimicrobial only on demand when the illumination lamps are turned on.

The application discloses: a) two-wall and four-wall container for lyophilizing, storing, and transfusing a blood component comprising a wall made from a porous polymer permeable to water vapor and resistant to liquid water; b) methods of lyophilising biological material including pre-evaporation step or step of killing bacteria with photosensitizer and light; c) a system (apparatus) for use in lyophilising biological material comprising two plates and the system of increasing or decreasing the space between them and d) a method of preparing blood component for lyophilisation including pre-evaporation and optionally disinfection.

The invention discloses a gold nanocomposite particle having plasma photothermal/photodynamic therapy performance, and a preparation method thereof. The structure of the gold nanocomposite particle contains a gold nanoparticle used for the photodynamic therapy, a plasma photothermal therapy photosensitizer attached to the gold nanoparticle, and a hydrophilic polymer polyethylene glycol modifying the surface. The invention also relates to a use of the gold nanocomposite particle in the photodynamic/plasma photothermal collaborative therapy. The gold nanocomposite particle has the advantages of simple preparation, low price and substantial curative effect.