1021 results about "Photosens" patented technology

The invention provides a photosensitive resin composition containing a photobleaching aminomethyl anthracene photosensitizer and application thereof.The structural main body anthracene ring of the photosensitizer introduces an aminomethyl functional group to the 9th and / or 10th site: through introduction of the aminomethyl functional group, while the electron cloud density of polycyclic aromatic hydrocarbon is maintained, the maximum absorption wavelength is subjected to red shift, and the photosensitive resin composition is especially suitable for a 405nm illumination system; the initiation efficiency is obviously improved; the exposure energy is reduced; compared with an existing DBA type photoinitiator, the problem of alkoxy carbon-oxygen bond breakage caused by p-pi conjugation of DBA is avoided, generation of small molecule fragments is effectively inhibited, defects are reduced, and the yield is increased. In addition, compared with DPHA and DAcOA, the photosensitizer also shows better solubility and formula compatibility. The preparation method has the characteristics of simple preparation process and low cost, and can be widely applied to the photocuring fields of dry films, paints, coatings, printing inks, forming materials and the like.

The invention discloses a photodynamic inactivation parameter adjusting method based on hybrid fuzzy-PID control, relates to the technical field of parameter fuzzy control, and aims at the problem that photodynamic inactivation efficiency and aquatic organism safety in aquaculture are difficult to consider at the same time through multi-sensor fusion and environment prediction. Then, a fuzzy-PID self-adaptive putting technology is adopted to be coupled with an illumination strategy, and accurate matching of the photosensitizer dosage and the light intensity is achieved; water body fluctuation and pathogen diffusion are dealt with through real-time closed-loop and multi-scene collaborative scheduling; multi-dimensional index evaluation is utilized, reinforcement learning is introduced to carry out self-learning optimization, and putting and illumination parameters are continuously improved; and finally, the method is expanded to large-scale distributed control and cloud big data training, and efficient inactivation and flexible deployment can be kept in different breeding scenes. Pathogens can be effectively prevented from being rapidly diffused in an adverse environment, damage to aquatic animals caused by excessive accumulation of reactive oxygen species (ROS) is reduced, and meanwhile energy consumption and resource waste are reduced.

The invention discloses an optical fiber balloon catheter, and relates to the technical field of medical instruments. The optical fiber balloon catheter comprises a catheter main body, a balloon and a flow slowing component, the balloon is arranged at the far end of the catheter body, and medicine is arranged on the surface of the balloon. At least in the process of conveying the balloon to a target part, the flow slowing part is located on the receiving side, receiving fluid impact, of the balloon, and the flow slowing part is used for slowing down flushing of fluid to medicine on the surface of the balloon in the process; wherein when the optical fiber balloon catheter performs reverse motion relative to fluid, the welcoming side is the far-end side of the balloon; when the optical fiber balloon catheter moves in the same direction relative to fluid, the receiving side is the near-end side of the balloon. The structure of the optical fiber balloon catheter is improved, scouring of fluid to the balloon in the conveying process is relieved, and loss of the photosensitizer on the surface of the balloon in the conveying process is effectively reduced.

The invention provides a photosensitive resin composition containing an anthracene methyl quaternary ammonium salt photosensitizer and application of the photosensitive resin composition, a structural main body anthracene ring of the photosensitizer is introduced into methylene substituted by a quaternary ammonium group at a position 10 and / or a position 9, and an acid radical or halogen is adopted as an equilibrium anion; compared with a commercially available anthracene photosensitizer, the photosensitizer has excellent fat solubility and good water solubility through introduction of the quaternary ammonium salt on the premise that the photobleaching property is retained, great potential is brought to formula design of the photosensitive composition, and development waste in a later development process can be greatly reduced; the method can be widely applied to the photo-curing fields of dry films, paints, coatings, printing ink, forming materials and the like.

The preparation method comprises the following steps: synthesizing gold nanostars (GNS) by using a seed growth method, coating mesoporous cerium dioxide (mCeO2) by using a template method, and loading a photosensitizer indocyanine green (ICG), so as to form a nano enzyme diagnosis and treatment system with chemical activity, photoactivity and photothermal effects. In the system, the gold nanostars have a good photo-thermal effect due to the multi-branched structure of the gold nanostars; on one hand, the mesoporous cerium dioxide coated on the outer layer has a chemical effect due to the nano-enzyme effect, and on the other hand, the mesoporous structure of the mesoporous cerium dioxide can better load the photosensitizer indocyanine green. All the components have good stability and biological safety, also have peroxidase simulation activity and a drug loading function, can improve the level of reactive oxygen species (ROS) in a tumor microenvironment and load photosensitizer drugs, and have an excellent anti-tumor effect and small side effects.

The invention provides triazole anthracene methyl formate for a photosensitive resin composition, and relates to the field of photopolymerization. The invention also comprises a photosensitive resin composition containing the triazole anthracene methyl formate, a photosensitive dry film containing the triazole anthracene methyl formate, and applications of the photosensitive resin composition and the photosensitive dry film. The triazole formic acid anthracene methyl ester disclosed by the invention has photosensitivity, can be used as a photosensitizer in the photosensitive resin composition, can improve the adhesive force of the photosensitive resin composition on various metal surfaces, and has the characteristic of low migration; the method can be widely applied to the photo-curing fields of dry films, paints, coatings, printing ink, forming materials and the like.

The invention discloses a dual-mechanism antibacterial photosensitizer as well as a preparation method and application thereof, and relates to the technical field of biomedical photoelectric functional materials. The invention relates to a triphenylamine derivative, which can realize fluorescence imaging of bacterial or fungal infection by utilizing fluorescence characteristics, can generate active oxygen under illumination to play a photodynamic therapy role, is suitable for preparing photodynamic therapy preparations and developing antibacterial materials, and can also be applied to the fields of environment and public health and tumor treatment. The problems that an existing photosensitizer is insufficient in broad spectrum, different in fungus drug resistance mechanism, limited in single treatment effect and the like can be effectively solved, and the photosensitizer has wide application prospects.

The invention provides anthracene methylthiosalicylic acid for a photosensitive resin composition, and relates to the field of photopolymerization. The invention also comprises a photosensitive resin composition containing the anthracene methylthio-salicylic acid, a photosensitive dry film containing the anthracene methylthio-salicylic acid, and applications of the photosensitive resin composition and the photosensitive dry film. The anthracene methyl thiosalicylic acid has photosensitivity and can be used as a photosensitizer in the photosensitive resin composition; the migration characteristic is low; the photosensitive resin composition has good solubility in conventional monomers, and the degree of freedom of formula design of the photosensitive resin composition is greatly improved; the developing agent also has very good solubility in alkali liquor, so that developing garbage can be greatly reduced, and the product yield is improved; the adhesive force of the photosensitive resin composition on various metal surfaces can be improved; the method can be widely applied to the photo-curing fields of dry films, paints, coatings, printing ink, forming materials and the like.

The invention discloses an antibacterial film loaded with a fucoxanthin nano material and a preparation method of the antibacterial film. The antibacterial film is prepared by taking a nitrogen-rich hollow carbon material-fucoxanthin (NHC-FX) nano material as an antibacterial photosensitizer, chitosan as a substrate of a film and glycerol as a plasticizer of the film through a solution casting method. The antibacterial film disclosed by the invention is good in hydrophobicity and high in stability, can reduce transmission of ultraviolet light, and has a good photodynamic antibacterial effect. The antibacterial food packaging material can be used as an antibacterial food packaging material or a preservative film, can prevent food from being polluted by microorganisms, and can isolate damage of ultraviolet rays to the food.

The invention discloses an acid responsive nanoprobe as well as preparation and anti-tumor application thereof. The nanoprobe has a core-shell structure, takes a nanoparticle self-assembled by a polycation aggregation-induced emission (AIE) photosensitizer and functional nucleic acid as a core, and takes a hyaluronic acid modified metal polyphenol network as a shell. The nanoprobe utilizes the acid responsiveness and broad-spectrum absorption performance of the metal polyphenol network and the diagnosis and treatment advantages of the polycation AIE photosensitizer to realize the acid responsiveness'switch 'controllable diagnosis and treatment of the tumor nanoprobe. In a neutral environment, the fluorescence is weak, the generation of ROS is less, and the background noise signal of the nanoprobe and the toxicity of non-targeted tissues are reduced; in an acid environment, fluorescence is enhanced, the ROS yield is improved, and the treatment efficiency and the curative effect monitoring accuracy are improved. The nano diagnosis and treatment probe is ingenious in design and simple to prepare, and can realize PDT and gene therapy synergistic anti-tumor, in-situ real-time report of early tumor treatment effect and assistance in precise cancer treatment.

The invention discloses a composite film based on light-biological synergistic gradient degradation and a preparation method thereof, the composite film sequentially comprises a light response layer, a transition layer and a biological response layer from outside to inside, and the light response layer comprises a polycaprolactone matrix, a tetraphenylporphyrin iron photosensitizer and anatase type TiO2 nanorods; the transition layer is a gradient blend of polylactic acid and modified starch; the biological response layer comprises polyhydroxyalkanoate and bacterial cellulose nanofibers; through the design of the three-layer gradient structure and the construction of the bionic microchannel, the synergistic effect of light degradation, hydrolysis and biodegradation is realized; the composite membrane has excellent mechanical properties and environmental adaptability, the degradation period can be accurately regulated and controlled within 30-180 days, and the soil degradation rate within 60 days reaches 91% or above; the preparation method comprises the processes of electrostatic spinning, gradient co-extrusion and bacterial cellulose in-situ culture. The material can be widely applied to the fields of agricultural mulching films, food packaging and the like, and the problems that a traditional degradable film is poor in mechanical property and uncontrollable in degradation are solved.

The invention provides an aza-BODIPY molecule with NIR-II fluorescence emission and I-type photodynamic activity and a preparation method thereof. The aza-BODIPY molecule has good light absorption in a near-infrared (NIR) region, the emission peak of the aza-BODIPY molecule is prolonged to a near-infrared second region (NIR-II), and the aza-BODIPY molecule shows an ultrahigh NIR-II fluorescence quantum yield of 13%. Meanwhile, the photosensitizer prepared by adopting aza-BODIPY molecules can effectively generate I-type active oxygen species, namely superoxide anion free radicals, under the excitation of 808nm laser. On the basis, high-resolution tumor fluorescence imaging can be realized by utilizing NIR-II fluorescence of the aza-fluorine boron fluorescent sensitizer, and the aza-fluorine boron fluorescent sensitizer is used for accurate and efficient NIR-II fluorescence imaging mediated I-type photodynamic therapy of deep tumor tissues.

Method and apparatus for directing pulsed light beams at an in vivo treatment site to create thermoelastic expansion of tissue which generates ultrasonic pulse waves in the mega hertz range. One or more photosensitizers are applied to the treatment site. Further, the ultrasonic pulse waves either singly, or in combination with the pulsed light waves cause the activation of the photosensitizers to generate singlet oxygen at the treatment site.

The invention designs and synthesizes a tetraphenyl ethylene covalent molecular cage with pyridine functionalization, and an AIE supermolecule photosensitizer is obtained through coordination and the synergistic effect of a subject and an object. The TPE unit enhances the photophysical properties of the photosensitizer and endows the photosensitizer with the AIE characteristic; the molecular cage and tetraphenylporphyrin are combined through a host and a guest, so that self-aggregation of porphyrin in water is further inhibited, ROS generation is promoted, and cancer cells are effectively killed through photocatalysis NADH oxidation assistance.

The invention belongs to the technical field of biological medicine, and discloses a bionic nano-particle suspension formulation based on orthoester compounds and a preparation method of the bionic nano-particle suspension formulation. The bionic nanoparticle suspension formulation comprises a liquid auxiliary material, a photosensitizer and bionic nanoparticles, wherein the photosensitizer and the bionic nanoparticles are dispersed in the liquid auxiliary material. According to the present invention, an orthoester compound represented by a formula I is adopted as a liquid auxiliary material, bionic nanoparticles and a photosensitizer are simultaneously introduced into OE to obtain the bionic nanoparticle suspension formulation having multiple antitumor mechanisms, the bionic nanoparticles are cancer cell membrane vesicle-coated nano-drugs, and the cancer cell membrane vesicle-coated nano-drugs can be prepared through a cancer cell membrane biomimetic technology, such that the cancer cell membrane vesicle-coated nano-drugs can be prepared into the bionic nanoparticle suspension formulation having multiple antitumor mechanisms; the homologous targeting function provided by the cancer cell membrane is utilized, and the active targeting property and cellular uptake of the nano-drug are remarkably improved. Formula I: # imgabs0 #

The invention relates to the technical field of dry films, in particular to a photosensitive resin composition, a photosensitive dry film and a preparation method of the photosensitive dry film. Comprising alkali-soluble resin, a photopolymerizable monomer with at least one vinyl unsaturated group, a photosensitizer and other additives, and the alkali-soluble resin at least comprises a nitrogen-containing heterochain or nitrogen heterocyclic ring monomer chain segment group; the alkali-soluble adhesive resin containing aza-chain or azacyclo-containing monomer chain segment groups is prepared by introducing an aza-chain or azacyclo-containing monomer, such as a monomer containing primary amine, secondary amine, tertiary amine, quaternary ammonium salt, pyridines, imidazoles and other groups, into alkali-soluble resin, and is used for improving the adhesive force and binding force between the resin and the surfaces of metals such as copper and the like; therefore, the resolution and adhesion capability of the photosensitive resin composition or the photosensitive dry film is improved.

Method and kit for topical treatment of a skin infection, in particular of superficial skin infections, caused by Staphylococcus aureus. The method comprises the steps of applying a photosensitizer to at least a part of the skin affected by the infection, and subjecting said part of the skin to first photons with a majority energy between 2.8 eV and 3.5 eV at a first energy level; and second photons with a majority energy between 1.24 eV and 1.65 eV at a second energy level, the ratio between the first and the second energy levels being in the range from about 10:1 to 2:1. By the method efficient treatment of Staphylococcus aureus infections can be achieved without the administration of topical antibiotics.

The invention discloses a multifunctional nano delivery system based on targeted ferritin as well as a preparation method and application of the multifunctional nano delivery system. According to the system, traditional Chinese medicine active ingredients, namely neogambogic acid GNA, a photosensitizer Ce6 and ferritin targeting peptide HKN15 are integrated through a self-assembly technology, a synergistic treatment system integrating photodynamic therapy PDT and ferroptosis induction is constructed, and the treatment effect on non-small cell lung cancer NSCLC can be remarkably enhanced. According to the nano delivery system, precise targeting of a tumor site is achieved through the ferritin targeting peptide HKN15, and a double anti-tumor mechanism is formed by utilizing the photodynamic effect of the photosensitizer Ce6 and the ferroptosis induction effect of GNA. The preparation process is based on a molecular self-assembly principle, and has the advantages of high tumor accumulation efficiency, low system toxicity, remarkable tumor inhibition effect and the like, and an innovative solution is provided for precise treatment of the non-small cell lung cancer.

The invention relates to the technical field of photoinitiators, and provides a triplet-triplet energy transfer (TTET) free radical I type photoinitiation system, a photocuring composition and application thereof. The system comprises a boron dialkylated dipyrromethene free radical I type photoinitiator and a long wave absorption photosensitizer, the photosensitizer is preferably an osmium (II) complex, and the mass ratio of the photosensitizer to the photoinitiator is preferably 1: 5-1: 200. Under the irradiation of a 650-750 nm light source (preferably a 690 nm LED), the photosensitizer enters a triplet state through intersystem crossing and generates TTET to the photoinitiator, so that the photoinitiator is uniformly split in the triplet state to generate free radicals, thereby initiating polymerization / cross-linking curing of monomers such as (methyl) acrylate and the like. The embodiment shows that the double bond conversion rate of the TPGDA can reach more than 80% within 10 minutes under the conditions of LED at 690 nm and 80 mW / cm < 2 >.

The invention discloses a Janus air filtering membrane for capturing, detecting and sterilizing integrated biological aerosol and a preparation method of the Janus air filtering membrane, and belongs to the technical field of filtering membranes. According to the technical scheme, the air filtering membrane is provided with an asymmetric two-side structure and a soluble micro-nano porous network structure, the surface of the filtering membrane is asymmetrically modified through an amphiphilic AIE photosensitizer, the Janus structure is constructed on the basis that the overall structure of the filtering membrane is not damaged, aggregation of the AIE photosensitizer on the single side of the filtering membrane is achieved, and therefore the air filtering membrane is formed. The air filter membrane has green capture detection performance and AIE photodynamic disinfection performance. The preparation method comprises the steps of solution preparation, filter membrane forming, surface asymmetric modification and drying. According to the Janus air filtering membrane, efficient capture and enrichment of biological aerosol can be achieved, the Janus air filtering membrane is used for microbiological detection under the guidance of near-infrared fluorescence imaging after being colored, and effective inactivation of air pathogens can be achieved by means of white light irradiation.

The invention relates to the technical field of anti-tumor, in particular to a supramolecular assembly, a preparation method thereof and application of the supramolecular assembly in preparation of anti-tumor drugs. According to the present invention, tetraphenylporphyrin (TPP-Lys and TPP-Gln) modified by lysine and glutamine respectively and fully methylated cyclodextrin (Bio-PMeCD) modified by biotin are adopted as a carrier and a targeting agent to construct an assembly, and the assembly is used for intracellular enzymatic in-situ polymerization reaction, such that the application of the assembly in the aspects of photosensitizer retention time prolonging and photodynamic treatment effect improving is achieved.

The invention discloses a C60-BODIPY triplet photosensitizer as well as a preparation method and photodynamic antibacterial application thereof. In the preparation process, a fullerene pyrrole ring compound and a BODIPY molecule are connected together through a benzene bridge group, and two ends of a bridge bond are respectively connected to a C atom on a fullerene pyrrole ring and a 6th site of the BODIPY molecule; a BODIPY-C60 binary molecule is formed; the preparation method comprises the following steps: reacting 9-anthracene formaldehyde with 2, 4-dimethyl pyrrole to generate a boron-dipyrromethene molecule of which the meso position is substituted by 9-anthryl, brominating the boron-dipyrromethene molecule at the 6 position by N-bromosuccinimide, coupling the boron-dipyrromethene molecule with p-formylphenylboronic acid, and carrying out Prato reaction on the coupled boron-dipyrromethene molecule with C60 and N-methylglycine to prepare the BODIPY-C60 binary triplet photosensitizer. The triplet photosensitizer has excellent photodynamic activity and relatively high reactive oxygen quantum yield, and can effectively kill bacteria.

The invention discloses a preparation method of photoresponse COFs coated CeO2 nano-enzyme, and relates to the field of nano-materials. According to the invention, FePc, TAPP and 2, 5-dihydroxy-1, 4-phthalaldehyde are used for creating a core-shell material CeO2 (at) FePC / por-COF of photoresponse peroxidase based on COFs (Covalent Organic Frameworks), and the core-shell material CeO2 (at) FePC / por-COF is used for preparing the photoresponse peroxidase based on COFs. According to the invention, the highly ordered structural characteristic of the COFs material is utilized, so that the problem of fluorescence quenching caused by aggregation of traditional micromolecule photosensitizers (such as porphyrin, phthalocyanine and the like) in the use process is effectively solved. According to the present invention, the photoresponsive peroxidase activity is significant, and the chromogenic substrate of tetramethyl benzidine (TMB) can be effectively catalyzed; fePc is integrated into a COFs structure, so that the photoresponse activity of the COFs under near-infrared 808 nm is enhanced, and the COFs have excellent reactive oxygen species (ROS) generation capacity, and have great potential in the aspects of photodynamic therapy, antibacterial treatment, cell imaging and the like in biomedical application.

The present invention provides a nanoparticle loaded with a photosensitizer Ce6 and targeting mitochondria of breast cancer cells, and a preparation method therefor and a use thereof. The nanoparticle uses hollow mesoporous silica as a carrier; a photosensitizer Ce6 is loaded at the hollow position of the carrier; a red cell membrane is encapsulated outside the carrier; and one side of the carrier after being encapsulated by the red cell membrane is modified with a Pt nanocluster, and the other side of the carrier is modified with an LXL-1 aptamer and TPP. The present invention also provides a preparation method for the nanoparticle and a use of the nanoparticle in preparation of a drug for treating breast cancer.

The present invention discloses a water-soluble thionaphthalimide photosensitizer, a preparation method thereof and an application thereof, belonging to the field of organic optofunctional materials. The photosensitizer of the present invention uses thionaphthalimide containing an electron-donating effect as a parent body, and at the same time introduces a water-soluble polyethylene glycol (PEG) group at its amide position. In an aqueous solution, the photosensitizer can self-assemble into nanoparticles with a particle size of 147 nm without other nanocarriers, and has good absorption at 570 nm. The method of the present invention has the advantages of easily available raw materials, simple synthesis and easy separation. The prepared photosensitizer has good reactive oxygen generation ability under white light irradiation, good water solubility, and good photo, thermal and chemical stability. The ultraviolet-visible absorption tail peak can reach the near-infrared region. The nanoparticles have good photodynamic killing effect on cancer cells.

The invention provides a photosensitive resin composition, a photosensitive dry film and application thereof. The photosensitive resin composition comprises alkali-soluble resin, a photopolymerization monomer, a photoinitiator and a photosensitizer, the photosensitive resin composition provided by the invention has excellent photosensitive characteristics, can provide excellent resolution and adhesive force, and is uniformly cured during exposure, a formed anti-corrosion pattern port is rectangular, the side wall is flat, an electroplating solution is not easily polluted in an electroplating process, the yield of a product can be remarkably improved, and the service life of the electroplating solution is prolonged.

The invention belongs to the technical field of drug system delivery, and particularly relates to a radiotherapy sensitization microneedle and application thereof. The invention relates to a design of a mitochondrial targeting photosensitive microneedle system and an application of the mitochondrial targeting photosensitive microneedle system in melanoma radiosensitization radiotherapy. According to the invention, an intelligent delivery platform of the microneedles (MNs) is fused with mitochondrial targeted photodynamic therapy, and a new normal form is developed for radiosensitization therapy of melanoma. According to the invention, a soluble hyaluronic acid (HA) microneedle array is adopted, and a mitochondrial targeting photosensitizer is loaded. After penetrating through the cuticle, the microneedle is rapidly dissolved in the corium layer, the photosensitizer is released, and mitochondrial targeted enrichment is achieved. Then, under the condition of 660 nm illumination, the photosensitizer generates active oxygen in a mitochondrial matrix to directly destroy the mitochondrial structure and function, so that the mitochondrial ROS storm is induced, and the tumor radiotherapy sensitivity is improved.

The invention provides temperature-sensitive ink suitable for various printing modes, a preparation method thereof and a printed product. The ink is prepared from the following raw materials in percentage by mass: 15 to 45 weight percent of aromatic polyurethane acrylic resin, 5 to 45 weight percent of modified epoxy acrylic resin, 5 to 10 weight percent of ethoxylated trimethylolpropane triacrylate, 5 to 10 weight percent of 1, 6-hexanediol diacrylate, 5 to 10 weight percent of tetrahydrofuran acrylate, 5 to 10 weight percent of acryloyl morpholine, 5 to 10 weight percent of co-initiator, 0.5 to 1.5 weight percent of polyethylene wax, 4 to 10 weight percent of photosensitizer, 0.5 to 1.5 weight percent of heat stabilizer and 5 to 15 weight percent of calcium carbonate. According to the invention, the resin which is easy to yellow in a high-temperature environment is added into the formula, and the excessive and active photosensitizer is combined, so that the coating can obtain an excellent temperature band color change effect and an irreversible color change effect under a high-temperature condition.

The invention relates to a quinoxalinone derivative targeting poly ADP ribose polymerase and an androgen receptor as well as a preparation method and application of the quinoxalinone derivative. The structural formula of the quinoxalinone derivative is as follows: # imgabs0 #, R1 is one of hydrogen, methoxyl, methyl and halogen, the substituent position of R1 is at least one of 5, 6, 7 and 8 sites of a quinoxalinone ring, and X is a carbon atom or a nitrogen atom. The quinoxalinone derivative provided by the invention can be used as an active photosensitizer, a PARP inhibitor and an androgen receptor antagonist and can induce cell synthesis and death, and the process can improve the oxidation state and oxygen concentration in cells and improve the hypoxic microenvironment in tumors, so that the photodynamic therapy effect is further enhanced, namely, the effect of the quinoxalinone derivative is improved. The PDT therapy and the PARP inhibitor have a synergistic effect.

The invention provides an anti-inflammatory and anti-vascular bidirectional trapping combined self-luminous power compound based on neutrophil nano-vesicles as well as a preparation method and application thereof, and belongs to the technical field of biological medicine manufacturing. The compound takes a neutrophil nano-vesicle as a carrier, and is also loaded with bis (2, 4, 5-trichlorosalicylic acid n-amyl ester) oxalate (CPPO) and a photosensitizer Ce6, and meanwhile, the surface of the compound is modified with ranibizumab through ketal mercaptan responded by ROS (reactive oxygen species). The compound has the characteristics of trapping anti-inflammatory factors and spontaneously targeting corneal neovascularization diseased regions, Ranibizumab is responsively released on the basis of ROS to be combined with vascular endothelial growth factors, the anti-angiogenesis function is achieved, meanwhile, chemical energy generated by CPPO under the high-oxygen condition stimulates Ce6 to generate singlet oxygen, and therefore the vascular endothelial cell tubulogenesis capacity is inhibited. The invention provides a new means for treatment of eye disease related diseases.