18 results about "Atheromatous Plaques" patented technology

Some embodiments of a rotational atherectomy device can remove (partially or completely) stenotic lesions in blood vessels by rotating one or more abrasive elements in an orbital path to abrade and breakdown the lesion. In particular implementations, multiple abrasive elements are arranged along a distal portion of a drive shaft with an improved configuration so as to facilitate both efficient navigation into smaller blood vessels below the ankle or in the heart and effective orbital paths for abrading stenotic material in such smaller vessels.

An atherectomy device includes a catheter that is coupled to a handle. The catheter includes an outer sheath and a drive shaft carried within and rotatable relative to the outer sheath. A cutter assembly is coupled to and extends distally relative to the outer sheath. The cutter assembly includes a housing coupled to and extending distally from the outer sheath. A proximal cutting element is rotatably carried by the housing, and the proximal cutting element is coupled to and extends distally from the drive shaft. The proximal cutting element includes at least one proximal cutting blade, and the at least one proximal cutting blade has a negative rake angle. A distal cutting element is rotatable with the proximal cutting element relative to the housing. The distal cutting element includes at least one distal cutting blade, and the at least one distal cutting blade has a positive rake angle.

An atherectomy system includes an advancer assembly and a drive assembly that is adapted to translate relative to the advancer assembly. A control knob extends from the drive assembly such that translating the control knob results in the drive assembly translating relative to the advancer assembly. A drive shaft is operably coupled with the drive assembly, the drive shaft translating relative to the advancer assembly as the drive assembly translates relative to the advancer assembly. A feedback modifier is operably coupled between the drive assembly and the advancer assembly and is adapted to provide a user of the atherectomy system with similar feedback via the control knob regardless of whether the user is moving the drive assembly in an anterograde ablation direction or a retrograde ablation direction.

Atherectomy-angioplasty devices, systems, and methods reduce the device costs, procedure times, and risks associated with clinician error and patient trauma that accompany separate atherectomy and angioplasty devices. An example atherectomy-angioplasty device includes a tubular body, an elongate rotor, a plaque-debulking element, and an elongate balloon. The tubular body includes a rotor lumen and an inflation lumen. The elongate rotor is disposed in the rotor lumen. The plaque-debulking element is configured to debulk atherosclerotic or restenotic plaques in a blood-vessel lumen of a patient. To do so, the plaque-debulking element is actuated by the elongate rotor when the elongate rotor is rotated around its longitudinal axis in the rotor lumen. The elongate balloon is over a distal portion of the tubular body. The elongate balloon is fluidly connected to the inflation lumen for inflating or deflating the elongate balloon, as desired, for preventing dispersion of atherosclerotic debris, angioplasty, or both.

A rotational atherectomy device for cutting or abrading tissue. The atherectomy device comprises a rotatable drive shaft (120) having a longitudinal axis and comprising one or more internal guiding tracks (121) extending along the length of the drive shaft (120). The rotational atherectomy device further comprises one or more flexible shafts (111, 113) arranged to be longitudinally moveable along a respective internal guiding track, and an abrasive head (110) disposed at the distal end of the one or more flexible shafts (111, 113). The abrasive head (110) comprises one or more abrasive elements (111), each abrasive element connected to a respective flexible shaft (111, 113). The one or more guiding tracks (121) are arranged such that distal movement of the one or more flexible shafts (111, 113) causes the abrasive head (110) to move from a radially contracted configuration to a radially expanded configuration.

The invention provides oral cyclodextrin inclusion complex formulations in which inclusion complexes of borneol and trans-cinnamaldehyde are provided together with nattokinase and with an enzyme having a cyclodextrin-degrading activity capable of digesting cyclodextrins, so that upon delivery of the formulation to a target tissue the CD- degrading enzyme is activated and releases the borneol and trans-cinnamaldehyde from the cyclodextrins. These cyclodextrin inclusion complex formulations may be used for treating atheromatous plaque and related diseases.

The invention provides a traditional Chinese medicine composition and application thereof in preparation of a medicine for treating atherosclerosis, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following raw material components in parts by mass: 8-10 parts of Guangxi curcuma zedoary, 8-12 parts of peach kernels, 8-12 parts of cassia twigs, 8-12 parts of poria cocos, 25-35 parts of raw astragalus membranaceus, 8-12 parts of moutan bark, 8-12 parts of red peony roots, 10-20 parts of fructus mali, 10-15 parts of herba lycopi and 25-35 parts of oysters. The traditional Chinese medicine composition can improve the lesion degree of atherosclerosis, reduce the blood fat level and reduce the generation of atheromatous plaques, thereby improving the atherosclerosis; meanwhile, the traditional Chinese medicine composition has an anti-AS effect in the aspects of stabilizing vulnerable plaques, promoting reverse transport of cholesterol, adjusting energy metabolism and water metabolism of mitochondria, resisting inflammation and resisting oxidative stress.

The ultrasonic system includes an ultrasonic device having an ultrasonic transducer and a core wire having a proximal end coupled to the ultrasonic transducer and a distal end portion terminating at a distal tip. An ultrasonic energy source is electrically connected to the ultrasonic transducer. The ultrasonic energy source includes an ultrasonic signal generator circuit, a modulator circuit, and a controller. The ultrasonic signal generator circuit generates an ultrasonic electrical signal. The modulator circuit amplitude-modulates the ultrasonic electrical signal with a macromotion electrical signal to generate a modulated ultrasonic electrical signal. The controller executes program instructions to select between an engagement mode and a transverse mode, where in the engagement mode, a first ultrasonic electrical signal is provided from the ultrasonic energy source to the ultrasonic transducer, and in the transverse mode, a modulated ultrasonic electrical signal is provided from the ultrasonic energy source to the ultrasonic transducer.

An atherectomy system includes an atherectomy burr and a driveshaft adapted to carry the atherectomy burr. The atherectomy burr includes a cavity that extends distally into the atherectomy burr from a proximal end region. The driveshaft extends into the cavity. An adhesive is within the cavity to secure the atherectomy burr to the driveshaft. At least one of the cavity and / or the driveshaft are adapted to align a centerline of the atherectomy burr with a centerline of the driveshaft.

An atherectomy system may include an atherectomy device and a guidewire that is adapted to be used in combination with the atherectomy device. The atherectomy device includes a driveshaft and an atherectomy burr that is secured to the driveshaft. The guidewire includes a distal region having a distal region diameter ranging from 0.01 inches (0.254 millimeters) to 0.013 inches (0.33 millimeters) and a bending stiffness that emulates that of stainless steel having a diameter of 0.0077 inches (0.178 millimeters). The guidewire includes a proximal region having a proximal region diameter that is greater than the distal region diameter. The guidewire includes an intervening taper region. In some cases, the proximal region of the guidewire may have a bending stiffness that emulates that of stainless steel having a diameter of 0.009 inches (0.229 millimeters).

The present disclosure relates to a rotational atherectomy device and a medical device including the rotational atherectomy device. The rotational atherectomy device includes a drive shaft and a rotational atherectomy component connected to the drive shaft. The rotational atherectomy component includes a base and a rotational atherectomy block. The rotational atherectomy block is relatively movably assembled on the base. When the rotational atherectomy component rotates, the rotational atherectomy block moves in a direction away from the base.

An atherectomy system includes an atherectomy burr and a driveshaft adapted to carry the atherectomy burr. The atherectomy burr includes a cavity that extends distally into the atherectomy burr from a proximal end region. The driveshaft extends into the cavity. An adhesive is within the cavity to secure the atherectomy burr to the driveshaft. At least one of the cavity and / or the driveshaft are adapted to align a centerline of the atherectomy burr with a centerline of the driveshaft.

Telescopic, self-propelled, and side-pump atherectomy devices are provided, each with a flexible sheath, a helically fluted cutter, and a drive assembly. The drive assembly may have a flexible drive shaft that rotates and moves with the lumen of the flexible sheath, a positive displacement pump for transporting the cut tissue, and a flexible drive shaft that may be longer than the flexible sheath to allow reversible telescoping of the drive assembly away from the lumen of the flexible sheath. The positive displacement pump may be a screw pump with a portion of the drive screw exposed to contact the vascular lumen, allowing self-propulsion of the device through the vascular lumen. A reversibly expandable side-pump element may be included at the distal end of the flexible sheath to laterally push the cutter.Improved cutting heads and methods for their manufacture are provided, for cutting a combination of soft and hard plate.

An apparatus includes a laser atherectomy catheter configured to remove, from a patient body, a medical lead implanted in a blood vessel at a binding site comprising calcium. The laser atherectomy catheter includes a catheter lumen configured to receive the medical lead during removal of the medical lead from the patient body, and an optical fiber. The apparatus also includes a sheath configured to be positioned around the laser atherectomy catheter. At least one of the laser atherectomy catheter or the sheath define a fluid delivery lumen separate from the catheter lumen, where the fluid delivery lumen is configured to deliver a photoreactive fluid into the blood vessel. The optical fiber is configured to deliver a first laser pulse to the photoreactive fluid for lithotripsy of the calcium before or during the removal of the medical lead.

The application belongs to the field of biological medicine research and development, and particularly relates to application of umbilical cord mesenchymal stem cell-derived vascular endothelial precursor cells in preparation of medicines for preventing and treating atherosclerosis. By interfering with expression of related factors in a pyroptosis inflammatory signaling pathway of NLRP3, ASC, Caspase-1, GSDMD, IL-1β and IL-18 at a transcription and protein level, the serum triglyceride concentration, total cholesterol concentration and low-density lipoprotein concentration can be reduced, the serum oxidized low-density lipoprotein and oxygen free radical concentration can be reduced, the serum high-density lipoprotein concentration can be increased, and the atherosclerotic plaque area can be reduced and cell apoptosis in the atheromatous plaque can be inhibited.

An atherectomy catheter for performing an atherectomy procedure, the atherectomy catheter includes a catheter body defining one or more lumens, a core wire extending through a core wire lumen of the one or more lumens of the catheter body, and an abrasive bead slidably mounted to the core wire. The core wire is configured to be coupled to an excitation device and operation of the excitation device causes the abrasive bead to rotate about and slide longitudinally along the core wire.

Described herein are atherectomy catheters, systems and methods of use. The atherectomy catheters may include a driveshaft within an elongate body. An optical fiber may run through the driveshaft and have a distal end that is attached to an opening of a cutter at distal end of the driveshaft. The cutter and the optical fiber may be rotated respect to the elongate body by rotating the driveshaft with respect to the elongate body. The driveshaft may be longitudinally displaced to expose a distal cutting edge of the cutter for cutting tissue or plaque from a vessel lumen. Images of the vessel lumen collected through the opening of the cutter may be captured in real time with the optical fiber.

Methods, Apparatuses, and Systems of operating a laser atherectomy system to perform an endoscopic atherectomy procedure within a vessel at a therapeutic region of an anatomical condition by use of an atherectomy laser device coupled to an ultrasound imaging probe. The atherectomy laser device operates to generate photoacoustic signals from a light source of the atherectomy laser device to for guidance within the vessel and to characterize tissue about the therapeutic region by delivery of pulsed wavelengths within the vessel, and to perform operations of tissue ablation directed to the anatomical condition. This enables guidance of the atherectomy laser device by feedback from the viewing of photoacoustic images based on photoacoustic signals generated the atherectomy laser device and created in response to changes in acoustic intensity due to changes of optical wavelength monitored by the ultrasound imaging probe.