The invention discloses a synthetic method of
taurocholic acid. The method comprises the following steps: A, mixing and stirring
cholic acid with
acetone and cooling to -10 to 30 DEG C, adding organic alkali, dripping
ethyl chloroformate below 30 DEG C after evenly stirring, reacting for 1-3 hours after dripping is finished, and filtering to obtain filtrate; B, adding the filtrate in the step A to a solution formed by
taurine and water, adjusting the pH to 7-11 by using organic alkali, then reacting at 20-30 DEG C for 3-5 hours, and filtering to obtain filtrate after reaction is finished; C, adjusting the pH of the filtrate in the step B to below 1 by using 10-30% of
hydrochloric acid, concentrating in vacuum at 40-65 DEG C to dry, adding
methanol, heating for dissolving, adding
acetone to evenly stir, and cooling to -5 to 0 DEG C for crystallizing; filtering after
crystallization is finished; washing a
filter cake by
acetone, draining and
drying in vacuum. The invention aims at providing the synthetic method of
taurocholic acid, which is simple in technology, relatively low in production cost, high in yield of
taurocholic acid, and convenient for industrial production.