43results about How to "Reduce tumor weight" patented technology

The invention relates to application of protosappanin B, in particular to application of a 0.2 to 2.4 percent protosappanin B solution in preparation of bladder cancer resistant perfusion fluid. For filling up the research blank of the protosappanin B at home and abroad, the invention provides new application of the protosappanin B. Human bladder cancer cell strains T24 or mouse bladder cancer cell strains BTT are inoculated to mouse bodies to form bladder cancer, and the mice are grouped and respectively subjected to experiments with injection water, mitomycin and the protosappanin B; experiment results show that the lives of the mice injected with the mitomycin and the protosappanin B are prolonged, the tumor weight is reduced, and a tumor inhibiting effect is achieved; and the protosappanin B has a remarkable bladder cancer inhibiting effect, and can be widely applied to preparation of the bladder cancer resistant perfusion fluid.

Disclosed is a method of treating cancer in a patient comprising administering to the patient an effective amount of a diazeniumdiolated (N₂O₂-containing) compound or a pharmaceutically acceptable salt thereof, wherein the cancer cell has an elevated level of reactive oxygen species (ROS) and/or a decreased level of one or more of PRX1, PRX6, and OGG1, compared to a normal cell of the same tissue or tissue type. An example of a diazeniumdiolated compound is Formula (I), wherein X and Q are defined herein. Also disclosed are diazeniumdiolated compounds, pharmaceutical compositions, and methods of use including enhancing the chemotherapeutic treatment of chemotherapeutic agents and high energy radiation.

The present invention provides a fusion protein of human interferon and a targeting peptide, and preparation thereof. The fusion protein has a structure of IFN-M-S, wherein S represents a targeting peptide, M represents a linkage peptide, IFN represents interferon, an amino acid sequence of S can be any one selected from S1, S2, S3 and S4, an amino acid sequence of M contains 0-10 amino acid residues, preferably 4-6 amino acid residues, and IFN can be any one of I type interferon and II type interferon.

The invention relates to an antineoplastic Chinese medicinal composition and preparing process thereof, wherein the composition has appreciable effect in treating malignant tumor such as digestive tract tumor. The invention provides the significant part of subprostrate sophora root alkaloids extracted from subprostrate sophora root and the related preparing process. The alkaloids content in the subprostrate sophora root alkaloid significant part is higher than 50%. The invention further provides a Chinese medicinal preparation using subprostrate sophora root alkaloids as the medicinal effective composition.

The invention discloses a medicament composition for treating tumors, which is a Chinese medicinal preparation mainly prepared from the raw materials such as rabdosia rubescens, salvia chinensis, seaweed, zedoary, ground beetles, herba scutellariae barbatae, Indian mockstrawberry herb, bistort rhizome, astragalus roots, liquorice and coix seeds. The medicament has the advantages of simple unique prescription, low price, remarkable efficacy, effects of strengthening healthy energy and eliminating pathogens, as well as synergism. The invention also discloses a method for preparing the medicament. The medicament is prepared by extracting Chinese medicaments with different solvents respectively, performing other pretreatment and then compounding the obtained products pro rata according to the different characteristics of each Chinese medicament.

The invention discloses an isoflavones composition and medicine made of the same. The isoflavones composition comprises methylophiopogonanone B, methylophiopogonanone A, 6-formylisoophiopogonone A, 5,7,2',6'-tetrahydroxy-4'-methoxyl-6,8-dimethylophiopogonanone, ophiopogonanone E, 5,7,4'-trihydroxy-3'-methoxyl-6,8-dimethylophiopogonanone, 2,5,7- trihydroxy-4'-methoxyl-6,8-dimethylophiopogonanone, 6-formylisoophiopogonone B, 5,7,4'-trihydroxy-6-dimethylophiopogonanone and 5,7,4'-trihydroxy-6-methylophiopogonanone. The medicine can be used for treatment and prevention of cancers.

The invention provides uses of calenduloside E in preparation of anti-tumor medicines. Experiments about influences of the calenduloside E on activity of B16F10 melanoma cells prove that the calenduloside E can inhibit activity of tumor cells. Experiments about influences of the calenduloside E on activity of human umbilical vein endothelial cells (HUVECs) and lumen formation experiments prove that the calenduloside E can inhibit activity of vascular endothelial cells and inhibit lumen formation capability of the vascular endothelial cells. Experiments about influences of calenduloside E administration on growth of B16F10 melanoma cells in mice prove that the calenduloside E can inhibit in-vivo tumor cell growth and has anti-tumor activity.

The invention discloses a medicinal composition for treating tumors, which is a Chinese medicinal preparation prepared by using Chinese sage herb, seaweed, common burreed rhizome, barbed skullcap herb, Indian mockstrawberry herb and bistort rhizome as the main raw materials. The invention has simple and unique formula, low price and obvious curative effect, and has effects of strengthening the body resistance, eliminating the pathogenic factor and enhancing effectiveness. The invention also discloses a preparation method for the medicament. The medicament is prepared according to different characteristics of each Chinese medicament in proportion after pretreatments of extracting respectively by different solvents and the like.

The invention discloses application of 1,2,3,4,6-pentagalloylglucose, or an optical isomer, or a racemate, or a solvate, or a pharmaceutically acceptable salt in the preparation of drugs for the treatment or prevention of renal cancer or prostate cancer. According to the application, an experiment shows that the 1,2,3,4,6-pentagalloylglucose can significantly reduce the cell activity of Renca renal cancer and RM-1 prostate cancer in vitro, can reduce the tumor weight of tumor bearing mice in vivo, and it is proved that the 1,2,3,4,6-pentagalloylglucose has an inhibitory effect on two kinds oftumors, and PD-L1 gene expression is detected in two kinds of tumor bearing mice, so that it can be preliminarily inferred that the 1,2,3,4,6-pentagalloylglucose may play an anti-tumor role mainly byblocking PD1/PD-L1.

The present invention discloses one kind of soft capsule of tonkin sophora root total alkaloid. The soft capsule consists of two parts, inclusion and covering. The inclusion includes Tonkin sophora root total alkaloid, dispersing medium and stabilizer; and the covering includes gelatin, glycerin, water and preservative. The present invention also discloses the preparation process. The preparation process is simple, and the soft capsule of tonkin sophora root total alkaloid has high stability, controllable quality, easy taking and high antitumor effect.

The invention relates to a traditional Chinese medicinal composition, and concretely relates to an antitumor traditional Chinese medicinal composition and an antitumor active component composition, and a use and a preparation thereof. The antitumor traditional Chinese medicinal composition comprises, by weight, 30-60 parts of Panax Notoginseng, 5-15 parts of artificial bezoar, 1-8 parts of artificial musk and 1-10 parts of snake galls. The antitumor active component composition comprises, by weight, 10-30 parts of Panax notoginseng saponins, 1-8 parts of cholic acid, 0.1-1 part of musk ketoneand 0.1-1 part of taurocholic acid. The traditional Chinese medicinal composition or the active component composition has the advantages of low price, clear components, clear mechanism, accurate dosage, safety and effectiveness, and is used for preventing or treating various malignant tumors.

The present invention relates to a picrasma quassioides extract obtained by using Chinese medicinal material picrasma quassioides as raw material and adopting solvent extraction and resin separation and purification processes. The total alkaloid content in said extract is above 50%. Said invention also provides a pure Chinese medicine preparation containing said picrasma quassioides extract for resisting tumor and its concrete preparation method.

The present invention discloses c-MYC-siRNA formulation as a potential therapeutic target for cisplatin-resistant ovarian cancer. It is disclosed targeting c-MYC with small interfering RNA (siRNA) in the cisplatin-resistant ovarian cancer cell line inducing a significant cell growth arrest and inhibition of cell proliferation. Apoptosis and arrest of cell cycle progression were also observed after c-MYC-siRNA-based silencing of c-MYC. Furthermore, delivering nanoliposomal c-MYC-siRNA, decreased tumor weight and number of tumor nodules compared with a liposomal-negative control siRNA.

The invention relates to a KD (ketogenic-diet) composition eaten by tumor patients and a preparation method of the KD composition. The composition comprises raw materials in parts by mass as follows:1 part of fats, 0.1-0.8 part of protein, 0.2-0.4 part of dietary fiber and 0.05-0.2 part of whole silkworm freeze-dried powder. The whole silkworm freeze-dried powder is freeze-dried powder obtained after ultralow-temperature freezing and crushing of adult silkworms. The preparation method of the KD composition comprises the 5 steps as follows: raw material cleaning, ultralow-temperature freezing,spray drying, powdering and mixing, disinfection and packaging. In the KD composition, the dietary fiber and the whole silkworm freeze-dried powder are added clearly, and the proportions of the dietary fiber and the whole silkworm freeze-dried powder are clear; and the KD composition can supplement high-quality protein through the whole silkworm freeze-dried powder and enhance immunity, KD can selectively make tumor cells hungry, physiological ketonemia can regulate key accesses in production and development of tumor, anti-tumor acting bodies can be produced, and the KD composition can be directly eaten by various cancer patients as a food therapy substance.

The invention belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating brain glioma as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following ingredients by weight: 20 parts of ganoderma, 6 parts of mint, 10 parts of cenchrus echinatus, 10 parts of purslane, 10 parts of malus hupehensis leaf, 20 parts of astragalus membranaceus, 15 parts of ligusticum wallichii, 13 parts of hairyvein agrimonia herb and bud, 5 parts of turmeric, 5 parts of lily, 10 parts of radix paeoniae rubra, 12 parts of radix codonopsitis, 8 parts of panax notoginseng, 9 parts of coptis chinensis, 11 parts of centella, 4 parts of lucid asparagus, and 10 parts of poria cocos. The traditional Chinese medicine composition has an excellent curative effect on treating brain glioma, and has a remarkable clinical popularization value.

The invention relates to a traditional Chinese medicine composition for treating glioma and a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition for treating glioma comprises the following components in parts by weight: 20 parts of semen cuscutae, 6 parts of radix cynanchi paniculati, 10 parts of radix et caulis acanthopanacis senticosi, 10 parts of herba plantaginis, 10 parts of fructus evodiae, 20 parts of wogonin, 15 parts of rehmannia dride rhizome, 13 parts of rhizoma arisaematis, 5 parts of wormwood, 5 parts of semen ziziphi spinosae, 10 parts of flos lonicerae, 12 parts of fructus gardeniae preparatus, 8 parts of radix sanguisorbae, 9 parts of herba hedyotis, 11 parts of radix puerariae, 4 parts of tripterygium wilfordii hook. f and 10 parts of radix glycyrrhizae. The traditional Chinese medicine composition achieves a good treatment effect on the aspect of treating glioma, and has significant clinical popularization values.

The invention discloses preparation of a dendrobium officinale polysaccharide lozenge and an application of the dendrobium officinale polysaccharide lozenge in immunopotentiation. The total extractionprocess of the polysaccharide comprises the following steps: decocting and extracting dendrobium officinale coarse powder with 40 times of water for 2 hours, filtering, concentrating the filtrate to0.2 g of crude drug/ml, and precipitating with 5 times of ethanol by a water extraction and alcohol precipitation method to obtain the dendrobium officinale polysaccharide powder. The mannitol, aspartame, magnesium stearate, microcrystalline cellulose, menthol and povidone are added into the dendrobium polysaccharide powder to prepare lozenge. The lozenge can improve yin deficiency symptoms of yindeficiency model mice caused by thyroid hormone. Peripheral blood leukocyte WBC reduction of S180 tumor-bearing mice caused by 60Co radiotherapy is improved, and the number of bone marrow nucleated cells is increased. The effects of improving the activity of the body, resisting oxidative damage and enhancing immunity are shown. The dendrobium officinale polysaccharide lozenge prepared by the optimal dendrobium officinale polysaccharide extraction process screened by the invention has an obvious immunopotentiation effect, and can be used in the fields of immunopotentiation medicines, health-care products and foods.

The invention belongs to the technical field of medicines, and particularly relates to a camptothecin-based dimer compound as well as preparation and application thereof. The dimer compound has a structure represented by a formula (I), wherein in the formula (I), m is an integer of 1-4, and n is an integer of 1-4. The dimer compound is connected with camptothecin and immunomodulatory small molecules NLG919 through reductive disulfide bonds, so that combination of tumor chemotherapy and immunotherapy is realized, and the anti-tumor curative effect is enhanced. The compound prepared by the invention can be reduced into original camptothecin and NLG919 under a reducing condition, has good anti-tumor activity in tumors such as liver cancer, breast cancer, colon cancer, melanoma, ovarian cancerand the like, and can be used for inhibiting the activity of indoleamine 2,3-oxygenase, increasing DC cell maturation and reducing the number of immunosuppressive Treg cells; the drug resistance of tumor stem cells to camptothecin is reduced, and the tumor immune response is enhanced.

The present disclosure is drawn to the combination therapy of a C—C Chemokine Receptor 4 (CCR4) antagonist and one or more immune checkpoint inhibitors in the treatment of cancer.

The invention discloses a synergetic medicinal composition for nasopharynx cancer chemoradiotherapy, and aims to solve the treatment problem of nasopharynx cancer. The synergetic medicinal composition is characterized by comprising the following raw medicinal materials in percentage by weight: elsholtzia rugulosa, pungent litse flower, leycesteria formosa, rhizoma pinelliae, polygonum multiflorum, trifolium pratense, groundsel, Chinese honey locust, acorus gramineus, cassia twig and peach gum. The clinical experiments show that the synergetic medicinal composition is synergetic with the chemotherapy, good in in curative effect, high in safety, and worthy of clinical application and popularization.

The present invention relates to a method of treating leukemia using rice prolamin, comprising administering a daily dose of isolated prolamin to a patient suffering from leukemia for a period of time from 5 days to 10 days. For the treatment application, the rice prolamin can stimulate human peripheral blood mononuclear cell (PBMC) to produce cytokines, such as tumor necrosis factor-alpha, to inhibit growth of and induce differentiation of human leukemia cells. The rice prolamin is gluten-free, thus will not trigger gastrointestinal allergic reaction, it also can decrease the tumor weight without changes in body weight and can inhibit the growth of peripheral blood leukocyte in leukemia mouse model.

The invention discloses a preparation method of a nasopharynx cancer chemoradiotherapy assisting skin ointment, and aims to solve the treatment problem of nasopharynx cancer. The preparation method is characterized by comprising the following steps: (1) extracting volatile oil from groundsel, acorus gramineus and polygonum multiflorum coarse powder for later use; (2) grinding Chinese honey locust and peach gum to form fine powder for later use; (3) conducting aqueous extraction on elsholtzia rugulosa, pungent litse flower, leycesteria formosa, rhizoma pinelliae (decocted in a bag), trifolium pratense, cassia twig and the dregs obtained in the step 1, and conducting vacuum concentration and drying to obtain a primary material; (4) heating sesame oil, adding pine needles to the heated oil, filtering the oil material, adding the primary material and the Chinese honey locust and peach gum powder to the oil material at 120 DEG C, cooling, spraying the volatile oil, mixing uniformly, and subpackaging to obtain the product. The clinical experiments show that the nasopharynx cancer chemoradiotherapy assisting skin ointment is synergetic with the chemotherapy, good in in curative effect, high in safety, and worthy of clinical application and popularization.

The invention discloses antitumor application of an apios americana flower ethanol extract. The antitumor application is characterized in that subcutaneous area of a nude mouse is inoculated with a hepatoma carcinoma cell Huh7 to form a tumor; meanwhile, the intervention of the apios americana flower ethanol extract is performed, and change conditions of body weight of the nude mouse in the experiment process are monitored. After an intervention experiment is ended, a subcutaneous tumor is stripped off, the weight of the tumor is recorded and secretion conditions of cytokines in serum are monitored, so that the intervention of the apios americana flower ethanol extract has obvious antitumor effect.