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Total alkaloids of subprostrate sophora root soft capsules and preparation method and application thereof

A technology of total alkaloids and soft capsules, which can be used in capsule delivery, drug combination, and pharmaceutical formulations. Dosage, the effect of reducing toxic and side effects

Active Publication Date: 2007-11-28
北大世佳科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Chinese patent with the publication number CN1457778A discloses the oral preparation, preparation method and application of the root of the mountain bean root, and mainly relates to a liver-protecting oral preparation made from the active ingredient extract of the root of the mountain root. The patent adopts conventional acid-base adjustment The pH value method prepares the root extract of the mountain bean root, the technical content is low, the use amount of the acid and alkali is too large, and the environmental pollution is large; The content of alkaloids only shows that the content of matrine in the total alkaloids is ≥ 70%, making it difficult to control the quality of preparations made from this extract
It also increases the risk of using the preparation

Method used

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  • Total alkaloids of subprostrate sophora root soft capsules and preparation method and application thereof
  • Total alkaloids of subprostrate sophora root soft capsules and preparation method and application thereof
  • Total alkaloids of subprostrate sophora root soft capsules and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1: the preparation method of Shandougen total alkaloid soft capsule

[0050] Composition and weight ratio of contents: total alkaloids of bean root: dispersion medium (soybean oil): beeswax = 1:0.8:0.125

[0051] Capsule shell composition and weight ratio: gelatin: glycerin: water: padin ethyl ester = 0.8: 0.5: 1: 0.002

[0052] Take beeswax and put it in soybean oil, heat until dissolved, add the total alkaloids of bean root, mix well, let cool to room temperature, and get the contents of the soft capsule; take the gelatin, glycerin and water in the above ratio, mix well, filter, and add the filtrate Nipponin ethyl ester, mixed evenly, to prepare soft capsule capsule material; adopting pressing method, pressing No. 5 soft capsule, setting the shape, washing the pills, drying, and obtaining the total alkaloid soft capsule of Shandougen.

Embodiment 2

[0053] Embodiment 2: the preparation method of Shandougen total alkaloid soft capsule

[0054] Composition and weight ratio of contents: total alkaloids of bean root: dispersion medium (glycerol: polyethylene glycol = 1: 1.5) = 0.8: 2.5

[0055] Capsule shell composition and weight ratio: gelatin: glycerin: polyethylene glycol: water = 1: 0.35: 0.12: 1.2

[0056] Take the total alkaloids of bean root, mix them with glycerin in a water bath at 65°C, and disperse evenly, then add polyethylene glycol to stir, and mix evenly to obtain the contents of soft capsules; take the gelatin, glycerin, Mix water and polyethylene glycol uniformly to prepare soft capsule capsule material; use pressing method to compress No. 6 soft capsule, set the shape, wash the pills, and dry to obtain the total alkaloid soft capsule of Shandougen.

Embodiment 3

[0057] Embodiment 3: the preparation method of Shandougen total alkaloid soft capsule

[0058] Contents composition and weight ratio: total alkaloids of bean root: dispersion medium (glycerol: propylene glycol = 1: 2) = 1.2: 3

[0059] Capsule shell composition and weight ratio: gelatin: glycerin: water: methyl sorbate = 1.2: 0.2: 1: 0.005

[0060] Take the total alkaloids of bean root, mix them with glycerin in a water bath at 65°C, and disperse evenly, then add propylene glycol to stir, and mix evenly to obtain the contents of soft capsules; take the gelatin, glycerin, and water in the above ratio and mix evenly , filtered, and the filtrate was added with methyl sorbate, mixed evenly, to prepare the soft capsule capsule material; the No. 6 soft capsule was pressed by the compression method, shaped, the pills were washed, and dried to obtain the total alkaloid soft capsule of Soba root.

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Abstract

The present invention discloses one kind of soft capsule of tonkin sophora root total alkaloid. The soft capsule consists of two parts, inclusion and covering. The inclusion includes Tonkin sophora root total alkaloid, dispersing medium and stabilizer; and the covering includes gelatin, glycerin, water and preservative. The present invention also discloses the preparation process. The preparation process is simple, and the soft capsule of tonkin sophora root total alkaloid has high stability, controllable quality, easy taking and high antitumor effect.

Description

technical field [0001] The invention belongs to the field of research and development of new traditional Chinese medicines. In particular, it relates to a soft capsule preparation of total alkaloids of bean root and a preparation method thereof, and at the same time, the invention also relates to the application of the preparation in the preparation of antitumor drugs. Background technique [0002] Shandou root is derived from the dried roots and rhizomes of Sophora tonkinesis Gapnep, a leguminous plant. It is bitter in taste, cold in nature, and poisonous. Return lung, stomach warp. Functions and indications: clearing away heat and detoxification, reducing swelling and relieving sore throat. For accumulation of fire and poison, sore throat, gingival swelling and pain. It is a medicine for clearing throat, reducing swelling and relieving pain. The efficacy of Shandougen was first recorded in "Kaibao Materia Medica": "It mainly relieves the poison of various medicines, r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61K9/48A61K47/34A61P35/00A61K47/10
Inventor 周亚伟
Owner 北大世佳科技开发有限公司
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