3 results about "Sophora Root" patented technology

The invention discloses a cattle feed additive. The cattle feed additive consists of the following raw materials in parts by weight: 4-16 parts of perilla frutescens, 2-20 parts of cyrtomium rhizomes, 10-30 parts of cod-liver oil, 2-10 parts of sodium selenite, 3-13 parts of Haixiao, 5-25 parts of radix polygalae, 2-12 parts of longan aril, 4-20 parts of Chinese yam rhizomes, 5-25 parts of vietnamese sophora roots, 3-17 parts of folium isatidis, 2-12 parts of endothelium corneum gigeriae galli, 4-16 parts of actinolitum brevifibrum, 2-12 parts of herba asari, 4-12 parts of origanum vulgare, 3-13 parts of Chinese pulsatilla roots, 4-16 parts of fleeceflower roots, 2-18 parts of radix achyranthis bidentatae, 1-9 parts of a bacillus natto agent, 2-10 parts of bacillus and 1-7 parts of active dry yeast. The cattle feed additive disclosed by the invention has the advantages of being rich in nutrition, capable of improving beef quality, increasing the survival rate of cattle and the like.

The invention discloses an application of subprostrate alkali in preparation of a melanoma immunotherapy drug, and relates to the technical field of medicines, and the subprostrate alkali is used for immunotherapy of melanoma by down-regulating the PD-1 protein level in T cells. Downregulation of the PD-1 protein level in T cells is realized by promoting ubiquitination of PD-1 through subprostrate alkali and inducing degradation of PD-1 through an endosome-lysosome way; the subprostrate alkali inhibits growth of melanoma by enhancing immune killing ability of T cells on melanoma cells and promoting immune infiltration of the T cells, can effectively promote ubiquitination modification of PD-1 protein in the T cells and induce degradation of the PD-1 protein in an endosome-lysosome way, so that the protein expression level of PD-1 is remarkably reduced, and the subprostrate alkali can be used for preparing a medicine for treating melanoma. The action does not depend on gene transcriptional regulation, the subprostrate alkali can obviously enhance the immune killing ability of the T cells to melanoma cells, and the survival rate of the tumor cells is obviously reduced in a co-culture system.