The invention provides a lightyellow
sophora root
fermentation extract, a preparation method and application in an anti-
hair loss product, the preparation method comprises the following steps: step 1, soaking lightyellow
sophora root in water,
cutting up, then inoculating a
paecilomyces cicadae seed solution for
fermentation culture, and after
paecilomyces cicadae
mycelium overgrows the lightyellow
sophora root,
drying to obtain a
paecilomyces cicadae-lightyellow
sophora root bidirectional
fermentation product; and 2, crushing the
paecilomyces cicadae-radix sophorae flavescentis bidirectional fermentation product, extracting by adopting a
bifidobacterium liquid fermentation extraction method, or a
hot water extraction method or an absolute ethyl
alcohol extraction method, and
drying to obtain the radix sophorae flavescentis fermentation extract. The
sophora flavescens fermentation extract prepared by the method has good II type 5 alpha
reductase inhibition capability, and the
ethanol extract CH-KS-A of the
penicillium-
sophora flavescens bidirectional fermentation product particularly has broad-spectrum
antibacterial activity on
staphylococcus aureus,
propionibacterium acnes and
malassezia furfur, and has good anti-inflammatory and
antioxidant activity; the composition can be used in anti-
hair loss products.