This invention relates to the field of *
Penicillium cicadae* technology, specifically to a high-efficiency
fermentation process for *
Penicillium cicadae* based on a composite culture medium, comprising the following steps: inoculating *
Penicillium cicadae* strain into a composite culture medium; subsequently controlling temperature and
aeration according to the
fermentation stage; adding a
metabolism promoter after 72 hours of
fermentation; and obtaining the
fermentation broth and separating *Penicillium cicadae* after fermentation. This invention rapidly delivers nutrients in a
liquid phase to promote rapid mycelial proliferation, while utilizing the porous structure of the
solid phase to enhance the adsorption and expansion capacity of the
mycelium, thereby increasing mycelial density and the synthesis efficiency of metabolically active substances. A precise
temperature control strategy matches the physiological transition from mycelial growth to product accumulation, ensuring
enzyme activity and reducing heat damage. The addition of a
metabolism promoter synergistically stimulates the efficient expression of target metabolites, improving the yield and quality of the target product.