The invention relates to the technical field of
paecilomyces cicadae, in particular to an efficient
paecilomyces cicadae
fermentation process based on a composite culture medium, which comprises the following steps: inoculating
paecilomyces cicadae strain into the composite culture medium; then regulating and controlling the temperature and the ventilatory capacity according to the
fermentation stage; meanwhile, adding a
metabolism accelerant after fermenting for 72 hours; and after
fermentation is completed, obtaining fermentation liquor, and separating to obtain
paecilomyces cicadae.
Nutrient substances are rapidly conveyed through the
liquid phase to promote rapid proliferation of hyphae, meanwhile, the adsorption and expansion capacity of the hyphae is enhanced through the porous structure of the
solid phase, and therefore the density of the hyphae and the synthesis efficiency of metabolic active substances are improved; a precise
temperature control strategy is matched with physiological transformation from
hypha growth to product accumulation,
enzyme activity is guaranteed, and heat damage is reduced; and the
metabolism accelerant is added to synergistically stimulate the high-efficiency expression of the target
metabolite, so that the yield and quality of the target product are improved.