Efficient fermentation process of paecilomyces fumosaeruleus based on complex medium

By using a composite culture medium and a multi-stage temperature-controlled fermentation process for *Penicillium ciliata*, the problem that traditional culture media cannot meet the complex nutritional needs of *Penicillium ciliata* was solved, achieving efficient synthesis of mycelial density and metabolically active substances, and improving product yield and quality.

CN120737979BActive Publication Date: 2026-05-26青岛海科生物技术有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
青岛海科生物技术有限公司
Filing Date
2025-08-04
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing technologies using traditional single-component liquid culture media and fixed fermentation parameters cannot meet the complex nutritional needs of *Penicillium cicadae* at different growth stages, resulting in limited microbial growth, low yield of metabolites, and long fermentation cycles.

Method used

A fermentation process based on a composite culture medium is adopted, which provides a porous structure and rapid nutrient delivery through the combination of liquid and solid phases. Combined with three-stage temperature control and the use of metabolic promoters, mycelial growth and metabolic activity are optimized.

Benefits of technology

It improved mycelial density and the synthesis efficiency of metabolically active substances, shortened the fermentation cycle, and increased the yield and quality of the target product.

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Abstract

This invention relates to the field of *Penicillium cicadae* technology, specifically to a high-efficiency fermentation process for *Penicillium cicadae* based on a composite culture medium, comprising the following steps: inoculating *Penicillium cicadae* strain into a composite culture medium; subsequently controlling temperature and aeration according to the fermentation stage; adding a metabolism promoter after 72 hours of fermentation; and obtaining the fermentation broth and separating *Penicillium cicadae* after fermentation. This invention rapidly delivers nutrients in a liquid phase to promote rapid mycelial proliferation, while utilizing the porous structure of the solid phase to enhance the adsorption and expansion capacity of the mycelium, thereby increasing mycelial density and the synthesis efficiency of metabolically active substances. A precise temperature control strategy matches the physiological transition from mycelial growth to product accumulation, ensuring enzyme activity and reducing heat damage. The addition of a metabolism promoter synergistically stimulates the efficient expression of target metabolites, improving the yield and quality of the target product.
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Citation Information

Patent Citations

  • Method for artificially culturing paecilomyces cicadae and application of culturing product thereof

    CN102242070A

  • Rapid liquid submerged fermentation method for producing paecilomyces cicadae powder

    CN105647814A

  • Paecilomyces cicadae fermentation culture medium and method for preparing ergosterol by paecilomyces cicadae fermentation

    CN109749941A