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248 results about "Ergosterol" patented technology
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Ergosterol (ergosta-5,7,22-trien-3β-ol) is a sterol found in cell membranes of fungi and protozoa, serving many of the same functions that cholesterol serves in animal cells. Because many fungi and protozoa cannot survive without ergosterol, the enzymes that synthesize it have become important targets for drug discovery. In human nutrition, ergosterol is a provitamin form of vitamin D₂; exposure to ultraviolet (UV) light causes a chemical reaction that produces vitamin D₂.
Method for production of isoprenoids
The present invention is directed to variant squalene synthase enzymes, including Saccharomyces cerevisiae squalene synthase enzymes, and to nucleic acid molecules encoding these variant enzymes. These variant enzymes produce squalene at a lower rate than the wild-type enzyme, allowing more farnesyl pyrophosphate to be utilized for production of isoprenoid compounds, while still producing sufficient squalene to allow the S. cerevisiae cells to grow without the requirement for supplementation by sterols such as ergosterol. These variant enzymes, therefore, are highly suitable for the efficient production of isoprenoids.
Owner:EVOLVA INC
Method for propagating fungi using solid state fermentation
InactiveUS6558943B1Easy to produceIncrease productionBiocideOrganic active ingredientsLiquid mediumCulture mediums
A solid state fermentation (SSF) method is provided which is effective for both small- and large-scale fungal cultivation. Also provided is SSF media for fungal cultivation. The media preferably contains a carbon source and nitrogen source to provide a carbon to nitrogen ratio of about 5:1 to about 25:1 by weight. The media may also contain a vitamin and an inorganic substance. A preferred SSF medium contains malt extract, yeast extract, peptone, glucose, water, solid base, and calcium carbonate or gypsum. Before propagating fungal mycelia in the SSF medium, the mycelia may be pre-cultivated in a solid culture medium and then in a liquid medium. Although the SSF method can be used in growing most fungi, preferred fungi include Cordyceps sinensis, Ganoderma lucidum, Antrodia camphorata, Trametes versicolor, and Agaricus blazei. The SSF method not only produces high yield of fungi, but also stimulates the production of fungal metabolites, particularly the kinds with pharmaceutical and medicinal activities. Cordyceps sinensis is preferably grown to produce the active compound H1A which is a derivative of ergosterol.
Owner:KING ANTICANCERING BIOTECH +1
Flours produced from fungus myceliated grain
The present patent relates to a method for producing flours from grain myceliated with macroscopic fungi (mushrooms). These flours can be used to prepare food for human consumption, such as bread and biscuits, and for animal consumption, such as fodder. Active principles (ergosterol, beta glucan, linoleic and oleic acids, lectins), enzymes, proteins, amino acids, vitamins, mineral salts, inter alia, can also be extracted from these flours for use in the chemical, foodstuff and cosmetic industries, for producing phytotherapeutic agents, pharmaceuticals, textiles, paper products, pharmaceuticals and fodder for animals.
Owner:EMPRESA BRASILEIRA DE PESQUISA AGROPECUARIA EMBRAPA +2
Cnidiadin and its built composition for preventing and controlling crop powdery mildew
The present invention provides the application of cnidiadin in preventing and controlling powdery mildew of crop and agricultural chemical composition for preventing and controlling powdery mildew of crop. The agricultural chemical composition consists of cnidiadin and one kind of germicide for inhibiting the synthesis of fungal ergosterol and selected from myclobutanil, triazolone, tebuconazole and propiconazol in the weight ratio of 1 to 1-20, preferably 1 to 1-10. It is especially suitable for preventing and controlling powdery mildew of cucumber, pumpkin, strawberry horse bean and grape.
Owner:JIANGSU ACAD OF AGRI SCI
Method for measuring sterol in tobaccos
InactiveCN101963604AEasy to quantifyTest accurateComponent separationNicotiana tabacumDerivatization
The invention discloses a method for measuring sterol in tobaccos. The method comprises the following steps of: (1) deploying sterol standard templates containing internal standard with different concentrations, carrying out GC-MS (Gas Chromatography-Mass Spectrometer) analysis after derivatization, and plotting by utilizing the ratio of the sterol to internal standard peak area and the ratio of the sterol to internal standard concentration to obtain a standard curve; (2) carrying out acid hydrolysis, saponification and direct ultrasonic extraction on samples to be measured, and taking 1 muL for carrying out GC-MS analysis after derivatization; and (3) reading the ratio of the sterol to the internal standard concentration from the standard curve by utilizing the ratio of the sterol to theinternal standard peak area, and then calculating the amount of the sterol. The invention can be used for analyzing cholesterol, ergosterol, campesterol, stigmasterol and beta-sitosterol with a plurality of forms in tobacco leaves at the same time, has the advantages of accurate measurement and simple and convenient operation, and can be widely applied to tobacco industry.
Owner:CHINA TOBACCO SICHUAN IND CO LTD +1
Compositions and methods for detecting and killing termites
Significant concentrations of naphthalene were detected in carton nests of Formosan subterranean termites, Coptotermes formosanus Shiraki, collected from Florida, Hawaii, and Louisiana. This is the first report of naphthalene being associated with termites or any other insects. Naphthalene and other compounds associated with termite carton nests may be used to increase termite bait acceptance. New attractant molecules include 2-phenoxyethanol. New feeding stimulants include ergosterol. A list of volatile compounds associated with termite nests is presented, compounds that may be used to detect termite nests.
Owner:BOARD OF SUPERVISORS OF LOUISIANA STATE UNIV & AGRI & MECHANICAL COLLEGE
Inhibitors and Enhancers of Uridine Diphosphate-Glucuronosyltransferase 2B (UGT2B)
ActiveUS20090074708A1Increase heightReduced activityBiocideHydroxy compound active ingredientsPolyethylene glycolEriodictyol
A UGT2B inhibitor capable of increasing the bio-availability of a drug, is a compound in a free base or a pharmaceutically acceptable salt form that is selected from the group consisting of: capillarisin, isorhamnetin, β-naphthoflavone, α-naphthoflavone, hesperetin, terpineol, (+)-limonene, β-myrcene, swertiamarin, eriodictyol, cineole, apigenin, baicalin, ursolic acid, isovitexin, lauryl alcohol, puerarin, trans-cinnamaldehyde, 3-phenylpropyl acetate, isoliquritigenin, paeoniflorin, gallic acid, genistein, glycyrrhizin, protocatechuic acid, ethyl myristate, umbelliferone, PEG (Polyethylene glycol) 400, PEG 2000, PEG 4000, Tween 20, Tween 60, Tween 80, BRIJ® 58, BRIJ® 76, Pluronic® F68, Pluronic® F127, and a combination thereof. A UGT2B enhancer capable of enhancing a clearance rate of morphine-like analgesic agents, is a compound in a free base or a pharmaceutically acceptable salt form that is selected from the group consisting of: nordihydroguaiaretic acid, wogonin, trans-cinnamic acid, baicalein, quercetin, daidzein, oleanolic acid, homoorientin, hesperetin, narigin, neohesperidin, (+)-epicatechin, hesperidin, liquiritin, eriodictyol, formononetin, quercitrin, genkwanin, kaempferol, isoquercitrin, (+)-catechin, naringenin, daidzin, (−)-epicatechin, luteolin-7-glucoside, ergosterol, rutin, luteolin, ethyl myristate, apigenin, 3-phenylpropyl acetate, umbelliferone, glycyrrhizin, protocatechuic acid, poncirin, isovitexin, 6-gingerol, cineole, genistein, trans-cinnamaldehyde, and a combination thereof.
Owner:NAT DEFENSE MEDICAL CENT
Method for simultaneous production of ergosterol and glutathione by yeast fermentation
ActiveCN1844407AIncrease profitEasy to synthesizeMicroorganism based processesFermentationSucroseMetabolite
The invention discloses a method of yeast fermentation coproduction ergot sterol and glutathion, utilizing conspecific yeast bacterial fermentation to produce simultaneous two kinds of metabolite-ergot sterol and glutathion, the utilization bacterial of fermentation is Saccharomyces cerevisiae, candida utilis, candida tropicalis or engineering bacterial reconstructed by mutagenesis and gene engineering, the utilization yeast culture medium contain the carbon source such as glucose, cereal mash, sucrose molasses and so on, the nitrogen source such as maize milk, yeast powder, protease leather, carbonyldiamide, ammonia and so on, inorganic salt and the metallic ion that the yeast need. The invention utilizes fermentation coproduction ergot sterol and glutathion, simultaneously, accomplish high-density culture of the yeast cell, and make the biomass of yeast expression coproduction come up to the standard of the high level in individual fermentation ergot sterol and glutathion, full utilization culture medium substrate, increasing availability ratio of raw material, decreasing the cost of manufacture.
Owner:BEIJING UNIV OF CHEM TECH
Methods for preparing cholesterol, and derivatives and analogs thereof
The present invention relates to the field of pharmaceutical chemistry, and in particular to methods of preparing cholesterol,and derivatives and analogs thereof. The cholesterol derivatives include, but not limited to, 7-dehydrocholesterol, 25-hydroxycholesterol, 25- hydroxy7dehydrocholesterol and ergosterol. In the invention, phytosterol can be used as a raw material to prepare the compound shown in the formula I through microbial conversion, and then cholesterol and the derivatives and analogues thereof are prepared.
Owner:HUNAN KEREY BIOTECH
Cnidiadin and its built composition for preventing and controlling crop powdery mildew
Owner:JIANGSU ACAD OF AGRI SCI
Method for increasing vitamin D2 in edible mushrooms
InactiveCN108185408AOther quality effectsDoes not cause changes in color and shapeFood scienceVitamina D2Edible mushroom
The invention provides a processing method for increasing vitamin D2 in edible mushrooms. The processing method comprises the following steps of performing radiation treatment on the edible mushroomsby pulse glare, wherein the spectral of pulse glare consists of UV-A of which the wavelength is 315nm-400nm, UV-B of which the wavelength is 280nm-315nm and UV-C of which the wavelength is 200nm-280nm. According to the processing method disclosed by the invention, the pulse glare treatment is adopted, so that the situation that ergosterol in the edible mushrooms is converted into vitamin D2 can bequickly promoted, and the effect of the processing method is far better than that of ultraviolet radiation; and before the pulse glare treatment is performed, the edible mushrooms are cut into slices, so that the conversion rate of the ergosterol can be obviously increased, and the browning reaction degree of fruiting bodies cannot be increased.
Owner:陈麒宇
Cordyceps sinensis health-care edible oil
InactiveCN101926393AMeet health needsImprove disease resistanceEdible oils/fatsFood preparationAdditive ingredientCoronary heart disease
The invention discloses cordyceps sinensis health-care edible oil, which is mainly characterized by adding the active ingredients of cordyceps sinensis to the edible oil. The product not only has the functions of the traditional edible oil, but also has various active ingredients contained in cordyceps sinensis, such as polysaccharides, mannitol, ergosterol, nucleoside, etc, has the health-care effects of improving immunity, protecting hepatic and nephridial tissues, resisting inflammation, resisting tumors, resisting pathogenic microorganisms, resisting fatigue, delaying aging, nourishing kidney and deficiency, nourishing yin and tonifying yang, moistening lung to relieve asthma, maintaining beauty, preventing arrhythmia, coronary heart disease and angina, etc and can promote the appetite, thus achieving the effects of health care and seasoning.
Owner:朱宗强
Anticancer Composition for Oral Use Comprising Liposome Containing Phytosterols and Prevention or Treatment for Cancer Using the Liposome
InactiveUS20080102111A1Significantly inhibit cancer metastasisInhibiting cancer metastasisOrganic active ingredientsBiocideOral medicationCancer metastasis
A novel use is disclosed of liposomes that contain phytosterol (e.g., β-sitosterol, campesterol, stigmasterol, brassicasterol, ergosterol, and ergostadienol, and so forth). It has been newly discovered that liposomes that contain phytosterol have a cancer metastasis inhibiting activity. Cancer metastasis is inhibited by the oral administration of liposomes that contain phytosterol and these liposomes are therefore useful for the prevention and treatment of cancer.
Owner:SUNSTAR INC
Pesticidal Compound Mixtures
InactiveUS20110212834A1Reduced dose rateBroaden spectrumBiocideDead animal preservationTransfluthrinErgosterol biosynthesis
The present invention relates to novel pesticidal compositions comprisingas component A: transfluthrin,as component B: an inhibitor of ergosterol biosynthesis,that show surprisingly good insecticidal, acaricidal, nematicidal and fungicidal activities. In particular, these compositions are suited for the treatment of seed.
Owner:BAYER CROPSCIENCE AG
Anti-virus feed additive for reducing cholesterol, production process thereof and application
ActiveCN101637220AReduce cholesterolReduce the effect of disease preventionPeptide/protein ingredientsMetabolism disorderAnti virusAir filtration
The invention relates to an anti-virus feed additive for reducing cholesterol, a production process thereof and application, which belong to the technical field of biological products. The additive comprises the following effective components in percentage by weight: 90 to 95 percent of unsaturated fatty acid, 1 to 5 percent of glucosamine, 1.5 to 5 percent of organic acid, 1.5 to 5 percent of ergosterol and 1 to 6 percent of beta glucanase. The process flow comprises the following steps: (1) performing sterilization by fermentation equipment and sterile air filtration equipment; (2) cultivating bacterial strains; (3) fermenting; (4) extracting; and (5) spray-drying. The additive is added into feed of table poultries, laying hens, pigs, meat quails, egg quails, meat pigeons and laying pigeons in a small amount, can reduce meat and egg cholesterol of livestock and poultry effectively, reasonably and safely, has the anti-virus function, is not added with any Chinese or western medicinalpreparations and chemical compositions in the production process, and is a pure microbial fermentation additive.
Owner:山东环亿生物科技有限公司
Novel preparation method for nicergoline
InactiveCN103159756AQuality improvementHigh selectivityOrganic chemistryPhotocatalytic reactionSynthesis methods
The invention discloses a novel synthesis method for the raw material medicine of nicergoline (shown in formula I). The novel synthesis method disclosed by the invention comprises the following steps of: reacting ergosterol with 5-bromonicotinate derivatives to generate carboxylic ester; then performing a photocatalytic reaction with methanol in an acidic condition; and then performing a methylation reaction with a methylation reagent to generate nicergoline. With the adoption of the novel synthesis method disclosed by the invention, the cumbersome operation of the methods disclosed by the existing patents is avoided, the used solvent is low in toxicity, and the yield is high. The novel synthesis method is beneficial to industrialized popularization and application.
Owner:SHANDONG FANGMING PHARMACEUTICAL CO LTD
Preparation method of dydrogesterone intermediate
ActiveCN111171101AConcentrated luminous bandsHigh yieldChemical recyclingKetal steroidsPhotocatalytic reactionUltraviolet
The invention discloses a preparation method of a dydrogesterone intermediate. The preparation method is characterized by comprising the following steps: dissolving 5,7-diene steroid compound in an organic solvent to obtain a solution as a raw material; and carrying out a photocatalytic reaction and separating to obtain the dydrogesterone intermediate, wherein the 5,7-diene steroid compound is 7-dehydropregnenolone acetate, pregna-5,7-diene-3,20-diketodivinyl ketal, 7-dehydropregnenolone, ergosterol or pregna-5,7-diene-3,20-diketo-3-vinyl ketal, and a lamp used in the photocatalytic reaction comprises an LED ultraviolet lamp with the wavelength range of 295-335 nm. The preparation method of the dydrogesterone intermediate is high in yield, low in cost, safer in preparation and friendlier to environment.
Owner:上海璟兆实业有限公司
Solid fermentation tank as well as method for preparing red kojic rice by using solid fermentation tank and product prepared by method
The invention discloses a solid fermentation tank as well as a method for preparing red kojic rice by using the solid fermentation tank and a product prepared by the method, and belongs to the technical field of biological fermentation. The solid fermentation tank comprises a horizontal fermentation bucket, a temperature detecting opening, a humidity detecting opening, a pressure detecting opening, an inoculation opening, a sampling opening, a feeding hole, sight glass, an inlet pipe, an outlet pipe, a balance plate, a rolling bracket, a material baffle and an outside-bucket jacket. The method is used for preparing healthy nutritional red kojic rice by using the solid fermentation tank by the following steps: soaking materials; washing the materials; steaming the materials; cooling; separating; inoculating; mixing; keeping the temperature; keeping the humidity; fermenting; harvesting; and drying and the like. By virtue of the design of the invention, the environmental protection property, economic efficiency and stability of the solid fermentation tank as well as the homogeneity of the same batch of fermentation products are improved; the solid fermentation tank is applied to the preparation method; the preparation condition is optimized; the contents of red rice protein, red rice polysaccharide, ergosterol and amino acid in the prepared red kojic rice are respectively not lower than 3.0%, 2.0%, 1.0% and 1.0%; the limit amount of citrinin is not higher than 0.01mg / kg and the limit amount of monacolin K is not higher than 0.01%.
Owner:东莞市双红生物技术有限公司 +1
Production method and use of ergosterol
InactiveCN105884850AGood chromatographyClear resultOrganic active ingredientsAntinoxious agentsDissolutionSilica gel
The invention discloses a production method of ergosterol. The production method includes the following steps: adding an extracting solvent to a dried Monascus purpureus-fermented sample, extracting by an extraction process to obtain crude extract, eluting the crude extract by column chromatography to obtain primary purified eluent, subjecting the primary purified elution to silica gel thin-layer chromatography, combining eluents with same silica gel thin-layer chromatography results and performing column chromatography again to obtain secondary purified eluent, removing the solvent from the secondary purified eluent, and recrystallizing through petroleum ether to obtain ergosterol. The preparation of ergosterol from Monascus purpureus as material is provided for the first time, crude extract of the sample is extracted first, and an optimal column chromatography eluent is screened then according to distribution conditions and dissolutions in different solvents, so that ergosterol is isolated and purified effectively. The production method of the ergosterol is simple, easy to implement and low in time consumption, the material is easy to obtain and low in cost, and batch production of ergosterol is achieved.
Owner:周礼红
Method for extracting ergosterol from starch yeast
The invention belongs to the field of pharmaceutical intermediate and particularly discloses a method for extracting ergosterol from a starch yeast. The method comprises the following steps: (1) adding a solvent and a saponifying agent in the starch yeast containing the ergosterol to obtain to-be-filtered liquid I; (2) cooling and filtering the to-be-filtered liquid I; (3) adding an extracting agent in filter residues and stirring to obtain to-be-filtered liquid II; (4) cooling and filtering the to-be-filtered liquid II; (5) distilling a filtrate to obtain a crystal substance; (6) collecting the crystal substance, adding an extracting agent to re-dissolve, adding a coloring agent and stirring to obtain to-be-filtered liquid III; (7) filtering the hot to-be-filtered liquid III, collecting afiltrate and slowly cooling to precipitate out an ergosterol crude product; (8) adding a re-crystallization solvent in the collected ergosterol crude product, heating, then slowly reducing the temperature and collecting a crystal substance to obtain an ergosterol product. The method disclosed by the invention is short in short process; less in resource waste, resource-saving; high in product purity, less in harmful impurity and capable of environmental protection.
Owner:刘健
Preparation method of ginkgo leaf lipoid components having antibacterial activities
The invention discloses a preparation method of ginkgo leaf lipoid components having antibacterial activities. Ginkgo leaf which is a raw material is extracted with a non-polar solvent, and undergoes molecular distillation separation, column chromatography, re-crystallization and purification to obtain eight compounds (sequentially comprising isophytol, nerolidol, linalool, beta-sitosterol acetate, beta-sitosterol, stigmasterol, ergosterol and daucosterol), polypentenol, ginkgo leaf lipoid total unsaponifiable matters, ginkgo leaf lipoid crystals, a ginkgo leaf lipoid light fraction and a ginkgo leaf lipoid heavy friction. The eight compounds, polypentenol, the ginkgo leaf lipoid total unsaponifiable matters, the ginkgo leaf lipoid crystals, the ginkgo leaf lipoid light fraction and the ginkgo leaf lipoid heavy friction have inhibition effects on salmonellas, Staphylococcus aureus and Aspergillus niger.
Owner:邳州恒翔生物制品有限公司
Method for controlling quality of spore oil, powder and preparation of ganoderma lucidum
ActiveCN1872097AAccurate measurementEasy to operateComponent separationTesting medicinal preparationsSporeThin layer
An oil or powder of ganodema spore is disclosed. Its quality control method features that the efficient liquid-phase chromatographic method and the thin-layer scanning chromatography method are used to measure the content of ergosterol in the product.
Owner:GUANGZHOU HANFANG PHARMA
Method for produce monascus by using distillers' grain fermentation
InactiveCN103320473AImprove metabolic efficiencyGood effectMicroorganism based processesFermentationThermal insulationAlpha-amylase
Owner:ZHEJIANG GUOQU BIO TECH
Saccharomyces ergosterol high-producing strain, and breeding method and application for same
InactiveCN102911883AMild growing conditionsEasy to operateFungiMutant preparationMicrobiologyFermentation broth
The invention discloses a saccharomyces ergosterol high-producing strain, and a breeding method and application for the same. The saccharomyces ergosterol high-producing strain is named as saccharomyces cerevisiae scut-B6305 and is preserved in the China Center for Type Culture Collection in Wuhan, China, the preservation date is April 10, 2012, and the preservation number is CCTCC (China Center for Type Culture Collection) NO:M2012105. A saccharomyces lysate producing strain is continuously subjected to stress oriented domestication by dimethyl sulfoxide for a long time so as to breed the saccharomyces ergosterol high-producing strain. The content of ergosterol in unit cell of the saccharomyces ergosterol high-producing strain reaches 5.63mg / g and is increased by 30.32% as compared with the original strain, the production capacity of unit volume of fermentation liquor of the saccharomyces ergosterol high-producing strain is 90.8mg / 100mL and is 1.91 times of that of unit volume of fermentation liquor of the original strain, and the saccharomyces ergosterol high-producing strain can be used for obtaining the ergosterol during production.
Owner:SOUTH CHINA UNIV OF TECH
Preparation method of RGD peptide and penetrating peptide R8 co-modified ergosterol and cis-platinum active drug-loading liposome
ActiveCN105796592AHigh encapsulation efficiencySmall toxicityOrganic active ingredientsHeavy metal active ingredientsSide effectRGD peptide
The invention discloses a preparation method of an RGD peptide and penetrating peptide R8 co-modified ergosterol and cis-platinum active drug-loading liposome. The method comprises the main steps of ergosterol liposome preparation, ammonium chloride gradient formation, drug loading and co-modification. The method is simple in technology and easy to carry out, and the encapsulation rate of a drug is high; ergosterol is adopted to partially replace cis-platinum to exert efficacy, an ergosterol and cis-platinum active drug-loading liposome is obtained, the effect of resisting a lung cancer is guaranteed, the toxic and side effects of the drug are significantly reduced, and damage to human bodies is small; meanwhile, the RGD peptide and the penetrating peptide R8 serve as target heads, the targeting property is good, and the drug exertion effect is good.
Owner:ZHEJIANG CHINESE MEDICAL UNIVERSITY
Application of ergosterol and ergosterol liposome prepared from ergosterol
ActiveCN105769878AReduce harmTargetedOrganic active ingredientsRespiratory disorderCholesterolCytotoxicity
The invention discloses application of ergosterol and ergosterol liposome prepared from the ergosterol, and particularly relates to the application of the ergosterol on treating lung cancer, and the ergosterol liposome for treating the lung cancer. In the ergosterol liposome, the drug loading capacity of the ergosterol is 5-20 wt%; the liposome consists of lecithin and cholesterol, wherein the mole ratio of the lecithin to the cholesterol is (1:1)-(7:1). The ergosterol liposome disclosed by the invention has remarkable lung cancer resistant effects, low cytotoxicity, small damage to human bodies, and target ability.
Owner:ZHEJIANG CHINESE MEDICAL UNIVERSITY
Method for photochemically synthesizing vitamin D2 and D3 in tubular reactor
The invention relates to a method for photochemically synthesizing vitamin D2 and D3 in a tubular reactor. The method is characterized in that the vitamin D2 and D3 are synthesized by ultraviolet light of different bands, the residence time of reaction liquid fed at different times in the tubular reactor is controlled to be the same by not dissolving with reaction liquid, not participating in reaction liquid separation and carrying ergosterol and 7-dehydrocholesterol reaction liquid and enhancing internal disturbance of the reaction liquid; the method has the advantages of continuous, stable and high efficiency of solar energy utilization, the operation is simple, and the process is controllable; the method has great prospect in the industrial production of the photochemically synthesizedvitamin D2 and D3.
Owner:SHANDONG TSINGCHUANG CHEMICALSCO LTD +1
Truffle hydrophilic solvent extract and application of the same in preparing food, health food, and medicament for treating prostate gland disease etc.
The invention provides a truffle hydrophilic solvent extractive and a drug, food and the health food thereof containing the truffle hydrophilic solvent extractive. The preparation method of the truffle hydrophilic solvent extractive includes the step that a hydrophilic solvent is used for extracting truffle, and the truffle hydrophilic solvent extractive includes ergosterol and the fat type and has an obvious ultraviolet absorption at 195 to 220nm wavelength position. The invention also provides the application in preparing the drug for curing prostate disease, male sexual disorder and low immunizing power of a human body or the food or the health food for improving the associative function thereof by taking the extractive of the truffle in a hydrophilic solvent as the active ingredient.
Owner:曹晋忠
Method for photochemosynthesis of vitamin D2
InactiveCN1733718AIncrease concentrationIncreased crystallization yieldOrganic chemistryHigh concentrationLysergol
The invention relates to a method for photochemosynthesis of vitamin D2, which comprises dissolving lysergol into a mixed system of nonpolar-polar solvent at the presence of nitrogen protection, charging anti-oxidant, controlling temperature of the photochemical reaction solution at 23-30 deg C, guaranteeing high concentration with mixed solvent, controlling conversion rate of the lysergol below 35%, using non-reacted lysergol as the raw material for next photochemical reaction. The process can substantially increase the concentration of the reactants.
Owner:TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
Polyene Antibiotics, Compositions Containing Said Antibiotics, Method and Micro-Organisms Used to Obtain Same and Applications Thereof
InactiveUS20090221520A1Preventing polar effectClear pharmacological advantageAntibacterial agentsBiocideCell membraneAntibiotic Y
The invention relates to novel polyenes having formula (I), wherein: R1 represents alkyl C1-C3; and R2 represents a functional group selected from CH3— or CONH2— (methyl- or primary amide-). The aforementioned polyenes have a biocide action on organisms comprising cell membranes that contain ergosterol, e.g., fungi or parasites. Said compounds can be obtained using a method that consists in cultivating a producing micro-organism under conditions that enable the production thereof. In addition, the invention also relates to a mechanism for the in vitro production of amidated polyenes, consisting in incubating carboxylated polyenes with cell-free extracts (or proteinaceous fractions) of the producers of same in the presence of ATP / Mg++ and an amide- group donor compound (preferably glutamine).
Owner:CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)
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