10 results about "Malassezia" patented technology

This invention discloses a targeted antibacterial and repairing scalp shampoo containing a four-herb compound and its segmented preparation process, belonging to the technical field of functional herbal hair care products. Based on the traditional Chinese medicine theory of principal, assistant, and adjuvant herbs, this invention uses a precise compound of four herbs—Platycladus orientalis leaf, Clematis chinensis, Dictamnus dasycarpus bark, and Paeonia suffruticosa—combined with an amino acid cleansing system and multiple antibacterial and repairing components to create a synergistic formula. It employs a unique segmented salt-addition and low-temperature step-by-step feeding process, locking in the activity of the herbs at 35℃~40℃. Stability is regulated through two salt additions, and properties are optimized through constant-temperature maturation, solving the problems of traditional products such as activity loss, poor stability, single efficacy, and disordered formulation. This product can target and inhibit Malassezia, eradicate stubborn dandruff, reduce inflammation and itching, balance oil and water, repair the scalp barrier, and nourish hair roots. Its pH is suitable for the slightly acidic environment of the scalp, making it gentle and non-irritating, suitable for long-term treatment of sensitive, seborrheic, and permed / dyed scalps. The formula and process are novel, creative, and practical, and can be industrially mass-produced.

This invention discloses a composition with hair-care effects on damaged hair and its application, comprising *Ulva prolifera* extract, *Angelica sinensis* extract, *Lichen davidii* extract, and *Camellia chrysantha* extract, wherein the weight ratio of the *Ulva prolifera* extract, *Angelica sinensis* extract, *Lichen davidii* extract, and *Camellia chrysantha* extract is (1-3):(1-2):(3-7):(5-8). It has the effects of repairing hair cuticles, nourishing hair, improving hair shine, improving combability, scavenging free radicals, and inhibiting Malassezia.

This application provides the use of an antimicrobial peptide in the preparation of skin care products. The antimicrobial peptide of this application can effectively inhibit *Propionibacterium acnes* and *Malassezia*, thereby preventing skin problems such as acne, skin inflammation, and dandruff caused by the overgrowth of these two bacteria. Therefore, the antimicrobial peptide of this application has skin care uses in inhibiting acne, relieving skin inflammation such as folliculitis, pityriasis versicolor, and seborrheic dermatitis, and in inhibiting dandruff, and has significant practical value.

This invention discloses the application of an artemisia annua compound as the sole active ingredient in the preparation of topical formulations for the prevention or improvement of blackheads and acne. Based on 100% of the total mass of the topical formulation, the artemisia annua compound accounts for 0.1% to 0.22%, and is composed of the following raw materials in parts by mass: camphene 4 to 10 parts, artemisinin 1 part. This invention also discloses a topical formulation for the prevention or improvement of blackheads and acne, the sole active ingredient of which is an artemisia annua compound. Based on 100% of the total mass of the topical formulation, the artemisia annua compound accounts for 0.1% to 0.22%, and is composed of the following raw materials in parts by mass: camphene 4 to 10 parts, artemisinin 1 part. The artemisia annua compound of this invention can significantly reduce the formation of squalene peroxide in a UVA-induced squalene photo-oxidation model, and shows stronger inhibition against Malassezia and less impact on Staphylococcus epidermidis in a Malassezia vs. symbiotic bacteria comparison model.

This invention addresses the prevalent hair loss problem in modern people by providing a pharmaceutical composition comprising Sanguisorba officinalis extract and Sophora flavescens extract. Topical application improves hair growth in a hair loss model mouse, resulting in thicker, shinier hair. Both hair weight and length show significant improvement compared to the model group, the Sanguisorba officinalis-only group, and the Sophora flavescens-only group, indicating synergistic effects. This may be related to its inhibition of Malassezia scalp, thereby improving the scalp environment. In particular, the co-decoction extract of Sanguisorba officinalis and Sophora flavescens shows superior efficacy compared to physically mixed Sanguisorba officinalis and Sophora flavescens extracts in the same proportion. Optimal efficacy was achieved at a Sanguisorba officinalis:Sophora flavescens weight ratio of 2:8, demonstrating the therapeutic advantage of the co-decoction extract. In volunteer use cases, the co-decoction extract showed similar excellent effects in improving scalp sebum secretion and narrowing the hair loss area, as well as a significant clearing effect on folliculitis.

The present application provides a kind of emulsion for improving pet skin problems and its preparation method, it is related to the technical field of traditional Chinese veterinary medicine pharmacy.The emulsion is prepared by emulsification homogenization from traditional Chinese medicine extract, traditional Chinese medicine essential oil, plant fatty acid, emulsifier and water, wherein the traditional Chinese medicine extract is Astragalus and ginseng extract, and the traditional Chinese medicine essential oil is a compound of clove basil oil, angelica oil, rose oil and kempas seed oil.The present application solves the problems of large irritability, easy drug resistance of chemical drugs and poor absorption of traditional Chinese medicine by synergistic compounding of active ingredients.The product has the functions of antibacterial, barrier repair, sebum regulation and moisturizing, and the inhibition zone diameters of staphylococcus aureus and malassezia are 12.5±0.5 mm and 10.2±0.3 mm respectively, and it can significantly improve skin moisturizing function, and is mild and non-irritating, suitable for the treatment and care of various skin problems of pets.

The application discloses a kind of nanometer composition for scalp deep anti-inflammatory and improving hair follicle environment and its preparation method and application.The composition is made of nanometer ascorbic acid palmitate 5-10 parts, liposome VC 3-8 parts, menthol 15-25 parts, collagen 5-10 parts, vitamin B6 2-4 parts, zinc 0.5-1 part.The application significantly enhances the transdermal penetration of active ingredients by nanotechnology;Synergistic effect of each component can effectively inhibit the growth of malassezia, reduce the expression of inflammatory factors IL-6 and TNF-α, promote the production of type I collagen, realize scalp deep anti-inflammatory and hair follicle repair.Experiments show that the bacteriostatic effect of the composition is significantly better than that of commercially available products, and the anti-inflammatory and repair effect is equivalent to that of positive control, and the total effective rate reaches 88.3%.The application is safe and non-irritating, and is suitable for hair care products such as shampoo and hair conditioner.

The application discloses a bacteriostatic, itching-relieving and antioxidant traditional Chinese medicine composition taking a prepared radix polygoni multiflori extract as a main active ingredient, which is composed of the following ingredients in parts by weight: the prepared radix polygoni multiflori extract 15-35 parts, the cypress leaf extract 5-20 parts, the black sesame seed extract 3-12 parts and the ligustrum lucidum fruit extract 3-12 parts. The ultrasonic-assisted cellulase extraction is adopted to greatly improve the dissolution rate of stilbene glucoside in the prepared radix polygoni multiflori and the active ingredient content of the extract is high; the multi-flavor traditional Chinese medicine is compounded to realize the bacteriostasis (staphylococcus aureus and malassezia), itching relief and antioxidant effects in a synergistic manner, the bacteriostasis circle diameter is greater than or equal to 15 mm, and the DPPH free radical scavenging rate is greater than or equal to 75%; the natural traditional Chinese medicine ingredient is mild and non-irritating, is suitable for a scalp care scene, and can be widely used in hair washing and hair care daily chemical products.

The present application provides a plant composition for oil control, dandruff removal and nourishment and a hair product thereof, and belongs to the field of medical, dental or cosmetic preparations. The composition is composed of Sophora flavescens, Radix Angelicae Sinensis, Sapindus, Anemarrhena asphodeloides, and optional extracts of Scutellaria baicalensis and Passiflora incarnata, and is prepared by precise processes such as directional extraction of liposoluble alkaloids, directional extraction of water-soluble saponins and gradient solvent extraction. Through multi-target synergistic action, the components can significantly inhibit the proliferation of Malassezia, regulate the secretion of sebaceous glands, and improve the microcirculation of the scalp. The present application has multiple effects of oil control, dandruff removal, itching relief and nourishment, and is mild and non-irritating, and is suitable for various hair washing and care products.