Anti-dandruff composition and application thereof

Abstract

The invention provides an anti-dandruff composition and application thereof. The anti-dandruff composition is prepared from the following components in parts by weight: 0.05 to 1 part of piroctone olamine salt, 0.01 to 1 part of hinokiol and 0.01 to 1 part of paeonol. Piroctone ethanolamine, hinokiol and paeonol are matched, hinokiol and paeonol can enhance the inhibition effect of piroctone ethanolamine on malassezia, paeonol can repair damaged scalp barriers, hinokiol protects scalp health through the anti-oxidation effect, hinokiol and paeonol jointly act, the effect of hinokiol and paeonol on the scalp is achieved, and the effect of hinokiol and paeonol on the scalp is achieved. The scalp inflammation can be effectively relieved, and scalp itching and discomfort are reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of scalp care, and particularly to an anti-dandruff composition and its application. Background Art

[0002] The problem of dandruff is a common scalp health problem, mainly caused by the overgrowth of Malassezia, the impairment of the scalp barrier function, and the inflammatory response. With the increasing demand of consumers for scalp care, anti-dandruff products are gradually developing towards the direction of multi-function, mildness, and naturalness from single-functional products.

[0003] Currently, the anti-dandruff products on the market mainly rely on chemically synthesized ingredients, such as zinc pyrithione (ZPT), octopirox ethanolamine salt (OCT), etc. Although these ingredients have certain anti-dandruff effects, there are also some limitations. For example, long-term use may cause problems such as scalp irritation, dryness, or drug resistance, and cannot comprehensively solve the scalp health problems. Summary of the Invention Aiming at the deficiencies of the prior art, the purpose of the present invention is to provide an anti-dandruff composition and its application, aiming to solve the technical problem of poor anti-dandruff effect in the prior art.

[0004] To achieve the above purpose, the present invention is implemented through the following technical solutions: an anti-dandruff composition, characterized in that it comprises the following components by weight: 0.05 parts to 1 part of octopirox ethanolamine salt, 0.01 parts to 1 part of hinokitiol, and 0.01 parts to 1 part of paeonol.

[0005] According to one aspect of the above technical solution, the anti-dandruff composition comprises the following components by weight: 0.1 parts to 0.5 parts of octopirox ethanolamine salt, 0.05 parts to 0.5 parts of hinokitiol, and 0.05 parts to 0.5 parts of paeonol.

[0006] On the other hand, the present invention also discloses the application of the above anti-dandruff composition in scalp care products.

[0007] According to one aspect of the above technical solution, the scalp care product is a shampoo, and the shampoo comprises the anti-dandruff composition and the following components by weight: 1 part to 5 parts of polyol, 15 parts to 30 parts of surfactant, 0.1 part to 1 part of thickener, 0.05 part to 0.5 part of pH regulator, 0.01 part to 1 part of chelating agent, 0.1 part to 1 part of preservative, 0.05 part to 0.3 part of essence, and the balance of deionized water.

[0008] According to one aspect of the above technical solution, the polyol is 1,3-propanediol; The surfactant is at least one of sodium lauryl polyether sulfate, cocamidopropyl betaine, and sodium methyl cocoyl taurate; The thickener is at least one of cationic guar gum and polyquaternium-10; The pH regulator is at least one of citric acid, sodium citrate, lactic acid, and triethanolamine; The chelating agent is at least one of disodium EDTA, tetrasodium EDTA, and sodium citrate.

[0009] According to one aspect of the above technical solution, the preparation method of the shampoo comprises the following steps: Mix the surfactant, thickener, pH regulator, chelating agent, and solvent, heat to a first preset temperature, and stir evenly; When the mixture is cooled to a second preset temperature, add a mixture of piroctone olamine, hinokitiol, paeonol, and polyol, and stir evenly; Add a preservative and essence, continue to stir until completely dissolved, and cool to room temperature to obtain the shampoo.

[0010] According to one aspect of the above technical solution, the first preset temperature is 75 °C, and the second preset temperature is 60 °C.

[0011] According to one aspect of the above technical solution, the scalp care product is a scalp essence, and the scalp essence comprises the anti-dandruff composition and the following components by weight: 1 to 5 parts of a humectant, 3 to 10 parts of a penetration enhancer, and the balance of deionized water.

[0012] According to one aspect of the above technical solution, the humectant is glycerol, and the penetration enhancer is ethanol.

[0013] According to one aspect of the above technical solution, the preparation method of the scalp essence comprises the following steps: Mix the penetration enhancer, humectant, and deionized water, and stir evenly; Add piroctone olamine, hinokitiol, and paeonol, stir until completely dissolved, and then filter to obtain the hair essence.

[0014] Compared with the prior art, the beneficial effects of the present invention are as follows: By formulating piroctone olamine salt, hinokitiol, and paeonol, hinokitiol and paeonol can enhance the inhibitory effect of piroctone olamine salt on Malassezia, paeonol can repair the damaged scalp barrier, and hinokitiol can protect scalp health through antioxidant action. The combined action of hinokitiol and paeonol can effectively relieve scalp inflammation, reduce scalp itching and discomfort. Description of the Drawings

[0015] Figure 1 This is the flow chart of the preparation method of the shampoo in the ninth embodiment of the present invention; The following specific embodiments will further illustrate the present invention in conjunction with the above-mentioned drawings. Specific Embodiments

[0016] For ease of understanding the present invention, the present invention will be described more comprehensively below with reference to the relevant drawings. Several embodiments of the present invention are given in the drawings. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, these embodiments are provided to make the disclosure of the present invention more thorough and comprehensive.

[0017] It should be noted that when an element is referred to as being "fixed to" another element, it can be directly on the other element or there can also be a middle element. When an element is considered to be "connected to" another element, it can be directly connected to the other element or there may be a middle element at the same time. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are only for the purpose of illustration.

[0018] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the technical field to which the present invention belongs. The terms used in the specification of the present invention herein are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more of the related listed items.

[0019] Embodiment 1 An anti-dandruff composition, comprising the following components: piroctone olamine, hinokitiol and paeonol. Specifically, in this embodiment, the piroctone olamine is 1 part, the hinokitiol is 1 part, and the paeonol is 1 part.

[0020] Embodiment 2 An anti-dandruff composition, comprising the following components: piroctone olamine, hinokitiol and paeonol. Specifically, in this embodiment, the piroctone olamine is 0.05 part, the hinokitiol is 1 part, and the paeonol is 0.5 part.

[0021] Embodiment 3 An anti-dandruff composition, comprising the following components: piroctone olamine, hinokitiol and paeonol. Specifically, in this embodiment, the piroctone olamine is 0.1 part, the hinokitiol is 0.01 part, and the paeonol is 1 part.

[0022] Embodiment 4 An antidandruff composition, comprising the following components: piroctone olamine, hinokitiol and paeonol. Specifically, in this embodiment, the piroctone olamine is 0.1 part, the hinokitiol is 0.5 part, and the paeonol is 0.01 part.

[0023] Example Five An antidandruff composition, comprising the following components: piroctone olamine, hinokitiol and paeonol. Specifically, in this embodiment, the piroctone olamine is 0.5 part, the hinokitiol is 0.05 part, and the paeonol is 0.5 part.

[0024] Example Six An antidandruff composition, comprising the following components: piroctone olamine, hinokitiol and paeonol. Specifically, in this embodiment, the piroctone olamine is 0.5 part, the hinokitiol is 1 part, and the paeonol is 0.05 part.

[0025] Example Seven An antidandruff composition, comprising the following components: piroctone olamine, hinokitiol and paeonol. Specifically, in this embodiment, the piroctone olamine is 0.3 part, the hinokitiol is 0.2 part, and the paeonol is 0.2 part.

[0026] Example Eight An antidandruff composition, comprising the following components: piroctone olamine, hinokitiol and paeonol. Specifically, in this embodiment, the piroctone olamine is 0.2 part, the hinokitiol is 0.1 part, and the paeonol is 0.1 part.

[0027] Example Nine The application of the antidandruff composition in the above embodiments in a scalp care product is provided in Example Nine of the present application.

[0028] In this embodiment, the above scalp care product is a shampoo, and the shampoo comprises the antidandruff composition and components by weight: 1 part - 5 parts of polyol, 15 parts - 30 parts of surfactant, 0.1 part - 1 part of thickener, 0.05 part - 0.5 part of pH regulator, 0.01 part - 1 part of chelating agent, 0.1 part - 1 part of preservative, 0.05 part - 0.3 part of essence, and the balance of deionized water.

[0029] Specifically, in this embodiment, the polyol is 1,3 - propanediol; The above surfactant is at least one of sodium lauryl polyether sulfate, cocamidopropyl betaine, and sodium cocoyl methyl taurate; The thickener is at least one of cationic guar gum and polyquaternium - 10; The pH regulator is at least one of citric acid, sodium citrate, lactic acid, and triethanolamine; The chelating agent is at least one of disodium EDTA, tetrasodium EDTA, and sodium citrate.

[0030] Preferably, in this embodiment, the preparation method of the above shampoo comprises the following steps: Step S100, mix the surfactant, thickener, pH regulator, chelating agent, and solvent, heat to a first preset temperature and stir evenly. In this embodiment, the above surfactant is preferably 14 parts of sodium lauryl polyether sulfate and 3 parts of cocoamidopropyl betaine, the thickener is preferably 0.4 parts of cationic guar gum, the above pH regulator is preferably 0.1 part of citric acid, the above chelating agent is preferably 0.05 part of disodium EDTA, and the balance in the total ratio is the solvent using deionized water.

[0031] Step S200, when the mixture is cooled to a second preset temperature, add a mixture of piroctone olamine, hinokitiol, paeonol, and polyol, and stir evenly. Preferably, the above polyol is preferably 2 parts of 1,3-propanediol, piroctone olamine is preferably 0.3 part, hinokitiol is preferably 0.2 part, and paeonol is preferably 0.2 part, that is, the anti-dandruff composition in Example VII.

[0032] Step S300, add a preservative and a fragrance, continue to stir until completely dissolved, and cool to room temperature to obtain the shampoo. Preferably, the above preservative is preferably 0.2 part of methylparaben, and the proportion of the above fragrance by weight is 0.1 part.

[0033] Example X Embodiment X of the present application provides the application of the anti-dandruff composition in the above embodiments in a scalp care product.

[0034] The difference between this embodiment and Embodiment IX is that the anti-dandruff composition in the shampoo is the anti-dandruff composition in Embodiment I.

[0035] Example XI Embodiment XI of the present application provides the application of the anti-dandruff composition in the above embodiments in a scalp care product.

[0036] The difference between this embodiment and Embodiment IX is that the anti-dandruff composition in the shampoo is the anti-dandruff composition in Embodiment II.

[0037] Example XII Embodiment XII of the present application provides the application of the anti-dandruff composition in the above embodiments in a scalp care product.

[0038] The difference between this embodiment and Embodiment IX is that the anti-dandruff composition in the shampoo is the anti-dandruff composition in Embodiment III.

[0039] Example Thirteen Example Thirteen of the present application provides the application of the anti-dandruff composition in the above embodiments in a scalp care product.

[0040] The difference between this example and Example Nine is that the anti-dandruff composition in the shampoo is the anti-dandruff composition in Example Four.

[0041] Example Fourteen Example Fourteen of the present application provides the application of the anti-dandruff composition in the above embodiments in a scalp care product.

[0042] The difference between this example and Example Nine is that the anti-dandruff composition in the shampoo is the anti-dandruff composition in Example Five.

[0043] Example Fifteen Example Fifteen of the present application provides the application of the anti-dandruff composition in the above embodiments in a scalp care product.

[0044] The difference between this example and Example Nine is that the anti-dandruff composition in the shampoo is the anti-dandruff composition in Example Six.

[0045] Example Sixteen Example Sixteen of the present application provides the application of the anti-dandruff composition in the above embodiments in a scalp care product.

[0046] The difference between this example and Example Nine is that the anti-dandruff composition in the shampoo is the anti-dandruff composition in Example Eight.

[0047] Example Seventeen Example Seventeen of the present application provides the application of the anti-dandruff composition in the above embodiments in a scalp care product.

[0048] The difference between this example and Example Nine is that the shampoo includes the anti-dandruff composition and the following components by weight: 1 part of polyol, 15 parts of surfactant, 0.1 part of thickener, 0.05 part of pH regulator, 0.01 part of chelating agent, 0.1 part of preservative, 0.05 part of essence, and the balance of deionized water.

[0049] Example Eighteen Example Eighteen of the present application provides the application of the anti-dandruff composition in the above embodiments in a scalp care product.

[0050] The difference between this example and Example Nine is that the shampoo includes the anti-dandruff composition and the following components by weight: 5 parts of polyol, 30 parts of surfactant, 1 part of thickener, 0.5 part of pH regulator, 1 part of chelating agent, 1 part of preservative, 0.3 part of essence, and the balance of deionized water.

[0051] Example XIX Example XIX of the present application provides the application of the anti-dandruff composition in the above embodiments in a scalp care product.

[0052] In this embodiment, the above scalp care product is a scalp essence, and the scalp essence includes the anti-dandruff composition and the following components in parts by weight: 1 to 5 parts of a humectant, 3 to 10 parts of a penetration enhancer, and the balance being deionized water.

[0053] Specifically, in this embodiment, the humectant is glycerol and the penetration enhancer is ethanol. Preferably, in this embodiment, the preparation method of the scalp essence includes the following steps: Mix the penetration enhancer, humectant and deionized water, and stir evenly. Preferably, the above humectant is 3 parts of glycerol, the above penetration enhancer is 5 parts of ethanol, and the balance in the total ratio is the solvent of deionized water.

[0054] Add piroctone olamine, hinokitiol, and paeonol, stir until completely dissolved, and then filter to obtain the hair essence. Preferably, the above piroctone olamine is preferably 0.2 parts, hinokitiol is preferably 0.1 part, and paeonol is preferably 0.1 part.

[0055] Example XX Example XX of the present application provides the application of the anti-dandruff composition in the above embodiments in a scalp care product.

[0056] The difference between this embodiment and Example XIX is that: the scalp essence includes the anti-dandruff composition and the following components in parts by weight: 1 part of a humectant, 3 parts of a penetration enhancer, and the balance being deionized water.

[0057] Example XXI Example XXI of the present application provides the application of the anti-dandruff composition in the above embodiments in a scalp care product.

[0058] The difference between this embodiment and Example XIX is that: the scalp essence includes the anti-dandruff composition and the following components in parts by weight: 5 parts of a humectant, 10 parts of a penetration enhancer, and the balance being deionized water.

[0059] Comparative Example 1 This comparative example provides a shampoo, and the difference between this comparative example and Example IX is that: the components in the anti-dandruff composition include 0.3 parts of piroctone olamine salt.

[0060] Comparative Example 2 This comparative example provides a shampoo, and the difference between this comparative example and Example 9 is that: the components in the anti-dandruff composition include 1.5 parts of piroctone olamine, 0.005 part of hinokitiol, and 0.005 part of paeonol.

[0061] Comparative Example 3 This comparative example provides a shampoo, and the difference between this comparative example and Example 9 is that: the components in the anti-dandruff composition include 0.3 part of piroctone olamine and 0.1 part of hinokitiol.

[0062] Comparative Example 4 This comparative example provides a shampoo, and the difference between this comparative example and Example 9 is that: the components in the anti-dandruff composition include 0.3 part of piroctone olamine, 0.2 part of salicylic acid, and 0.2 part of menthol.

[0063] Comparative Example 5 This comparative example provides a shampoo, and the difference between this comparative example and Example 9 is that: the components in the anti-dandruff composition include 0.3 part of ketoconazole, 0.2 part of hinokitiol, and 0.2 part of paeonol.

[0064] The anti-dandruff compositions in Examples 1 to 8 and Comparative Examples 1 to 5 were tested for antibacterial effects against Malassezia. Specifically: The anti-dandruff composition was dissolved in deionized water to obtain a sample solution with a concentration of 1%. The Malassezia suspension (1×10 6 CFU / mL) was evenly coated on the surface of a modified Leeming-Notman agar medium (pH 6.0) containing 1% olive oil. Holes (6 mm in diameter) were punched in the agar, and 50 μL of the sample solution was added to each hole. After anaerobic culture at 28°C for 7 days, the diameter of the inhibition zone (including the hole diameter) was measured. Each group was repeated 3 times, and the data was expressed as mean ± standard deviation. One-way analysis of variance (ANOVA) was used to verify the significance (p < 0.05).

[0065] The experimental results are shown in Table 1 below: Table 1

[0066] Analysis of the data in the above table shows that the diameters of the antibacterial zones (10.5 - 14.2 mm) and the inhibition rates against Malassezia (98.7% - 99.5%) in Examples 1 to 8 are mostly higher than those in Comparative Examples 1 to 5, indicating that the compound of piroctone olamine, hinokitiol and paeonol has a synergistic antibacterial effect. Among them, Example 7 (antibacterial zone 12.5 mm, inhibition rate 99.5%) and Example 1 (14.2 mm, 99.5%) exhibit the optimal antibacterial activity. This may be because hinokitiol reduces the generation of lipid oxidation products by inhibiting the lipid metabolism of Malassezia, while piroctone olamine enhances the antibacterial effect by disrupting the integrity of the fungal cell membrane. In contrast, the antibacterial effect of Comparative Example 1 (containing only piroctone olamine) decreased significantly (75.2%), verifying that hinokitiol is the core antibacterial component.

[0067] The anti - inflammatory effects of the anti - dandruff compositions in Examples 1 to 8 and Comparative Examples 1 to 5 were tested. Specifically: The anti - dandruff composition was dissolved in a serum - free cell culture medium to obtain a sample medium. Human keratinocytes (HaCaT cells) were placed in DMEM high - glucose medium + 10% fetal bovine serum (FBS) and cultured at 37°C and 5% CO2 until 80% confluence. An inflammatory response was induced with lipopolysaccharide (LPS, 1 μg / mL) for two hours to activate the TLR4 pathway, and then the cells were added to the sample medium containing the anti - dandruff composition and cultured for 24 hours. The supernatant was collected and centrifuged at 3000 rpm for 10 minutes to remove cell debris. Using an IL - 6 kit, the concentration was detected according to the instructions of the manual. Taking the LPS - stimulated group as the benchmark (100% inflammatory level), the inhibition rate of the sample group was calculated. THP - 1 monocytes (differentiated macrophages) were placed in RPMI - 1640 medium + 0.05 mM β - mercaptoethanol and induced to differentiate into macrophages by 100 nM PMA. After 48 hours of differentiation, the medium without PMA was replaced and the cells were allowed to stand for 24 hours. An inflammatory response was induced with lipopolysaccharide (LPS, 1 μg / mL) for two hours to activate the NF - κB pathway, and then the cells were added to the sample medium containing the anti - dandruff composition and cultured for 24 hours. The supernatant was collected and centrifuged at 3000 rpm for 10 minutes to remove cell debris. Using a TNF - α ELISA kit, the concentration was detected according to the instructions of the manual. Taking the LPS - stimulated group as the benchmark (100% inflammatory level), the inhibition rate of the sample group was calculated. The experimental results are shown in Table 2 below: Table 2

[0068] Analysis of the data in the above table shows that Example VII (IL-6 inhibition rate of 92.1%, TNF-α inhibition rate of 88.7%) has both high antibacterial properties (inhibition zone of 12.5 mm), inhibits the release of inflammatory factors by blocking the NF-κB pathway, and at the same time reduces the intensity of the immune response by decreasing the TLR4 activation induced by Malassezia. In Comparative Example IV (salicylic acid replacing paeonol), although the inhibition zone reaches 10.2 mm, the IL-6 inhibition rate is only 45.1%, indicating that it only reduces the attachment of bacteria by keratolysis and lacks the ability to regulate the anti-inflammatory pathway. In addition, in Comparative Example V (ketoconazole replacing piroctone), although the inhibition of Malassezia reaches 97.1%, the IL-6 inhibition rate is only 32.5%, verifying that anti-inflammation depends on the synergistic effect of hinokitiol and piroctone.

[0069] In the description of this specification, the descriptions referring to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples", etc. mean that the specific features, structures, materials, or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described can be combined in a suitable manner in any one or more embodiments or examples.

[0070] The above-described embodiments merely represent several implementation manners of the present invention. The descriptions are relatively specific and detailed, but should not be construed as limiting the scope of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present invention, several modifications and improvements can still be made, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the present invention should be subject to the appended claims.

Claims

1. An anti-dandruff composition, characterized in that, It comprises the following components by weight parts: 0.05 part to 1 part of piroctone olamine, 0.01 part to 1 part of hinokitiol, and 0.01 part to 1 part of paeonol.

2. The anti-dandruff composition according to claim 1, wherein The anti-dandruff composition comprises the following components by weight parts: 0.1 part to 0.5 part of piroctone olamine, 0.05 part to 0.5 part of hinokitiol, and 0.05 part to 0.5 part of paeonol.

3. Application of the anti-dandruff composition according to claim 1 or 2 in a scalp care product.

4. The application according to claim 3, characterized in that, The scalp care product is a shampoo, and the shampoo comprises the anti-dandruff composition and the following components by weight parts: 1 part to 5 parts of polyol, 15 parts to 30 parts of surfactant, 0.1 part to 1 part of thickener, 0.05 part to 0.5 part of pH regulator, 0.01 part to 1 part of chelating agent, 0.1 part to 1 part of preservative, 0.05 part to 0.3 part of essence, and the balance being deionized water.

5. The application according to claim 4, wherein The polyol is 1,3-propanediol; The surfactant is at least one of sodium lauryl polyether sulfate, cocoamidopropyl betaine, and sodium methyl cocoyl taurate; The thickener is at least one of cationic guar gum and polyquaternium-10; The pH regulator is at least one of citric acid, sodium citrate, lactic acid, and triethanolamine; The chelating agent is at least one of disodium EDTA, tetrasodium EDTA, and sodium citrate.

6. The application according to claim 4, characterized in that, The preparation method of the shampoo comprises the following steps: Mix the surfactant, thickener, pH regulator, chelating agent and solvent, heat to a first preset temperature and stir evenly; When the mixture is cooled to a second preset temperature, add the mixture of piroctone olamine, hinokitiol, paeonol and polyol, and stir evenly; Add the preservative and essence, continue to stir until completely dissolved, and cool to room temperature to obtain the shampoo.

7. The application according to claim 6, wherein The first preset temperature is 75 °C, and the second preset temperature is 60 °C.

8. The application according to claim 3, characterized in that The scalp care product is a scalp essence, and the scalp essence comprises the anti-dandruff composition and the following components by weight parts: 1 part to 5 parts of humectant, 3 parts to 10 parts of penetration enhancer, and the balance being deionized water.

9. The application according to claim 8, wherein The humectant is glycerol, and the penetration enhancer is ethanol.

10. The application according to claim 8, wherein The preparation method of the scalp essence comprises the following steps: Mix the penetration enhancer, humectant and deionized water, and stir evenly; Add piroctone olamine, hinokitiol, and paeonol, stir until completely dissolved, and then filter to obtain the hair essence.

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