17 results about "Trichophyton rubrum" patented technology

The invention relates to the technical field of biological medicine, in particular to application of a combination of a Cd1 and Mdr1 double-target inhibitor and an azole drug in preparation of an antifungal drug. Based on the fact that the compound as shown in the formula (I) can be used as a CCd1 and Mdr1 double-target inhibitor, the inhibition effect of the compound on candida albicans, candida auricula, candida glabrata, candida tropicalis, trichophyton rubrum and trichophyton indicus when the compound is combined with azole drugs is further evaluated, and the result shows that the compound as shown in the formula (I) has no obvious antibacterial activity on various fungi, and can be used for preparing a medicine for treating various fungi. The drug resistance of CCd1 and Mdr1 overexpression drug-resistant fungi can be reversed, the activity of Candida albicans, Candida auricula, Candida glabrata, Candida tropicalis, Trichophyton rubrum and Trichophyton indicus can be synergistically inhibited when the drug is combined with azole drugs, the treatment dosage of the azole drugs is effectively reduced, and the drug toxicity is small. Therefore, the compound shown in the formula (I) can improve the antifungal effect of azole drugs and reduce the drug resistance of the azole drugs.

The invention discloses a copper-based multifunctional close-fitting textile and a preparation method thereof. The copper-based multifunctional close-fitting textile comprises a copper conductive fiber layer which is blended and woven with any other fibers; the natural fiber layer is selected from any natural fiber and is blended with the copper conductive fiber layer, the product integrates antifungal, deodorizing and dustproof synergy and is selectively applied to various use fields, and the blended spinning of the copper conductive fiber layer and the natural fiber layer can make the antistatic performance be improved in a breakthrough manner; in a dry environment, due to static electricity generated by friction in natural fibers, copper ions can quickly disperse electrostatic charges and guide the electrostatic charges to the ground through an electron conduction mechanism, and static electricity accumulation is eliminated. Dust prevention is realized by electrostatic adsorption of particles. The copper ions can destroy bacterial cell membranes and inhibit reproduction of the bacterial cell membranes, and can treat common bacteria such as escherichia coli and staphylococcus aureus and fungi such as trichophyton rubrum and trichophyton asthenia. The photocatalytic material is used for photothermal catalytic decomposition of peculiar smell molecules.

This invention relates to the field of traditional Chinese medicine technology, and more particularly to a traditional Chinese medicine composition and its application in the preparation of antifungal drugs. The composition provided by this invention comprises Dioscorea hypoglauca, Cnidium monnieri, Bistorta officinalis, Dioscorea nipponica, Murraya paniculata, Dioscorea opposita, Polygonum multiflorum, and Terminalia chebula. This composition has the effect of inhibiting the growth of superficial dermatophytes (such as Trichophyton rubrum and Candida albicans), which helps to reduce the occurrence of superficial dermatophyte infections and has the potential to be developed into a drug for treating superficial dermatophyte infections.

The invention discloses a multiple qPCR (quantitative polymerase chain reaction) detection reagent for detecting pathogens of a superficial fungal disease. The multiple qPCR detection reagent comprises specific primers and probes for detecting trichophyton rubrum, epidermophyton flocculent, microsporum canine, trichophyton beard, candida parapsilosis, candida albicans, malassezia furfur and gliocladium breviculare, wherein the specific primers and the probes are used for detecting trichophyton rubrum, epidermophyton flocculent, microsporum canine, trichophyton beard, candida parapsilosis; according to the invention, different fluorescently-labeled probes are utilized to add specific primers and probes of multiple pathogens into a reaction system to detect multiple targets at the same time, and the method has the advantages of good specificity, high sensitivity, high detection speed, capability of detecting multiple pathogens at the same time, rapidness, simplicity, convenience and economy; a convenient method is provided for rapid detection of superficial fungal disease pathogens, and the kit has important significance in epidemiological research, clinical early molecular diagnosis and the like.

The invention relates to the field of dermatological external preparations, in particular to a compound external ointment for treating trichophyton rubrum infection and a preparation process of the compound external ointment. The ointment specifically comprises the following components in percentage by weight: 0.50-1.50% of an antifungal active ingredient; 0.50% to 2.00% of saturated phosphatidylcholine; 0.20%-0.40% of a cross-linked acrylic rheology modifier; 4.0 to 10.0% of an oil phase; 0.10%-0.30% of a cationic film forming agent; 0.02 to 0.05 percent of a metal ion chelating agent; and water to 100%. And the pH value is adjusted to 4.6-4.9. Through cooperation of the saturated phosphatidylcholine, the cross-linked acrylic acid gel, the cationic film-forming agent and the chelating agent and pH control, the formula does not collapse, does not cause phase separation and is stable in release in the presence of sweat, the effective dose of the skin superficial layer can be maintained, and trichophyton rubrum can be continuously inhibited.

The invention relates to the field of daily chemicals, and discloses a plant-derived sterilization deodorant and application thereof in daily chemical products. The sterilizing deodorant comprises at least two, preferably three, of pepper leaf extract, celery leaf extract and syzygium jambos leaf extract, and is matched with decyl glucoside, citric acid, a chelating agent and an optional deep eutectic solvent to form a stable water-alcohol system. Through specific proportion compounding and process condition control, efficient bacteriostasis on staphylococcus aureus, staphylococcus epidermidis, candida albicans and trichophyton rubrum is achieved, meanwhile, the concentration of odor substances is remarkably reduced, and the deodorant has the functions of source bacteriostasis and direct deodorization. The physical stability and the antibacterial activity retention rate of the system are further improved by adopting a deep eutectic solvent composed of glycerol and choline chloride, so that the deep eutectic solvent is suitable for preparing daily chemical products such as shoe and sock spray, body spray and fabric freshener.

The invention belongs to the technical field of traditional Chinese medicine preparations, and relates to a traditional Chinese medicine composition for treating beriberi. The invention discloses a traditional Chinese medicine composition for treating beriberi, which is a compound nano-particle spray and comprises compound nano-particles prepared from folium artemisiae argyi, dandelion, oriental wormwood, motherwort, rhizoma nardostachyos, radix angelicae extract and lactic acid-glycolic acid copolymer (PLGA) in specific parts by weight. The traditional Chinese medicine composition can effectively inhibit and kill trichophyton rubrum and destroy a fungal biofilm so as to achieve the effect of treating beriberi.

The present application relates to the technical field of biological medicine, in particular to the application of Cdr1 and Mdr1 double-target inhibitor combined with azole drugs in the preparation of antifungal drugs. Based on the compound shown in formula (I) can be used as Cdr1 and Mdr1 double-target inhibitor, the inhibitory effect of the compound on Candida albicans, Candida auris, Candida glabrata, Candida tropicalis, Trichophyton rubrum and Trichophyton indiana combined with azole drugs was further evaluated. The results show that the compound shown in formula (I) itself has no obvious antibacterial activity on various fungi, but can reverse the drug resistance of Cdr1 and Mdr1 overexpression drug-resistant fungi. The combination of the compound with azole drugs can synergistically inhibit the activity of Candida albicans, Candida auris, Candida glabrata, Candida tropicalis, Trichophyton rubrum and Trichophyton indiana, effectively reduce the therapeutic dose of azole drugs, and the drug toxicity is small. Therefore, the compound shown in formula (I) can improve the antifungal effect of azole drugs and reduce the drug resistance of azole drugs.

This invention provides a topical traditional Chinese medicine preparation for treating fungal skin infections and its preparation method, belonging to the field of biomedical technology. The topical traditional Chinese medicine preparation is based on traditional Chinese medicine theory and scientifically formulated, using *Ling Shou Ci*, *Da Cha Gen*, *Fu Fang Teng*, *Mesona chinensis*, *Bai La Jiao*, *Bai Niu Wei Qi*, *Nai Zhi Shu*, *Di Yu*, and *Er Cao* as raw materials. The extracts prepared from the above-mentioned medicinal materials exhibit strong antibacterial and bactericidal effects against *Trichophyton rubrum*, *Trichophyton mentagrophytes*, and *Microsporum gypseum*, inhibiting the development of pathogens at the source. The topical traditional Chinese medicine preparation can significantly inhibit the body's inflammatory response, effectively improving and alleviating skin lesions such as erythema, papules, desquamation, alopecia, and inflammatory infiltration caused by fungal infections. It has a significant therapeutic effect on fungal skin diseases, and the topical traditional Chinese medicine preparation provided by this invention has great potential for application in the treatment of fungal skin diseases.

The invention discloses a novel medical application of sodium new houttuyfonate in prevention and treatment of pathogenic bacteria, including application of sodium new houttuyfonate in preparation of drugs for prevention and treatment of pathogenic fungus infection or drugs for inhibition of pathogenic fungi. The pathogenic fungi are selected from one or more of cryptococcus neoformans, cryptococcus gattii, trichophyton rubrum, trichophyton purple, microsporum canis, candida niticola complex bacteria, candida albicans, trichophyton mentagrophytes and trichophyton broken. Researches show that sodium new houttuyfonate has important significance in preventing and treating infection of different pathogenic bacteria, especially has a remarkable curative effect on cryptococcus neoformans lung infectious diseases and skin traumatic infectious diseases, and compared with traditional antibacterial drugs, the sodium new houttuyfonate is not prone to causing drug resistance of pathogenic bacteria and has a good application prospect. The compound is expected to be developed into a candidate drug for clinically treating different pathogenic bacteria, is efficient, non-toxic and broad-spectrum, is expected to solve the problem of drug resistance of the pathogenic bacteria, and has a good application prospect.

The present invention relates to a composition for the treatment of fungal infections of C. albicans and C. non-albicans, such as C. auris, C. glabrata, C. tropicalis, C. krusei and Trichophyton spp., in particular Trichophyton mentagrophytes complex, Tricophyton rubrum.

The invention discloses an impatiens balsamina gel pharmaceutical composition for onychomycosis and a drug delivery system thereof, the onychomycosis treatment system comprises: a treatment gel, the active component of which comprises an organic solvent extract of impatiens balsamina petals; the fixing patch device is used for bearing the treatment gel and continuously applying the treatment gel to the affected nail; the fixing patch device comprises a breathable base material, a pressure-sensitive adhesive layer arranged on the breathable base material, and a sponge pad connected to the pressure-sensitive adhesive layer and used for adsorbing the treatment gel. The pharmaceutical composition has a synergistic antifungal effect, natural active ingredients such as naphthoquinone and flavonoid in the white garden balsam petals have broad-spectrum inhibitory activity on trichophyton rubrum, trichophyton mentagrophytes and pseudomonas aeruginosa, the natural active ingredients and 60% ethanol form a synergistic permeation system under a reflux process at 70 + / -2 DEG C, and the deck penetrating efficiency of the pharmaceutical composition is remarkably improved.

The invention relates to the use of kahalalide-type depsipeptide compounds of formulae I and / or II, obtained from the green alga Pedobesia sp., for controlling a broad spectrum of fungal plant pathogens. The invention also encompasses fungicidal compositions comprising said compounds with a phytologically acceptable carrier, a process for their preparation from Pedobesia biomass, and their use for the preparation of a medicament for treating mycosis such as that caused by Candida albicans or Trichophyton rubrum.

The application discloses a Cnidii Fructus extract-mediated synthesized nano-silver material and a preparation method and application thereof. The nano-silver material is in a spherical core-shell structure, the inside of which is aggregated silver ions, and the outside of which is covered with Cnidii Fructus extract. The nano-silver material is synthesized by Cnidii Fructus extract and silver nitrate, and the average particle size is 44.6 nm. The nano-silver material has good antifungal activity on Trichophyton rubrum, Trichophyton mentagrophytes and Candida albicans, and the minimum inhibitory concentrations (MIC 90 ) are 3.125 μg / mL, 3.125 μg / mL and 0.78125 μg / mL, respectively. The Cnidii Fructus extract, which is commonly used in the treatment of tinea, is used to synthesize nano-silver, the synthesis method is simple, the particle size is small, the stability is good, and the nano-silver is highly dispersed. The preparation method is green and environment-friendly, and can be popularized on a large scale as the preparation of high-efficiency antifungal materials.

The present invention discloses a nucleic acid aptamer and a detection kit for detecting Trichophyton rubrum and Microsporum canis, wherein the nucleic acid aptamer includes a nucleic acid aptamer Seq1-LR, and the nucleotide sequence of the nucleic acid aptamer Seq1-LR is a DNA fragment shown in SEQ ID NO.1. The detection kit is a kit comprising nucleic acid aptamers for detecting Trichophyton rubrum and Microsporum canis. The nucleic acid aptamer and the detection kit of the present invention can sensitively, simply, efficiently, specifically and broadly identify and detect Trichophyton rubrum and Microsporum canis, and the nucleic acid aptamer has the advantages of higher affinity and specificity than protein antibodies, no immunogenicity, chemical synthesis, small molecular weight, stability, easy storage and labeling. The nucleic acid aptamer provides a new idea and method for the detection of skin fungal infections, and is expected to achieve rapid and accurate detection of skin fungal infections in the original site clinically.

The present invention relates to a pharmaceutical preparation based on the use of an active ingredient from the family of phosphonium salts derived from Michael acceptors. These four molecules have dermatophyte inhibitory activity of up to 99.9% inhibition of the fungal population intended for use in the treatment of nail fungus, dermatophytes. The CPS molecule inhibits Trichophyton ruhrum at a concentration of 0.031 mg / mL, and also Microsporum canis at a concentration of 0.062 mg / mL. The other compounds CP1, CP3, and CP4 inhibit Trichophyton ruhrum and Microsporum canis at a concentration of 0.25 mg / mL. Compound CP1 inhibits Candida albicans at a concentration of 0.25 mg / mL. Furthermore, these molecules have no lytic or toxic effect on dermatophytes, particularly Trichophyton rubrum, Microsporum canis, and Candida albicans. These synthetic molecules are used as a remedy and treatment for nail diseases caused by dermatophytes, specifically Trichophyton rubrum, Microsporum canis, and Candida albicans.

The present invention relates to a natural antifungal formulation made with a combination of essential oils, tinctures, and hydrosols obtained from aromatic and medicinal plant species for the control and treatment of the fungus Trichophyton rubrum, the causative agent of athlete's foot. The essential oils of Thymus vulgaris L., Tagetes lunulata Ort., and Syzygium aromaticum (L.) Merr. & LM Perr. that comprise it exhibit antifungal activity by inhibiting fungal growth. In addition, the essential oil of Lavandula angustifolia Mill. and Salvia rosmarinus Spenn., along with the hydrosol of Salvia rosmarinus Spenn., have an anti-inflammatory effect. This is a natural alternative with no adverse effects and can be used by immunocompromised individuals and those with chronic illnesses.