117 results about "Trichophyton rubrum" patented technology

The invention encompasses hexapeptides consisting of alternating hydrophobic residues (B) at positions 2, 4, and 6, hydrophilic, hydrophilic, charged residues (X) at positions 1 and 3, and a naphthylalanine (Nal), an aliphatic or aromatic residue (O) at position five, represented generally by the formula XBXBOB, which exhibit antimicrobial activity against infections caused by a variety of pathogens. These pathogens may include gram positive or negative bacteria, acid-fast bacteria such a mycobacteria, parasites, dermatophytes, or fungal pathogens. Typical fungal pathogens include Candida albicans and typical dermatophytes include Trichophyton rubrum and Trichophyton mentagrophytes. The hexapeptides of the present invention exhibit antifungal activity, antibacterial activity, desirable stability, and lack toxicity to the mammal receiving treatment.

A composition obtained primarily from plant materials provides antimicrobial activity for use as an anti-fungal agent. The anti-fungal agent is effective in inhibiting the growth of Trichophyton rubrum, the fungus that is the most common cause of Tinea pedis. The composition includes selective mixtures of the origanum oil, menthol, and Atlantic cedarwood oil, thuja oil, cedarwood oil, cinnamon oil, clove oil, cumin oil, fennel oil, peppermint oil, or rosemary oil.

Method and apparatus for using computer controlled, fiber-coupled laser delivery of treatment specific wavelength, intensity and duration of UV irradiation to control bacterial, fungal, viral and mold infections in bodily cavities, fluids and external applications. The method of treatment is focused on DNA breakdown beyond repair by natural DNA repair mechanisms of the pathogen, with less than damaging doses to tissues being treated, thus avoiding mutagenicity and carcinogenicity. The minimal intensity and duration and exposure area of any given surface of tissue to be treated is to be pre-determined by tissue and pathogen testing to optimize the therapeutic ratio. External applications include specifically Trichophyton Rubrum (toenail fungus) through the nail and Pseudomonas Aeruginosa infections in burns and elsewhere.

Dermatophytes which belong to one of the three genera Epidermophyton, Trichophyton and Microsporum are the main cause of fungal infections of skin, hair and nails. Traditional diagnostic procedures consist of microscopy and culture, but due to the slow growth rate of dermatophytes typically two to four weeks are needed before a final diagnosis is obtained. The present invention is a rapid DNA extraction method extracting nucleic acids from fungi (e.g. dermatophytes and other pathogenic fungi) which can be performed from directly on hair, nail or skin specimens from humans, from naturally or experimentally infected animals or from cultured fungal colonies for the use in PCR amplification and detection assays. The present invention also includes specific primer sets for detection of any dermatophyte and for species specific detection of Trichophyton rubrum and Epidermophyton floccosum by PCR and a kit for diagnosing fungal infections.

Provided is anti-bacterial fabric for shoes and a production process thereof. Warp-knitted spacer fabric is adopted and comprises a surface layer for decoration, an inner layer in contact with the skin, and a spacing layer arranged between the surface layer and the inner layer. The inner layer is formed in such a manner that far infrared polyester fibers and chinlon-based cupric ion anti-bacterial fibers are interwoven. The far infrared polyester fibers serve as the spacing layer. In a bacteriostatic test of fabric, the bacteriostasis rate of Candida albicans reaches at 95.76%, the bacteriostasis rate of trichophyton rubrum reaches at 96.96%, the bacteriostasis rate of staphylococcus aureus reaches at 99.23%, and the bacteriostasis rate of colibacillus reaches at 99.99%. The anti-bacterial fabric has composite functions of heat preservation, bacteria prevention, health care, moisture conductivity and perspiration.

The present invention relates to a formulation and method for the treatment of fungal nail infections, such as those caused by Trichophyton rubrum and / or Aspergillus niger. The formulation of the invention comprises glucose oxidase, D-glucose and hydrogen peroxide in an aqueous solution. Advantageously, the formulation of the invention provides a two-stage hydrogen peroxide release for the treatment of the fungal nail infections.

A ring-shaped toe-patch is provided for treatment and prevention of tinea pedis, commonly known as athlete's foot. The toe-patches are made of rubber-foam, attached to a hydrophobic material for elimination of fungus like T. rubrum. The toe-patch has cuts extending into the patch from the central circle in the toe-patch. Due to its perfect fit the toe-patch comes close to the affected area making it possible for a hydrophobic material attached to foam to effectively bind the fungi. Simultaneously with the elimination of the fungi the toe-patch works as a toe separator creating space between the toes.

The invention discloses an antifungal compound extract, a preparation and a preparation method of the extract. The antifungal compound extract comprises the following components in parts by weight: 1-3 parts of a gallnut extract, 1-3 parts of a fructus cnidii extract, 1-3 parts of a pogostemon cablin extract, 0.5-1.5 parts of a galangal extract, 0.5-1.5 parts of a radix sophorae flavescentis extract, 0.5-1.5 parts of a radix clematidis extract, 0.5-1.5 parts of a fructus kochiae extract and 0-80 parts of an ethanol-water solution. The components of the antifungal compound extract are extractedby adopting a hot reflux extraction method; and ethanol-separated and purified liquid obtained after separation and purification of macroporous adsorption resin has an obvious effect of resisting trichophyton rubrum and tritirachium album and can be used for preventing and treating fungal infection of human skin, hair and nails. Meanwhile, plant extracts are compounded to be prepared into powderygranules, the solubility is increased, the state is good, the medicine curative effect is long, and the medication form is convenient.

The invention relates to application of oxidized resveratrol and combined oxidized resveratrol and antibiotic in the preparation of an anti-fungal-infection product, belonging to the technical field of medicines. Oxidized resveratrol contains nautical components, is good in safety and has good antibacterial capacity to trichophyton rubrum and Candida albicans. When the oxidized resveratrol and an antibiotic, namely econazole nitrate jointly act on the two bacteria, the antibacterial effects on the two bacteria are superior to the antibacterial effects of dependent independent oxidized resveratrol and antibiotic on the two bacteria under the same use concentration, so that natural oxidized resveratrol is used for replacing partial econazole nitrate so as to inhibit fungi, the use amount of econazole nitrate can be reduced, and the research and development of novel, efficient and natural anti-fungal-infection drugs are benefited.

The invention provides a triazole compound shown as a general formula (I), optical isomers or the pharmaceutically acceptable salts thereof, and application of the compound, optical isomers or pharmaceutically acceptable salts thereof to preparation of medicaments for resisting fungi, especially Candida albicans, Candida parapsilosis, Candida glabrata, Cryptococcus neoformans, Microsporum flavescens, Trichophyton rubrum and / or Aspergillus fumigatus. The invention provides a pharmaceutical composition, comprising a therapeutically effective amount of one or more selected from the compound shown in the formula (I), optical isomers and pharmaceutically acceptable salts thereof and pharmaceutic adjuvants.

An embodiment of the invention discloses a trichophyton rubrum infection model preparation method and application. The preparation method includes the steps: separating a corium layer and a cuticularlayer of prepuce tissues, and digesting and culturing the cuticular layer to obtain human keratinocytes; finally, adding the human keratinocytes to a collagen scaffold and culturing the human keratinocytes to form a tissue engineering skin model. The model is simple to operate and easy to observe and solves the problem that a current trichophyton rubrum infection animal model is not easily observed. Seeds of the trichophyton rubrum infection model are the human keratinocytes and closer to the biological state of human skin fungal infection.

The invention provides application of an evodiamine derivative in preparation of a medicine for treating superficial fungal infection. The evodiamine derivative disclosed by the invention is prepared by taking a methyl anthranilate compound and tryptamine as initial raw materials through amine-ester exchange and a one-step ring closing reaction catalyzed by Lewis acid. The evodiamine derivative disclosed by the invention can show good antibacterial activity on three fungi, namely trichophyton rubrum, trichophyton mentagrophytes and candida albicans. Moreover, cell walls, cell membranes and organelles of fungal spores are destroyed to a certain extent, the hydrophobicity of fungal biomembranes can be influenced to a certain extent, phenomena of dark red erythema, skin hardening and generation of a large amount of scurf caused by errhysis spots of skin subjected to dermabrasion treatment can be obviously relieved, and phenomena of thickened epidermal layer of skin tissue, small-area epidermal layer necrosis, cuticle small-area parakeratosis and the like are avoided. The evodiamine derivative has low toxicity and low drug resistance and can be applied to preparation of drugs for treating the superficial fungal infection.

The invention discloses an antibacterial anti-inflammatory medical gel. The antibacterial anti-inflammatory medical gel is prepared from agarose, sodium alginate, nopol, rue oil, artemisia apiacea oil, diallyl disulfide, terpinene, sodium diacetate, histidine, sodium lactate, silymarin, cyanobacteria extract, magnesium chloride, vitamin P, tween-20, glycerin, and water. The invention also discloses a preparation method of the antibacterial anti-inflammatory medical gel. The antibacterial anti-inflammatory medical gel possesses excellent antibacterial anti-inflammatory effect; inhibition rate on staphylococcus aureus, pseudomonas aeruginosa, trichophyton rubrum, and candida albicans is 93.5% or higher; it is confirmed by rabbit skin test that no skin erythema, or edema, or irritation is caused by the antibacterial anti-inflammatory medical gel, and the antibacterial anti-inflammatory medical gel is safe and reliable to use.

The invention relates to an application of ellagic acid to preparation of drugs for treating and preventing fungal infection of a human body. According to the application, the in-vitro fungi inhibition activity of ellagic acid to 23 fungi is studied and the MIC (minimal inhibitory concentration) value is measured; an in-vitro activity result of ellagic acid to the fungi shows that the MIC value of ellagic acid to 6 dermatophytes is 6.25-50 microgram / ml, and ellagic acid has a better inhibition effect on clinical common superficial pathogenic fungi and is especially sensitive to trichophyton rubrum; the MIC value of ellagic acid to 6 clinical common candida is 25-200 microgram / ml; ellagic acid is orally taken and externally used to treat a cavy skin trichophyton rubrum infection model, and the effect of treating a mouse fungal infection model by injecting ellagic acid or ellagic acid and fluconazole is studied; a study result shows that ellagic acid has a certain treatment effect on the cavy skin trichophyton rubrum infection model after being orally taken and externally used.

The invention relates to the technical field of medicines, particularly to six triterpene glycosides antifungal compounds HolotoxinD-I separated from a sea cucumber. The chemical structural formula isas follows on the right. An in vitro anifungal experiment shows that the compounds have obvious inhibitory effect on Candida ablbicans SC5314, Cryptococcus neoformans BLS108, Candida tropicalis, Trichophyton rubrum, Mircrosporum gypeseum and fuming Aspergillus. The invention can provide leading compounds for developing novel antifungal drug, and has a significant value on exploiting and using marine medical resources in China.

The present invention relates to the technical field of medicines and discloses dryopteris fragrans phloroglucinol derivatives, a separation and preparation method for isomers thereof and an application thereof Phloroglucinol compounds are separated and prepared from dryopteris fragrans(L.)Schott, which belongs to dryopteridaceae dryopteris plants, for the first time, and 4 pairs of isomers are discovered, wherein the 4 pairs of isomeric compounds have relatively strong effect of resisting skin superficial fungi. According to the in-vitro bacteriostatic experiment, the compounds provided by the present invention have good bacteriostatic effect on two skin pathogenic fungi, namely trichophyton rubrum and microsporum gypseum, and have characteristics of being low in side effect and being not liable to become resistant to the drug, and the like, thereby providing a novel natural compound for the treatment of skin superficial fungi infection and providing powerful technical support for preparing anti skin superficial fungi infection drugs or pharmaceutical compositions.

The invention discloses a folium artemisiae argyi extract and a preparation method and application thereof to dermatophyte antibacterial agents, and belongs to the field of technical application of plant source antibacterial agents. The antibacterial agents are folium artemisiae argyi extracts prepared by taking traditional Chinese medicinal materials of folium artemisiae argyi as raw materials through ultrasonic extraction (5-75% ethanol) or ethanol reflux extraction, and have an efficient inhibition effect on dermatophytes such as trichophyton rubrum, trichophyton mentagrophytes and microsporum gypseum. After the folium artemisiae argyi extracts are separated and purified through macroporous adsorption resin, 40-95% ethanol separation components have different degrees of inhibition activity on the dermatophytes, wherein the 95% ethanol separation components are most significant. Meanwhile, the main chemical components in the 95% ethanol separation components are eupatilin, physcion, vitexin, brown cyanidin and the like. The folium artemisiae argyi extract can efficiently inhibit the dermatophytes, has the advantages of safety, high efficiency and low toxic and side effects, and provides a new drug source for prevention and treatment of dermatophyte diseases such as tinea of feet and hands.

The invention relates to a method for determining the activity of a trichophyton rubrum keratinase. The method comprises the following steps: (1), constructing an artificial skin containing epidermis and dermis structures: resuspending human skin fibroblast cells in a collagen liquid, dropwise adding into a cell culture well plate and culturing; after the cells are completely expanded, dropwise adding a human keratinocyte suspension to the surface of collagen gel and continuously culturing; carrying out air-liquid interface culture when the human keratinocytes completely cover the surface of the collagen gel; and stopping culturing until a cuticular layer is differentiated into 5-8 layers; (2) carrying out artificial infection on trichophyton rubrum; and (3) determining the activity of the keratinase. The artificial skin, which is constructed by the method disclosed by the invention, becomes a natural inducer for production of the keratinase and has the following advantages that firstly, the artificial skin contains the dermal layer, the epidermal layer and 5-8 cuticular layers and the structure and function are closer to those of the human skin; secondly, keratin secreted by the keratinocyte in the epidermal layer is used as a natural substrate to induce the production of the keratinase; and, thirdly, the keratinase produced by inducing the natural substrate keratin, is accurate, real and stable in the determination of the activity.

The invention relates to a usage of an ocean fungal extract-active natural product B. According to the result of an in vitro research trial, the active natural product B has certain inhibitory effecton common clinical pathogenic fungi such as white tritirachium album limber, cryptococcus neoformans, trichophyton rubrum and aspergillus fumigatus and the like, is able to inordinately inhibit the growth of tumor cell lines such as liver cancer, breast cancer and lung cancer and the like, and is able to have stronger protective effect on pathological mechanism damages caused by rat multi-infarctcerebral ischemia damage and the like, thus being capable of obviously improving the learning and memory functions of dementia rat, and being applied to prepare dementia product having anti-angiogeniceffect. The invention provides a new pharmaceutical source for the curing of clinical antifungal, antitumor and anti-vascular dementia and directly related diseases thereof, having important value for developing and utilizing the pharmaceutical resource of our country.

The invention relates to application of formononetin in trichophyton rubrum. The technical scheme of the invention is the application of formononetin in preparing medicaments for treating antifungal infected diseases, wherein the fungus is trichophyton rubrum. The compound has an excellent antifungal activity on various superficial and deep funguses, has the advantages of high activity, low toxicity, broad antifungal spectrum and the like when being compared with an antifungal medicament in existing clinical application, and can be used for preparing antifungal medicaments.

The invention provides a preparation method of antibacterial sol for shoemaking and an antibacterial finishing method. The preparation method and the antibacterial finishing method include: using TEOSas the precursor, EtOH as the solvent and HNO3 as the catalyst, adding a certain amount of GPTMS and TH, electrically stirring for 5 hours at hydrolysis temperature of 30 DEG C, and standing at roomtemperature for a certain period of time to obtain the transparent antibacterial sol; using a padding finishing process to perform antibacterial finishing on lining fabric for shoes, soaking the fabric into the transparent antibacterial sol for a certain period of time, using a rolling manner to press the transparent antibacterial sol into the gaps of the fabric, and removing the redundant transparent antibacterial sol at the same time. Compared with the prior art, the antibacterial finishing method has the advantages that the two-dipping two-rolling process with the pick up being 70-80% is used under the conditions that dipping time is 10 seconds, pre-drying temperature is 130 DEG C, pre-drying time is 2.5 minutes, drying temperature is 190 DEG C and drying time is 40 seconds, the processed shoe material is good in antibacterial effect on Candida albicans and Trichophyton rubrum, and the antibacterial rate is larger than 90%.

The invention relates to an application of Scopariusins in the preparation of antihuman fungal medicines, and belongs to the medicinal field. Scopariusins has a very strong Trichophyton rubrum, Microsporum lanosum or Trichophyton tonsurans inhibition effect, so the Scopariusins can be used as an antihuman fungal compound, and is expected to be applied in the preparation of related medicines. The skeleton type of the Scopariusins is a brand new skeleton type, and the Scopariusins has a strong human fungus inhibition activity, has prominent substantive characteristics, and is a substantial improvement in the prevention and treatment of human fungal infection.

The invention discloses a coconut fiber and chemical fiber blended yarn which is formed by blending coconut fibers with chemical fibers, the chemical fibers are one or more of copper ammonia fibers, acrylic fibers, chinlon, modal, tencel and viscose glue. The coconut fiber and chemical fiber blended yarn disclosed by the invention is smooth in material surface, good in air permeability, high in toughness and heatproof and can resist the damage caused by escherichia coli O157, staphylococcus aureus, trichophyton tonsurans, trichophyton schoenleinii, trichophyton rubrum, candida albicans and other pathogenic bacteria.

The invention discloses a novel compound II with antifungal activity. The chemical components of Selaginella pulvinata Maxim are subjected to systematic intensive study, and the spectrum and mass spectrometric data analysis proves that the novel compound II is separated from the Selaginella pulvinata Maxim. The in-vitro antifungal activity research proves that the compound II disclosed by the invention has the effects of obviously inhibiting multiple pathogenic fungi such as Candida albicans, aspergillus fumigatus, trichophyton rubrum and alpha fungus, is low in toxicity and safe in clinical administration, and is expected to be developed into a novel antifungal medicament.

The invention relates to an antibacterial peptide and an application thereof in preparation of medicines or cosmetics. The antibacterial peptide has significant inhibitory activity on human pathogenicfungi trichophyton rubrum, and the compound also has the advantage of low toxicity, so that the antibacterial peptide can be used for preparing antifungal drugs and cosmetics.

The invention provides freesia hybrida essential oil with antibacterial activity as well as a preparation method and application of the freesia hybrida essential oil. The freesia hybrida essential oilis obtained by distilling and extracting freesia hybrida flowers in a blooming period by adopting a steam distillation method. The results of antibacterial and bacteriostatic drug sensitivity tests,a minimum inhibitory concentration (MIC) and a minimum bactericidal concentration (MBC) show that the essential oil has an antibacterial effect on bacteria (escherichia coli, bacillus subtilis, staphylococcus aureus, staphylococcus epidermidis and the like) and fungi (candida albicans, Shenkei sporidium, trichophyton rubrum, saccharomyces cerevisiae and the like), and presents a broad-spectrum inhibition effect on bacteria and fungi. Therefore, it is found that the freesia hybrida essential oil can be used for development and application of sterilization products and daily products.

The invention discloses a new compound I with the antifungal activity. The new compound I is obtained by systematic in-depth study on the chemical components of selaginella pulvinata maxim and separation from the selaginella pulvinata maxim through analysis on wave spectrum and mass spectrum data. Shown by in-vitro antifungal activity, the new compound I provided by the invention has obvious inhibiting effect on candida albicans, aspergillus fumigates, trichophyton rubrum and alpha fungus and the like, is low in toxicity and can be developed into a new antifungal medicine.