108 results about "Salicylic acid" patented technology

This invention discloses a class of aminosalicylic acid derivative compounds, their pharmaceutical compositions, and uses. The aminosalicylic acid derivatives of this invention can significantly improve ischemic symptoms in rats with a cerebral ischemia-reperfusion model, and these compounds have broad application prospects in the preparation of drugs for the prevention and treatment of stroke.

This invention discloses a firming and wrinkle-reducing eye cream, comprising a moisturizer, a whitening agent, a skin repair additive composition, a thickener, a preservative, a film-forming agent, a skin moisturizer, and a surfactant. The weight ratio of the moisturizer, whitening agent, anti-aging additive composition, thickener, preservative, film-forming agent, skin moisturizer, and surfactant is 20:1:2:3:0.3:0.5:1:0.2. The moisturizer includes butylene glycol, glycerin, polydimethylsiloxane, and hydrogenated polyisobutylene. The skin-repairing additive composition includes hydroxypropyl tetrahydropyranotriol, adenosine, cell growth factors, ceramides, and salicylic acid, comprising olefins, betaine, trehalose, 1,2-hexanediol, hydrogenated lecithin, allantoin, and Euglena galactosides. The film-forming agents include polyacrylamide, cyclohexylsiloxane, and polydimethylsiloxane alcohol. The emollients include C13-14 isoparaffins, polydimethylsiloxane / vinyl dimethylsiloxane crosspolymers, and cyclopentamethoxysiloxane. This invention can repair cells and provide long-lasting anti-wrinkle and whitening protection for the corners of the eyes.

This invention discloses a method for culturing cherry cells and cherry cell exosomes. The culturing method includes the following steps: S1. Obtaining a cherry cell line; S2. Preparing a culture medium by adding salicylic acid and methyl jasmonate; S3. Culturing the cherry cell line obtained in step S1 under the following conditions: culturing at 20–30°C with UV-B illumination during the culture process. This invention improves the cherry cell culture method, increases production efficiency, and enhances the content of active ingredients, especially flavonoids and polyphenols, in the cherry cell culture. The cherry cell culture obtained by this invention, especially the exosomes extracted from it, has broad application potential in the cosmetics field.

The application belongs to the technical field of pharmaceutical chemistry, and particularly relates to clofazimine-organic acid co-crystals, a preparation method and application thereof. The clofazimine-organic acid co-crystal is one of clofazimine-ferulic acid monohydrate co-crystal, clofazimine-ferulic acid co-crystal, clofazimine-glutaric acid co-crystal, clofazimine-glycolic acid co-crystal (CFZ-GA 1:1), clofazimine-glycolic acid co-crystal (CFZ-GA 1:1.5), clofazimine-salicylic acid co-crystal, clofazimine-L-aspartic acid co-crystal, clofazimine-L-pyroglutamic acid co-crystal, clofazimine-gallic acid co-crystal, clofazimine-succinic acid co-crystal, clofazimine-tartaric acid co-crystal and clofazimine-DL-mandelic acid co-crystal. The clofazimine-organic acid co-crystal provided by the application significantly improves the solubility and fluidity of clofazimine, thereby improving the bioavailability of clofazimine, and has a broad medicinal prospect.

The present application provides a kind of planting method of reducing allelochemicals and improving polysaccharide content of Rhizoma Polygonati, belongs to plant cultivation technical field.The planting method is planted in acidic sandy loam soil, and "biochar C" is applied to the soil 1-2 times in September-October of the second and third years, and the fruits mature, the stems are laid down after the third year, and then it can be harvested."Biochar C" is a modified, loaded with salicylic acid and UDP-D-galactose biochar.The present application not only helps to improve the physicochemical properties and bacterial community diversity of Rhizoma Polygonati planting soil, thereby reducing the allelochemicals content of Rhizoma Polygonati rhizome, but also can improve the polysaccharide content of rhizome, which helps to improve the quality of Rhizoma Polygonati and enhance its efficacy.

This invention relates to a rooting agent and seedling cultivation method for promoting rooting of *Cyclocarya paliurus* cuttings, belonging to the field of plant asexual reproduction technology. It solves one of the problems in existing *Cyclocarya paliurus* seedling cultivation: low rooting rate, long rooting time, few and poor-quality adventitious roots, and low transplant survival rate. This invention discloses a rooting agent for promoting rooting of *Cyclocarya paliurus* cuttings, which consists of two components, A and B. Component A consists of potassium indolebutyrate, soluble starch, chlorogenic acid, salicylic acid, and talc; component B consists of indolebutyric acid, sucrose, chlorogenic acid, vitamin C, and talc. Using the above-mentioned rooting agent and the corresponding seedling cultivation method, rapid rooting of *Cyclocarya paliurus* cuttings is achieved, with a rooting rate as high as 93.06%, and a large number and good quality of adventitious roots, resulting in a transplant survival rate of 90.37%.

This invention discloses a nicotinamide-salicylic acid cocrystal, its preparation method, and its uses, relating to the field of cocrystal technology. The nicotinamide-salicylic acid cocrystal comprises nicotinamide and salicylic acid molecules, and the molecular formula of the nicotinamide-salicylic acid is C0. 13 H 12 N2O4, wherein the molar ratio of nicotinamide to salicylic acid is 1:1; the eutectic is monoclinic, space group P21 / n, with cell parameters a=11.080(2)Å, b=5.0000(10)Å, c=22.820(5)Å, α=90°, β=97.60(3)°, γ=90°, V=1253.1(4)Å. 3 The differential scanning calorimetry (DSC) spectrum of the eutectic showed a characteristic endothermic peak around 142.4 ± 2 °C. This invention addresses the problems of poor stability of nicotinamide, low solubility of salicylic acid, and strong irritation in existing technologies by optimizing intermolecular interactions to form a specific crystal form, thus providing a novel raw material with superior performance for the cosmetics industry. This is achieved through the preparation of a structurally stable, simple, and chemically superior nicotinamide-salicylic acid eutectic with excellent physicochemical properties.

The present application belongs to the technical field of fertilizer, and specifically discloses a foliar fertilizer for improving the disease resistance effect of Vietnamese ginseng, which is composed of 0.1-0.5% potassium dihydrogen phosphate, 0.1-0.2% boric acid, 0.3-0.7% urea, 0.005-0.02% chitosan, 0.0001% salicylic acid and 0.05% Tween-20, and the rest is water, according to the weight percentage. The foliar fertilizer prepared by the present application has a remarkable disease control effect on Vietnamese ginseng, and has a positive control effect on the infection of Fusarium oxysporum, Alternaria panax and Botryosphaeria dothidea. After using the foliar fertilizer of the present application, the growth of the pathogen is significantly inhibited from the phenotype, and the disease onset time of Vietnamese ginseng is significantly later than that of the control. The resistance gene expression of Vietnamese ginseng is significantly improved through testing.

This invention relates to the field of polymer materials technology, specifically disclosing a high-adhesion, low-stress, room-temperature curing epoxy potting compound and its application. The high-adhesion, low-stress, room-temperature curing epoxy potting compound is composed of component A and component B; component A includes 100 parts by weight of epoxy resin and 50-200 parts by weight of filler; the filler is composed of D... 50 Spherical silicon with a particle size of 20-35 μm and D 50 The invention is formulated with aluminum hydroxide with a particle size ≤2μm; component B includes 30-45 parts by weight of an amine curing agent and 0.5-5 parts by weight of an accelerator; the amine curing agent is a compound of polyetheramine and 3,3'-dimethyl-4,4'-diaminodicyclohexylmethane; the accelerator is a compound of 2,4,6-tris(dimethylaminomethyl)phenol and salicylic acid. This invention can be cured at room temperature, avoiding the energy consumption and damage to heat-sensitive components caused by high-temperature curing, significantly improving production efficiency and reducing production costs.

This invention discloses a method for synthesizing potassium 4-methoxysalicylate based on supramolecular-assisted methylation, belonging to the field of organic synthesis technology. The process is based on supramolecular chemistry principles and includes the following steps: (1) Preparation of a macrocyclic host molecule-methylating agent complex loaded with a methylating agent: The macrocyclic host molecule and the methylating agent are reacted at pH 7-9 and 25-40℃ to form a complex solution; (2) One-pot preparation of the target product: 2,4-dihydroxybenzoic acid is salted with potassium hydroxide, potassium carbonate is added, and the above complex solution is added dropwise. A selective methylation reaction is carried out at 55-65℃. After the reaction is complete, post-treatment yields the product. This invention utilizes the molecular recognition function of the macrocyclic host to achieve highly selective methylation of the 4-hydroxyl group under mild conditions. This process has the advantages of simple operation, high safety, low waste, and recyclable host molecules. The yield of potassium 4-methoxysalicylate can reach over 85%, and the purity exceeds 99.0%.

The present disclosure encompasses solid state forms of Lucerastat, in embodiments crystalline Lucerastat: L-Pyroglutamic acid, crystalline Lucerastat: Salicylic acid, crystalline Lucerastat: Fumaric acid, crystalline Lucerastat: Benzoic acid and crystalline Lucerastat: o-Acetylsalicylic acid, solid state form thereof, processes for preparation thereof, and pharmaceutical compositions thereof.

This invention is related to the fields of medical biotechnology, nanobiotechnology, and nanomedicine. It involves a nanomedicine product that can release HOC1 (hypochlorous acid) at the tumor site in a controlled manner to treat lung cancer. HOC1 is a potent antimicrobial and antitumor agent that can target tumor tissues while minimizing damage to healthy tissues. The produced nanoparticles have a two-layer structure: the inner layer contains alginate, PFP (perfluoropentane), and Ca(OCl)2 to release HOC1, and the outer layer has a chitosan coating with folate and salicylic acid for targeting and proton release. The production process involves nanoemulsion and coating with the ionic gelation technique. When the nanoparticles are delivered to the lungs and targeted to cancer cells with folate, ultrasound radiation triggers the release of HOC1 to induce apoptosis and destroy cancer cells effectively, reducing side effects and improving treatment outcomes for lung cancer patients.

This invention relates to the field of pharmaceutical application technology, and more specifically, to the application of heterocyclic compounds. Example I describes the application of the compound shown in Formula I in the preparation of an inhibitor that inhibits the activity of methylenetetrahydrofolate reductase. Furthermore, the compound shown in Formula I can be used alone, in combination with para-aminosalicylic acid, or in combination with a β-lactamase inhibitor, all of which exhibit good antibacterial activity against Mycobacterium tuberculosis, and can treat or prevent diseases caused by Mycobacterium tuberculosis, such as tuberculosis.

The objective is to provide a fragrance composition that has high reproducibility of the fragrance of forsythia flowers and excellent palatability. [Solution] The forsythia flower fragrance composition comprises (A) methyl salicylate and / or ethyl salicylate, (B) methyl benzoate and / or ethyl benzoate, and (C) linalool and / or limonene, wherein the total content of component (A) and component (B) is 50 to 90% by mass, and the mass ratio (A / B) is 1 to 10.

The present application relates to wastewater treatment technical field, specifically is a kind of automatic processing device of salicylic acid production wastewater, including the centrifugal extraction mechanism of phenolic substance in wastewater is separated and recovered, also include the treatment tank for demulsification separation of high salt substance in wastewater, the effluent port of treatment tank lower portion is communicated with the wastewater phase inlet of centrifugal extraction mechanism by connecting pipeline, the present application is pretreated to wastewater using treatment tank, by shear turbine one and shear turbine two rotation, mechanical shearing emulsion drop in wastewater to break its interface film, again using flow passage one, flow passage two, flow passage three and flow passage four to the emulsion drop that is broken up are gradually conducted and coalesce, simultaneously combining with the precise metering and putting of dosing assembly on dosing pipe to demulsifier, make the small emulsion drop that difficult to separate in wastewater coalesce and form size larger, easy to separate stable emulsion drop, finally realize the high quality, high efficiency separation of extraction agent phase and wastewater phase.

The present invention relates to a modified aldehyde based resin with enhanced tolerance to saline process waters and to the use of said resin as a binder for non-woven fibrous materials, such as mineral wool (glass and stone fiber), wood products, coatings, abrasives, foams and in the area of refractory, foundry, and impregnation. The invention further relates to a method for the manufacture of the modified resin and the manufacture of a sizing composition comprising said modified resin for mineral wool applications. Surprisingly, aromatic carboxylic acids, particularly salicylic acid, as modification agents for an aldehyde based resin led to an improved salt water tolerance and a decrease in resin formaldehyde curing emissions.

The application belongs to the technical field of medical cosmetology, and discloses a high-content salicylic acid composition with good solubility, a preparation method and application thereof. The composition comprises salicylic acid, polyethylene glycol-8 and PPG-14-polyglyceryl-2-ether, the weight ratio of salicylic acid, polyethylene glycol-8 and PPG-14-polyglyceryl-2-ether is 3:(4-6):(1-3), and the weight percentage of salicylic acid in the composition is 25%-30%. The composition of the application uses polyethylene glycol-8 and PPG-14-polyglyceryl-2-ether in a specific ratio as a eutectic solvent, forms a stable homogeneous system after eutectic reaction with salicylic acid, and has no salicylic acid melting peak in DSC scanning, thereby solving the problems of poor solubility of salicylic acid and easy crystallization and precipitation of salicylic acid in the formula. The preparation process of the application is simple and easy to operate, and is convenient for industrial production.

The present invention provides a cosmetic composition comprising alkoxysalicylic acid or a salt thereof, which has a good feel and stability. [Solution] (A) Formula (a): JPEG2026101540000011.jpg4474 Alkoxysalicylic acid or a salt thereof, represented by the formula, (wherein R a (These are alkyl groups with 1 to 6 carbon atoms.) (B) Lipopeptide compounds having a cyclic structure with an alkyl chain having 6 or more carbon atoms, or a salt thereof, (C) Anionic surfactant or amphoteric surfactant A cosmetic product containing [the specified ingredient].

This invention discloses the application of a drug in the prevention or treatment of hydrocephalus, belonging to the field of pharmaceutical formulation technology. The drug comprises a pharmaceutically acceptable formulation of one or more of the following active ingredients: compound A, compound B, or compound C, and their pharmaceutically acceptable salts, solvates, or crystal forms; compound A is carbaspirin calcium, compound B is aspirin, and compound C is salicylic acid. This invention utilizes the above-mentioned drug in the prevention or treatment of hydrocephalus. Carbaspirin calcium and its metabolites can significantly reduce ventricular enlargement in a hydrocephalus model rat, and carbaspirin calcium and its metabolites show promise in the preparation of drugs for treating hydrocephalus, providing an effective candidate drug to alleviate the suffering of hydrocephalus patients, reduce treatment risks and costs; it broadens the scope of action of carbaspirin calcium and optimizes the stability formulation of carbaspirin calcium.

This invention relates to the field of carbon dioxide fracturing technology, specifically to a special powder for carbon dioxide activators and its large-scale preparation process. The special powder uses potassium perchlorate, salicylic acid, and ammonium oxalate as main raw materials, compounded with trace functional additives. The formula is scientifically controlled, possessing both high exothermic properties and inherent safety. The preparation process includes: pre-treating the raw materials followed by multi-gradient drying, graded ball milling and sieving, pre-mixing, homogenization and mixing, and secondary drying. The special powder prepared by this invention has a component uniformity deviation of ≤1%, a shelf life of up to 24 months at room temperature with sealing, 100% ignition reliability, and is compatible with various carbon dioxide fracturing devices, exhibiting significant safety, environmental, and economic advantages in mining, municipal engineering, and high-gas mines.

This invention provides a composition with anti-inflammatory, acne-reducing, and oil-controlling effects, and its preparation method, comprising active functional components and excipients; wherein the active functional components are tea tree oil, benzoyl peroxide, azelaic acid, quaternary ammonium salt-73, niacinamide, zinc gluconate, retinaldehyde, salicylic acid, licorice extract, purslane extract, capryloyl glycine, acetylglucosamine, and asiaticoside; the excipients include skin conditioning agents, moisturizers, nonionic emulsifiers, and skin-nourishing agents. This invention, through targeted synergistic system design, covers the entire pathogenesis mechanism of acne, achieving synergistic effects of antibacterial acne reduction, oil control, keratinization unblocking, anti-inflammatory repair, and microecological balance; simultaneously, through gradient feeding, liquid crystal emulsification, and low-temperature activation locking preparation methods, the stability of active ingredients is preserved to the greatest extent, solving the industry pain points of traditional acne products where efficacy and gentleness cannot be simultaneously achieved, active ingredients are easily deactivated, and acne is prone to recurrence. It can be widely applied to the preparation of various acne-reducing and oil-controlling skin care products.

The application relates to the field of makeup, and specifically discloses a water-based self-emulsifying water mist lipstick and a preparation method thereof. The self-emulsifying water mist lipstick comprises the following raw materials in percentage by weight: 10-50% of polydimethylsiloxane / vinyl polydimethylsiloxane crosslinking polymer, 10-30% of cyclopentasiloxane, 5-30% of lauryl PEG / PPG-18 / 18 polymethylsiloxane, 1.1-12% of a humectant, 5-10% of polydimethylsiloxane, 0.1-0.5% of aminomethylpropanol, 10-50% of water, 0.1-0.5% of a thickening agent, 0.1-1% of emollient oil, 0.1-1% of a preservative, 0.02-0.4% of a water-soluble pigment, 0.1-2% of salicylic acid and 0.1-2% of an active liquid. The obtained lipstick has good self-emulsifying performance, good color development effect, good makeup duration, no staining and discoloration, high product moisturizing degree, can effectively moisturize the lips and reduce the appearance of lip wrinkles.

The present application relates to a kind of containing deep eutectic solvent pesticide preparation and its preparation method.Deep eutectic solvent is formed by mixing hydrogen bond donor and hydrogen bond acceptor, and the hydrogen bond donor is salicylic acid etc.;The hydrogen bond acceptor is choline chloride etc..Pesticide preparation containing deep eutectic solvent has high active ingredient content, excellent solubility, excellent surface activity and rapid diffusion performance.At the same time, it shows significant leaf affinity, can be fully deposited and dispersed on plant leaves.

This invention relates to the field of agricultural biotechnology and discloses a ternary hormone complex solution for promoting the germination of tetraploid Polygonatum sibiricum seeds. By mass percentage, it consists of the following raw materials: gibberellin 0.005%–0.02%, 6-benzyladenine 0.0005%–0.002%, salicylic acid 0.0005%–0.002%, with the balance being water. The germination method includes the following steps: S1: seed pretreatment; S2: hormone soaking; S3: substrate sterilization; S4: sand stratification for germination. This ternary hormone complex solution and germination method can significantly improve the germination rate of tetraploid Polygonatum sibiricum seeds and effectively reduce the mold rate during the seed germination period.

The application provides a preparation method of a cowpea leafhopper repellent and application thereof, and belongs to the technical field of green prevention and control of agricultural pests. The preparation method is as follows: activated biochar obtained by microwave pyrolysis of straw powder and activated by phosphoric acid is mixed with intercalated montmorillonite-PVA compound obtained by intercalating aluminum ions into montmorillonite and modifying the intercalated montmorillonite with polyvinyl alcohol, and then the mixture is modified with KH-550 to obtain a supported controlled-release carrier; linalool, geraniol and methyl salicylate are loaded on the supported controlled-release carrier to prepare a core; trans-2-hexenal and trans-2-octenal are loaded on the core to prepare a core-shell structure microsphere; the core-shell structure microsphere is coated with poly-N-isopropyl acrylamide to prepare a multi-stage controlled-release microsphere; and the multi-stage controlled-release microsphere is used to prepare the cowpea leafhopper repellent for preventing and controlling cowpea leafhoppers. The application improves the loading capacity and adsorption stability of active components, and improves the compatibility with the wax layer of cowpea leaves. The preparation of the application shows fast effect and long persistence.

This invention relates to the field of rubber materials technology, and proposes a high-temperature resistant hydraulic brake hose and its preparation method. A high-temperature resistant hydraulic brake hose comprises, from the inside out: an inner rubber layer, a first reinforcing layer, a middle rubber layer, a second reinforcing layer, and an outer rubber layer; both the inner and outer rubber layers are composed of rubber compounds, which include the following raw materials in parts by weight: 100 parts EPDM rubber, 20-30 parts fluorosilicone rubber, 50-70 parts modified carbon black, 13-15 parts first silica, 4-6 parts first zinc oxide, 2-3 parts first stearic acid, 5-10 parts first plasticizer, 1-2 parts dicumyl peroxide, 3-5 parts first accelerator, and 2-4 parts antioxidant; the modified carbon black is obtained by modifying the first carbon black with thiosalicylic acid. This technical solution solves the problem of poor high-temperature resistance in hydraulic brake hoses in related technologies.

The present invention relates to a bioceramic composition for temporary intracanal medication, which promotes the constant, controlled and balanced release of metal ions, hydroxyl (OH ‑ ) and metal-salicylate complexes, capable of providing bioactive, antimicrobial and anti-inflammatory properties. The present invention also provides methods for preventing or controlling endodontic infections and promoting tissue regeneration and repair by using the bioceramic composition.