47 results about "Dichlorophenol" patented technology

The invention relates to the technical field of nano-enzymes, and discloses a copper-based nano-enzyme with laccase and peroxidase double-enzyme activity and preparation and application thereof, and the copper-based nano-enzyme is a nano-material prepared by forming MOF through solvothermal reaction of copper ions and diamino terephthalic acid and then performing electrostatic adsorption on the MOF and polyoxometallate. The copper-based nano enzyme has high-efficiency laccase-like activity and peroxidase-like activity at the same time through the combination and synthesis process of the copper ion cluster and the organic ligand. The invention further discloses a preparation method of the copper-based nano-enzyme, peroxidase activity detection and application of the copper-based nano-enzyme to degradation and determination of dichlorophenol. The copper-based nano-enzyme provided by the invention has high catalytic activity and stability, is low in cost and easy to prepare, and can be applied to biosensing detection of hydrogen peroxide and environmental remediation degradation of organic pollutants such as phenols and dyes.

This invention discloses an extraction solvent recovery device for reducing the unit consumption of dichlorophenol (oxadiazon), belonging to the field of chemical equipment. The device includes: an extraction vessel, rotatably connected to a stirring shaft, with a partition plate attached to the inner wall of the extraction vessel. The partition plate has several evenly distributed sedimentation ports. A lifting frame is slidably connected to the stirring shaft, with sealing plates corresponding to each sedimentation port. A lifting assembly is connected to the partition plate, and the lifting assembly is driven by a drive mechanism. This assembly moves the lifting frame and the sealing plates, sealing the sedimentation ports and thus isolating the upper and lower layers of liquid within the extraction vessel, allowing for the extraction of the upper layer. Simultaneously, by isolating the upper and lower solutions within the extraction vessel, the device effectively improves the convenience and efficiency of phenol recovery, solving the problem of high unit consumption of dichlorophenol in existing solutions.

The invention discloses preparation and visual detection application of an Ag / {001} Bi2Fe4O9 nanosheet, relates to the technical field of visual ultra-sensitive detection of 2, 4-dichlorophenol, and aims to realize an in-situ and ultra-sensitive visual detection method for the 2, 4-dichlorophenol. The method comprises the following steps: uniformly mixing a xanthene dye fluorescein aqueous solution, an Ag / {001} Bi2Fe4O9 nanosheet suspension and a 2, 4-dichlorophenol aqueous solution to obtain a solution to be detected; the method comprises the following steps: putting a solution to be detected into a Pomfiley multi-channel photocatalytic reactor, carrying out dark adsorption by stirring without illumination, then starting visible light, carrying out sufficient illumination, filtering by adopting a 22-micron water-phase filtering membrane, and finally testing by adopting an ultraviolet and visible spectrophotometer, thereby completing photosensitization detection of 2, 4-dichlorophenol. According to the invention, the Ag / {001} Bi2Fe4O9 nanosheet can be prepared and applied to visual detection.

The present application relates to a kind of high efficiency energy-saving preparation process of phloroglucinol.The preparation process uses phenol as raw material, generates 2,6-dichlorophenol and dichlorophenol isomer through chlorination reaction, then is alkaline hydrolysis and acidification into product phloroglucinol, after the intermediate dichlorophenol is generated in the chlorination reaction of raw material phenol, it is not concentrated and separated, directly add base to carry out alkaline hydrolysis reaction, realize chlorination-alkaline hydrolysis two-step reaction continuous production.The present application uses alkaline hydrolysis reaction to also convert the original dichlorophenol isomer impurity in situ into product phloroglucinol, realizes waste to treasure, improves yield about 8-10%;In the preparation process, 2,6-dichlorophenol intermediate is not separated, it is directly used in the next step alkaline hydrolysis reaction, the operation unit such as the solvent, crystallization, centrifugation, drying, packaging etc. for its concentration replacement is saved, at the same time, the pungent odor generated in the large production process of 2,6-dichlorophenol is fundamentally avoided, and the environmental pollution problem in the production process of phloroglucinol is avoided.

The invention discloses a method for detecting phenyl sulfide in rectification residual liquid of 2, 4-dichlorophenol through high performance liquid chromatography, and belongs to the technical field of chemical detection and analysis. The method comprises the following steps: dissolving a to-be-detected 2, 4-dichlorophenol rectification residual liquid sample to prepare a to-be-detected sample, and preparing phenyl sulfide standard substance solutions with different concentrations; the method comprises the following steps: determining a to-be-detected sample and a phenyl sulfide standard substance solution by adopting a high performance liquid chromatograph, drawing a standard curve and a linear regression equation according to a detection result of the phenyl sulfide standard substance solution, and analyzing the phenyl sulfide in the sample by combining the linear regression equation and a chromatographic peak map of the to-be-detected sample, wherein the mobile phase comprises a phase A and a phase B, the phase A is an aqueous solution of phosphate buffer salt, the phase B is methanol, and an isocratic elution mode is adopted. According to the present invention, with the method, the accurate determination of the phenyl sulfide content in the 2, 4-dichlorophenol rectification residual liquid is achieved, the timely and accurate data guidance is provided for the 2, 4-D production process, and the target of production cost saving is ultimately achieved.

This utility model discloses an apparatus for preparing 2,4,4'-trichloro-2'-nitrodiphenyl ether, relating to the technical field of 2,4,4'-trichloro-2'-nitrodiphenyl ether production apparatus. The inlet of the reaction vessel is connected via pipelines to a 2,4-dichlorophenol tank, a 2-nitro-4-chlorophenol tank, a sodium hydroxide tank, and an N,N-dimethylformamide tank. The outlet of the reaction vessel is connected via pipelines to an extraction tank. The inlet of the extraction tank is connected via pipelines to a deionized water tank and an ethyl acetate tank. The outlet of the extraction tank is connected via pipelines to an organic phase tank. The outlet of the organic phase tank is connected via pipelines to a drying tank. The inlet of the drying tank is connected via pipelines to an anhydrous sodium sulfate tank. The outlet of the drying tank is connected via pipelines to a vacuum distillation tank. The bottom outlet of the vacuum distillation tank is connected via pipelines to a product tank. The process is simple, and the product yield and purity are high.

Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASH, or drug induced liver injury (DILI).

The invention discloses a desorption regeneration method of chlorinated phenol adsorption resin, which comprises the following steps: adsorbing 2, 4-dichlorophenol by using macroporous adsorption resin to obtain a byproduct 5-crude hydrochloric acid, then respectively carrying out desorption regeneration by using a first regenerant and a second regenerant, washing the obtained resin with water, and recycling to adsorb impurities in the crude hydrochloric acid. And the first regenerant and the second regenerant can be uniformly collected, separated and recycled. According to the method, methylbenzene and alcohol substances are respectively used as regenerant, efficient desorption and regeneration of the macroporous adsorption resin containing impurities such as chlorophenol are realized, and the method is simple, low in cost and capable of meeting environmental protection requirements.

The invention belongs to the field of medicine synthesis, and particularly relates to a preparation method of Remetirom (Remetirom). The preparation method comprises the following steps: reacting 2, 3, 6-dichloropyridazine, isobutyric acid, a catalyst, acid and a free radical initiator in a solvent to obtain an intermediate I; reacting the intermediate I with 4-amino-2, 6-dichlorophenol under the conditions of inert gas protection, catalyst and alkalinity to obtain an intermediate II; reacting the intermediate II with nitrous acid ester and N-cyanoacetyl ethyl carbamate under an acidic condition to obtain an intermediate III; and the intermediate III is subjected to a one-pot self-reaction in a carboxylate-carboxylic acid solvent to obtain the remetirol. The method provided by the invention has the advantages of short steps, low cost, mild reaction conditions, high total yield, suitability for industrial production and the like.

The invention provides a method for resource utilization of 2, 4-dichlorophenol rectification residual liquid, and belongs to the technical field of chemical production waste treatment. According to the method, the 2, 4-dichlorophenol rectification residual liquid is used as a raw material, and the 2, 4, 6-trichlorophenol component and the phenyl sulfide catalyst are effectively separated from the 2, 4-dichlorophenol rectification residual liquid through sectional distillation operation and optimization of distillation conditions, the cyclic utilization proportion of the phenyl sulfide catalyst and the use amount of a Lewis acid catalyst, so that the 2, 4, 6-trichlorophenol and the phenyl sulfide catalyst are effectively separated from the 2, 4-dichlorophenol rectification residual liquid. According to the method, the content of 2, 4-dichlorophenol in the chlorinated liquid obtained by efficiently recycling the 2, 4, 6-trichlorophenol component and recycling the polyphenylene sulfide catalyst is greater than 96%. According to the method, the production efficiency is improved, the 2, 4-dichlorophenol rectification residual liquid needing to be treated is reduced, and the production cost is remarkably reduced; the method is simple to operate and easy to implement, avoids complex operation steps in an existing recovery method, effectively solves the problems of high cost and poor adaptability of a traditional process, and provides powerful support for large-scale industrial production and application.

The application provides a surgical auxiliary instrument material with bacteriostatic performance and a preparation method thereof, relates to the technical field of bacteriostatic medical instruments, and comprises the following steps: heating and mixing polyethylene, polycaprolactone, styrene-butadiene block copolymer and a bacteriostatic precursor to obtain a mixture of the surgical auxiliary instrument material with bacteriostatic performance, and the raw materials of the bacteriostatic precursor include flax lignan, 4-vinyl-2,6-dichlorophenol and imino methacrylate. In view of the problem of poor wear resistance of the bacteriostatic surgical auxiliary instrument, the bacteriostatic precursor with high polymer coating flax lignan is prepared, the compatibility of flax lignan and the remaining high molecular materials (polyethylene, polylactic acid, styrene-butadiene block copolymer) is improved, the interface bonding performance is improved, the synergistic effect between flax lignan and other materials is exerted, the antibacterial substance is no longer a heterogeneous phase particle in the bacteriostatic surgical instrument, and the continuity, wear resistance and oxidation resistance of the whole material are maintained.

The invention discloses a preparation method and application of a pH-responsive multi-enzyme active fluorescent nano-enzyme, and belongs to the technical field of nano-enzyme preparation and application research. The multi-enzyme active fluorescent nano-enzyme is prepared by taking D-tryptophan or L-tryptophan, silver nitrate and chloroauric acid as raw materials and adopting a heating reflux method, and the preparation process is simple and convenient to operate, green, mild, stable and efficient. The prepared multi-enzyme active fluorescent nano-enzyme not only has strong blue fluorescence, but also shows excellent multi-enzyme activity, including oxidase, laccase and catecholase, and switching of the three enzyme activities can be realized by adjusting pH. In addition, the method is applied to quantitative detection of malathion and 2, 4-dichlorophenol by utilizing the characteristics of different enzyme activities.

The invention discloses a peptide-copper co-assembly laccase catalyst and a preparation method thereof, and belongs to the technical field of biological catalysis. The catalyst disclosed by the invention shows relatively high substrate affinity and catalytic efficiency. 2, 4-dichlorophenol is used as a substrate, the Km of Pep3 / Cu is the lowest and is about 0.1119 mM, and the Vmax of Pep2 / Cu is the highest and is about 4.296 mu M.min <-1 >. The catalyst keeps activity in a wide temperature range, the heat resistance is obviously superior to that of natural laccase, and the catalyst is suitable for running in a high-temperature environment. The catalyst disclosed by the invention is insensitive to pH change, keeps good activity in a storage process, has a catalytic effect on various phenolic compounds, and has broad-spectrum substrate adaptability. The peptide-copper co-assembled bionic laccase catalyst provided by the invention has outstanding performance in the aspects of catalytic efficiency, environmental tolerance, application range and the like, and is expected to become an efficient green catalytic material in environmental governance and food industry.

The present application relates to a simple preparation method of p-chlorophenol, which comprises the following steps: putting phenol into a four-necked flask, adding dichloromethane, stirring and dissolving, then adding a catalyst, slowly dropping chlorinating reagent, pouring the solution in the four-necked flask into a quenching kettle after the reaction is completed, adding water again, separating layers, discarding the water layer, removing dichloromethane to obtain a crude p-chlorophenol, wherein the weight ratio of raw materials is catalyst: phenol: water: chlorinating reagent: dichloromethane = 1:120:40:172:780; sending the crude product into a rectification kettle for rectification, receiving main fraction p-chlorophenol when the tower top is 65 DEG C; the yield is 82%, and the purity is 99.6%. The advantages are that p-chlorophenol is synthesized by taking phenol as a starting raw material and taking sulfuryl chloride as a chlorinating reagent at a temperature of 40-50 DEG C; the method is reasonable, the operation is simple, the yield is high, and the purity meets the quality research requirements. By rechlorination, the by-product o-chlorophenol can be changed into 2,4-dichlorophenol, and the by-product can be used for production.

A functionalized graphene oxide nitrile rubber and A tooth-scar-free tooth block is provided. The functionalized graphene oxide nitrile rubber comprises the following components in parts by weight: 100-140 parts of nitrile rubber, 30-90 parts of a functionalized graphene oxide nitrile rubber masterbatch, 1.8-2.52 parts of a vulcanizing agent, 1.2-1.68 parts of a vulcanization accelerator, 5-7 parts of a vulcanization activator, 17-23.8 parts of a plasticizer, 2-2.8 parts of antioxidant, 59-86.6 parts of a filler, 0.1-0.14 parts of a curing agent, and 2-2.8 parts of dichlorophenol. The functionalized graphene oxide nitrile rubber above has excellent mechanical properties, a wide applicable temperature range and strong stability in use, and can be prepared into a tooth-scar-free tooth block.

This invention belongs to the field of organic synthesis, specifically relating to a method for preparing 2,6-dichlorofluorobenzene, comprising: phenol and a chlorination reagent. N Chlorosuccinimide undergoes a chlorination reaction in the presence of a Pd catalyst and 1,10-phenanthroline-5,6-dione to produce 2,6-dichlorophenol. 2,6-Dichlorophenol, fluorinating agent NFSI, photocatalyst 4-CzIPN, and an ionic liquid undergo a deoxyfluorination reaction under blue LED irradiation to produce 2,6-dichlorofluorobenzene. This invention offers high product yield and purity, mild reaction conditions, and avoids the use of hazardous raw materials, making it suitable for industrial production.

The invention discloses a reaction proportioning device for reducing unit consumption of dichlorophenol as an oxadiazon raw material, and belongs to the field of oxadiazon production. The device comprises a storage tank and a tank cover, wherein the top of the storage tank is of an open structure; the tank cover fixedly covers the top opening of the storage tank; the tank cover is connected with a pressurizing mechanism; a bearing column is vertically inserted into the tank cover; the lower end of the bearing column extends to the bottom of the storage tank; a discharge channel is vertically formed in the bearing column; the discharging channel penetrates through the lower end face of the bearing column. And the upper end part of the bearing column is connected with an output pipeline communicated with the discharge channel. The dichlorophenol is stored in the storage tank, the pressurizing mechanism is used for inputting air to the top of the storage tank to promote the air pressure in the storage tank to be increased, and then the dichlorophenol in the storage tank is pressed into the output pipeline through the discharging channel, so that the feeding continuity and stability of the dichlorophenol are improved; moreover, the feeding precision of the dichlorophenol is also ensured, and meanwhile, the proportioning effect of the dichlorophenol during the production of the oxadiazon is also ensured.

The present application relates to a kind of wide-range lead ion colorimetric detection method based on four manganese oxide laccase activity anti-competitive inhibition, it is related to lead ion colorimetric detection technical field.The method utilizes the activity change of Mn3O4 catalysis 2,4-dichlorophenol and 4-aminoantipyrine color reaction as signal output, when Pb (II) exists in system, color reaction is inhibited, the absorbance of solution at 510 nm is significantly reduced;The detection range of the method to Pb (II) covers 1~2000 μM, the detection limit in low concentration interval is as low as 0.31 μM, in high concentration interval still maintains good linear response, the detection range is far more than most of the colorimetric detection methods currently reported, and simultaneously, the method has excellent selectivity and anti-interference to Pb (II).

This invention relates to a rare-earth-selenium tungsten oxide nanocluster material functionalized with mixed organic ligands, the chemical formula of which is [HDMEA]. 9 Na 12 H3[Ce6(DMEA)3(H2O)9W9(HTA)6O 18 (SeW9O 33 [6]ˑ81H2O, where DMEA = N,N-dimethylethanolamine and H3TA = hydroxymalonic acid. This material is prepared by a one-step self-assembly reaction of sodium tungstate dihydrate, N,N-dimethylethanolamine, sodium selenite, hydroxymalonic acid, and cerium nitrate hexahydrate in aqueous solution. The experimental operation is simple and the cost is low. This material can be used as a polyanionic polymer to form a thin film material by layer-by-layer assembly with positively charged chitosan. This multilayer film can be used as a sensitizing material to combine with polypyrrole containing template molecules (2,4-dichlorophenol) to form a molecularly imprinted polymer. This polymer can be used to construct an electrochemical sensor for detecting 2,4-dichlorophenol. Experimental results show that this electrochemical sensor has high sensitivity, strong stability, a wide detection range (1 μM–1 mM), and a low detection limit (0.125 μM).

The invention discloses a kind of functionalized water-based paint and preparation method thereof, belong to the technical field of water-based acrylic resin coating.The functionalized water-based paint includes 75.00-90.00 parts of water-based acrylic resin, 1.00-8.00 parts of alkyd resin, 2.00-8.00 parts of hexamethoxymethyl melamine and / or silane coupling agent, 1.00-3.00 parts of dipropylene glycol butyl ether, 1.00-3.00 parts of composite fungicide and 5.00-15.00 parts of water, wherein, the composite fungicide includes the organic mildew-proof agent of isothiazolinone class of specific proportion, iodopropynyl n-butyl carbamate, 4-bromo-2,5-dichlorophenol, 4-tolyl diiodomethyl sulfone, metconazole organic mildew-proof agent, surfactant, stabilizer, benzyl alcohol and water.The functionalized water-based paint of the present invention has excellent antibacterial and mildew-proof function, high stability, strong anti-loss property, strong weather resistance, can be used outdoors for a long time.

The present invention belongs to the technical field of chemical analysis and detection, and relates to a method for rapidly detecting sodium ions in cigarette paper using a nanoenzyme laccase. The method uses 2-aminoterephthalic acid, copper nitrate, and cerium nitrate as precursors, polyvinylpyrrolidone as a stabilizer, and a solvothermal method to synthesize a copper-cerium MOF-based nanoenzyme with laccase-like activity, namely, the Cu / Ce-BDC-NH2 nanoenzyme; the Cu / Ce-BDC-NH2 nanoenzyme oxidizes 2,4-dichlorophenol and 4-aminoantipyrine to obtain a red product, and the potassium pyroantimonate ligand is adsorbed on the Cu / Ce-BDC-NH2 surface, inhibiting the catalytic effect, resulting in a decrease in laccase-like activity and Na + The introduction of NH2-containing laccase reacts with potassium pyroantimonate to form a stable complex, thereby restoring the activity of Cu / Ce-BDC-NH2 laccase and deepening the red color of the solution. Based on this, the present invention establishes a new method for rapid colorimetric detection of sodium ions.

The utility model discloses a triclosan preparation device relates to triclosan production technical field, including first reactor, the inlet of first reactor is respectively through pipeline intercommunication with 2,4 - dichlorophenol jar, sodium hydroxide solution jar, xylene jar I and tetrabutyl ammonium bromide jar, the outlet of first reactor is through pipeline intercommunication with second reactor, the inlet of second reactor is respectively through pipeline intercommunication with 2 - chloro - 5 - nitrobenzene methyl ether jar, dilute hydrochloric acid solution jar, ZnCl2 - Al2O3 solid acid jar, nano TiO2 jar and xylene jar II, the outlet of second reactor is through pipeline intercommunication with third reactor, the inlet of third reactor is through pipeline intercommunication with acetic acid jar, the top gas phase export of third reactor is through pipeline intercommunication with first condenser, and the outlet of first condenser is through pipeline intercommunication with crude product jar, improves the yield of product.

The preparation method comprises the following steps: mixing a zinc salt aqueous solution with a 2-methylimidazole aqueous solution to prepare ZIF-8 nano-particles, dispersing the ZIF-8 nano-particles into an alcoholic solution to obtain a ZIF-8 alcoholic solution, mixing the ZIF-8 alcoholic solution with a polyphenol aqueous solution, and carrying out colorimetric analysis on the ZIF-8 alcoholic solution to obtain the manganese-based nano-enzyme. The preparation method comprises the following steps: preparing polyphenol cross-linked ZIF-8 nano-particles, dispersing the polyphenol cross-linked ZIF-8 nano-particles into water to obtain a polyphenol cross-linked ZIF-8 aqueous solution, and mixing the polyphenol cross-linked ZIF-8 aqueous solution with a potassium permanganate aqueous solution to obtain the manganese-based nano-enzyme. The method comprises the following steps: mixing 2, 4-dichlorophenol, 4-aminoantipyrine and manganese-based nano-enzyme, adding a buffer solution to obtain a mixed solution, mixing a tobacco shred leachate with the mixed solution to obtain a reaction solution, and rapidly detecting glyphosate in tobacco shreds by observing the color change of a reaction system and the change of an ultraviolet absorbance value. The method saves a lot of time for detecting the glyphosate in the tobacco shreds.

The application belongs to the field of material chemistry, and particularly relates to a chiral manganese dioxide nanomzyme with high laccase activity and high selectivity, and a preparation method and application thereof. The application mainly comprises the following aspects: synthesis of the chiral manganese dioxide nanomzyme and optimization of the synthesis conditions, a 2,4-dichlorophenol (2,4-DP) degradation method: using the laccase-mimicking property of the chiral manganese dioxide nanomzyme to catalyze 2,4-dichlorophenol, and selective catalysis of chiral substrates: using the selective catalysis of the chiral manganese dioxide nanomzyme on chiral substrates L-DOPA and D-DOPA. The application provides a synthesis method of a biomimetic laccase with a catalytic efficiency 20 times higher than that of natural laccase and a chiral manganese dioxide nanomzyme with selective catalysis, and the biomimetic laccase and the chiral manganese dioxide nanomzyme have good application prospects.

The present application relates to the field of photocatalytic degradation, and discloses a preparation method and application of a phthalocyanine iron loaded metal oxide Z-type heterojunction photocatalyst.The present application aims to solve the problems of instability, low visible light utilization, easy recombination of photo-generated electron-hole pairs, high cost, and low resource recycling efficiency of high-performance photocatalysts synthesized by the prior art.A phthalocyanine iron (FePc) loaded metal oxide material XFePc / CeO2 is designed and developed.The method comprises the following steps: taking cerium oxide and phthalocyanine iron as raw materials, and adopting a one-pot method to prepare the phthalocyanine iron loaded metal oxide Z-type heterojunction photocatalyst.Under visible light, the XFePc / CeO2 composite material can be applied to degrade 2,4-dichlorophenol pollutants, and has high degradation rate and high catalytic activity.Under visible light irradiation conditions, the catalytic degradation performance of the composite material is greatly improved compared with that of a single-component, for example, a 1FePc / CeO2 photocatalyst sample exhibits an ultrahigh degradation efficiency within 150 minutes, which is 3 times that of pure CeO2.

The application relates to a two-dimensional covalent organic framework material based on Fe doping and bipyridine ligands, a preparation method and application thereof, and belongs to the technical field of covalent organic framework materials. N,N,N',N'-tetra-(p-aminophenyl)-p-phenylenediamine (TAPD) and 2,2'-bipyridine-5,5'-diformyl (BPDA) are used as ligands to synthesize JLNU-305, and JLNU-305-Fe is obtained after reaction with ferrous sulfate heptahydrate, which has multiple active sites (Fe 2+ , Fe 3+ and pyridine N), and exhibits excellent catalytic performance in the activation of sodium persulfate (PDS) for the degradation of 2,4-dichlorophenol (2,4-DCP) under room temperature conditions. At room temperature, 10mg / L of 2,4-dichlorophenol can be removed at a removal rate of 100% by JLNU-305-Fe in only 8min, and the performance is far superior to that of inorganic or organic porous organic polymers, and the JLNU-305-Fe has good reusability.

The invention discloses a preparation method of PFC-1-UiO-66 heterojunction nano-enzyme and application of the PFC-1-UiO-66 heterojunction nano-enzyme in multi-mode detection of catechol, and relates to the technical field of biochemical analysis and detection. The method comprises the following steps: dissolving cerium salt in a mixed solvent, heating to react, cooling with ice water, adding DMF (Dimethyl Formamide) dissolved with terephthalic acid, and reacting to obtain UiO-66; and dissolving 1, 3, 6, 8-tetra (4-carboxybenzene) pyrene in DMF (Dimethyl Formamide), adding UiO-66, heating to react, cooling after the reaction, adding acetone and stirring, centrifuging, washing and drying to obtain the heterojunction nano-enzyme. A detection reagent constructed on the basis of the heterojunction nano enzyme can react with TMB (tetramethylbenzidine) under an acidic condition to realize 652 nm colorimetric detection, can react with 2, 4-dichlorophenol / 4-aminoantipyrine under a neutral condition to realize 510 nm colorimetric detection, and can generate a photo-thermal signal through 808 nm near-infrared light illumination to realize colorimetric and photo-thermal dual-mode detection. The method has the advantages of high detection sensitivity, strong interference resistance and good stability.

The application belongs to the field of pharmaceutical chemical industry, and particularly relates to a preparation method of Lenvatinib. The preparation method is as follows: 4-chloro-7-methoxy quinoline-6-amide is reacted with 3,4-dichlorophenol under the action of alkali, the obtained product is reacted with 1-cyclopropylimidazolidine-2,4,5-trione, and then Lenvatinib is obtained through alkaline 1-cyclopropylimidazolidine-2,4,5-trione ring opening. In the application, 1-cyclopropylimidazolidine-2,4,5-trione is used as a synthetic subunit of a functional group 'urea', the use of chloroformate phenyl, which is highly toxic, is avoided, the operation is simple, the yield is higher, and the application is more suitable for industrial mass production.

The invention relates to a preparation method of an MCM-41 molecular sieve containing iron and titanium, the molecular sieve and application of the molecular sieve, coal gasification coarse slag and coal gasification fly ash are reacted under the supercritical reaction condition, then hydrothermal crystallization and roasting are carried out, the MCM-41 molecular sieve containing iron and titanium is efficiently synthesized, the obtained MCM-41 molecular sieve containing iron and titanium is large in specific surface area, and the specific surface area of the MCM-41 molecular sieve containing iron and titanium is larger than that of the MCM-41 molecular sieve containing iron and titanium. And the catalyst contains components with photocatalytic activity, so that 2, 4-dichlorophenol in wastewater can be efficiently removed by combining adsorption and photocatalysis. According to the invention, resource utilization of solid wastes is realized, and products with high added values are obtained.

The application discloses a preparation method of 2,4-dichlorophenoxyacetic acid synthesized by composite molecular sieve ZSM-5 and a water-reducing process, and relates to the following steps: under alkaline conditions, 2,4-dichlorophenol is reacted with a sodium chloroacetate solution under the catalysis of a composite molecular sieve catalyst to obtain 2,4-dichlorophenoxyacetic acid sodium salt crude product through condensation; and then hydrolysis and hydrochloric acid acidification are carried out to obtain 2,4-dichlorophenoxyacetic acid product. The process can reduce energy consumption, shorten reaction time and reduce production cost in obtaining 2,4-dichlorophenoxyacetic acid, and can improve the conversion rate and yield of the product and the color of the product. When a new batch of 2,4-dichlorophenoxyacetic acid sodium salt crude product is dissolved in the acidification reaction, the washing water of the last batch of 2,4-dichlorophenoxyacetic acid is used as the solvent reaction liquid, and the washing water of the last batch is used for the first water washing of the final product and is used in turn. The water consumption is reduced, the wastewater treatment cost is reduced, the conversion rate and yield of the product are improved, the product has high purity, the process is simple, the conditions are mild, and the raw materials can be recycled.