33 results about "Chloroacetic acid" patented technology

This invention provides a continuous method for preparing high-purity creatine monohydrate, comprising the following steps: a) adding chloroacetic acid aqueous solution dropwise to an aqueous methylamine solution, stirring at room temperature for 2 hours after the addition is complete; b) heating to 50-60°C and holding for 1 hour to remove most of the methylamine, then heating to 95°C to evaporate the methylamine aqueous solution for 1 hour; c) adding sodium hydroxide solution dropwise to the solution from step b) at 95°C, then heating to 105°C and concentrating under reduced pressure for 1.5 hours to approximately half the original volume, obtaining a creatine solution with a concentration of 30%-40%; d) cooling the solution from step c) to 40-60°C and adding a catalyst; e) drying to obtain pure creatine monohydrate. This invention reduces the methylamine equivalent, saving costs, and eliminates the need for purifying creatine for direct use in the next reaction; it can simultaneously lower the system reaction temperature and pH value to inhibit the formation of byproducts dicyandiamide and creatinine, and eliminates the need for debittering agents for purification and debittering, thus saving production costs.

The application provides a preparation method of a rare earth metal adsorption and separation resin and a resin extraction column. The preparation method comprises the following steps: adding an oil phase composed of styrene, divinylbenzene, a pore former and an initiator into an aqueous phase containing a dispersant and an inorganic salt to perform suspension polymerization, so as to obtain a white ball resin; performing phthalimide and hydrolysis on the white ball resin, so as to obtain a primary amine resin; performing reaction on the primary amine resin with chloroacetic acid and an alkaline medium, so as to perform carboxymethylation on part of the primary amine sites; and performing reaction on the obtained intermediate resin with phosphorous acid, formaldehyde and an acidic medium, so as to perform phosphonic acid methylation on the remaining part of the primary amine sites. The white ball resin is first subjected to amination, and then part of the carboxymethylation and part of the phosphonic acid methylation are sequentially performed, so that the carboxyl type chelation sites and the phosphonic acid type chelation sites are simultaneously reserved in the same resin bead, thereby being beneficial to improving the comprehensive adsorption performance and separation performance of the resin on the rare earth metal.

This invention discloses a rice straw-based liquid mulch film emulsion, its preparation method, and its application. The preparation method includes: treating pretreated rice straw with an alkaline solution in sodium hydroxide to obtain rice straw fibers and a silicon-containing black liquor; washing and bleaching the rice straw fibers to obtain bleached rice straw fibers; allowing the silicon-containing black liquor to stand, adjusting the pH value, and allowing it to stand again to obtain a silicon-containing dispersion; mixing and activating the bleached rice straw fibers with an alkaline alcohol solution, followed by etherification with chloroacetic acid to obtain carboxymethyl cellulose; mixing polyvinyl alcohol and carboxymethyl cellulose solutions, adding the silicon-containing dispersion under stirring, and then adding water to obtain the rice straw-based liquid mulch film emulsion. The rice straw-based liquid mulch film emulsion prepared by this invention can be used for soil covering in cultivated soils, exhibiting excellent film-forming strength, toughness, light-blocking properties, and soil cover adaptability. It has a wide range of raw material sources, a simple preparation process, and is suitable for large-scale promotion.

The present invention provides a production method for purified dichloroacetic acid and an efficient production method for nucleic acid molecules using same. Specifically, the present invention provides: a production method for purified dichloroacetic acid in which the molar ratio of formaldehyde to dichloroacetic acid is 81×10-5 or lower and the molar ratio of dichloroacetic anhydride to dichloroacetic acid is 20×10-5 or lower, wherein dichloroacetic acid having a formaldehyde and / or dichloroacetic anhydride content higher than the aforementioned ratios is brought into contact with at least one compound having a lower boiling point than dichloroacetic acid selected from the group consisting of aliphatic alcohols, aliphatic amines, and water, and a fraction including an aprotic inert solvent having a boiling point lower than that of dichloroacetic acid is distilled from the produced mixed liquid in the presence of the solvent; and a production method for nucleic acid molecules in which the purified dichloroacetic acid is used as a deprotection agent.

This invention belongs to the field of recycling and purification technology, specifically relating to a method for recovering the β isomer from a CME solution containing both β and α isomers. The method includes the following steps: concentrating the CME solution containing both β and α isomers and dissolving it in methanol with trichloroacetic acid to form a salt, followed by cooling and crystallization and filtration to obtain the trichloroacetic acid salt of the CME β isomer; then, ionizing the trichloroacetic acid salt of the CME β isomer in methanol with ammonia to obtain the CME β isomer. By reacting trichloroacetic acid with the α and β isomers of CME to form a salt, the different solubilities of the trichloroacetic acid salts of the α and β isomers are utilized to separate the trichloroacetic acid salt of the CME β isomer, and then ionizing the trichloroacetic acid salt of the CME β isomer with ammonia, the CME β isomer is recovered.

This invention relates to the field of dichloroacetic acid preparation technology, specifically a method for preparing high-purity dichloroacetic acid. The method uses anhydrous dichloroacetic acid alkyl ester or anhydrous dichloroacetyl chloride as a single raw material. The method includes: adding deionized water to a corrosion-resistant reactor, starting stirring and cooling to 10-30°C, adding the single raw material and an acidic catalyst, reacting at 40-80°C for 1-8 hours, and then refining through multi-stage separation to obtain high-purity dichloroacetic acid. The anhydrous dichloroacetic acid alkyl ester is selected from methyl dichloroacetate, ethyl dichloroacetate, propyl dichloroacetate, or isopropyl dichloroacetate. The acidic catalyst is a ZrO₂-TiO₂ supported acid solid catalyst or a complex liquid organic acid catalyst.

An improved method of producing monochloroacetic acid (MCAA) is disclosed, which affords a colorless monochloroacetic acid product in any form that can be obtained by this method.

This invention discloses a cross-linked carboxymethyl corn starch adsorbent, its preparation method, and its application. The method involves first mixing corn starch with 85%-95% ethanol (by mass) and stirring until homogeneous; adjusting the pH of the starch emulsion to 10-12, preheating at 50-60°C, adding 0.1%-0.15% epichlorohydrin (by dry starch weight), and continuously stirring for 1-2 hours; after cooling to room temperature, adding solid sodium hydroxide for alkalization, adding chloroacetic acid to the alkalized system, and reacting at 50-60°C for 2-4 hours; after the reaction, adjusting the pH of the reaction system to 6-7, filtering, washing, drying, and sieving to obtain the cross-linked carboxymethyl corn starch adsorbent. This invention overcomes the defects of poor structural stability and low adsorption capacity of unmodified starch. The resulting adsorbent is environmentally friendly, has excellent adsorption performance, and the preparation process is simple, controllable, and low-cost.

This invention relates to an extracellular polysaccharide of *Lactobacillus delbrueckii* subsp. bulgaricus CB-01 with immunomodulatory effects and its applications. The extracellular polysaccharide is prepared by a method comprising the following steps: inoculating *Lactobacillus delbrueckii* subsp. bulgaricus CB-01 into sterilized sugar-containing milk for fermentation; centrifuging the fermentation broth; collecting the supernatant; precipitating with alcohol; collecting the crude polysaccharide precipitate; redissolving the precipitate in water; mixing it with trichloroacetic acid solution; centrifuging to collect the supernatant; precipitating again with alcohol; redissolving the precipitate; and dialyzing to obtain the extracellular polysaccharide. In this invention, by inoculating CB-01 into a specific sugar-containing milk for fermentation, it was unexpectedly discovered that CB-01 can efficiently secrete extracellular polysaccharides in the fermented milk matrix. The prepared *Lactobacillus delbrueckii* subsp. bulgaricus extracellular polysaccharide exhibits significant immunomodulatory capabilities, and its use in preparing immune-enhancing foods, health products, or medical nutritional products shows great promise.

This invention discloses a preparation process for titanium anodes used in electrolytic copper foil, relating to the field of anode plate manufacturing technology. In preparing the titanium anode for electrolytic copper foil, porous titanium is pretreated and then reacted sequentially with sodium hydroxide and chloroacetic acid to obtain nanowire titanium dioxide coated porous titanium; an iridium-tantalum pentoxide / titanium anode is prepared by mixing chloroiridium hexahydrate and tantalum ethoxide to form an iridium-tantalum pentoxide coating solution; polypyrrole is polymerized and coated onto graphene oxide to obtain polypyrrole-coated graphene oxide; a composite coating solution is prepared by reacting polypyrrole-coated graphene oxide, nickel chloride hexahydrate, and ferric chloride hexahydrate, followed by reduction with hydrazine hydrate; this composite coating solution is then coated onto the iridium-tantalum pentoxide / titanium anode to obtain the titanium anode for electrolytic copper foil. The titanium anode for electrolytic copper foil prepared by this invention exhibits excellent electrocatalytic performance and service life.

This utility model discloses an easy-to-clean resin processing discharge device, relating to the field of resin processing technology. It includes: a screening box; a screening mechanism disposed inside the screening box; a feed inlet disposed at the top of the screening box; a high-quality material discharge outlet disposed at the bottom center of the screening box; a coarse material discharge outlet disposed at the bottom side of the screening box; a support frame disposed at the bottom outer side of the screening box; a control panel disposed at the bottom side of the support frame; a water tank disposed at the top side of the support frame; a water pump disposed inside the water tank; collection boxes disposed at the bottom of both the high-quality material discharge outlet and the coarse material discharge outlet; a filter plate disposed at the center of one side of the collection box; and a disassembly mechanism disposed on one side of the filter plate. This utility model directly screens the finished chloroacetic acid resin during the discharge process, ensuring the product quality of the chloroacetic acid resin. Simultaneously, the rapid replacement and cleaning of the filter plate improves the overall water circulation quality and efficiency of the device.

Topical formulations comprising peroxyacids prepared in situ from trichloroacetic acid, dichloroacetic acid, monochloroacetic acid or acetic acid and hydrogen peroxide are useful for promoting hair growth and for preventing hair loss.

This invention relates to the field of biopharmaceutical technology, specifically to the application of dichloroacetate in the preparation of drugs for preventing high-altitude pulmonary edema. This invention is the first to propose and verify the application of dichloroacetate in preventing high-altitude pulmonary edema. By administering dichloroacetate to mice via drinking water three days in advance as a preventative measure, the degree of pulmonary edema was reduced, providing new drug selection and experimental evidence for the prevention and treatment of altitude sickness.

The application discloses a solid catalyst for preparing glycine and application of the solid catalyst in preparation of glycine. At normal temperature and pressure, a reaction solvent and the solid catalyst for preparing glycine are added into a reaction container; the temperature is controlled; a chloroacetic acid solution and ammonia water are added dropwise into the reaction container; the pH value of the system is controlled through the dropping speed of the ammonia water; after the dropping is completed, the reaction is carried out at 45-60 DEG C for 1.5-2 hours; filtration is carried out; the filtrate is subjected to alcohol precipitation with methanol and temperature reduction crystallization; the crystal is dissolved with water; and glycine is obtained through separation and purification. The application solves the problem of'secondary pollution' caused by catalyst decomposition through the self-prepared solid catalyst for preparing glycine, reduces the catalyst usage amount in single reaction, realizes recycling of the catalyst, and reduces the cost. Through the water-phase reaction mode of bidirectional dropping of the chloroacetic acid solution and the ammonia water, the pH value of the reaction system can be controlled to be maintained in a range favorable to generation of glycine, and the occurrence of side reactions is effectively inhibited.

This invention discloses a method for preparing carboxymethylated sodium lignin sulfonate for coal-water slurry dispersion, comprising the following steps: 1) adding an alkaline substance to a sodium lignin sulfonate solution under stirring conditions and carrying out an alkalization reaction at a certain temperature; 2) adding chloroacetic acid in batches to the alkalization system to carry out a carboxymethylation reaction; 3) after the reaction is completed, cooling, neutralizing, and drying the reaction system. This invention, by precisely controlling the conditions of the alkalization and etherification reactions, successfully introduces a large amount of carboxymethyl (-CH2COOH) groups onto the phenolic and alcoholic hydroxyl groups of the sodium lignin sulfonate molecule, using it as a coal-water slurry dispersant, significantly improving the hydrophilicity and anionic charge density of the product. This allows the modified carboxymethylated sodium lignin sulfonate, as a coal-water slurry dispersant, to more effectively adsorb onto the surface of coal particles, generating stronger electrostatic repulsion and a hydration film, thereby greatly improving the dispersibility and flowability of the coal-water slurry and effectively reducing its apparent viscosity.

The present application belongs to the field of microbial technology, and relates to a high-efficiency dichloroacetic acid degrading Pseudomonas aeruginosa and application thereof, the high-efficiency dichloroacetic acid degrading Pseudomonas aeruginosa is named SJTX, and the preservation number is CGMCC No. 36706. The Pseudomonas aeruginosa SJTX in the present application can grow by using dichloroacetic acid as a sole carbon source, can efficiently degrade dichloroacetic acid, and the degradation rates of the Pseudomonas aeruginosa on 10 mg / L, 50 mg / L and 100 mg / L dichloroacetic acid within 24 hours are 45.8%, 42.4% and 24.4% respectively, and the Pseudomonas aeruginosa has good adaptability to high salt and heavy metals, and is suitable for effectively removing and bioremediating dichloroacetic acid pollutants in water bodies, soil and other environments. The strain of the present application has good comprehensive performance in the degradation efficiency of dichloroacetic acid and environmental tolerance compared with the dichloroacetic acid degrading strains found.

The application relates to the field of membrane materials and membrane separation technology, in particular to a preparation method of a negatively charged ceramic composite nanofiltration membrane.The commercial ceramic nanofiltration membrane is cleaned and soaked first, then is subjected to a grafting reaction in an ethanol solution of 3-aminopropyltrimethoxysilane, then the grafted ceramic nanofiltration membrane is immersed in a water solution of chloroacetic acid for reaction, and finally, the ceramic nanofiltration membrane grafted with N,N-diacetic acid-3-(trimethoxysilyl)propylamine can be obtained.The membrane can effectively intercept negatively charged small-molecule organic pollutants in water and divalent or multivalent salt ions of sulfate in water; the silicon carbide-based ceramic composite nanofiltration membrane prepared by the method has the advantages of simple preparation method, mild preparation condition, and low preparation cost.

The present application relates to the technical field of determination of nifursol metabolite content, and particularly relates to a method for determining the residual amount of nifursol metabolite in royal jelly. The method comprises the following steps: the royal jelly sample is sequentially subjected to trichloroacetic acid hydrolysis, o-nitrobenzaldehyde derivatization and ethyl acetate purification, and is treated with acetonitrile aqueous solution to constant volume, the pretreated sample is subjected to gradient elution using 5 mmol / L ammonium acetate aqueous solution-acetonitrile as a mobile phase, and is determined by liquid chromatography-tandem mass spectrometry, and the isotopic internal standard method is used for qualitative and quantitative analysis during determination. The royal jelly sample is hydrolyzed using a trichloroacetic acid solution before derivatization treatment, so that the to-be-measured component is well separated from the sample matrix, the matrix influence is reduced, and then the liquid chromatography-tandem mass spectrometry analysis is performed in combination with the selection of the mobile phase and the isotopic internal standard method, thereby improving the qualitative and quantitative accuracy of the residual amount of nifursol metabolite in royal jelly.

This invention belongs to the field of ultra-high performance concrete technology, specifically relating to a modified ultra-high performance concrete, its preparation method, and its application. The modified ultra-high performance concrete comprises the following raw materials in parts by weight: 60-80 parts cement, 30-40 parts mineral admixtures, 5-10 parts fiber, 120-140 parts sand, 1-1.5 parts water-reducing agent mother liquor, and 0.5-1 parts retarder, with a water-cement ratio of 0.14-0.2; the water-reducing agent mother liquor has a solid content of 35-42 wt% and is copolymerized from acrylate monomers, acrylate monomers, unsaturated sulfonate monomers, and unsaturated polyethers; the retarder is a compound of carboxylated tea polyphenols and salicylic acid, with the carboxylated tea polyphenols obtained by modifying tea polyphenols with chloroacetic acid. The water-reducing agent is first adsorbed onto the surface of cement particles, and the long polyether side chains extend into the water to form a steric hindrance layer, which disperses the cement particles and prevents agglomeration. The carboxylated tea polyphenols and salicylic acid are combined as a retarder to inhibit the dissolution of cement minerals and the crystallization of calcium hydroxide, thus delaying cement hydration. The modified ultra-high performance concrete has low viscosity and controllable retarding.

Provided is the large-scale preparation of a high-purity hydrolyzed colanic acid or a salt thereof. The method comprises: 1) adding a solution containing a colanic acid or a salt thereof to a colanic acid degradation enzyme comprising an amino acid sequence as shown in SEQ ID NO: 1 or having at least 90% sequence identity thereto; and 2) performing an enzyme termination reaction, wherein the termination in step 2) is achieved by means of a termination agent, a boiling water bath and / or an ice bath, wherein the termination agent is selected from one or more of activated carbon, absolute ethanol, methanol, EDTA, trichloroacetic acid and sodium carbonate, and preferably, activated carbon is used to achieve the termination in step 2), so as to obtain the hydrolyzed colanic acid or a salt thereof. The molecular structure of the hydrolyzed sodium colanate prepared by the provided method features acetylation and pyruvic acid modification. Moreover, the preparation conditions are mild, the production cost is low, continuous production can be achieved, and industrial scale-up is easily implemented. The prepared hydrolyzed sodium colanate has the characteristics of high purity and low endotoxin residue, and has potential and broad application value in fields such as cosmetics, medical devices, and oligosaccharide drugs.

The application relates to an environment-friendly dust suppressant and a preparation method thereof, and belongs to the technical field of dust suppressants. The preparation method of the environment-friendly dust suppressant comprises the following steps: 1) reacting cellulose and sodium hydroxide in an ethanol solution for 1-2 hours to obtain an alkalization solution, then adding chloroacetic acid and ethanol into the alkalization solution, reacting at 65-70 DEG C for 1-2 hours, adjusting the pH value to 6-7, performing solid-liquid separation, washing, and obtaining a CMC sample; 2) adding the CMC sample prepared in the step 1) into water at 65-70 DEG C and uniformly mixing, then adding sodium silicate or modified sodium silicate, polyvinyl alcohol and uniformly mixing, and the environment-friendly dust suppressant is obtained. The water retention, permeability and wind erosion resistance of the environment-friendly dust suppressant are all good, the water retention, wetting property and permeability of the environment-friendly dust suppressant are better than those of traditional dust suppressants, and the environment-friendly dust suppressant can maintain nearly 100 percent dust suppression effect under the conditions of wind speeds of 6-7 m / s and 12-13 m / s.

This invention provides an apparatus and method for controlling particle size and crystal form in a multi-stage continuous crystallization process of glycine. The apparatus includes a seed crystal generator, a primary crystallization vessel, a secondary crystallization vessel, and a final crystallization vessel connected in sequence. The material outlet of the seed crystal generator is connected to the material inlet of the primary crystallization vessel, the material outlet of the primary crystallization vessel is connected to the material inlet of the secondary crystallization vessel, the material outlet of the secondary crystallization vessel is connected to the material inlet of the final crystallization vessel, the material outlet at the top of the final crystallization vessel is connected to the material inlet of the primary crystallization vessel, and a solid-liquid separation device is connected to the material outlet at the bottom of the final crystallization vessel. This invention uses glycine mother liquor from the ammonolysis of chloroacetic acid containing impurities such as ammonium chloride and hexamethylenetetramine as raw material, achieving stable and continuous production of pure α-crystalline glycine with uniform particle size, low agglomeration, and high purity, significantly improving production efficiency and product consistency.

This invention pertains to the preparation technology of chemical intermediates and aims to provide a method for the continuous production of dichloroacetic acid and dichloroacetyl chloride. The method includes: continuously feeding sulfuric acid, water, and tetrachloroethylene into a continuous flow reactor, heating to carry out a continuous reaction; discharging gas from the top of the continuous flow reactor, and overflowing liquid from the top of the reactor; separating the gas and liquid phases to obtain the products dichloroacetic acid and / or dichloroacetyl chloride; controlling the ratio of dichloroacetic acid and dichloroacetyl chloride by adjusting the feed rates of sulfuric acid, water, and tetrachloroethylene. This invention utilizes a continuous flow reactor to allow the raw materials to contact in a continuous gas-liquid turbulent flow, ensuring thorough mixing, promoting the reaction, and improving the mass transfer effect between reactants. Compared with existing technologies, this invention significantly improves reaction efficiency, significantly reduces equipment costs, and enhances operational safety, enabling continuous production.

The present disclosure relates to the technical field of chloroacetic acid tail gas treatment, and one embodiment of the present disclosure provides a processing device for monochloroacetic acid synthesis tail gas, which comprises a first acetic acid absorption tower, a second acetic acid absorption tower, a third acetic acid absorption tower and a gas inlet pipeline, and further comprises heat preservation covers, sun protection covers, fixing mechanisms, heat preservation and sun protection mechanisms and connecting mechanisms, two heat preservation covers are movably sleeved on the first acetic acid absorption tower, the second acetic acid absorption tower and the third acetic acid absorption tower, and the sun protection covers are installed on the outer sides of the heat preservation covers. Through the above technical solution, the technical problem that the tail gas inlet pipeline and the acetic acid recovery tower in the processing device for monochloroacetic acid synthesis tail gas lack effective heat preservation and sun protection structures in the prior art, so that the temperature inside the tail gas inlet pipeline and the acetic acid recovery tower is affected by the outside world and rises, the tail gas is greatly lost when the air temperature is high, and the tail gas is easily greatly lost, thereby affecting the recovery efficiency of acetic acid is solved.

This invention discloses a method for preparing glycine amide hydrochloride, comprising adding water and a catalyst to a reaction vessel, introducing ammonia gas at 0-5°C, then adding chloroacetic acid dropwise, stirring the reaction, raising the temperature to 30-35°C after the addition is complete, introducing ammonia gas again, and continuing the reaction for 2-3 hours until the reaction is complete, removing ammonia and water, adding methanol solvent to crystallize and obtain glycine amide hydrochloride product, and then scraping off and collecting the crystals. This invention uses chloroacetic acid to generate glycine amide hydrochloride under the action of ammonia and a catalyst, and then crystallizing the product with alcohols. This avoids the use of hydrogen chloride gas or large amounts of alcohols as solvents, reducing the safety risks caused by the concentrated use of large amounts of alcohols, shortening the reaction time, improving product quality and yield, and simplifying subsequent processing. The removed ammonia is absorbed by the removed water, and then the ammonia gas is circulated for reuse, without generating wastewater, making it environmentally friendly. This invention is applicable to the preparation of glycine amide hydrochloride.

This invention belongs to the field of pathological testing and tissue specimen preservation technology, and in particular, it is a compound solvent-based tissue fixative, which is made by mixing the following raw materials in weight percentages: the main solvent is a 60%-80% ethanol solution; the co-solvent and penetrant is 5%-10% polyethylene glycol tetrahydric acid and 3%-8% diethylene glycol; the dehydrating and hardening regulator is 5%-10% acetone; the pH adjuster and protein precipitant is a 2%-5% glacial acetic acid and 1%-3% trichloroacetic acid solution; the antibacterial and antistatic agent is a 0.5%-2% quaternary ammonium salt solution, wherein the quaternary ammonium salt solution is a 1% octyldecyl dimethyl ammonium chloride solution; and the stabilizer is 1%-3% methoxy-3-methylbutanol. This invention significantly reduces the health risks to operators by eliminating toxic reagents such as formaldehyde and glutaraldehyde and using food-grade ethanol as the main solvent, thus meeting green and environmentally friendly requirements. This characteristic enables the fixative to provide safer working conditions in environments such as pathology laboratories where long-term contact with fixatives is required, thus protecting the health of operators.

The present application relates to chloroacetic acid reaction device technical field, and disclose a kind of chloroacetic acid reaction device with defoaming function, including reaction kettle body, reaction kettle cover and the stirring rod in reaction kettle body and reaction kettle cover, the stirring rod outside is fixedly installed with multiple groups of stirring vane, the present application when stirring rod passes through stirring vane and is mixed to reactant, stirring rod drives slider synchronous rotation, slider drives each sector housing rotation along the circumferential direction of reaction kettle body, sector housing in the process of rotation, its open end is constantly collected to sector housing by foam generated at liquid level, by the cooperation of horizontal groove and arc groove, realize periodic lifting motion, so that it repeatedly experiences the switching of " completely sink below liquid level " and " part is located above liquid level " two states in the process of rotation, when sector housing sinks below liquid level, the foam collected in its cavity is directly contacted with reaction liquid, rapidly dissolved or broken under the action of stirring, realize the instant melting of foam.