461 results about "Chronic wound" patented technology

The present invention provides bioactive polymer compositions that can be formulated to release a wound healing agent at a controlled rate by adjusting the various components of the composition. The composition can be used in an external wound dressing, as a polymer implant for delivery of the wound healing agent to an internal body site, or as a coating on the surface of an implantable surgical device to deliver wound healing agents that are covalently attached to a biocompatible, biodegradable polymer and/or embedded within a hydrogel. Methods of using the invention bioactive polymer compositions to promote natural healing of wounds, especially chronic wounds, are also provided. Examples of biodegradable copolymer polyesters useful in forming the blood-compatible, hydrophilic layer or coating include copolyester amides, copolyester urethanes, glycolide-lactide copolymers, glycolide-caprolactone copolymers, poly-3-hydroxy butyrate-valerate copolymers, and copolymers of the cyclic diester monomer, 3-(S)[(alkyloxycarbonyl)methyl]-1,4-dioxane-2,5-dione, with L-lactide. The glycolide-lactide copolymers include poly(glycolide-L-lactide) copolymers formed utilizing a monomer mole ratio of glycolic acid to L-lactic acid ranging from 5:95 to 95:5 and preferably a monomer mole ratio of glycolic acid to L-lactic acid ranging from 45:65 to 95:5. The glycolide-caprolactone copolymers include glycolide and ε-caprolactone block copolymer, e.g., Monocryl or Poliglecaprone.

The invention relates to a dressing comprised of microbial-derived cellulose for aesthetic application The dressing is capable of donating liquid to dry substrates and is also capable of absorbing exudating wounds. Delivery of various medicaments using the dressing is possible. Positive clinical outcomes including reduced pain and discomfort, faster epithelialization, and healing were observed with use of the dressing.

The present invention provides wound healing or wound care polymer compositions that can be formulated to release a wound healing agent at a controlled rate by adjusting the various components of the composition. The compositiona can be used in an external wound dressing, as a polymer implant for delivery of the wound healing agent to an internal body site, or as a coating on the surface of an implantable surgical device to deliver wound healing agents that are dispersed in a biodegradable polymer or hydrogel, or both. Methods of using the invention bioactive polymer compositions to deliver wound healing agents that promote natural healing of wounds, especially chronic wounds, are also provided.

Methods for treating chronic wounds in a human are described by topically administering a dermatological composition comprising a TNF antagonist, a TACE inhibitor, a neutrophil antagonist, or a combination of a TNF antagonist and/or TACE inhibitor and a neutrophil antagonist. The TNF antagonist administered includes alefacept, efalizumab, etanercept, adalimumab, and onercept, while the neutrophil antagonist administered includes dapsone, colchicine, its analogs and prodrugs. The combination of TNF-antagonist and neutrophil antagonist administered includes sulfapyridine, sulfasalazine, mesalamine, and derivatives and prodrugs thereof. The topical compositions can be formulated to include the one or more of the antagonists in dissolved, semi-dissolved, and micro-particulate states.

An antimicrobial composition with synergistic biocidal activity is described which comprises at least one antimicrobial polymeric biguanide and at least one antimicrobial vicinal diol, said vicinal diol comprises at least one monoalkyl glycol, monoalkyl glycerol, or monoacyl glycerol, to diminish or eliminate biofilm communities. Such synergistic interaction is effective in wound treatment, particularly for chronic wounds, burns and battlefield-induced wounds, as well as for disinfecting non-biological surfaces. The antimicrobial composition can also be prepared as viscous solutions or as gels. The antimicrobial composition may be added to a substrate and dried, such as to a catheter, or to a foam, or to a fiber wound dressing, or coated as a viscous solution or gel upon such devices, to provide controlled release antimicrobial activity.

Cells, compositions, and methods of cell therapy for administering a therapeutically effective amount of stem cells or cell concentrate to achieve accelerated wound healing of normal and chronic wounds, while minimizing the formation of scar tissue.

A wound care device comprising foam composition wherein the retention factor Rv=R/Δ?V of the foam is at least 0.05 wherein R is the retention capacity (g/g) and Δ?V is the expansion of volume (% v/v) of the foam when wetted. A wound care device comprising foam with a high retention and low expansion of volume is achieved, which is desired in the treatment of wounds, especially chronic wounds.

Chronic wounds may be treated by debriding necrotic and other devitalized tissue from the wound, and applying to the wound an extracellular polymeric substance solvating system comprising a metal ion sequestering agent, surfactant and buffering agent. The solvating system disrupts biofilms which may be present in the wound and aids or enables the resumption of normal healing.

An electrosurgical method for treating chronic wound tissue, comprising: positioning an active electrode in close proximity to the chronic wound, the active electrode being disposed on a distal end of an electrosurgical shaft; applying a high-frequency voltage potential difference across the active electrode and a return electrode sufficient to develop a high electric field intensity associated with a vapor layer proximate the active electrode and in close proximity to the wound tissue; and stimulating an expression of at least one healing mediator.

The invention relates to a wound healing hydrogel dressing applicable to nursing various acute and chronic wounds and a preparation method. The hydrogel dressing comprises a hydrogel layer, a fixing non-woven fabric and a medical adhesive tape, the hydrogel layer is fixed on a surface of the non-woven fabric, and the other surface of the non-woven fabric is adhered on the medical adhesive tape. The preparation method includes fixing cross-linking agent on the non-woven fabric; coating solution of a raw material of hydrogel onto one surface of the non-woven fabric, adhering the other surface of the non-woven fabric onto the medial adhesive tape with pressure-sensitive adhesive after crosslinking is finished, arranging the pressure-sensitive adhesive onto one surface of the medical adhesive tape while arranging a separate film backing on the other surface of the medical adhesive tape, and attaching an isolating film on one surface of the hydrogel; and sterilizing after the medical hydrogel dressing is packaged. The medical hydrogel dressing is convenient in use, can rapidly absorb exudation of the wound, prevents the exudation of the wound from excessively steeping the wound, creates a moist wound healing condition, and promotes wound healing. A self-adhesion function of the wound healing hydrogel dressing is greatly convenient for clinic service.

Present invention features methods for induction of angiogenesis by administration of lysine (l-&d-) or lysine oligomers (molecular weight approx between 500 and 2500), both homo and hetero-oligomers, consisting of either l-or d- or both enantiomers. Induction of Angiogenesis by the methods of the invention can be use in therapeutic angiogenesis, in, for example, treatment of ischaemic conditions and syndromes, such as chronic wounds (e.g diabetic wounds and ulcers, bed sores and other pressure sores, burns of various degrees and extents etc.) as well as coronary and cerebral ischaemia and peripheral vascular ischaemic conditions. Induction of angiogenesis by the described methods also will be useful in inducing/enhancing radiosesitivity in some solid tumors.

The present invention relates to the field of electrotherapy and measuring by means of electric currents for diagnostic purposes, and more particularly to an electrode arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing having an electrode arrangement. A wound dressing according is described which includes at least two impedance reference electrodes, a frame like counter-electrode and stimulation electrodes in a form of an array; and a bioadhesive affinity layer surrounding the stimulation electrodes; said wound dressing being suited for applying on top of the wound so that the stimulation electrode array is on the wound area, and that the at least two impedance reference electrodes and the frame like counter-electrode are suited for placing in contact with the healthy skin surrounding the wound area; which electrodes, are suited for applying LIDC type electrical stimulation current to the wound area and for bioimpedance measurement. The wound dressing can provide a continuous, non-invasive and objective solution for monitoring chronic wound healing without disturbing the delicate healing process.

An apparatus and method for the treatment of chronic wounds using electromagnetic energy. The apparatus includes a generator and at least one applicator. The generator can produce electromagnetic energy and the applicator can apply the electromagnetic energy produced by the generator. A detector is disposed on the applicator that can measure the field strength of the electromagnetic energy applied.

A medical compress for use in treating chronic wounds includes a non-woven textile fabricated from air laid fibers containing a superabsorbent material. The superabsorbent material is enclosed by a knitted mesh which can be formed to the shape of the wound. An irrigation solution is preferably contained by the compress to keep the wound irrigated and to encourage healing.

The present invention relates to the use of one or more natural or modified oxygen carriers, devoid of plasma or cellular membrane constituents, for the production of an agent for the external treatment of open wounds, particularly chronic wounds. Hemoglobin or myoglobin of human or animal origin are suitable as oxygen carriers. The oxygen carriers can also preferably be modified. Suitable modifications are cross-linking, reaction with polyalkylene oxides, chemically reactive or chemically non-reactive effectors, or combinations. The agent is applied to the wound area particularly by means of spraying on an aqueous solution containing the oxygen carrier(s). The oxygen carriers can be used in particularly effective manner in the case of chronic wounds resulting from tissue degeneration, particularly diabetic tissue degeneration.

The subject invention pertains to methods and compositions for wound treatment. The methods and compositions provide for promoting and accelerating wound healing; provide for inhibition of microbial infection; provide for a protective scab-like covering on a wound; and/or for arresting the flow of blood or body fluids from an open wound. The methods and compositions can be used to increase granulation and epithelialization in a wound. In one embodiment, a substantially anhydrous compound of a salt ferrate and a cation exchange material is provided. Compositions of the invention can also include silver compounds. In use, compositions of the invention are preferably applied as a dry dressing to an exuding chronic wound site. If the chronic wound site is dry, the wound site may be wetted with a suitable liquid or aqueous media prior to applying the dressing in dry form.

The invention relates to an antibacterial fiber dressing containing nanometer metal and a preparation method thereof. Nanometer metal particles are distributed on the fiber surface of the dressing. The content of the nanometer metal is 0.5-10 wt%. As a dressing for wound treatment, the fiber wound dressing has the capability of continuously releasing sufficient nanometer metal particles, is especially suitable for chronic wound treatment, can provide long-term and effective antibacterial functions, and can effectively prevent wound infection caused by various bacteria and microbe.

A system for subatmospheric pressure therapy in connection with healing a surgical or chronic wound includes a wound dressing adapted for positioning relative to a wound bed of a subject and a subatmospheric pressure mechanism. The subatmospheric pressure mechanism includes a housing; a vacuum source disposed in the housing and associated with a vacuum port; a collection canister defining an internal chamber in fluid communication with the vacuum source through the vacuum port and with the wound dressing for collecting exudates removed from the wound bed under influence of the vacuum source; a hydrophobic filter in fluid communication with the vacuum source and the internal chamber of the collection canister; and a screen disposed proximally of the filter. The filter is adapted to prevent exudates from reaching the vacuum source while allowing passage of air to the vacuum source. The screen includes compounds for cleaving proteins in the exudates to prevent clogging of the filter by the exudates in the collection canister.