187 results about "Chronic wound" patented technology

This invention discloses a method for preparing a pH / glucose dual-responsive chronic wound dressing containing frankincense essential oil, comprising: (1) using 4-formaldehyde phenylboronic acid as a crosslinking agent to form Schiff base and borate ester bonds with carboxymethyl chitosan and two different molecular weight hyaluronic acids, respectively, to prepare a hydrogel capable of filling skin surface wounds and performing dual dynamic covalent crosslinking adhesion, and freeze-drying for later use; (2) preparing frankincense essential oil into microcapsules by emulsification coagulation method, and freeze-drying for later use; (3) mixing the hydrogel with the freeze-dried powder of frankincense essential oil microcapsules, adding deionized water or PBS and stirring to reconstitute to form a pH / glucose dual-responsive hybrid hydrogel dressing coated with frankincense essential oil microcapsules. The composite dressing prepared by this invention has anti-inflammatory, antioxidant, antibacterial, and healing-promoting effects, is quick and easy to prepare, and has the ability to respond to the acidic / high-glucose microenvironment of diabetic wounds, and has important practical application value.

Embodiments of the present invention generally relate to novel immunostimulatory compositions of use to stimulate non-specific immune responses in a subject. In certain embodiments, immunogenic compositions disclosed herein can be directed to use in the eye of a subject. In some embodiments, the immunogenic compositions disclosed herein enhance non-specific immune responses in the eye of a subject to treat or reduce the risk of onset of an eye condition. In other embodiments, compositions disclosed herein can be used to treat eye infections due to a microorganism, tumors of the eye, as well as, chronic wounds or infections of the eye. In some embodiments, immunogenic ocular formulations disclosed herein include combinations of agents for prolonged exposure to the eye for improved outcomes.

The invention belongs to the technical field of medicines, and particularly relates to a hydrogel dressing for promoting healing of diabetic wounds as well as a preparation method and application of the hydrogel dressing. According to the hydrogel dressing for promoting healing of the diabetic wound, glycyrrhizic acid and S-allyl-L-cysteine are used as raw materials, a buffer solution is used as a dispersion medium, and the glycyrrhizic acid and S-allyl-L-cysteine are compounded and self-assembled by controlling the mass ratio of the raw materials, the reaction temperature, the reaction time and the pH value. The hydrogel shows tissue-like viscoelasticity characteristics, can adaptively deform along with wound movement, provides continuous protection for chronic wounds under dynamic physiological conditions, and has flexibility of adapting to dynamic requirements in different healing stages.

The invention belongs to the technical field of wound assessment, and discloses a chronic wound assessment and diagnosis system based on intelligent image recognition, which comprises an image acquisition module, a region recognition module, a three-dimensional reconstruction module, an assessment module and a treatment scheme recommendation module, the image acquisition module can acquire multi-source heterogeneous chronic wound image data through a unified interface protocol; and the region identification module can segment a wound region from the processed chronic wound image data through a U-Net3 network algorithm and an analysis model, generate an edge weight map, classify necrotic tissues and analyze the trend of the restored sinus tract. The wound area is accurately segmented through the deep learning network, the wound features are intelligently recognized in combination with the image, the accuracy and reliability of evaluation are improved, the dynamic three-dimensional point cloud model is further constructed by applying the binocular vision principle, the spatial form, depth, area, volume, sneaking, sinus tract and flaccidity duct information of the wound is visually displayed, and the evaluation accuracy and reliability are improved. And the subsequent wound assessment effect can be improved.

The invention relates to the technical field of medical instruments, in particular to a photo-piezoelectric hydrogel dressing for wound repair. The hydrogel dressing realizes self-energized micro-electrical stimulation and anti-oxidation-antibacterial-anti-inflammatory integrated treatment through'energy-drug 'double closed-loop synergy: the PVDF / ZnO nanofiber on the upper layer can convert human body micro-motion and external light into micro-electrical stimulation to promote cell migration, proliferation and angiogenesis; the curcumin at the lower layer cooperates with the nano-silver to block the'oxidative stress-inflammation-infection 'vicious circle of chronic wounds. The dressing is soft and fit, does not need an external power supply, is excellent in biocompatibility, provides a self-driven multifunctional nursing scheme for refractory wounds, and has wide clinical popularization and market application prospects.

The invention discloses a targeted anti-aging microneedle drug delivery system for chronic wound repair as well as a preparation method and application of the targeted anti-aging microneedle drug delivery system. The system is composed of functionalized nanoparticles and a microneedle platform: a nano drug-loading unit which takes a polydopamine nanosphere as a carrier, entraps an anti-aging drug Bem, and modifies the surface of the nano drug-loading unit with a targeting peptide E7; according to the micro-needle delivery unit, hyaluronic acid-nitrogen carboxymethyl chitosan hydrogel is used as a matrix, a nano drug-loading unit and silver ions (Ag) are loaded, a micro-needle array is formed, and minimally invasive transdermal drug delivery is achieved. According to the invention, multiple mechanisms of anti-aging (APCs aging inhibition), antioxidation (ROS removal), antibiosis (Agaction) and immunoregulation (macrophage M2 type polarization promotion) are synergistically exerted, and the bottleneck problems of single intervention target, low drug availability and difficulty in regulating and controlling pathological microenvironment of chronic wounds (such as diabetic foot ulcer) in the traditional therapy are effectively solved.

The invention discloses a preparation method of a fibroin / collagen composite sponge for chronic wound repair, which comprises the following steps: S1, freeze-drying a silk fibroin solution with the mass concentration of 0.02-0.07 g / mL to obtain a silk fibroin sponge; s2, immersing the silk fibroin sponge into an alcohol solution for incubation, and then washing and drying to obtain insoluble silk fibroin sponge; and S3, immersing the insoluble silk fibroin sponge into a collagen solution with the mass concentration of 0.001-0.006 g / mL and the pH value of 5.0-5.5, so that after the insoluble silk fibroin sponge absorbs the collagen solution, freeze-drying to prepare the fibroin / collagen composite sponge. The fibroin / collagen composite sponge prepared by the method has excellent water binding capacity, moisture permeability and water retention capacity, can effectively remove wound exudate, adjust and maintain a wet healing environment, also can actively induce tissue regeneration and promote wound healing, and can meet the use requirements of chronic wounds on ideal wound dressing materials.

The invention provides a D-A-D type near-infrared organic molecule as well as a preparation method and application thereof. The compound disclosed by the invention has a near-infrared emission characteristic adaptive to chronic wound diagnosis and treatment and can effectively penetrate through superficial tissues to middle tissues of a wound, and self-absorption interference of the compound is remarkably reduced due to reasonable Stokes displacement; the PDT-PTT performance is excellent, and the application requirements of wound treatment are met. The excellent light diagnosis and treatment activity further guarantees the stability of diagnosis and treatment signals and the energy transmission efficiency. (I).

The invention relates to a preparation method and application of nitric oxide gas release hydrogel for chronic wound repair of diabetes mellitus, and belongs to the technical field of biomedical materials. According to the invention, hyaluronic acid is modified by tris (hydroxymethyl) aminomethane with mechanical properties and structural stability, so that the stability of the hydrogel is improved, and the problem that traditional hydrogel is fragile and easy to collapse is solved; the epsilon-polylysine is introduced, so that the hydrogel has a sterilization effect, and infectious bacteria at chronic wounds can be efficiently sterilized; nitric oxide donor small molecules are introduced into hydrogel, and on-demand release in a pathological environment is realized by combining a high active oxygen response mechanism; through dynamic inclusion of the hollow meso-porous silicon-selenium hybrid nanostructure and cyclodextrin, the drug loading efficiency and release stability of the nanoparticles are further improved, and the nanoparticles are endowed with good responsiveness, controllability and synergistic function. The prepared nitric oxide gas release hydrogel can significantly accelerate healing of chronic wound surfaces of diabetes, the preparation process is mild, simple and convenient, and large-scale production is easy.

The invention discloses a double-response controlled-release hydrogel for promoting wound healing of astaxanthin and an amino small molecule drug as well as a preparation method and application of the hydrogel, and belongs to the field of biomedical materials. The material is composed of a drug-loaded nano-micelle and a self-healing hydrogel network. Hydrophilic modification of astaxanthin and dynamic coupling of the astaxanthin and an amino small molecule drug are achieved through an astaxanthin-polyethylene glycol-benzaldehyde intermediate, and the drug-loaded nano-micelle has the pH response drug release capacity; the hydrogel network is formed by crosslinking phenylboronic acid modified carboxymethyl chitosan and dopamine through dynamic phenylboronic acid ester bonds, and has ROS responsiveness and self-healing characteristics; the multifunctional intelligent wound dressing can intelligently respond to high ROS and acidic pH microenvironment of chronic wounds, controllably release astaxanthin and amino-containing small molecule drugs, synergistically remove ROS, improve cell oxidative stress, inhibit inflammation, promote blood vessel and tissue regeneration and accelerate chronic wound healing, is excellent in self-healing performance and biocompatibility, and is an ideal multifunctional intelligent wound dressing.

The present application relates to a kind of water gel based on crude polysaccharide of Radix Trichosanthis and its preparation method and application.The water gel based on crude polysaccharide of Radix Trichosanthis is prepared by the following method:1) preparing crude polysaccharide of Radix Trichosanthis;2) making aldehyde group of crude polysaccharide of Radix Trichosanthis to obtain aldehyde group of crude polysaccharide of Radix Trichosanthis;And 3) aldehyde group of crude polysaccharide of Radix Trichosanthis and carboxymethyl cellulose are covalently combined to form the water gel by Schiff base reaction.The multifunctional water gel of the present application is expected to become the candidate dressing of clinical protection and treatment of cachexia wound and other immunosuppressive chronic wound.

The present application relates to the technical field of wound repair material, in particular to a chronic wound dressing and a preparation method thereof, the wound dressing is prepared from a first contact layer, an intermediate transition layer and a backing layer which are in direct contact with the wound, through the unique three-layer structure design, a chronic wound dressing with fast healing speed, strong anti-inflammatory and antibacterial properties, high liquid absorption and effective regulation of the microenvironment of the wound is prepared, the first contact layer is in direct contact with the wound, absorbs the exudate, plays an anti-inflammatory and antioxidant role, the intermediate transition layer guides the exudate from the first contact layer to the backing layer through the asymmetric fiber membrane structure on both sides and does not back permeate, the backing layer has a connected microporous structure, has strong air permeability and can absorb a large amount of exudate, provides a humid environment for the wound, inhibits bacterial growth and promotes wound healing, compared with the prior art, has a wide application prospect.

The invention provides special gel for medical surgical site ice compress and a preparation method thereof, and relates to the technical field of medical treatment. The preparation raw materials at least comprise: a main polymer: polyvinyl alcohol (PVA), bacterial nanocellulose (BNC), and poly N-isopropylacrylamide; the functional additives comprise double modified starch (OSA + phosphate), nano-silver (the particle size is 20-50 nm), a thrombin-fibrinogen compound and EGF / bFGF microspheres (PLGA); and the auxiliary components comprise glycerol, citric acid and purified water. According to the multifunctional ice compress gel, a structure which is loose outside and tight inside is formed through freeze drying, the cold compress uniformity and the air circulation performance are improved, the double modified starch and the cross-linking agent cooperate, the degradation period is prolonged to 72 h, the replacement frequency is reduced, the multifunctional ice compress gel has the functions of physical cooling, hemostasis repair, antisepsis and anti-inflammation, the cooperative requirement of postoperative cold compress and wound surface nursing is met, and the multifunctional ice compress gel is worthy of popularization and application. The device is suitable for postoperative incision cold compress, burn / acute stage cooling and hemostasis of wounds and auxiliary repair of chronic wounds.

A treatment modality for use in the remediation of damaged tissues that involves protease down regulator solution impregnated microspheres, and the methods of production and therapeutic use thereof.

The invention relates to the technical field of biological medicines, and particularly discloses a chronic wound healing promoting traditional Chinese medicine compound loaded wound and ulcer paste, which comprises a hydrogel matrix and a traditional Chinese medicine compound, and the traditional Chinese medicine compound is prepared from the following raw materials in parts by weight: 5-15 parts of rheum officinale, 4-8 parts of bletilla striata, 15-25 parts of astragalus membranaceus, 5-15 parts of salvia miltiorrhiza, 1-5 parts of cinnamon and 0.5-1.5 parts of borneol. The wound and ulcer paste loaded with the traditional Chinese medicine compound for promoting chronic wound healing can continuously and stably act on a target organ, the wound is isolated from the outside to prevent infection, meanwhile, the drug effect can be better brought into play, and therefore the treatment effect of chronic wound healing is improved.

This invention discloses a near-infrared light-responsive porous membrane, its preparation method, and its applications, relating to the field of dressing technology. The near-infrared light-responsive porous membrane is composed of polyurethane, PDA@ZnO nanoparticles, and the antibacterial agent QCS. Under near-infrared light excitation, this near-infrared light-responsive porous membrane can generate reactive oxygen free radicals and heat, and release biofunctional zinc ions. Addressing the clinical challenges of chronic wounds, such as their susceptibility to infection and slow healing, this invention provides a new approach to improving the clinical treatment of chronic wounds by using a PDA@ZnO / QCS / TPU porous membrane that achieves highly efficient and precise sterilization under the synergistic effect of specific wavelengths of light, thereby preventing wound infection and promoting wound healing.

The invention belongs to the technical field of dressings, and discloses a magnetic control double-effect intelligent dressing, a preparation method thereof and a chronic wound treatment device, the magnetic control double-effect intelligent dressing comprises an antibacterial fabric and a conductive coating; the preparation method comprises the following steps: reducing antibacterial metal ions on the surface of a fabric by using a reducing compound to obtain an antibacterial fabric, depositing a conductive coating on the surface of the antibacterial fabric to obtain the magnetic control double-effect intelligent dressing, and after reducing the antibacterial metal ions by using the reducing compound, converting the reducing compound into a polymer to obtain the magnetic control double-effect intelligent dressing. The antibacterial metal ions are converted into antibacterial metal nanoparticles, and the polymer wraps the surfaces of the antibacterial metal nanoparticles; the treatment device comprises a rotating magnetic field generator and the magnetic control double-effect intelligent dressing. The rotating magnetic field generator is used for generating a rotating magnetic field, and the magnetic control double-effect intelligent dressing is located in the rotating magnetic field. According to the invention, the behaviors of cell proliferation, migration, differentiation and the like can be regulated and controlled, the release of antibacterial metal ions of the dressing can be regulated and controlled as required, and the antibacterial performance of the dressing is enhanced.

The invention relates to the field of biological medicine, and discloses application of an acellular fat extract in preparation of a medicine for accelerating chronic wound healing. Researches show that CEFFE can improve healing of chronic wounds of diabetic mice. This is achieved by the pro-angiogenesis and anti-inflammatory activity of CEFFE. The existence of various growth factors in the CE FFE can explain the influence of the growth factors on the functions of epidermal cells, endothelial cells, fibroblasts and macrophages. CEFFEE may be used as a therapeutic drug for treating chronic wounds of diabetic patients, and is expected to improve the overall prognosis of the diabetic patients and improve the life quality of the patients.

The application discloses a chronic ulcer wound repairing gel and a preparation method and application thereof, and belongs to the technical field of medical materials. Since bacterial cellulose has the advantages of good biocompatibility, high water retention and moisturizing capacity, strong mechanical property, good air permeability, low toxicity and the like, the bacterial cellulose is used to prepare the bacterial cellulose-based chronic ulcer wound repairing gel capable of promoting chronic wound healing by compounding functional components. The gel can bidirectionally regulate the wet balance of a wound surface; contains a large amount of hydroxyl groups, can highly retain water, has an ice-cool feeling, effectively relieves pain, simultaneously reduces irritation to a wound and a mucous membrane, reduces the sensitivity of exposed nerves, and reduces pain; the photosensitizer in the gel can inhibit bacterial infection by irradiation of near-infrared laser; active components can inhibit inflammatory diffusion, promote collagen deposition and angiogenesis, and the like, so as to promote the healing of a chronic ulcer wound surface.

The invention discloses a preparation method of metal zinc-curcumin complex doped alginate-based antibacterial hydrogel, which comprises the following steps: preparing a metal zinc-curcumin complex by utilizing the coordination effect between metal zinc ions and curcumin molecules, and then mixing and reacting the metal zinc-curcumin complex with a hydroxyapatite nano material to prepare a composite nano material. And preparing a dispersion liquid from the obtained composite nano material, adding polyvinyl alcohol and sodium alginate, stirring and mixing, and adding CaCl2 for crosslinking, thereby obtaining the alginate-based antibacterial hydrogel. The metal zinc-curcumin complex is doped, so that the obtained hydrogel has good antibacterial performance, and the obtained hydrogel has a communicated macroporous structure, so that the absorption capacity of the material to wound exudate can be remarkably improved, a necessary space channel can be provided for migration and adhesion of fibroblasts, and the wound exudate can be effectively absorbed. The method is crucial for maintaining long-term stability of a chronic wound environment and promoting wound healing, so that the method has a good application prospect.

The application discloses a paper-based microfluidic intelligent wound monitoring bandage based on a laser-induced graphene electrode array and a preparation and signal processing method thereof. The bandage comprises a calcium alginate / zinc oxide antibacterial base, a wax-printed paper-based lateral chromatographic microfluidic channel layer, a CO2 laser direct writing LIG multifunctional electrode array, a colorimetric indication area, an NFC wireless communication module and a silver nanowire electrically controlled drug release module. The LIG electrode is fixed and modified by enzymes to detect uric acid, lactic acid, glucose and pH value respectively; the paper-based colorimetric disc detects bacterial protease and TNF-alpha; the NFC radio frequency field provides energy to realize battery-free operation. The built-in signal processing method comprises temperature compensation, cross interference elimination, multi-parameter fusion infection risk scoring and double-threshold closed-loop drug delivery decision. The preparation process mainly uses laser direct writing, screen printing and ion crosslinking, has low material cost and is green and environmentally friendly, and is suitable for closed-loop monitoring and treatment of chronic wounds at home and in clinic.

The invention relates to the technical field of artificial dermis, in particular to a preparation method and application of artificial dermis based on bionic acellular matrix. The artificial dermis comprises a bionic acellular matrix component A and an auxiliary material component B, wherein the component A comprises type I collagen, type VI collagen, elastin, fibronectin, laminin, mother cell protein and glucan; the component B comprises antibacterial peptide, antibiotics and a high-molecular polymer material; the mass ratio of the component A to the component B is (4-6): (1-4). The preparation method comprises the following steps: respectively preparing procedure mother liquor of the component A and the component B, preparing hydrogel with a double-layer gradient structure through step-by-step crosslinking, and then carrying out freeze drying and sterilization treatment. The artificial dermis disclosed by the invention has good biocompatibility and antibacterial property, can effectively promote wound healing, is suitable for repairing acute and chronic wounds of four limbs, faces and trunk parts, and is particularly suitable for repairing complex wounds with exposed bones, tendons, nerves and blood vessels.

This invention belongs to the field of medical technology, specifically relating to a tandem controlled-release nucleic acid nanoprobe composite hydrogel and its application in the diagnosis and treatment of wound infections. First, the invention modifies the surface of gold nanoparticles with nucleic acid sequences via Au-S bonds to prepare a DNA-gold nanoparticle probe (NAFP), achieving highly specific detection of sulfides, a wound infection marker. Then, using mesoporous silica as a carrier, an antibacterial drug is loaded, constructing mesoporous silica D@MSNs loaded with a double-stranded DNA molecule valve-type bactericide. Subsequently, the NAFP and D@MSNs are formulated into a gel to obtain a therapeutic dressing. This dressing can trigger conformational changes in nucleic acids through infection markers, achieving precise matching of drug release to the degree of infection, thereby enabling in-situ detection of bacteria. It also possesses highly efficient antibacterial activity, physical protection, and moisturizing functions. The dressing is easy to operate, has low clinical translation costs, and is suitable for the diagnosis and treatment of acute and chronic wound infections, showing broad application prospects.

The application discloses a konjac glucomannan microneedle patch for diabetic wound healing and a preparation method and application thereof, and belongs to the technical field of medical device preparation. The microneedle patch is composed of a needle tip array and a backing layer, wherein the needle tip array and the backing layer are both formed by an oxidized konjac glucomannan and a mixed aqueous solution of hyaluronic acid, and a CuGA-MOF material is added to the aqueous solution for making the microneedle patch. The microneedle patch provided by the application can treat diabetic wounds in a minimally invasive manner. In vitro and in vivo verification shows that the konjac glucomannan microneedle patch loaded with the CuGA-MOF can inhibit bacterial growth, remove active oxygen, regulate macrophage M2 polarization and promote angiogenesis, and can effectively realize rapid healing of diabetic wounds. In addition, the raw material of the microneedle patch is abundant, the preparation method is simple, the cost is low, the safety is high, and the microneedle patch has a wide application prospect in the field of treating infected wounds and chronic wounds.

The invention provides a composition and application thereof in promoting wound healing and reducing scar formation. The composition comprises 10 < 4 >-10 < 9 > particles / mL of exosomes and 5-1000 [mu] g / mL of fibronectin. Through collaborative design of the exosome and fibronectin, multi-mode regulation of promoting repair, controlling inflammation, regulating matrix and reducing scars on wound healing is realized, and the exosome has the advantages of comprehensive action mechanism, stable treatment effect and wide application range; the obvious application value and clinical transformation potential are realized in the fields of chronic wound repair, scar prevention and treatment and skin regeneration.

This invention belongs to the field of biomedical materials technology, and discloses a cellulose-based long-acting antibacterial material, its preparation method, and its application. The cellulose-based long-acting antibacterial material includes: a cellulose backbone; EDTA groups covalently grafted onto the cellulose backbone via ester bonds; and an ionic liquid anchored to the EDTA groups via multiple hydrogen bonds. The EDTA groups act as molecular bridges connecting the cellulose backbone and the ionic liquid, which remains in a monomeric state and is stably immobilized on the material surface through hydrogen bonds. This invention utilizes EDTA groups as molecular bridges to stably anchor the ionic liquid to the cellulose backbone surface through multiple hydrogen bonds, avoiding the problem of easy loss of physical load and overcoming the influence of covalent polymerization on antibacterial activity. After a 95-day accelerated aging test, the material still exhibits an antibacterial rate exceeding 99.9% against *Escherichia coli* and *Staphylococcus aureus*, meeting the needs of chronic wound care throughout the entire process.

The invention provides a preparation method of injectable self-adaptive hydrogel for diabetic wounds, and relates to the technical field of biomedicine.The hydrogel is constructed through a multiple dynamic cross-linking strategy, 3-aminobenzene boron (3-APBA) is grafted to a hyaluronic acid (HA) skeleton to form a pH responsive HA-PBA network, polydopamine nanoparticles are introduced to provide photo-thermal responsiveness, and the injectable self-adaptive hydrogel is used for treating diabetic wounds. And an anti-inflammatory drug quercetin is loaded to realize synergistic anti-oxidation regulation. The injectable self-adaptive hydrogel can be self-adaptive to complex and irregular chronic wounds, and has excellent antibacterial and antioxidant properties and excellent healing promoting capability.

This invention discloses an integrated method and system for wound area recognition and recovery time prediction. Belonging to the interdisciplinary fields of medical image processing, artificial intelligence, and clinical nursing, this invention aims to solve the problems of low segmentation accuracy, subjective recovery time prediction, and low operational efficiency caused by the separation of wound recognition and recovery time prediction in traditional wound assessment methods. The key technical points are: employing optimized U-Net++ network technology to achieve accurate wound segmentation, then fusing multi-dimensional features with an XGBoost model to predict recovery time, and integrating image acquisition, processing, quantification calculation, and result output functions. This system is adaptable to various scenarios such as hospital clinical assessment and home nursing monitoring, providing objective and quantifiable assessment data for acute and chronic wounds such as trauma and pressure ulcers. Simultaneously, it achieves integrated processing of wound condition assessment and recovery prediction, significantly improving the accuracy and efficiency of nursing work.

The invention discloses a method for scar-free healing in treatment of wounds / wounds by miR-185-5p, relates to the field of biological medicine and plastic surgery and beauty repair, and comprises application of scar-free healing in acute / subacute / chronic wounds related to any skin injury (including burn, laceration, bruise, operation, perforation and vaccination) of deep dermis. Wound healing is a series of complex and elaborately-planned overlapping stages arranged according to a time sequence, wherein the stages comprise four stages of hemostasis, inflammation, proliferation and remodeling. No matter at any stage, the skin stability after wound healing and whether scars are formed or not can be directly influenced. The miR-185-5p is used in an animal skin model caused by an acute wound, so that the wound healing time is integrally shortened, the reepithelization formation of the wound is promoted, the number of skin appendages is increased, and the regeneration of hair follicles is promoted. The secretion amount of the collagen I is reduced, and the formation of the collagen III is improved.

The invention discloses a temperature-sensitive hydrogel dressing as well as a preparation method and application thereof. The method comprises the following steps: preparing an alkynylation temperature-sensitive block copolymer, azidated mussel protein, an alkynylation MOF (at) QK nano-enzyme compound, an ROS responsive HA-ss-RGD compound and a traditional Chinese medicine yellow wine extract; the components are covalently assembled through click chemistry to obtain a precursor solution. The dressing forms gel in situ at the body temperature, powerful wet tissue adhesion is achieved through mussel protein, long-acting ROS removal and QK peptide continuous release are achieved through MOF (at) QK, RGD peptide on-demand release is achieved through phenylboronic acid ester bond ROS responsive breakage of HA-ss-RGD, and multi-target-point coordinated regulation is achieved through traditional Chinese medicine extracts. Nano-enzyme catalysis, ROS responsive drug release and traditional Chinese medicine multi-target regulation are combined, all the characteristics have a synergistic effect, chronic wound healing is remarkably promoted, and the ROS responsive drug release nano-enzyme is used for preparing oxidative stress related chronic wound repair materials.