Exosome derived from endometrial mesenchymal stem cells and application of exosome in preparation of medicine for treating diabetic wounds

Exosomes were extracted from the culture supernatant of human endometrial mesenchymal stem cell by differential centrifugation, and applied to medical dressings or compound preparations, which solved the problem of limited effect of exosomes on diabetic wound treatment in the prior art, and achieved the promotion of angiogenesis and collagen deposition, and promoted the rapid healing of diabetic wounds.

CN120381464APending Publication Date: 2025-07-29SHANXI MEDICAL UNIV
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Patent Information

Application Number
CN202510556252.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-04-29
Publication Date
2025-07-29

AI Technical Summary

Technical Problem

The existing exosomes have limited therapeutic effects on diabetic wounds, especially in improving the vascular status of wound tissue and accelerating the repair of damaged tissue.

Method used

Differential centrifugation method is used to extract exosomes from the culture supernatant of human endometrial mesenchymal stem cells and applied it to medical dressings or compound preparations for the treatment of diabetic wounds, promote physiological closure of wounds and reconstruction of skin barriers, and accelerate wound healing by promoting angiogenesis and collagen deposition.

Benefits of technology

Effectively promote HUVEC tube formation ability, promote wound angiogenesis in diabetic model mice, increase collagen deposition, reduce wound area, achieve rapid healing of diabetic wounds, and provide treatment strategies for other chronic wounds.

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Abstract

The invention provides an endometrial mesenchymal stem cell-derived exosome and application thereof in preparation of a medicine for treating diabetic wounds, and belongs to the technical field of biological medicines. The endometrial mesenchymal stem cell-derived exosome provided by the invention can effectively promote HUVEC tube forming ability, promote wound angiogenesis of diabetic model mice, increase collagen deposition and reduce wound area, finally achieves the purpose of promoting healing of diabetic wounds, and solves the problem of limited treatment effect of exosomes in the prior art. The endometrial mesenchymal stem cell-derived exosome provided by the invention can be used as a medicine for promoting angiogenesis and wound healing to be applied to diabetes wound treatment, and also provides a new strategy for treatment of other chronic wounds including burn.
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