448 results about "Crosslinking reagent" patented technology

The present invention relates to altering the physical and/or chemical properties of at least part of at least one tissue in the eye. In a specific embodiment, it relates to the treatment and/or prevention of myopia. An activating energy source is utilized to photopolymerize or crosslink molecules in the sclera, thereby increasing the strength of the tissue. The individual is administered a crosslinking reagent or photopolymerizable molecule that becomes associated with the membrane, which is then precisely exposed to an energy source, such as light or ultrasound.

The invention provides a class of samples that model the human body. This family of samples is based upon emulsions of oil in water with lecithin acting as the emulsifier. These solutions that have varying particle sizes may be spiked with basis set components (albumin, urea and glucose) to simulate skin tissues further. The family of samples is such that other organic compounds such as collagen, elastin, globulin and bilirubin may be added, as can salts such as Na+, K+ and Cl-. Layers of varying thickness with known index of refraction and particle size distributions may be generated using simple crosslinking reagents, such as collagen (gelatin). The resulting samples are flexible in each analyte's concentration and match the skin layers of the body in terms of the samples reduced scattering and absorption coefficients, mums and muma. This family of samples is provided for use in the medical field where lasers and spectroscopy based analyzers are used in treatment of the body. In particular, knowledge may be gained on net analyte signal, photon depth of penetration, photon radial diffusion, photon interaction between tissue layers, photon density (all as a function of frequency) and on instrument parameter specifications such as resolution and required dynamic range (A/D bits required). In particular, applications to delineate such parameters have been developed for the application of noninvasive glucose determination in the near-IR region from 700 to 2500 nm with an emphasis on the region 1000 to 2500 nm (10,000 to 4,000 cm-1).

The invention provides processes for manufacturing cell-binding agent-cytotoxic agent conjugates of improved homogeneity comprising performing the modification reaction at a lower temperature. The inventive processes comprise contacting a cell-binding agent with a bifunctional crosslinking reagent at a temperature of about 15° C. or less to covalently attach a linker to the cell-binding agent and thereby prepare a mixture comprising cell-binding agents having linkers bound thereto.

The invention relates to a series of multifunctional polyglycosides derivatives that are made by the polymerized by the reaction of polyoxyalkylene containing crosslinking reagent and polyglycosides, together with a functionalizing agent that contains a sulfate, sulfonate, quaternary nitrogen, or a phosphate group. The preferred polymers are cross linked having more than one group per molecule. They are made with mild reagents to avoid discoloration and mal odor.

A moldable, bioresorbable, biocompatible, non-allergenic crosslinked collagen derivative dressing for the prevention of post extraction alveolar osteitis (dry socket) pain is disclosed along with methods for use of the gel. The dressing is placed at the time of surgery acting as a bone covering obtundant and physiologic scaffolding for the conduction of normal alveolar bone healing sequence of fibroblast ingrowth, blood vessel formation, and reossification of the extraction site defect. In one form, the dressing is a flowable, moldable, biocompatible, bioresorbable dressing prepared by reacting (i) a collagen derivative, such as gelatin or atelocollagen, and (ii) a non-cytotoxic crosslinking agent.

Latex foams for filling cavities and crevices and for forming foamed products are provided. The latex foam includes a functionalized latex, a crosslinking agent and a blowing agent package, and optionally a non-functionalized latex. The foamable compositions may be two-part, having an A-side and a B-side to keep reactants separate until use. The blowing agent package may be the combination of two or more chemicals, such as acid and base, that when mixed together form a gas. In two-part compositions, the acid and base preferably are in separate sides to prevent premature gassing; in alternative one-part compositions, the spray latex foam may include a functionalized latex, a crosslinking agent, and an encapsulated dry acid and dry base. The encapsulating agent may be a protective, non-reactive shell that can be broken or melted at the time of application. The acid and/or base are preferably dry powder particulates, for example milled bicarbonate having a median particle diameter of from about 0.5 to about 40 microns, e.g. from about 2 to about 40 microns or from about 0.5 to about 5 microns.

The invention relates to a controllable expanded plugging agent used for drilling plugging operation of an oil and gas field. The controllable expanded plugging agent has the characteristics of expansion controllability, deformability, adaptivity and the like. A technical scheme of the invention is that the ingredients and contents of raw materials used for preparing the plugging agent are as follow: 120 g of water, 7-12 g of acrylic acid, 18-23 g of acrylic amine, 3-6 g of ultrathin CaCO3 (Calcium Carbonate), 12-20 g of neutralizer, 0.05-1 g of crosslinking agent, 0.4-0.8 g of initiators, 3-7 g of emulsifier and 35-45 g of paraffin wax; a preparation method of the plugging agent comprises the steps of putting 120 g of water into a reaction tank; adding the acrylic acid and the acrylic amine at the same time of stirring; dropping the neutralizer NaOH (Sodium Hydroxide) after the solution is dissolved and regulating the pH value of the solution to be 9-11; then adding the ultrathin CaCO3, the crosslinking agent NMBH (Novel Microemulation-based Hydrogel) and initiators Na2SO3 (Sodium Sulfite) and (NH4)S2O8 (Ammonium Persulfate); stirring to react for 50-150 minutes at 40-60 DEG C soas to obtain a sample; heating the paraffin wax to a liquid state; adding the sample into the paraffin wax; adding Span 80; and uniformly stirring, drying and grinding to obtain the product. The product of the invention, which is a multifunctional plugging agent with a controllable expansion speed, is used for the drilling plugging operation of the oil and gas field.

A polyolefin polymer comprising one or more terminal polymerizable methacryloyl groups (i.e. tethered to the main body of the polymer) and a novel process for preparing same are herein disclosed. A hyperbranched polyethylene polymer and a process for preparing same are also disclosed. The polymer is prepared by a novel one-pot copolymerization reaction of an olefin, such as ethylene, and a heterobifunctional comonomer comprising a methacryloyl group, catalyzed by a late transition metal α-diimine catalyst which is selectively non-reactive towards methacryloyl groups. The process allows for preparation of polymers with various chain topologies, including linear, branched, and hyperbranched topologies. The terminal methacryloyl groups within the polymer are reactive in further polymerization reactions. Thus, the polymer may be used in materials and applications which require cross-linking or further polymerization, for example, UV/thermal/radical curable crosslinkers for use in thermoset applications.

The invention provides processes for manufacturing cell-binding agent-cytotoxic agent conjugates of improved stability comprising performing the modification reaction at a high pH. The inventive processes comprise contacting a cell-binding agent with a bifunctional crosslinking reagent in a solution having a pH of 7.1 to 9 to covalently attach a linker to the cell-binding agent and thereby prepare a mixture comprising cell-binding agents having linkers bound thereto.

The invention relates to a surface modification method and application of a porous material. The surface modification method of the porous material comprises the following steps: soaking the porous material in a zwitter-ion reaction solution and fully wetting the porous material; and taking out the wetted porous material and carrying out crosslinking to obtain a zwitter-ion hydrogel modified porous material. The zwitter-ion reaction solution comprises 10-50% of zwitter-ion monomers, 0.01-5% of a crosslinking agent, 0.01-0.5% of an initiator and a solvent. The method is a universal surface modification method; a modification process is simple and convenient; a modified coating can be stable in a complicated biotic environment for a long time, the modified surface has a certain pore structure, therefore, the porous material loaded with a water-soluble and hydrophobic drug can be modified, and the purposes of releasing the drug in a sustained manner and improving the bioavailability of the drug are achieved; and the surface modification method can be used for modifying surfaces of porous metal or alloy, and is applied to repair or replacement of materials such as skin, cardiac valves,bones, cartilages or vascular tissues.

Water-borne cross-linking polymeric compositions and related embodiments, such as methods of making and using the compositions, as well as products formed with said compositions are described. For example, the water-borne composition may comprise polymers incorporating cross-linking functionality such as, but not limited to, carbonyl or epoxy functionality, and a blocked cross-linking agent, for example, a hydrazone. The cross-linking functionality does not react with the blocked cross-linking agent; however, the blocked cross-linking agent is capable of reacting with the alternative form cross-linking agent such as, but not limited to, a hydrazide, to yield a cross-linked polymer. The alternative form cross-linking agent may be formed in an equilibrium reaction including the blocked cross-linking agent.

The invention relates to a low compression set liquid silastic and a preparation method thereof. The low compression set liquid silastic is prepared from components A and B according to a certain mass ratio, wherein the component A is prepared from the following components in parts by weight: 100 parts of liquid silastic base rubber and 0.2-0.5 part of a catalyst; the component B is prepared from following components in parts by weight: 100 parts of liquid silastic base rubber, 6-25 parts of a crosslinking agent and 0.1-0.3 part of an inhibitor.

Surface-modified nanoparticles are produced by associating ligand interactive agents with the surface of a nanoparticle. The ligand interactive agents are bound to surface modifying ligands that are tailored to impart particular solubility and/or compatibility properties. The ligand interactive agents are crosslinked via a linking/crosslinking agent, such as hexamethoxymethylmelamine or a derivative thereof. The linking/crosslinking agent may provide a binding site for binding the surface modifying ligands to the ligand interactive agents.

A method of improving the resistance of collagenous tissue to mechanical degradation in accordance with the present invention comprises the step of contacting at least a portion of a collagenous tissue with an effective amount of a crosslinking reagent. The crosslinking reagent includes a crosslinking agent such as genipin and/or proanthrocyanidin. Further, the crosslinking reagent may include a crosslinking agent in a carrier medium. The collagenous tissue to be contacted with the crosslinking reagent is preferably a portion of an intervertebral disc or articular cartilage. The contact between the tissue and the crosslinking reagent is effected by injections directly into the select tissue using a needle. Alternatively, contact between the tissue and the crosslinking reagent is effected by placement of a time-release delivery system such as a gel or ointment, or a treated membrane or patch directly into or onto the target tissue. Contact may also be effected by, for instance, soaking.

The invention relates to a preparation method of fossilized active sludge and a micro-sewage treatment method in the technical field of environmental protection. The preparation method of fossilized active sludge comprises the following steps: dissolving a polyethylene glycol prepolymer in water; adding active sludge and stirring; then, adding a bis-acrylamide crosslinking agent and benzoin dimethyl ether and uniformly mixing to obtain a solution; and illuminating the solution under an ultraviolet light source, cutting and washing to obtain the fossilized active sludge. The micro-sewage treatment method by utilizing the prepared fossilized active sludge comprises the following steps: filling the fossilized active sludge in a reactor; and adding sewage to the reactor for aeration; and treating the sewage to obtain purified water. The fossilized active sludge particles are convenient to prepare, have low cost, and have high efficiency of removing ammonia nitrogen and organic matter whenbeing applied to a micro-sewage source; meanwhile, required equipment is simple and is easy to manage and maintain.

The invention discloses a chitosan hydrogel. The structural unit of the chitosan hydrogel is shown in the specification; and in the structural unit, m is a natural number in a range of 400-700, and n is a natural number in a range of 30-100. The invention also discloses a preparation method of the chitosan hydrogel, and an application of the chitosan hydrogel. The method comprises the following steps: polyethylene glycol and tyramine molecules are grafted to a chitosan molecular chain in order to obtain a highly-water-soluble chitosan derivative, and the derivative is processed under the action of a crosslinking reagent to obtain the chitosan hydrogel. The process of the preparation method is simple, and the prepared chitosan hydrogel has the advantages of good physical, chemical and biological performances, good histocompatibility, environmental protection, and non-toxicity, and can be safely and effectively applied in restoration of wound tissues.

A method of improving the resistance of collagenous tissue to mechanical degradation in accordance with the present invention comprises the step of contacting at least a portion of a collagenous tissue with an effective amount of a crosslinking reagent. Methods and devices for enhancing the body's own efforts to stabilize discs in scoliotic spines by increasing collagen crosslinks. This stability enhancement is caused by reducing the bending hysteresis and increasing the bending stiffness of scoliotic spines, by injecting non-toxic crosslinking reagents into the convex side of discs involved in the scoliotic curve. Alternatively, contact between the tissue and the crosslinking reagent is affected by placement of a time-release delivery system directly into or onto the target tissue. Methods and devices that use crosslinking agents for increasing the permeability of an intervertebral disc, improving fluid flux to the intervertebral disc, and increasing the biological viability of cells within the intervertebral disc are provided.

The invention relates to a sinomenine hydrochloride controlled release patch, a preparation method thereof and application thereof in treating arthritis, pain relief and the like. The patch comprises sinomenine hydrochloride, a framework material, plasticizing agent, crosslinking agent, antioxidant and solvent. The preparation method can release medicament to local focus parts at a control rate and ensures that the medicament maintains daylong therapeutic effect with little adverse reaction.

A polymer composition suitable for wood treatment or binding comprises a reaction product of at least a polyol and at least a crosslinking agent. The crosslinking agent has at least 2 carboxylic acid groups per molecule. A wood product comprising a wood substrate and a polymer composition as well as a wood treatment process are also disclosed.

The bionic composite 3D bone tissue engineering rack material has pores of 200-500 microns and porosity over 80 %, and contains bioactive nanometer CaO-P2O5-SiO2 glass powder 50-80 wt%, type-I collagen 10-35 wt%, hyaluronic acid 2-8 wt% and phosphatidylserine 2-8 wt%. Its preparation process includes mixing the above said components homogeneously, adding buffering agent and cross-linking agent for cross-linking treatment, freezing, freeze drying to dewater completely, soaking in Na2HPO4 solution, washing, dewatering and vacuum drying. The material is used as bone substituting material for repairing damaged bone tissue in medical field.

The invention relates to a crosslinking agent for polymer hydrofracturing fluid as well as preparation and application of the crosslinking agent. The crosslinking agent comprises the following percentage by weight: 15-30 percent of organic acid, 4-8 percent of inorganic base, 10-18 percent of organic amine, 4-10 percent of trivalent metal ion salt, 7-15 percent of tetravalent zircon salt, 1-5 percent of aldehyde and the balance of water. The crosslinking agent is controllable in crosslinking time within 10-180 seconds and high in crosslinking agent and has the gel cross-linking temperature tolerance reaching 150DEG C; the crosslinking agent does not contain phenol, and the damages to the environment are reduced; the crosslinking agent can be synthesized in need of the condition of 35-65DEG C, and the finished product of the crosslinking agent can be obtained in a one-time manner without secondary blending; and the crosslinking agent contains triethanolamine, so that the gel crosslinking stability of the crosslinking agent is greatly improved.

The invention relates to a preparation method and a refining method of medical hemostatic polysaccharide starch. With pretreated potato starch as a raw material and epichlorohydrin as a crosslinking agent, a microsphere adopting a three-dimensional network structure is synthesized by an emulsifying and crosslinking technology. The medical hemostatic polysaccharide starch is high in biocompatibility; the medical hemostatic polysaccharide starch is full with wrinkles on the surface, so that the particle surface area is increased, the water absorbing rate is significantly improved and the hemostatic time is greatly reduced; the medical hemostatic polysaccharide starch is especially applicable to large-area blood seepage, deep bleeding, and bleeding at a part difficult to reach by operative procedures.

A method of improving the resistance of collagenous tissue to mechanical degradation in accordance with the present invention comprises the step of contacting at least a portion of a collagenous tissue with an effective amount of a crosslinking reagent. Methods and devices for enhancing the body's own efforts to stabilize discs in scoliotic and other progressively deforming spines by increasing collagen crosslinks. This stability enhancement is caused by reducing the bending hysteresis and increasing the elasticity and bending stiffness of progressively deforming spines, by injecting non-toxic crosslinking reagents into the convex side of discs involved in the potential or progressing deformity curve. Alternatively, contact between the tissue and the crosslinking reagent is effected by placement of a time-release delivery system directly into or onto the target tissue. Methods and devices that use crosslinking agents for increasing the permeability of an intervertebral disc, improving fluid flux to the intervertebral disc, and increasing the biological viability of cells within the intervertebral disc are provided.