406 results about "Crosslinking reagent" patented technology

The invention relates to the technical field of fracturing fluids, and discloses a preparation method of a temperature-resistant and salt-resistant fracturing fluid, which comprises the following steps: carrying out polymerization reaction on acrylamide, acrylic acid and an acrylamide sulfonic acid monomer to obtain a polymer thickening agent, and compounding the polymer thickening agent with a cross-linking agent, a clay stabilizer and the like to obtain the temperature-resistant and salt-resistant fracturing fluid. The polymer thickening agent contains long-chain alkyl, a physical cross-linked spatial network structure can be formed through a hydrophobic association effect, the hydrodynamic volume is increased, a good tackifying effect is achieved, and after high-speed shearing, the long-chain alkyl can be cross-linked again to form a spatial network structure, so that a solution still keeps very high apparent viscosity, and the viscosity of the solution is improved. Good anti-shearing performance is realized. The acrylamide sulfonic acid monomer contains a sulfonate group and is used as a temperature-resistant and salt-resistant monomer, so that the polymer thickening agent has good temperature resistance and salt resistance, and the fracturing fluid still keeps relatively high apparent viscosity after being subjected to high-temperature heat treatment and in formation water with high salinity.

The invention relates to the technical field of rubber compounds, and particularly discloses a bio-based and circulating material synergistically modified EPDM rubber compound and a preparation method thereof. The invention discloses a bio-based and circulating material synergistically modified EPDM rubber compound. The rubber compound is prepared from the following components: 100 parts of bio-based EPDM rubber, 100 to 130 parts of a reinforcing agent, 40 to 60 parts of paraffin oil, 5 to 7 parts of magnesium oxide, 0.5 to 1.5 parts of stearic acid, 6 to 8 parts of BIPB-40 peroxide, 2 to 5 parts of a Si-69 silane coupling agent, 1 to 3 parts of a dispersing agent and 1 to 3 parts of an assistant crosslinking agent, the reinforcing agent is composed of fast extruding furnace black N550, rice hull ash white carbon black and thermal cracking carbon black; and the assistant cross-linking agent is prepared from diallyl terephthalate and triallyl isocyanurate. The rubber compound prepared by utilizing the technical scheme provided by the invention can meet and maintain the mechanical property requirements, and meanwhile, carbon emission of the product in the whole life cycle is reduced from the aspects of formula and process.

The invention relates to the technical field of soil remediation, in particular to a charcoal-fungus symbiont for a freeze-thaw environment and a preparation method and application of the charcoal-fungus symbiont. The preparation method of the charcoal-fungus symbiont comprises the following steps: crushing a biomass raw material, and carrying out pyrolysis to prepare basic charcoal; placing the basic biochar in an iron oxide solution, and carrying out an iron oxide loading reaction to obtain iron oxide biochar; the preparation method comprises the following steps: dipping iron oxide biochar in a chitosan solution for coating modification, then continuously adding a cross-linking agent for cross-linking solidification, and freeze-drying to obtain chitosan-iron oxide composite modified biochar; and immersing the chitosan-iron oxide composite modified biochar into a bacterial suspension of functional microorganisms, oscillating and adsorbing, and freeze-drying to obtain the carbon-bacteria symbiont. The invention aims to improve the heavy metal pollution phenomenon of soil and the soybean root rot disaster in the freezing and thawing cycle environment at the same time.

The invention relates to the field of medical materials and medical instruments, and discloses a dry bioprosthetic valve and a preparation method thereof.The preparation method comprises the following steps that S1, pericardium and a cross-linking agent solution are mixed for a cross-linking reaction; s2, carrying out first dehydration treatment on the crosslinked pericardium by adopting a first dehydration solution with gradually increased concentration gradient under an ultrasonic condition; and S3, carrying out second dehydration treatment on the pericardium subjected to the first dehydration treatment by adopting a second dehydration solvent, so as to obtain the dried bioprosthetic valve. According to the preparation method provided by the invention, ethanol, isopropanol and water in a specific proportion are adopted to prepare a dehydration solution with gradient concentration, and two-step dehydration drying is carried out in combination with the physical effect of an ultrasonic technology and glycerol, so that rapid rehydration of the bioprosthetic valve is realized, and the original shape and mechanical property of the bioprosthetic valve can be better recovered after rehydration; and the immediate hemodynamic stability of the valve is improved.

The invention discloses a biomass-inorganic-organic ternary composite flocculant and a preparation method and application thereof, and belongs to the field of coking wastewater treatment.The preparation method comprises the steps that chitosan serves as a substrate material, glutaraldehyde serves as a cross-linking agent, and polyferric sulfate (PFS) and chitosan are subjected to chemical cross-linking to generate an intermediate product PFS and chitosan composite particles; then potassium persulfate is used as an initiator, graft copolymerization of acrylamide and methacryloyloxyethyl trimethyl ammonium chloride is initiated through hydroxyl on the surface of PFS-chitosan, a cationic branched chain is introduced, and a final product is obtained. Through multi-component cooperation and structural design, the defects that a traditional flocculating agent is not thorough in demulsification, large in sludge amount, unstable in floc combination and the like in coking wastewater treatment are overcome, and the flocculating agent is particularly suitable for treating oil pollutants in coking wastewater.

The invention provides glycosaminoglycan hydrogel with a physical and chemical double crosslinking mechanism as well as a preparation method and application thereof, and relates to the technical field of biological materials. The glycosaminoglycan hydrogel is prepared from the following raw materials: oxidized sodium hyaluronate, chondroitin sulfate, epsilon-polylysine hydrochloride, a polydopamine-titanium dioxide compound and a stabilizer. The glycosaminoglycan hydrogel is prepared through a physical and chemical double-crosslinking mechanism under the specific raw materials and proportion, the problems of cytotoxicity and the like caused by use of a crosslinking agent or introduction of other solvents are avoided, a stable covalent network is constructed through chemical crosslinking, the gel is endowed with the self-repairing characteristic through physical crosslinking, and the self-repairing performance of the hydrogel is improved. And the viscosity of the product is remarkably improved, so that the hydrogel has stronger mechanical support performance, is suitable for wound repair, wound healing and the like, and has good antibacterial activity and stability.

Functionalized and crosslinked material, which may optionally be employed as a sorbent, as well as methods of making such materials and systems of using such materials are provided. The processes, methods, systems and materials herein can be used for the separation of carbon dioxide from fluid streams. In one aspect, a method of forming functionalized crosslinked particles comprises introducing at least a portion of a surface of each porous particle in at least a subset of a plurality of porous particles to a crosslinking agent and a first reagent comprising at least one adsorbing moiety. Examples of adsorbing moiety include silane-functionalized amines, amino-functionalized silanes (aminosilane), and polyamines. In some aspects the method further comprises introducing the porous particles to a second reagent comprising at least one interaction moiety such as a silane-functionalized amine, amino-functionalized silane (aminosilane), or polyamine. Examples of crosslinking agent include dialdehyde, diisocyanates, dihaloalkane, diepoxide and dianhydrides.

The invention relates to the technical field of wound care, in particular to a responsive release microcapsule as well as a preparation method and application thereof. The preparation method comprises the following steps: S1, dissolving a polylactic acid-glycolic acid copolymer in an organic solvent, adding an emulsifier, and carrying out ultrasonic emulsification to form a water-in-oil emulsion; s2, mixing a polyphenol compound, elastin, vegetable fat and probiotic suspension to form a quaternary mixed solution, slowly dropwise adding the quaternary mixed solution into the water-in-oil emulsion, continuing ultrasonic emulsification to form multiple emulsion, and evaporating to remove an organic solvent to obtain a quaternary system active component mixed solution; and S3, dissolving PDMAEMA in deionized water, adding a cross-linking agent, stirring, slowly dropwise adding the quaternary system active component mixed solution, carrying out a cross-linking reaction, and freeze-drying to obtain the responsive release microcapsule. The microcapsule can accurately release corresponding active ingredients according to pH value changes in different stages of wound healing, effectively shorten the wound healing time, improve the healing quality and reduce scar formation.

The invention discloses a wear-resistant composite rubber packing sealing material for an oil pumping unit and a preparation method, and the sealing material is prepared from the following raw materials in parts by weight: a main body rubber material, which comprises 70-90 parts by weight of nitrile rubber and 10-30 parts by weight of polyurethane rubber, based on the total weight of 100 parts; 3-5 parts of zinc oxide; 2-3 parts of stearic acid; 30 to 60 parts of carbon black; 5 to 15 parts of graphite; 20-40 parts of an inorganic nano wear-resistant filler; 3-6 parts of an active agent; 5-10 parts of a softening agent; 2-3 parts of an anti-aging agent; 2-6 parts of an effective vulcanization cross-linking agent and 2-5 parts of a peroxide cross-linking agent; wherein the effective vulcanization cross-linking agent is a mixture of an accelerant and sulfur, and the peroxide cross-linking agent is dicumyl peroxide. According to the wear-resistant composite rubber packing sealing material for the oil pumping unit provided by the invention, by balancing the tensile strength, tearing strength, oil resistance and wear resistance of the material, the comprehensive performance of the material is remarkably improved, and the service life of the material is prolonged.

The invention discloses a medical catheter surface strong interface bonding hydrogel coating method based on subsurface initiated polymerization. The method comprises the steps that firstly, a mixed solvent of an organic solvent and water is adopted for conducting swelling pretreatment on the surface of a catheter base material, so that polymer chains on the surface layer of the base material are relaxed; a solution containing initiator molecules is injected into the inner cavity of the catheter, so that the initiator is diffused and anchored in the subsurface area of the base material; preparing a hydrogel monomer solution containing a hydrophilic monomer, a cross-linking agent and a catalyst, and pouring the hydrogel monomer solution into the inner cavity of the catheter; and finally, sealing the two ends of the conduit, and initiating polymerization reaction under a specific temperature condition, so that the initiator anchored on the subsurface is decomposed to generate free radicals. The hydrogel coating and the catheter base material form a double combination effect of physical interlocking and chemical bonding through a subsurface initiated polymerization mechanism, the firmness and stability of the coating are remarkably improved, and the method is particularly suitable for modification of the inner surfaces of various medical catheters with complex structures.

This invention discloses a method for preparing a pH / glucose dual-responsive chronic wound dressing containing frankincense essential oil, comprising: (1) using 4-formaldehyde phenylboronic acid as a crosslinking agent to form Schiff base and borate ester bonds with carboxymethyl chitosan and two different molecular weight hyaluronic acids, respectively, to prepare a hydrogel capable of filling skin surface wounds and performing dual dynamic covalent crosslinking adhesion, and freeze-drying for later use; (2) preparing frankincense essential oil into microcapsules by emulsification coagulation method, and freeze-drying for later use; (3) mixing the hydrogel with the freeze-dried powder of frankincense essential oil microcapsules, adding deionized water or PBS and stirring to reconstitute to form a pH / glucose dual-responsive hybrid hydrogel dressing coated with frankincense essential oil microcapsules. The composite dressing prepared by this invention has anti-inflammatory, antioxidant, antibacterial, and healing-promoting effects, is quick and easy to prepare, and has the ability to respond to the acidic / high-glucose microenvironment of diabetic wounds, and has important practical application value.

The invention discloses a vaginal repair hydrogel dressing based on microsphere-matrix synergistic response and a preparation method, the vaginal repair hydrogel dressing comprises a GA (at) CC microsphere and an SA-CC dynamic crosslinking matrix, the GA (at) CC microsphere takes glycyrrhizic acid as an active core and takes aldehyde chitosan as a shell layer; the SA-CC dynamic crosslinking matrix is used as a supporting frame, is of a porous honeycomb network structure and is formed by an SA solution, a CC solution and a calcium ion crosslinking agent in a synergistic mode. The GA (at) CC microspheres and the SA-CC dynamic crosslinking matrix are fixed through ionic bonds formed by bridging SA carboxyl and Ca < 2 + > of hydroxyl groups on the surfaces of the GA (at) CC microspheres. Through molecular design of a double-response gating mechanism, multi-network construction of a dynamic crosslinking matrix and space-time collaborative loading of functional components, the bottleneck of the traditional technology in response mechanism compatibility, mechanical-response balance and time-space drug release control is broken through, and comprehensive improvement of double-response accuracy, mechanical stability and function collaboration is achieved.

The invention discloses high-strength deformable porous hydrogel for postoperative abdominal cavity tissue effusion drainage, belongs to the technical field of medical porous hydrogel, and particularly relates to a temperature-sensitive hydrogel reaction solution obtained by adding a monomer, a cross-linking agent and an initiator into water and mixing, and freezing and polymerizing to obtain ice gel; treating the ice gel in a salting-out solution to obtain porous hydrogel; the cross-linking agent is prepared from at least one of N, N-methylene bisacrylamide, N, N-methylene bisacrylamide and polyethylene glycol diacrylate. The invention provides the high-strength deformable porous hydrogel for postoperative abdominal cavity tissue effusion drainage, which has a temperature-sensitive effect, can be dynamically controlled through electric heating, and has good mechanical properties and a good drainage effect.

The invention provides a preparation method and application of cystamine modified hyaluronic acid hydrogel. The preparation method comprises the step of synthesizing hydrogel with a three-dimensional network structure by taking hyaluronic acid as a carrier and cystamine as a cross-linking agent. The insoluble drug is entrapped by the hydrogel, so that the solubility of the insoluble drug is effectively improved. The preparation method disclosed by the invention is simple in process, the prepared hydrogel has excellent performance and has the characteristics of uniform pores, good hydrophilicity, high drug loading capacity and high encapsulation efficiency, and the prepared drug-loaded hydrogel can slowly and continuously release drugs and has good antioxidant and antibacterial properties.

The invention relates to the technical field of gel material preparation, in particular to a bio-based gel material for dangerous chemical leakage disposal and a preparation method thereof.The preparation method comprises the steps that gelatin and deionized water are added into a reaction container, a gelatin solution is obtained under the preset dissolution condition, alkaline protease is added into the gelatin solution for an enzymolysis reaction, and a gelatin solution is obtained; a modified gelatin solution is obtained; the preparation method comprises the following steps: adding a phytic acid-chitosan compound and magnesium-aluminum layered double hydroxide into dispersion equipment, and obtaining a composite inorganic matter dispersion liquid under a preset dispersion condition; adding the modified gelatin solution, the composite inorganic substance dispersion liquid, polyethylene glycol and phase change microcapsules into a mixing reactor, and obtaining a premixed solution under a preset mixing condition; sequentially adding an initiator, a cross-linking agent and tetramethylethylenediamine into the premixed liquid, and performing cross-linking reaction under preset cross-linking conditions to obtain a bio-based gel initial product. The plugging efficiency of the bio-based gel material on dangerous chemical leakage is improved.

The invention discloses an expandable rubber cable pipe plugging device and a preparation method thereof.The expandable rubber cable pipe plugging device is prepared from, by weight, 100 parts of EPDM rubber, 0.5-1.0 part of graphene, 0.2 part of silane coupling agent KH550, 10 parts of sodium carboxymethyl cellulose, 15 parts of sodium acrylate-acrylamide copolymer, 5 parts of polyvinyl alcohol, 8 parts of bentonite, 5 parts of expandable graphite and 3 parts of 4, 4 '-oxybisbenzenesulfonyl hydrazide foaming agent. The anti-aging coating is prepared from the following components in parts by weight: 1 part of zinc stearate, 2.5 parts of peroxide DCP, 2 parts of assistant crosslinker TAIC, 5 parts of zinc oxide, 1 part of stearic acid, 30 parts of fumed silica, 5 parts of modified nano montmorillonite, 20 parts of light calcium carbonate, 1.5 parts of anti-aging agent TMQ, 1 part of anti-aging agent 6PPD, 0.5 part of hindered phenol antioxidant 1076, 2 parts of UV absorbent UV-3292, 8 parts of naphthenic oil, 10 parts of microcapsules and 0.5 part of boron trifluoride diethyl etherate complex catalyst.

The invention discloses a nitrogen-doped porous carbon material and a preparation method thereof, and belongs to the technical field of porous carbon materials, and the preparation method comprises the following steps: adding an amino monomer and a carboxyl monomer into an organic solvent, carrying out a preliminary amidation reaction, further promoting the amidation reaction through heating, then adding an epoxy group cross-linking agent, and carrying out a reaction to obtain the nitrogen-doped porous carbon material. The preparation method comprises the following steps: carrying out amino-epoxy cross-linking reaction on an amino-epoxy resin, carrying out hydrolysis reaction on amide under an alkaline condition, mixing with a chemical activator to obtain a mixed material, putting the mixed material into a high-temperature furnace, carrying out high-temperature carbonization, and finally washing, pickling, filtering and drying the carbonized material to obtain the product. The nitrogen-doped porous carbon material with the nitrogen-doped characteristic, high pore volume, high specific surface area and high micropore rate is obtained by adopting a dual pore-forming strategy of internal nitrogen atom self-doping and chemical activation assisted chemical bond pore-forming, and the nitrogen-doped porous carbon material has the advantages of easily available raw materials, low cost, simple operation process, continuous production and the like, and has practical value and industrial prospect.

The invention discloses a curcumin-containing polyurethane hydrogel for promoting healing of scalded wounds. The hydrogel is prepared by a one-step method under the condition of no solvent and no catalyst. The raw materials comprise biodegradable polyester polyol, polyethylene glycol, bio-based diisocyanate, an acidic response chain extender, a zwitterionic chain extender, curcumin, a biodegradable cross-linking agent and a notoginsenoside aqueous solution. The hydrogel disclosed by the invention has the effect of promoting healing of scalded wounds; in a hemostasis stage, the hydrogel can quickly stop bleeding and construct a physical barrier; in the inflammation stage, the quaternary ammonium salt in the hydrogel and the physically loaded curcumin have a synergistic effect to effectively kill bacteria; in wound remodeling and hyperplasia stages, notoginsenoside slowly released by the hydrogel can regulate inflammatory response, improve collagen deposition and promote granulation tissue hyperplasia and neovascularization. The hydrogel has good biocompatibility, controllable degradation performance and multifunctional biological activity, and can be used as an efficient special dressing for scalded wounds.

The invention discloses a high-strength self-degradable gel temporary plugging agent and a preparation method thereof, and relates to the technical field of oil-gas field development. The temporary plugging agent is prepared by the following steps: firstly, reacting a diprimary amine compound with unsaturated glycidyl to prepare a multi-arm cross-linking agent, then reacting an acrylamide monomer, an acidic monomer, a rigid monomer and a 2-methacryloyloxyethyl phosphorylcholine monomer under the action of the multi-arm cross-linking agent and an initiator, and after the reaction is finished, crushing, drying and granulating to obtain the temporary plugging agent. The high-strength self-degradation gel temporary plugging agent prepared by the invention not only has relatively high strength, but also can be self-degraded, and the permeability recovery rate of a reservoir after degradation is relatively high, so that the influence on the reservoir is relatively small.

The present invention provides a urethane compound capable of obtaining a crosslinking agent that provides high water and oil repellency. The urethane compound (A) is composed of an isocyanate (A1) and a long-chain alcohol (A2) represented by the formula: HO-Z(Y-R) n [wherein each R is independently -O-, -NH-, -O-C(=O)-, -NH-C(=O)-, -C(=O)-NH-, -O-C(=O)-NH-, -NH-C(=O)-O-, -NH-C(=O)-NH-, -NH-S(=O)2-, -S(=O)2-NH-, -NH-(CH2) m -NH-S(=O)2- or -NH-(CH2) m -S(=O)2-NH-, etc. (where m is an integer of 1 to 5), Z is a direct bond or a divalent or trivalent hydrocarbon group having 1 to 5 carbon atoms, and n is 1 or 2].

The invention discloses a bio-based modified high polymer material and a preparation method thereof, and relates to the technical field of high polymer materials. When the bio-based modified high polymer material is prepared, firstly, lignin reacts with terephthalaldehyde to prepare formylated lignin; carrying out multi-component reaction on the aldehyde lignin to obtain modified lignin; the preparation method comprises the following steps: reacting 4-mercaptophenylboronic acid with 1-mercaptoglycerol to prepare a dimercaptoborate cross-linking agent; the preparation method comprises the following steps: reacting isophorone diisocyanate with polytetrahydrofuran ether glycol, and then reacting with a flame-retardant chain extender, 1, 2-propylene glycol and hydroxyethyl methylacrylate to prepare modified polyurethane; and mixing the modified polyurethane, the modified lignin and a dimercaptoborate cross-linking agent, casting and curing to obtain the bio-based modified high polymer material. The bio-based modified high polymer material prepared by the invention has the advantages of flame retardance, antibacterial property, aging resistance, self-repairing property, repeatable processing and high mechanical strength.

The invention relates to the technical field of cables, and provides a fireproof flame-retardant cable and a preparation method thereof. The fireproof flame-retardant cable comprises a conductor, an insulating layer and a sheath layer which are sequentially arranged from inside to outside, and the sheath layer is prepared from, by weight, 40-50 parts of high-density polyethylene, 30-40 parts of ethylene-vinyl acetate copolymer, 30-40 parts of flame retardant, 15-20 parts of filler, 8-10 parts of plasticizer, 2-4 parts of lubricant, 2-4 parts of antioxidant, 2-3 parts of stabilizer and 2-3 parts of cross-linking agent; the flame retardant is prepared from the following component raw materials in parts by weight: 30 to 40 parts of magnesium hydroxide, 10 to 15 parts of aluminum hydroxide, 4 to 5 parts of zinc borate, 3 to 4 parts of diethyl phosphoryl ethyl triethoxy silane and 1 to 1.5 parts of 2-(2-pyridyl) ethyl trimethoxy silane. According to the technical scheme, the problem of insufficient fireproof and flame-retardant performance of the cable in the prior art is solved.

The embodiment of the invention discloses a degradable filling plastic master batch and a preparation method thereof. The degradable filling plastic master batch comprises the following components: a bio-based material, an accelerant, a lubricant, a modifier, an antioxidant, a cross-linking agent and a coupling agent, wherein the bio-based material is polylactic acid; the accelerant is modified starch; the plastic modified material is calcium carbonate; the modifying agent comprises pe wax and / or ebs; the lubricant comprises zinc stearate and POE (Polyolefin Elastomer); the antioxidant is a composition of lignin and phosphite ester; the cross-linking agent is triallyl isocyanate, and / or epoxidized soybean oil; the coupling agent is a silane coupling agent or an aluminic acid coupling agent, can provide the strength of the degradable filling master batch, is not prone to deformation during stretching, has an anti-oxidation effect, is more reinforced and durable, and can achieve the purpose of rapid degradation after waste treatment.

To provide a microsphere-based retroreflective sheet with superior alkali resistance.SOLUTION: A microsphere-based retroreflective sheet 1 comprises a microsphere layer 30 having a plurality of light-transmissive microspheres 31 arranged in a plane, a specular reflective layer 50 facing the microspheres 31, and a light-transmissive focusing layer 40 filling the gap between the microspheres 31 and the specular reflective layer 50. The focusing layer 40 contains an acrylic resin as a base material containing acrylic acid and an epoxy-based or aluminum chelate-based crosslinking agent, where an acrylic acid content of the acrylic resin is 7.00 wt.% or less, and a crosslinking agent content of the acrylic resin is 0.10 or more in equivalent terms.SELECTED DRAWING: Figure 1

A bioprosthetic device includes a frame and a bioprosthetic tissue including collagen and a plurality of holes. The bioprosthetic tissue is attached to the frame. The bioprosthetic device includes a plurality of sutures extending through the plurality of holes. In aspects, a periphery of the plurality of holes has a greater collagen cross-linking density or elastic modulus than a bulk of the bioprosthetic tissue. The bioprosthetic device can be a prosthetic heart valve assembly. Alternatively, a collagen-containing scaffold can have predetermined location with has a greater collagen cross-linking density or elastic modulus than a bulk of the collagen-containing scaffold. Methods include applying a cross-linking agent to a predetermined location. Methods further include cross-linking collagen at the predetermined location by impinging the predetermined location\ with a light beam, but a majority of a surface area of the bioprosthetic tissue does not have collagen cross-linked by the impinging.

The invention provides a tissue repair filling composite gel as well as a preparation method and application thereof, and relates to the technical field of biomedical materials. The composite gel is mainly prepared from hyaluronic acid and biodegradable microspheres through freezing and thawing physical crosslinking, the molecular weight of the hyaluronic acid is 80000-3000000, and the biodegradable microspheres are hydroxyapatite microspheres. The tissue repair filling composite gel is composed of a hyaluronic acid matrix which is obtained through freeze-thaw physical crosslinking and has a porous three-dimensional network structure and hydroxyapatite microspheres uniformly dispersed in the hyaluronic acid matrix, in the filling repair process, hyaluronic acid provides an instant filling effect, the hydroxyapatite microspheres stimulate collagen regeneration, and the tissue repair effect is improved. According to the tissue repair filling composite gel, the technical problems that the safety is poor due to the fact that existing hyaluronic acid gel obtained by relying on a cross-linking agent is used for in-vivo filling, and a regenerative microsphere filling agent is inconvenient to inject and use are effectively solved.

The invention belongs to the technical field of heating bodies, and particularly relates to a preparation method of a porous LSMO heating body. The preparation method comprises the following steps: preparing a metal salt solution by using metal salt and a solvent; adding citric acid into the metal salt solution, and stirring to obtain complex sol; adding a PVA solution into the complex sol, adding or not adding the quantum dot dispersion liquid, and stirring to obtain a mixed solution; adding a pore-forming agent into the mixed solution, and carrying out ball-milling dispersion to obtain a precursor solution; and defoaming the precursor solution, adding a monomer, a cross-linking agent, an initiator and a catalyst, performing injection molding, and then performing drying, degreasing, low-temperature sintering and high-temperature sintering to obtain the porous LSMO heating element. The material disclosed by the invention can stably exist in a high-temperature sintering atmosphere, can be well compatible with an LSMO substrate, does not damage the integrity of a ceramic structure, and can improve the conductivity and the thermal response speed.

The application provides a flexible plugging agent for offshore oil and gas drilling fluid and a preparation method and application thereof, and belongs to the technical field of offshore oil and gas drilling and production. The plugging agent is prepared from the following raw materials: styrene, N-phenylmaleimide, 2-acrylamido-2-methylpropanesulfonic acid, sodium p-styrenesulfonate, 2-methacryloyloxyethylphosphorylcholine, a crosslinking agent, an initiator, a hydrophilic emulsifier, an oleophilic emulsifier and water. The plugging agent has excellent structural stability, heat resistance, salt resistance and hydration stability, has good adaptability to a low-density drilling fluid system, has a flexible deformation capacity, can effectively enter a complex leakage passage to achieve effective plugging, and can maintain the integrity and stability of a plugging layer under drilling fluid circulation shearing, temperature fluctuation and complex downhole conditions, thereby having applicability in a high-temperature and high-pressure drilling environment.

The invention relates to the technical field of biological materials, in particular to collagen gel for injection, a preparation method of the collagen gel and an injection preparation. The method comprises the following steps: providing recombinant humanized collagen subjected to alkali resistance screening, and mixing the recombinant humanized collagen with a stabilizer to prepare a collagen dispersion liquid, which comprises the following steps: activating a cross-linking agent in an alkaline activating solution to obtain an activated cross-linking agent solution; wherein the cross-linking agent is a diepoxide compound; carrying out cross-linking reaction on the activated cross-linking agent solution and the collagen dispersion liquid to form gel; wherein the mass concentration of the collagen dispersion liquid is 5-10%, and the mass ratio of the cross-linking agent to the collagen is 5-10%; the total weight percentage of the collagen and the cross-linking agent is 5.5 to 10.5 percent. The gel with a stable structure can be effectively formed when the content of the cross-linking agent is within the content range, the residual amount of the cross-linking agent is low, and the storage modulus, the swelling degree and the pushing force of the gel are excellent.

The application discloses an injectable self-healing self-assembling protamine extract hydrogel and a preparation method and application thereof, and belongs to the technical field of hydrogel materials and wound repair. The hydrogel is prepared by mixing protamine extract and a crosslinking agent solution; the crosslinking agent solution comprises a salt solution with a final concentration of 0.01-4.5 M, 0.01-0.1 M sodium citrate and 0.01-0.1 M sodium bicarbonate; the protamine extract is mixed with the crosslinking agent solution at different proportions (1%-50%, w / v%) and is stirred at 20-35 DEG C until complete gelation; and a series of hydrogels can be prepared after multiple freeze-thaw cycles. The hydrogel prepared by the application has good self-healing, injectable characteristics, blood compatibility and tissue regeneration capacity, and has a wide application prospect.