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Sinomenine hydrochloride controlled release patch and preparation method thereof

A technology of sinomenine hydrochloride and patch, which is applied in the field of sinomenine hydrochloride controlled-release patch and its preparation, which can solve problems such as easy contact with clothing, loss of viscosity, and easy slipping from affected parts of the skin to achieve compliance , reduce the effect of side effects

Inactive Publication Date: 2010-01-06
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the shortcoming that some cataplasms exist at present is mainly that the adhesiveness between the paste and the skin is not good, and it is easy to slip off from the affected part of the skin when sticking, especially the joints with large activities; Hardens with water, or loses stickiness by absorbing sweat from the skin when applied
CN 03134370.8 discloses sinomenine hydrochloride spray and its preparation method, but there are obvious defects in the skin spray, that is, the mist solution is easy to flow, making it difficult to accurately position the drug, and it is easy to contact with clothing, and it needs to be massaged by hand to treat it. Make the medicine more effective

Method used

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  • Sinomenine hydrochloride controlled release patch and preparation method thereof
  • Sinomenine hydrochloride controlled release patch and preparation method thereof
  • Sinomenine hydrochloride controlled release patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Sinomenine Hydrochloride 1.0g

[0022] Acrylic pressure sensitive adhesive (Eudragit E100) 100.0g

[0023] Succinic acid 3.2g

[0024] Triethyl citrate 40.0g

[0025] Sodium bisulfite 0.15g

[0026] Ethanol 6ml

Embodiment 2

[0028] Sinomenine Hydrochloride 2.0g

[0029] Acrylic pressure sensitive adhesive (Eudragit E100) 100.0g

[0030] Malic acid 4.8g

[0031] Diethyl sebacate 30.0g

[0032] Sodium metabisulfite 0.20g

[0033] Ethanol 4ml

Embodiment 3

[0035] Sinomenine Hydrochloride 4.0g

[0036] Acrylic pressure sensitive adhesive (Eudragit E100) 100.0g

[0037] Fumaric acid 3.3g

[0038] Diethyl phthalate 50.0g

[0039] Thiourea 0.10g

[0040] Ethanol 6ml

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Abstract

The invention relates to a sinomenine hydrochloride controlled release patch, a preparation method thereof and application thereof in treating arthritis, pain relief and the like. The patch comprises sinomenine hydrochloride, a framework material, plasticizing agent, crosslinking agent, antioxidant and solvent. The preparation method can release medicament to local focus parts at a control rate and ensures that the medicament maintains daylong therapeutic effect with little adverse reaction.

Description

technical field [0001] The invention relates to a sinomenine hydrochloride controlled-release patch and a preparation method thereof. The patch has the functions of treating rheumatoid arthritis and analgesia. Background technique [0002] Rheumatism and rheumatoid arthritis are frequently-occurring diseases, mainly in young adults, and the etiology has not been clarified so far. Modern medicine believes that rheumatoid arthritis mostly occurs in rheumatism. It is a kind of inflammation of the synovial membrane in the joint. If it does not heal for a long time, it will lead to thickening of the synovium, formation of pannus, destruction of cartilage and subchondral bone, and finally joint pain. Aberrant and tonic chronic systemic autoimmune disease. Rheumatoid arthritis is mostly an autoimmune disease. It is an inflammatory lesion with varying degrees in various systems and tissues of the whole body, and the lesions of the joints are the most prominent. This disease mostly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/70A61K31/485A61K47/32A61P29/00A61P19/02
Inventor 李馨儒刘艳
Owner PEKING UNIV
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